SALACIA

OTHER NAME(S):

Chundan, Kathala Hibutu Tea, Ponkoranti, SO, S. oblonga, Salacia oblonga, Salacia reticulata.<br/><br/>

Overview

Overview Information

Salacia is an herb that is native to India and Sri Lanka. The root and stem are used to make medicine.

Salacia has a long history of use as a treatment for diabetes in Ayurveda, traditional Indian medicine. Mugs made from salacia wood are used by people with diabetes to drink water.

In addition to treating diabetes, salacia is used for treating gonorrhea, asthma, itchiness, joint pain (rheumatism), obesity, thirst, and menstrual problems.

How does it work?

Chemicals in salacia seem to prevent sugars in food from being absorbed by the body.

Uses

Uses & Effectiveness?

Possibly Effective for

  • Diabetes. Early research suggests that consuming salacia tea with each meal might lower hemoglobin A1C (HbA1C) levels in people with type 2 diabetes. HbA1C is a measure of blood sugar control. A single dose of salacia, in combination with a meal, also seems to reduce after-meal insulin levels and reduce after-meal blood sugar in healthy volunteers and in people with type 2 diabetes. These reductions indicate better blood sugar control. Other early research suggests that taking salacia with food for 6 weeks seems to reduce pre-meal blood sugar and HbA1C levels in patients with type 2 diabetes.

Insufficient Evidence for

More evidence is needed to rate the effectiveness of salacia for these uses.

Side Effects

Side Effects & Safety

Salacia is POSSIBLY SAFE when taken by mouth, short-term. Single doses of salacia can be consumed safely in doses up to 1000 mg. Consuming salacia tea with food seems to be safe for most people for up to three months. There isn't enough information to know if salacia is safe when used for long periods of time.

Salacia can cause uncomfortable side effects such as gas, belching, pain in the abdomen, nausea, and diarrhea in some people.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking salacia if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Diabetes: Salacia can decrease blood sugar levels. Your diabetes medications might need to be adjusted by your healthcare provider.

Surgery: Salacia might lower blood sugar levels. There is some concern that it might interfere with blood sugar control during and after surgery. Stop using salacia at least 2 weeks before a scheduled surgery.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!

  • Medications for diabetes (Antidiabetes drugs) interacts with SALACIA

    Salacia might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking salacia along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.<br><nb>Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Dosing

Dosing

The appropriate dose of salacia depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for salacia. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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View References

REFERENCES:

  • Akase, T., Shimada, T., Harasawa, Y., Akase, T., Ikeya, Y., Nagai, E., Iizuka, S., Nakagami, G., Iizaka, S., Sanada, H., and Aburada, M. Preventive Effects of View abstract.
  • Arra, G. S., Arutla, S., and Krishna, D. R. Transdermal delivery of isosorbide 5-mononitrate from a new membrane reservoir and matrix-type patches. Drug Dev.Ind.Pharm 1998;24(5):489-492. View abstract.
  • Augusti, K. T., Joseph, P., and Babu, T. D. Biologically active principles isolated from View abstract.
  • Bates, R. B., Haber, W. A., Setzer, W. N., and Stessman, C. C. Cyclic hemiacetals with seven-membered rings from an undescribed View abstract.
  • Benalla, W., Bellahcen, S., and Bnouham, M. Antidiabetic medicinal plants as a source of alpha glucosidase inhibitors. Curr.Diabetes Rev. 7-1-2010;6(4):247-254. View abstract.
  • Bhat, R. G., Kumar, N. S., and Pinto, B. M. Synthesis of phosphate derivatives related to the glycosidase inhibitor salacinol. Carbohydr.Res. 9-3-2007;342(12-13):1934-1942. View abstract.
  • Carvalho, P. R., Silva, D. H., Bolzani, V. S., and Furlan, M. Antioxidant quinonemethide triterpenes from View abstract.
  • Chandrashekar, C., Madhyastha, S., and Benjamin, S. Wight extracts on drug induced diabetes mellitus in rats. Herba Polonica 2008;54:46-58.
  • Chen, W. and Pinto, B. M. Synthesis of aza- and thia-spiroheterocycles and attempted synthesis of spiro sulfonium compounds related to salacinol. Carbohydr.Res. 11-5-2007;342(15):2163-2172. View abstract.
  • Chen, W., Kuntz, D. A., Hamlet, T., Sim, L., Rose, D. R., and Mario, Pinto B. Synthesis, enzymatic activity, and X-ray crystallography of an unusual class of amino acids. Bioorg.Med Chem. 12-15-2006;14(24):8332-8340. View abstract.
  • Chen, W., Sim, L., Rose, D. R., and Pinto, B. M. Synthesis of analogues of salacinol containing a carboxylate inner salt and their inhibitory activities against human maltase glucoamylase. Carbohydr.Res. 9-3-2007;342(12-13):1661-1667. View abstract.
  • Choubdar, N. and Pinto, B. M. Attempted synthesis of 2-acetamido and 2-amino derivatives of salacinol. Ring opening reactions. J Org.Chem. 6-9-2006;71(12):4671-4674. View abstract.
  • Choubdar, N., Bhat, R. G., Stubbs, K. A., Yuzwa, S., and Pinto, B. M. Synthesis of 2-amido, 2-amino, and 2-azido derivatives of the nitrogen analogue of the naturally occurring glycosidase inhibitor salacinol and their inhibitory activities against O-GlcNAcase and NagZ enzymes. Carbohydr.Res. 7-21-2008;343(10-11):1766-1777. View abstract.
  • Choubdar, N., Sim, L., Rose, D. R., and Pinto, B. M. Synthesis of 2-deoxy-2-fluoro and 1,2-ene derivatives of the naturally occurring glycosidase inhibitor, salacinol, and their inhibitory activities against recombinant human maltase glucoamylase. Carbohydr.Res. 4-7-2008;343(5):951-956. View abstract.
  • Clemens, R. A. and Pressman, P. Questioning the clinical significance of View abstract.
  • Corsino, J., de Carvalho, P. R., Kato, M. J., Latorre, L. R., Oliveira, O. M., Araujo, A. R., Bolzani, V. D., Franca, S. C., Pereira, A. M., and Furlan, M. Biosynthesis of friedelane and quinonemethide triterpenoids is compartmentalized in Maytenus aquifolium and View abstract.
  • Deepa, M. A. and Narmatha, Bai, V. Antibacterial activity of View abstract.
  • Duarte, L. P., Silva de Miranda, R. R., Rodrigues, S. B., de Fatima Silva, G. D., Vieira Filho, S. A., and Knupp, V. F. Stereochemistry of 16a-hydroxyfriedelin and 3-Oxo-16-methylfriedel-16-ene established by 2D NMR spectroscopy. Molecules. 2009;14(2):598-607. View abstract.
  • Eskandari, R., Jayakanthan, K., Kuntz, D. A., Rose, D. R., and Pinto, B. M. Synthesis of a biologically active isomer of kotalanol, a naturally occurring glucosidase inhibitor. Bioorg.Med Chem. 4-15-2010;18(8):2829-2835. View abstract.
  • Eskandari, R., Jones, K., Rose, D. R., and Pinto, B. M. Probing the active-site requirements of human intestinal N-terminal maltase glucoamylase: the effect of replacing the sulfate moiety by a methyl ether in ponkoranol, a naturally occurring alpha-glucosidase inhibitor. Bioorg.Med Chem.Lett. 10-1-2010;20(19):5686-5689. View abstract.
  • Eskandari, R., Kuntz, D. A., Rose, D. R., and Pinto, B. M. Potent glucosidase inhibitors: de-O-sulfonated ponkoranol and its stereoisomer. Org.Lett. 4-2-2010;12(7):1632-1635. View abstract.
  • Figueiredo, J. N., Raz, B., and Sequin, U. Novel quinone methides from View abstract.
  • Flammang, A. M., Erexson, G. L., Mecchi, M. S., and Murli, H. Genotoxicity testing of a View abstract.
  • Flammang, A. M., Erexson, G. L., Mirwald, J. M., and Henwood, S. M. Toxicological and cytogenetic assessment of a View abstract.
  • Gallienne, E., Gefflaut, T., Bolte, J., and Lemaire, M. Synthesis of new nitrogen analogues of salacinol and deoxynojirimycin and their evaluation as glycosidase inhibitors. J Org.Chem. 2-3-2006;71(3):894-902. View abstract.
  • Gao, H. Y., Guo, Z. H., Cheng, P., Xu, X. M., and Wu, L. J. New triterpenes from View abstract.
  • Gao, X. H., Xie, N., and Feng, F. [Studies on chemical constituents of View abstract.
  • Gessler, M. C., Nkunya, M. H., Mwasumbi, L. B., Heinrich, M., and Tanner, M. Screening Tanzanian medicinal plants for antimalarial activity. Acta Trop. 1994;56(1):65-77. View abstract.
  • Ghavami, A., Chen, J. J., and Mario, Pinto B. Synthesis of a novel class of sulfonium ions as potential inhibitors of UDP-galactopyranose mutase. Carbohydr.Res. 1-22-2004;339(2):401-407. View abstract.
  • Ghavami, A., Johnston, B. D., and Pinto, B. M. A new class of glycosidase inhibitor: synthesis of salacinol and its stereoisomers. J Org.Chem. 4-6-2001;66(7):2312-2317. View abstract.
  • Ghavami, A., Johnston, B. D., Jensen, M. T., Svensson, B., and Pinto, B. M. Synthesis of nitrogen analogues of salacinol and their evaluation as glycosidase inhibitors. J Am.Chem.Soc. 7-4-2001;123(26):6268-6271. View abstract.
  • Ghavami, A., Johnston, B., and Maddess, M. Synthesis of 1,4-anhydro-D-xylitol heteroanalogues of the naturally occurring glycosidase inhibitor salacinol and their evaluation as glycosidase inhibitors. Canadian Journal of Chemistry 2002;80(8):937-942.
  • Giron, M. D., Sevillano, N., Salto, R., Haidour, A., Manzano, M., Jimenez, M. L., Rueda, R., and Lopez-Pedrosa, J. M. View abstract.
  • Guo, Z. H., Xi, R. G., Wang, X. B., Wu, L. J., and Gao, H. Y. [A new trincallane derivative from View abstract.
  • He, L., Qi, Y., Rong, X., Jiang, J., Yang, Q., Yamahara, J., Murray, M., and Li, Y. The Ayurvedic medicine View abstract.
  • Huang, T. H., He, L., Qin, Q., Yang, Q., Peng, G., Harada, M., Qi, Y., Yamahara, J., Roufogalis, B. D., and Li, Y. View abstract.
  • Huang, T. H., Peng, G., Li, G. Q., Yamahara, J., Roufogalis, B. D., and Li, Y. View abstract.
  • Im, R., Mano, H., Matsuura, T., Nakatani, S., Shimizu, J., and Wada, M. Mechanisms of blood glucose-lowering effect of aqueous extract from stems of Kothala himbutu ( View abstract.
  • Im, R., Mano, H., Nakatani, S., Shimizu, J., and Wada, M. Safety evaluation of the aqueous extract Kothala himbutu ( View abstract.
  • Jayakanthan, K., Mohan, S., and Pinto, B. M. Structure proof and synthesis of kotalanol and de-O-sulfonated kotalanol, glycosidase inhibitors isolated from an herbal remedy for the treatment of type-2 diabetes. J Am.Chem.Soc. 4-22-2009;131(15):5621-5626. View abstract.
  • Johnson, M. A., Jensen, M. T., Svensson, B., and Pinto, B. M. Selection of a high-energy bioactive conformation of a sulfonium-ion glycosidase inhibitor by the enzyme glucoamylase G2. J Am.Chem.Soc. 5-14-2003;125(19):5663-5670. View abstract.
  • Johnston, B. D., Ghavami, A., Jensen, M. T., Svensson, B., and Pinto, B. M. Synthesis of selenium analogues of the naturally occurring glycosidase inhibitor salacinol and their evaluation as glycosidase inhibitors. J Am.Chem.Soc. 7-17-2002;124(28):8245-8250. View abstract.
  • Johnston, B. D., Jensen, H. H., and Pinto, B. M. Synthesis of sulfonium sulfate analogues of disaccharides and their conversion to chain-extended homologues of salacinol: new glycosidase inhibitors. J Org.Chem. 2-3-2006;71(3):1111-1118. View abstract.
  • Kajimoto, O., Kawamori, S., and Shimoda, H. Effects of a diet containing
  • Karunanayake, E. H. and Sirimanne, S. R. Mangiferin from the root bark of View abstract.
  • Karunanayake, E. H., Welihinda, J., Sirimanne, S. R., and Sinnadorai, G. Oral hypoglycaemic activity of some medicinal plants of Sri Lanka. J Ethnopharmacol. 1984;11(2):223-231. View abstract.
  • Kishi, A., Morikawa, T., Matsuda, H., and Yoshikawa, M. Structures of new friedelane- and norfriedelane-type triterpenes and polyacylated eudesmane-type sesquiterpene from View abstract.
  • Kishino, E., Ito, T., Fujita, K., and Kiuchi, Y. A mixture of the View abstract.
  • Kishino, E., Ito, T., Fujita, K., and Kiuchi, Y. A mixture of View abstract.
  • Krishnakumar, K., Augusti, K. T., and Vijayammal, P. L. Anti-peroxidative and hypoglycaemic activity of View abstract.
  • Krishnakumar, K., Augusti, K. T., and Vijayammal, P. L. Hypoglycaemic and anti-oxidant activity of View abstract.
  • Krishnan, V. and Rangaswami, S. Proanthocyanidins of View abstract.
  • Kumar, N. S. and Pinto, B. M. Synthesis of D-lyxitol and D-ribitol analogues of the naturally occurring glycosidase inhibitor salacinol. Carbohydr.Res. 12-12-2005;340(17):2612-2619. View abstract.
  • Kumara, N., Pathirana, R., and Pathirana, C. Hypoglycemic activity of the root and stem of
  • Li, Y., Huang, T. H., and Yamahara, J. View abstract.
  • Liu, H. and Pinto, B. M. Efficient synthesis of the glucosidase inhibitor blintol, the selenium analogue of the naturally occurring glycosidase inhibitor salacinol. J Org.Chem. 1-21-2005;70(2):753-755. View abstract.
  • Liu, H., Nasi, R., Jayakanthan, K., Sim, L., Heipel, H., Rose, D. R., and Pinto, B. M. New synthetic routes to chain-extended selenium, sulfur, and nitrogen analogues of the naturally occurring glucosidase inhibitor salacinol and their inhibitory activities against recombinant human maltase glucoamylase. J Org.Chem. 8-17-2007;72(17):6562-6572. View abstract.
  • Liu, H., Sim, L., Rose, D. R., and Pinto, B. M. A new class of glucosidase inhibitor: analogues of the naturally occurring glucosidase inhibitor salacinol with different ring heteroatom substituents and acyclic chain extension. J Org.Chem. 4-14-2006;71(8):3007-3013. View abstract.
  • Matsuura, T., Yoshikawa, Y., Masui, H., and Sano, M. [Suppression of glucose absorption by various health teas in rats]. Yakugaku Zasshi 2004;124(4):217-223. View abstract.
  • Minami, Y., Kuriyama, C., Ikeda, K., Kato, A., Takebayashi, K., Adachi, I., Fleet, G. W., Kettawan, A., Okamoto, T., and Asano, N. Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases. Bioorg.Med Chem. 3-15-2008;16(6):2734-2740. View abstract.
  • Mohan, S. and Pinto, B. M. Towards the elusive structure of kotalanol, a naturally occurring glucosidase inhibitor. Nat.Prod.Rep. 4-24-2010;27(4):481-488. View abstract.
  • Mohan, S. and Pinto, B. M. Zwitterionic glycosidase inhibitors: salacinol and related analogues. Carbohydr.Res. 9-3-2007;342(12-13):1551-1580. View abstract.
  • Mohan, S., Jayakanthan, K., Nasi, R., Kuntz, D. A., Rose, D. R., and Pinto, B. M. Synthesis and biological evaluation of heteroanalogues of kotalanol and de-O-sulfonated kotalanol. Org.Lett. 3-5-2010;12(5):1088-1091. View abstract.
  • Morikawa, T., Kishi, A., Pongpiriyadacha, Y., Matsuda, H., and Yoshikawa, M. Structures of new friedelane-type triterpenes and eudesmane-type sesquiterpene and aldose reductase inhibitors from View abstract.
  • Muraoka, O., Morikawa, T., Miyake, S., Akaki, J., Ninomiya, K., and Yoshikawa, M. Quantitative determination of potent alpha-glucosidase inhibitors, salacinol and kotalanol, in View abstract.
  • Muraoka, O., Ying, S., Yoshikai, K., Matsuura, Y., Yamada, E., Minematsu, T., Tanabe, G., Matsuda, H., and Yoshikawa, M. Synthesis of a nitrogen analogue of salacinol and its alpha-glucosidase inhibitory activity. Chem.Pharm Bull.(Tokyo) 2001;49(11):1503-1505. View abstract.
  • Muraoka, O., Yoshikai, K., Takahashi, H., Minematsu, T., Lu, G., Tanabe, G., Wang, T., Matsuda, H., and Yoshikawa, M. Synthesis and biological evaluation of deoxy salacinols, the role of polar substituents in the side chain on the alpha-glucosidase inhibitory activity. Bioorg.Med Chem. 1-15-2006;14(2):500-509. View abstract.
  • Nakamura, S., Takahira, K., Tanabe, G., Morikawa, T., Sakano, M., Ninomiya, K., Yoshikawa, M., Muraoka, O., and Nakanishi, I. Docking and SAR studies of salacinol derivatives as alpha-glucosidase inhibitors. Bioorg.Med Chem.Lett. 8-1-2010;20(15):4420-4423. View abstract.
  • Nasi, R. and Pinto, B. M. Synthesis of new analogues of salacinol containing a pendant hydroxymethyl group as potential glycosidase inhibitors. Carbohydr.Res. 10-16-2006;341(14):2305-2311. View abstract.
  • Nasi, R., Patrick, B. O., Sim, L., Rose, D. R., and Pinto, B. M. Studies directed toward the stereochemical structure determination of the naturally occurring glucosidase inhibitor, kotalanol: synthesis and inhibitory activities against human maltase glucoamylase of seven-carbon, chain-extended homologues of salacinol. J Org.Chem. 8-15-2008;73(16):6172-6181. View abstract.
  • Nasi, R., Sim, L., Rose, D. R., and Pinto, B. M. New chain-extended analogues of salacinol and blintol and their glycosidase inhibitory activities. Mapping the active-site requirements of human maltase glucoamylase. J Org.Chem. 1-5-2007;72(1):180-186. View abstract.
  • Nasi, R., Sim, L., Rose, D. R., and Pinto, B. M. Synthesis and glycosidase inhibitory activities of chain-modified analogues of the glycosidase inhibitors salacinol and blintol. Carbohydr.Res. 9-3-2007;342(12-13):1888-1894. View abstract.
  • Oe, H. and Ozaki, S. Hypoglycemic effect of 13-membered ring thiocyclitol, a novel alpha-glucosidase inhibitor from Kothala-himbutu ( View abstract.
  • Ozaki, S., Oe, H., and Kitamura, S. Alpha-glucosidase inhibitor from Kothala-himbutu ( View abstract.
  • Pillai, N. R., Seshadri, C., and Santhakumari, G. Hypoglycaemic activity of the root bark of View abstract.
  • Rong, X., Kim, M. S., Su, N., Wen, S., Matsuo, Y., Yamahara, J., Murray, M., and Li, Y. An aqueous extract of View abstract.
  • Rossi, E. J., Sim, L., Kuntz, D. A., Hahn, D., Johnston, B. D., Ghavami, A., Szczepina, M. G., Kumar, N. S., Sterchi, E. E., Nichols, B. L., Pinto, B. M., and Rose, D. R. Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives. FEBS J 2006;273(12):2673-2683. View abstract.
  • Sabu, M. and Kuttan, R. Antioxidant activity of Indian herbal drugs in rats with aloxan-induced diabetes. Pharmaceutical Biology 2003;41:500-505.
  • Samy, R. P. Antimicrobial activity of some medicinal plants from India. Fitoterapia 2005;76(7-8):697-699. View abstract.
  • Sekiguchi, Y., Mano, H., Nakatani, S., Shimizu, J., and Wada, M. Effects of the Sri Lankan medicinal plant, View abstract.
  • Setzer, W. N., Holland, M. T., Bozeman, C. A., Rozmus, G. F., Setzer, M. C., Moriarity, D. M., Reeb, S., Vogler, B., Bates, R. B., and Haber, W. A. Isolation and frontier molecular orbital investigation of bioactive quinone-methide triterpenoids from the bark of View abstract.
  • Setzer, W. N., Setzer, M. C., Hopper, A. L., Moriarity, D. M., Lehrman, G. K., Niekamp, K. L., Morcomb, S. M., Bates, R. B., McClure, K. J., Stessman, C. C., and Haber, W. A. The cytotoxic activity of a View abstract.
  • Shao, Y., Osamu, M., Kazuya, Y., Yoshiharu, M., Eriko, Y., Toshie, M., Genzoh, T., Hisashi, M., Masayuki, Y., and You, Q. D. Synthesis of a salacinol analogue and its alpha-glucosidase inhibitory activity. Yao Xue.Xue.Bao. 2006;41(7):647-653. View abstract.
  • Shimada, T., Nagai, E., Harasawa, Y., Akase, T., Aburada, T., Iizuka, S., Miyamoto, K., and Aburada, M. Metabolic disease prevention and suppression of fat accumulation by View abstract.
  • Shimoda, H., Asano, I., and Yamada, Y. [Antigenicity and phototoxicity of water-soluble extract from View abstract.
  • Sim, L., Jayakanthan, K., Mohan, S., Nasi, R., Johnston, B. D., Pinto, B. M., and Rose, D. R. New glucosidase inhibitors from an ayurvedic herbal treatment for type 2 diabetes: structures and inhibition of human intestinal maltase-glucoamylase with compounds from View abstract.
  • Sim, L., Willemsma, C., Mohan, S., Naim, H. Y., Pinto, B. M., and Rose, D. R. Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains. J Biol.Chem. 6-4-2010;285(23):17763-17770. View abstract.
  • Singh, A. and Duggal, S.
  • Sneden, A. T. Isoiguesterin, a new antileukemic bisnortriterpene from View abstract.
  • Szczepina, M. G., Johnston, B. D., Yuan, Y., Svensson, B., and Pinto, B. M. Synthesis of alkylated deoxynojirimycin and 1,5-dideoxy-1,5-iminoxylitol analogues: polar side-chain modification, sulfonium and selenonium heteroatom variants, conformational analysis, and evaluation as glycosidase inhibitors. J Am.Chem.Soc. 10-6-2004;126(39):12458-12469. View abstract.
  • Tanabe, G., Matsuoka, K., and Minematsu, T. Structure-activity relationships of salacinol and kotalanol against alpha-glucosidase inhibitory activity and evaluation of
  • Tanabe, G., Xie, W., Ogawa, A., Cao, C., Minematsu, T., Yoshikawa, M., and Muraoka, O. Facile synthesis of de-O-sulfated salacinols: revision of the structure of neosalacinol, a potent alpha-glucosidase inhibitor. Bioorg.Med Chem.Lett. 4-15-2009;19(8):2195-2198. View abstract.
  • Tanabe, G., Yoshikai, K., Hatanaka, T., Yamamoto, M., Shao, Y., Minematsu, T., Muraoka, O., Wang, T., Matsuda, H., and Yoshikawa, M. Biological evaluation of de-O-sulfonated analogs of salacinol, the role of sulfate anion in the side chain on the alpha-glucosidase inhibitory activity. Bioorg.Med Chem. 6-1-2007;15(11):3926-3937. View abstract.
  • Tewari, N. C., Ayengar, K. N., and Rangaswami, S. Triterpenes of the root-bark of View abstract.
  • Thiem, D. A., Sneden, A. T., Khan, S. I., and Tekwani, B. L. Bisnortriterpenes from View abstract.
  • Umamaheswari, S. and Mainzen Prince, P. S. Antihyperglycaemic effect of 'Ilogen-Excel', an ayurvedic herbal formulation in streptozotocin-induced diabetes mellitus. Acta Pol.Pharm 2007;64(1):53-61. View abstract.
  • Vellosa, J., Khalil, N., and Gutierres, V.
  • Venkateswarlu, V. and Kumar, N. Development of transdermal drug delivery systems with a natural polymer from
  • Venkateswarlu, V., Kokate, C. K., Rambhau, D., and Veeresham, C. Antidiabetic Activity of Roots of View abstract.
  • Venkateswarlu, V., Kokate, C., and Rambhau, D. Pharmaceutical investigations of a film forming material isolated from roots of
  • Wen, X., Yuan, Y., Kuntz, D. A., Rose, D. R., and Pinto, B. M. A combined STD-NMR/molecular modeling protocol for predicting the binding modes of the glycosidase inhibitors kifunensine and salacinol to Golgi alpha-mannosidase II. Biochemistry 5-10-2005;44(18):6729-6737. View abstract.
  • Witczak, Z. J. and Culhane, J. M. Thiosugars: new perspectives regarding availability and potential biochemical and medicinal applications. Appl.Microbiol.Biotechnol. 2005;69(3):237-244. View abstract.
  • Yoshikawa, M., Morikawa, T., Matsuda, H., Tanabe, G., and Muraoka, O. Absolute stereostructure of potent alpha-glucosidase inhibitor, Salacinol, with unique thiosugar sulfonium sulfate inner salt structure from View abstract.
  • Yoshikawa, M., Murakami, T., Yashiro, K., and Matsuda, H. Kotalanol, a potent alpha-glucosidase inhibitor with thiosugar sulfonium sulfate structure, from antidiabetic ayurvedic medicine View abstract.
  • Yoshikawa, M., Pongpiriyadacha, Y., Kishi, A., Kageura, T., Wang, T., Morikawa, T., and Matsuda, H. [Biological activities of View abstract.
  • Yoshikawa, M., Zhang, Y., Wang, T., Nakamura, S., and Matsuda, H. New triterpene constituents, foliasalacins A(1)-A(4), B(1)-B(3), and C, from the leaves of View abstract.
  • Yoshino, K., Miyauchi, Y., Kanetaka, T., Takagi, Y., and Koga, K. Anti-diabetic activity of a leaf extract prepared from View abstract.
  • Yuan, G. and Yi, Y. [Studies on chemical constituents of the roots of View abstract.
  • Yuasa, H., Izumi, M., and Hashimoto, H. Thiasugars: potential glycosidase inhibitors. Curr.Top.Med Chem. 2009;9(1):76-86. View abstract.
  • Yuasa, H., Takada, J., and Hashimoto, H. Glycosidase inhibition by cyclic sulfonium compounds. Bioorg.Med Chem.Lett. 5-7-2001;11(9):1137-1139. View abstract.
  • Zandberg, W. F., Mohan, S., Kumarasamy, J., and Pinto, B. M. Capillary zone electrophoresis method for the separation of glucosidase inhibitors in extracts of View abstract.
  • Zhang, Y., Nakamura, S., Pongpiriyadacha, Y., Matsuda, H., and Yoshikawa, M. Absolute structures of new megastigmane glycosides, foliasalaciosides E(1), E(2), E(3), F, G, H, and I from the leaves of View abstract.
  • Collene AL, Hertzler SR, Williams JA, Wolf BW. Effects of a nutritional supplement containing Salacia oblonga extract and insulinogenic amino acids on postprandial glycemia, insulinemia, and breath hydrogen responses in healthy adults. Nutrition 2005;21:848-54. View abstract.
  • Franklyn AJ, Bettenridge J, Daykin J, et al. Long-term thyroxine treatment and bone mineral density. Lancet 1992;340:9-13. View abstract.
  • Heacock PM, Hertzler SR, Williams JA, Wolf BW. Effects of a medical food containing an herbal alpha-glucosidase inhibitor on postprandial glycemia and insulinemia in healthy adults. J Am Diet Assoc 2005;105:65-71. View abstract.
  • Huang TH, Yang Q, Harada M, et al. Salacia oblonga root improves cardiac lipid metabolism in Zucker diabetic fatty rats: Modulation of cardiac PPAR-alpha-mediated transcription of fatty acid metabolic genes. Toxicol Appl Pharmacol 2006;210:78-85. View abstract.
  • Ismail TS, Gopalakrishnan S, Begum VH, Elango V. Anti-inflammatory activity of Salacia oblonga Wall. and Azima tetracantha Lam. J Ethnopharmacol 1997;56:145-52. View abstract.
  • Jayawardena MH, de Alwis NM, Hettigoda V, Fernando DJ. A double blind randomised placebo controlled cross over study of a herbal preparation containing Salacia reticulata in the treatment of type 2 diabetes. J Ethnopharmacol 2005;97:215-8. View abstract.
  • Li Y, Peng G, Li Q, et al. Salacia oblonga improves cardiac fibrosis and inhibits postprandial hyperglycemia in obese Zucker rats. Life Sci 2004;75:1735-46. View abstract.
  • Matsuda H, Morikawa T, Masayuki Y. Antidiabetogenic constituents from several natural medicines. Pure Appl Chem 2002;74:1301-8.
  • Matsuda H, Murakami T, Yashiro K, et al. Antidiabetic principles of natural medicines. IV. Aldose reductase and qlpha-glucosidase inhibitors from the roots of Salacia oblonga Wall. (Celastraceae): structure of a new friedelane-type triterpene, kotalagenin 16-acetate. Chem Pharm Bull (Tokyo) 1999;47:1725-9. View abstract.
  • Matsuda H, Murakami T, Yashiro K, et al. Antidiabetic principles of natural medicines. IV. Aldose reductase and qlpha-glucosidase inhibitors from the roots of Salacia oblonga Wall. (Celastraceae): structure of a new friedelane-type triterpene, kotalagenin 16-acetate. Chem Pharm Bull (Tokyo) 1999;47:1725-9. View abstract.
  • Ratnasooriya WD, Jayakody JR, Premakumara GA. Adverse pregnancy outcome in rats following exposure to a Salacia reticulata (Celastraceae) root extract. Braz J Med Biol Res 2003;36:931-5. View abstract.
  • Williams JA, Choe YS, Noss MJ, et al. Extract of Salacia oblonga lowers acute glycemia in patients with type 2 diabetes. Am J Clin Nutr 2007;86:124-30. View abstract.
  • Wolf BW, Weisbrode SE. Safety evaluation of an extract from Salacia oblonga. Food Chem Toxicol 2003;41:867-74. View abstract.
  • Yoshikawa M, Ninomiya K, Shimoda H, et al. Hepatoprotective and antioxidative properties of Salacia reticulata: preventive effects of phenolic constituents on CCl4-induced liver injury in mice. Biol Pharm Bull 2002;25:72-6. View abstract.
  • Yoshikawa M, Nishida N, Shimoda H, et al. [Polyphenol constituents from Salacia species: quantitative analysis of mangiferin with alpha-glucosidase and aldose reductase inhibitory activities]. Yakugaku Zasshi 2001;121:371-8. View abstract.
  • Yoshikawa M, Shimoda H, Nishida N, et al. Salacia reticulata and its polyphenolic constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats. J Nutr 2002;132:1819-24. View abstract.

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