Holy basil is sometimes called "hot basil" because of its peppery taste. Chemicals in holy basil are thought to decrease pain and swelling. They also might lower blood sugar in people with diabetes. Holy basil oil might act as an antioxidant.
People use holy basil for anxiety, stress, diabetes, high cholesterol, and many other conditions, but there is no good scientific evidence to support any of these uses.
Don't confuse holy basil (Ocimum tenuiflorum) with basil (Ocimum basilicum), which is very commonly used in cooking.
Uses & Effectiveness ?
We currently have no information for HOLY BASIL overview.
When applied to the skin: Holy basil is possibly safe when used as a mouthwash, short-term.
Special Precautions and Warnings
Breast-feeding: There isn't enough reliable information to know if holy basil is safe to use during breast-feeding. Stay on the safe side and avoid use.
Hypothyroidism: People with hypothyroidism have low levels of the thyroid hormone called thyroxine. Holy basil might lower thyroxine levels. In theory, this could worsen hypothyroidism.
Surgery: Holy basil might slow blood clotting, so there is a concern that it could increase the risk of bleeding during and after surgery. Stop using holy basil at least 2 weeks before a scheduled surgery.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with HOLY BASIL
Holy basil might slow blood clotting. Taking holy basil along with medications that also slow clotting might increase the chances of bruising and bleeding. But there isn't enough information to know if this is a big concern.
Some medications that slow blood clotting include include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
Pentobarbital interacts with HOLY BASIL
Pentobarbital causes drowsiness. There is some concern that taking holy basil seed oil with pentobarbital might cause too much drowsiness. But there isn't enough information to know if this is a big concern.
Be cautious with this combination
Agarwal, P. and Nagesh, L. Comparative evaluation of efficacy of 0.2% Chlorhexidine, Listerine and Tulsi extract mouth rinses on salivary Streptococcus mutans count of high school children--RCT. Contemp.Clin Trials 2011;32(6):802-808. View abstract.
Ahmed, M., Ahamed, R. N., Aladakatti, R. H., and Ghosesawar, M. G. Reversible anti-fertility effect of benzene extract of Ocimum sanctum leaves on sperm parameters and fructose content in rats. J Basic Clin Physiol Pharmacol. 2002;13(1):51-59. View abstract.
Archana, R. and Namasivayam, A. A comparative study of different crude extracts of Ocimum sanctum on noise stress. Phytother.Res 2002;16(6):579-580. View abstract.
Archana, R. and Namasivayam, A. Effect of Ocimum sanctum on noise induced changes in neutrophil functions. J Ethnopharmacol. 2000;73(1-2):81-85. View abstract.
Aruna, K. and Sivaramakrishnan, V. M. Anticarcinogenic effects of some Indian plant products. Food Chem.Toxicol 1992;30(11):953-956. View abstract.
Balanehru, S. and Nagarajan, B. Protective effect of oleanolic acid and ursolic acid against lipid peroxidation. Biochem.Int 1991;24(5):981-990. View abstract.
Banerjee, S., Prashar, R., Kumar, A., and Rao, A. R. Modulatory influence of alcoholic extract of Ocimum leaves on carcinogen-metabolizing enzyme activities and reduced glutathione levels in mouse. Nutr.Cancer 1996;25(2):205-217. View abstract.
Bhat, J., Damle, A., Vaishnav, P. P., Albers, R., Joshi, M., and Banerjee, G. In vivo enhancement of natural killer cell activity through tea fortified with Ayurvedic herbs. Phytother.Res 2010;24(1):129-135. View abstract.
Bhattacharya, S. K., Bhattacharya, A., and Chakrabarti, A. Adaptogenic activity of Siotone, a polyherbal formulation of Ayurvedic rasayanas. Indian J Exp.Biol. 2000;38(2):119-128. View abstract.
Chattopadhyay, R. R. A comparative evaluation of some blood sugar lowering agents of plant origin. J Ethnopharmacol. 11-30-1999;67(3):367-372. View abstract.
Chattopadhyay, R. R. Hypoglycemic effect of Ocimum sanctum leaf extract in normal and streptozotocin diabetic rats. Indian J Exp.Biol. 1993;31(11):891-893. View abstract.
Devi, P. U. and Ganasoundari, A. Modulation of glutathione and antioxidant enzymes by Ocimum sanctum and its role in protection against radiation injury. Indian J Exp.Biol. 1999;37(3):262-268. View abstract.
Devi, P. U. and Ganasoundari, A. Radioprotective effect of leaf extract of Indian medicinal plant Ocimum sanctum. Indian J Exp.Biol. 1995;33(3):205-208. View abstract.
Devi, P. U., Bisht, K. S., and Vinitha, M. A comparative study of radioprotection by Ocimum flavonoids and synthetic aminothiol protectors in the mouse. Br J Radiol. 1998;71(847):782-784. View abstract.
Dharmani, P., Kuchibhotla, V. K., Maurya, R., Srivastava, S., Sharma, S., and Palit, G. Evaluation of anti-ulcerogenic and ulcer-healing properties of Ocimum sanctum Linn. J Ethnopharmacol. 2004;93(2-3):197-206. View abstract.
Ganasoundari, A., Devi, P. U., and Rao, B. S. Enhancement of bone marrow radioprotection and reduction of WR-2721 toxicity by Ocimum sanctum. Mutat.Res 2-2-1998;397(2):303-312. View abstract.
Ganasoundari, A., Devi, P. U., and Rao, M. N. Protection against radiation-induced chromosome damage in mouse bone marrow by Ocimum sanctum. Mutat.Res 2-3-1997;373(2):271-276. View abstract.
Ganasoundari, A., Zare, S. M., and Devi, P. U. Modification of bone marrow radiosensensitivity by medicinal plant extracts. Br J Radiol. 1997;70(834):599-602. View abstract.
Geeta, Vasudevan, D. M., Kedlaya, R., Deepa, S., and Ballal, M. Activity of Ocimum sanctum (the traditional Indian medicinal plant) against the enteric pathogens. Indian J Med Sci 2001;55(8):434-8, 472. View abstract.
Geetha, R. K. and Vasudevan, D. M. Inhibition of lipid peroxidation by botanical extracts of Ocimum sanctum: in vivo and in vitro studies. Life Sci 11-19-2004;76(1):21-28. View abstract.
Gholap, S. and Kar, A. Hypoglycaemic effects of some plant extracts are possibly mediated through inhibition in corticosteroid concentration. Pharmazie 2004;59(11):876-878. View abstract.
Goel, R. K., Sairam, K., Dorababu, M., Prabha, T., and Rao, ChV. Effect of standardized extract of Ocimum sanctum Linn. on gastric mucosal offensive and defensive factors. Indian J Exp.Biol. 2005;43(8):715-721. View abstract.
Grover, J. K., Vats, V., and Yadav, S. S. Pterocarpus marsupium extract (Vijayasar) prevented the alteration in metabolic patterns induced in the normal rat by feeding an adequate diet containing fructose as sole carbohydrate. Diabetes Obes.Metab 2005;7(4):414-420. View abstract.
Jagetia, G. C. and Baliga, M. S. The evaluation of nitric oxide scavenging activity of certain Indian medicinal plants in vitro: a preliminary study. J Med Food 2004;7(3):343-348. View abstract.
Kantak, N. M. and Gogate, M. G. Effect of short term administration of Tulsi (Ocimum sanctum Linn.) on reproductive behaviour of adult male rats. Indian J Physiol Pharmacol. 1992;36(2):109-111. View abstract.
Karthikeyan, K., Ravichandran, P., and Govindasamy, S. Chemopreventive effect of Ocimum sanctum on DMBA-induced hamster buccal pouch carcinogenesis. Oral Oncol. 1999;35(1):112-119. View abstract.
Mandal, S., Das, D. N., De, K., Ray, K., Roy, G., Chaudhuri, S. B., Sahana, C. C., and Chowdhuri, M. K. Ocimum sanctum Linn--a study on gastric ulceration and gastric secretion in rats. Indian J Physiol Pharmacol. 1993;37(1):91-92. View abstract.
Mondal, S., Mirdha, B. R., and Mahapatra, S. C. The science behind sacredness of Tulsi (Ocimum sanctum Linn.). Indian J Physiol Pharmacol. 2009;53(4):291-306. View abstract.
Mondal, S., Varma, S., Bamola, V. D., Naik, S. N., Mirdha, B. R., Padhi, M. M., Mehta, N., and Mahapatra, S. C. Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers. J Ethnopharmacol. 7-14-2011;136(3):452-456. View abstract.
Panda, S. and Kar, A. Ocimum sanctum leaf extract in the regulation of thyroid function in the male mouse. Pharmacol.Res 1998;38(2):107-110. View abstract.
Prashar, R., Kumar, A., Banerjee, S., and Rao, A. R. Chemopreventive action by an extract from Ocimum sanctum on mouse skin papillomagenesis and its enhancement of skin glutathione S-transferase activity and acid soluble sulfydryl level. Anticancer Drugs 1994;5(5):567-572. View abstract.
Rai, V., Iyer, U., and Mani, U. V. Effect of Tulasi (Ocimum sanctum) leaf powder supplementation on blood sugar levels, serum lipids and tissue lipids in diabetic rats. Plant Foods Hum.Nutr. 1997;50(1):9-16. View abstract.
Rani, P. and Khullar, N. Antimicrobial evaluation of some medicinal plants for their anti-enteric potential against multi-drug resistant Salmonella typhi. Phytother.Res 2004;18(8):670-673. View abstract.
Ravindran, R., Rathinasamy, S. D., Samson, J., and Senthilvelan, M. Noise-stress-induced brain neurotransmitter changes and the effect of Ocimum sanctum (Linn) treatment in albino rats. J Pharmacol.Sci 2005;98(4):354-360. View abstract.
Samson, J., Sheela, Devi R., Ravindran, R., and Senthilvelan, M. Biogenic amine changes in brain regions and attenuating action of Ocimum sanctumin noise exposure. Pharmacol.Biochem.Behav. 2006;83(1):67-75. View abstract.
Samudralwar, D. L. and Garg, A. N. Minor and trace elemental determination in the Indian herbal and other medicinal preparations. Biol.Trace Elem.Res 1996;54(2):113-121. View abstract.
Sarkar, A., Lavania, S. C., Pandey, D. N., and Pant, M. C. Changes in the blood lipid profile after administration of Ocimum sanctum (Tulsi) leaves in the normal albino rabbits. Indian J Physiol Pharmacol. 1994;38(4):311-312. View abstract.
Sembulingam, K., Sembulingam, P., and Namasivayam, A. Effect of Ocimum sanctum Linn on noise induced changes in plasma corticosterone level. Indian J Physiol Pharmacol. 1997;41(2):139-143. View abstract.
Sembulingam, K., Sembulingam, P., and Namasivayam, A. Effect of Ocimum sanctum Linn on the changes in central cholinergic system induced by acute noise stress. J Ethnopharmacol. 1-15-2005;96(3):477-482. View abstract.
Sen, P., Maiti, P. C., Puri, S., Ray, A., Audulov, N. A., and Valdman, A. V. Mechanism of anti-stress activity of Ocimum sanctum Linn, eugenol and Tinospora malabarica in experimental animals. Indian J Exp.Biol. 1992;30(7):592-596. View abstract.
Sharma, M., Kishore, K., Gupta, S. K., Joshi, S., and Arya, D. S. Cardioprotective potential of ocimum sanctum in isoproterenol induced myocardial infarction in rats. Mol.Cell Biochem. 2001;225(1-):75-83. View abstract.
Shokeen, P., Ray, K., Bala, M., and Tandon, V. Preliminary studies on activity of Ocimum sanctum, Drynaria quercifolia, and Annona squamosa against Neisseria gonorrhoeae. Sex Transm.Dis. 2005;32(2):106-111. View abstract.
Singh, S., Majumdar, D. K., and Rehan, H. M. Evaluation of anti-inflammatory potential of fixed oil of Ocimum sanctum (Holybasil) and its possible mechanism of action. J Ethnopharmacol. 1996;54(1):19-26. View abstract.
Singh, S., Majumdar, D. K., and Yadav, M. R. Chemical and pharmacological studies on fixed oil of Ocimum sanctum. Indian J Exp.Biol. 1996;34(12):1212-1215. View abstract.
Subramanian, M., Chintalwar, G. J., and Chattopadhyay, S. Antioxidant and radioprotective properties of an Ocimum sanctum polysaccharide. Redox.Rep. 2005;10(5):257-264. View abstract.
Udupa, S. L., Shetty, S., Udupa, A. L., and Somayaji, S. N. Effect of Ocimum sanctum Linn. on normal and dexamethasone suppressed wound healing. Indian J Exp.Biol. 2006;44(1):49-54. View abstract.
Uma, Devi P., Ganasoundari, A., Rao, B. S., and Srinivasan, K. K. In vivo radioprotection by ocimum flavonoids: survival of mice. Radiat.Res 1999;151(1):74-78. View abstract.
Uma, Devi P., Ganasoundari, A., Vrinda, B., Srinivasan, K. K., and Unnikrishnan, M. K. Radiation protection by the ocimum flavonoids orientin and vicenin: mechanisms of action. Radiat.Res 2000;154(4):455-460. View abstract.
Vats, V., Yadav, S. P., and Grover, J. K. Ethanolic extract of Ocimum sanctum leaves partially attenuates streptozotocin-induced alterations in glycogen content and carbohydrate metabolism in rats. J Ethnopharmacol. 2004;90(1):155-160. View abstract.
Vohora, S. B., Garg, S. K., and Chaudhury, R. R. Antifertility screening of plants. 3. Effect of six indigenous plants on early pregnancy in albino rats. Indian J Med Res 1969;57(5):893-899. View abstract.
Vrinda, B. and Uma, Devi P. Radiation protection of human lymphocyte chromosomes in vitro by orientin and vicenin. Mutat.Res 11-15-2001;498(1-2):39-46. View abstract.
Yanpallewar, S. U., Rai, S., Kumar, M., and Acharya, S. B. Evaluation of antioxidant and neuroprotective effect of Ocimum sanctum on transient cerebral ischemia and long-term cerebral hypoperfusion. Pharmacol.Biochem.Behav. 2004;79(1):155-164. View abstract.
Agrawal P, Rai V, Singh RB. Randomized placebo-controlled, single blind trial of holy basil leaves in patients with noninsulin-dependent diabetes mellitus. Int J Clin Pharmacol Ther 1996;34:406-9. View abstract.
Asha MK, Prashanth D, Murali B, et al. Anthelmintic activity of essential oil of Ocimum sanctum and eugenol. Fitoterapia 2001;72:669-70. View abstract.
Bhattacharyya D, Sur TK, Jana U, et al. Controlled programmed trial of Ocimum sanctum leaf on generalized anxiety disorders. Nepal.Med.Coll.J 2008;10:176-79. View abstract.
Godhwani S, Godhwani JL, Vyas DS. Ocimum sanctum: an experimental study evaluating its anti-inflammatory, analgesic and antipyretic activity in animals. J Ethnopharmacol 1987;21:153-63. View abstract.
Gupta D, Bhaskar DJ, Gupta RK, et al. A randomized controlled clinical trial of Ocimum sanctum and chlorhexidine mouthwash on dental plaque and gingival inflammation. J Ayurveda Integr Med 2014;5(2):109-16. View abstract.
Gupta SK, Prakash J, Srivastava S. Validation of traditional claim of Tulsi, Ocimum sanctum Linn. as a medicinal plant. Indian J Exp Biol 2002;40:765-73. View abstract.
Jaggi RK, Madaan R, Singh B. Anticonvulsant potential of holy basil, Ocimum sanctum Linn. and its cultures. Indian J Exp Biol 2003;41:1329-33. View abstract.
Juntachote T, Berghofer E, Siebenhandl S, Bauer F. Antioxidative properties and stability of ethanolic extracts of Holy basil and Galangal. Meat Sci 2006;72(3):446-56. View abstract.
Kar A, Choudhary BK, Bandyopadhyay NG. Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. J Ethnopharmacol 2003;84:105-8. View abstract.
Kasinathan S, Ramakrishnan S, Basu SL. Antifertility effect of Ocimum sanctum L. Indian J Exp Biol 1972;10:23-5.
Kelm MA, Nair MG, Strasburg GM, DeWitt DL. Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn. Phytomedicine 2000;7:7-13. View abstract.
Khanna N, Bhatia J. Antinociceptive action of Ocimum sanctum (Tulsi) in mice: possible mechanisms involved. J Ethnopharmacol 2003;88:293-6. View abstract.
Khanna S, Gupta SR, Grover JK. Effect of long term feeding of tulsi (Ocimum sanctum Linn) on reproductive performance of adult albino rats. Indian J Exp Biol 1986;24(5):302-4. View abstract.
Kothiwale SV, Patwardhan V, Gandhi M, Sohoni R, Kumar A. A comparative study of antiplaque and antigingivitis effects of herbal mouthrinse containing tea tree oil, clove, and basil with commercially available essential oil mouthrinse. J Indian Soc Periodontol. 2014 May;18(3):316-20. View abstract.
Kumar A, Agarwal K, Maurya AK, et al. Pharmacological and phytochemical evaluation of Ocimum sanctum root extracts for its antiinflammatory, analgesic and antipyretic activities. Pharmacogn Mag 2015;11(Suppl 1):S217-24. View abstract.
Mediratta PK, Sharma KK, Singh S. Evaluation of immunomodulatory potential of Ocimum sanctum seed oil and its possible mechanism of action. J Ethnopharmacol 2002;80:15-20. View abstract.
Mohan L, Amberkar MV, Kumari M. Ocimum sanctum Linn (Tulsi) - An overview. Int J Pharma Sci Rev Res. 2011;7(1):51-3.
Muruganandam AV, Kumar V, Bhattacharya SK. Effect of poly herbal formulation, EuMil, on chronic stress-induced homeostatic perturbations in rats. Indian J Exp Biol 2002;40:1151-60. View abstract.
Nadar BG, Usha GV, Lakshminarayan N. Comparative evaluation of efficacy of 4% tulsi extract (Ocimum sanctum), fluoridated and placebo dentifrices against gingivitis and plaque among 14-15 years school children in Davangere City, India - a triple blinded randomized clinical trial. Contemp Clin Dent 2020;11(1):67-75. View abstract.
Pandey G, Madhuri S. Pharmacological activities of Ocimum sanctum (Tulsi): a review. Int J Pharma Sci Rev Res 2010;5(1):61-6.
Penmetsa GS, Pitta SR. Efficacy of Ocimum sanctum, Aloe vera and chlorhexidine mouthwash on gingivitis: A randomized controlled comparative clinical study. Ayu. 2019;40(1):23-26. View abstract.
Prakash J, Gupta SK. Chemopreventive activity of Ocimum sanctum seed oil. J Ethnopharmacol 2000;72:29-34. View abstract.
Raina AP, Kumar A, Dutta M. Chemical characterization of aroma compounds in essential oil isolated from ''Holy Basil'' (Ocimum tenuiflorum L.) grown in India. Genet Resour Crop Evol 2013;60:1727-35.
Sakina MR, Dandiya PC, Hamdard ME, Hameed A. Preliminary psychopharmacological evaluation of Ocimum sanctum leaf extract. J Ethnopharmacol 1990;28:143-50. View abstract.
Sarangi SC, Joshi D, Kumar R, Kaleekal T, Gupta YK. Pharmacokinetic and pharmacodynamic interaction of hydroalcoholic extract of Ocimum sanctum with valproate. Epilepsy Behav 2017;75:203-9. View abstract.
Satapathy S, Das N, Bandyopadhyay D, et al. Effect of tulsi (Ocimum sanctum Linn.) supplementation on metabolic parameters and liver enzymes in young overweight and obese subjects. Indian J Clin Biochem 2017;32(3):357-63. View abstract.
Saxena RC, Singh R, Kumar P, et al. Efficacy of an extract of Ocimum tenuiflorum (OciBest) in the management of general stress: a double-blind, placebo-controlled study. Evid Based Complement Alternat Med 2012;2012:894509. Epub 2011 Oct 3. View abstract.
Seth SD, Johri N, Sundaram KR. Antispermatogenic effect of Ocimum sanctum. Indian J Exp Biol 1981;19:975-6.
Sharma MK, Kumar M, Kumar A. Ocimum sanctum aqueous leaf extract provides protection against mercury induced toxicity in Swiss albino mice. Indian J Exp Biol 2002;40:1079-82. View abstract.
Singh S, Majumdar DK. Effect of Ocimum sanctum fixed oil on vascular permeability and leucocytes migration. Indian J Exp Biol 1999 37:1136-8. View abstract.
Singh S, Majumdar DK. Evaluation of antiinflammatory activity of fatty acids of Ocimum sanctum fixed oil. Indian J Exp Biol 1997;35:380-3. View abstract.
Singh S, Majumdar DK. Evaluation of the gastric antiulcer activity of fixed oil of Ocimum sanctum (Holy Basil). J Ethnopharmacol 1999;65:13-9. View abstract.
Singh S, Rehan HM, Majumdar DK. Effect of Ocimum sanctum fixed oil on blood pressure, blood clotting time and pentobarbitone-induced sleeping time. J Ethnopharmacol 2001;78:139-43. View abstract.
Singh S. Comparative evaluation of antiinflammatory potential of fixed oil of different species of Ocimum and its possible mechanism of action. Indian J Exp Biol 1998;36:1028-31. View abstract.
Singh, S., Malhotra, M., and Majumdar, D. K. Antibacterial activity of Ocimum sanctum L. fixed oil. Indian J Exp Biol 2005;43(9):835-837. View abstract.
Somasundaram G, Manimekalai K, Salwe KJ, Pandiamunian J. Evaluation of the antidiabetic effect of Ocimum sanctum in type 2 diabetes patients. Int J Life Sci Pharma Res 2012;2(3):75-81.
Vats V, Grover JK, Rathi SS. Evaluation of anti-hyperglycemic and hypoglycemic effect of Trigonella foenum-graecum Linn, Ocimum sanctum Linn and Pterocarpus marsupium Linn in normal and alloxanized diabetic rats. J Ethnopharmacol 2002;79:95-100. View abstract.
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