SALACIA

OTHER NAME(S):

Chundan, Kathala Hibutu Tea, Ponkoranti, SO, S. oblonga, Salacia oblonga, Salacia reticulata.<br/><br/>

Overview

Overview Information

Salacia is an herb that is native to India and Sri Lanka. The root and stem are used to make medicine.

Salacia has a long history of use as a treatment for diabetes in Ayurveda, traditional Indian medicine. Mugs made from salacia wood are used by people with diabetes to drink water.

In addition to treating diabetes, salacia is used for treating gonorrhea, asthma, itchiness, joint pain (rheumatism), obesity, thirst, and menstrual problems.

How does it work?

Chemicals in salacia seem to prevent sugars in food from being absorbed by the body.

Uses

Uses & Effectiveness?

Possibly Effective for

  • Diabetes. Early research suggests that consuming salacia tea with each meal might lower hemoglobin A1C (HbA1C) levels in people with type 2 diabetes. HbA1C is a measure of blood sugar control. A single dose of salacia, in combination with a meal, also seems to reduce after-meal insulin levels and reduce after-meal blood sugar in healthy volunteers and in people with type 2 diabetes. These reductions indicate better blood sugar control. Other early research suggests that taking salacia with food for 6 weeks seems to reduce pre-meal blood sugar and HbA1C levels in patients with type 2 diabetes.

Insufficient Evidence for

More evidence is needed to rate the effectiveness of salacia for these uses.

Side Effects

Side Effects & Safety

Salacia is POSSIBLY SAFE when taken by mouth, short-term. Single doses of salacia can be consumed safely in doses up to 1000 mg. Consuming salacia tea with food seems to be safe for most people for up to three months. There isn't enough information to know if salacia is safe when used for long periods of time.

Salacia can cause uncomfortable side effects such as gas, belching, pain in the abdomen, nausea, and diarrhea in some people.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking salacia if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Diabetes: Salacia can decrease blood sugar levels. Your diabetes medications might need to be adjusted by your healthcare provider.

Surgery: Salacia might lower blood sugar levels. There is some concern that it might interfere with blood sugar control during and after surgery. Stop using salacia at least 2 weeks before a scheduled surgery.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!

  • Medications for diabetes (Antidiabetes drugs) interacts with SALACIA

    Salacia might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking salacia along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.<br><nb>Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Dosing

Dosing

The appropriate dose of salacia depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for salacia. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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View References

REFERENCES:

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  • Morikawa T, Kishi A, Pongpiriyadacha Y, et al. Structures of new friedelane-type triterpenes and eudesmane-type sesquiterpene and aldose reductase inhibitors from Salacia chinensis. J Nat Prod. 2003 Sep;66(9):1191-6. View abstract.
  • Nasi R, Patrick BO, Sim L, et al. Studies directed toward the stereochemical structure determination of the naturally occurring glucosidase inhibitor, kotalanol: synthesis and inhibitory activities against human maltase glucoamylase of seven-carbon, chain-extended homologues of salacinol. J Org.Chem. 8-15-2008;73(16):6172-6181. View abstract.
  • Oe H1, Ozaki S. Hypoglycemic effect of 13-membered ring thiocyclitol, a novel alpha-glucosidase inhibitor from Kothala-himbutu (Salacia reticulata). Biosci Biotechnol Biochem. 2008 Jul;72(7):1962-4. View abstract.
  • Ozaki S, Oe H, Kitamura S. Alpha-glucosidase inhibitor from Kothala-himbutu (Salacia reticulata WIGHT). J Nat Prod. 2008 Jun;71(6):981-4. View abstract.
  • Ratnasooriya WD, Jayakody JR, Premakumara GA. Adverse pregnancy outcome in rats following exposure to a Salacia reticulata (Celastraceae) root extract. Braz J Med Biol Res 2003;36:931-5. View abstract.
  • Rong X, Kim MS, Su N, et al. An aqueous extract of Salacia oblonga root, a herb-derived peroxisome proliferator-activated receptor-alpha activator, by oral gavage over 28 days induces gender-dependent hepatic hypertrophy in rats. Food Chem Toxicol. 2008 Jun;46(6):2165-72. View abstract.
  • Setzer WN, Holland MT, Bozeman CA, et al. Isolation and frontier molecular orbital investigation of bioactive quinone-methide triterpenoids from the bark of Salacia petenensis. Planta Med. 2001 Feb;67(1):65-9. View abstract.
  • Shimoda H1, Asano I, Yamada Y. [Antigenicity and phototoxicity of water-soluble extract from Salacia reticulata (Celastraceae)]. Shokuhin Eiseigaku Zasshi. 2001 Apr;42(2):144-7. View abstract.
  • Singh A, Duggal S. Salacia spp: Hypoglycemic principles and possible role in diabetes management. Integrative Medicine. 2010. 9:40-43.
  • Tanabe G, Matsuoka K, Minematsu T, et al.Structure-activity relationships of salacinol and kotalanol against alpha-glucosidase inhibitory activity and evaluation of Salacia extracts by LC-MS. Yakugaku Zasshi. 2007. 127(Suppl 4): 129-130.
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  • Venkateswarlu V, Kokate CK, Rambhau D, et al. Antidiabetic Activity of Roots of Salacia macrosperma. Planta Med. 1993 Oct;59(5):391-3. View abstract.
  • Venkateswarlu V, Kumar N, Sreekanth J. Development of transdermal drug delivery systems with a natural polymer from Salacia macrosperma. Indian Drugs. 2000. 37:407-411.
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  • Yoshikawa M, Morikawa T, Matsuda H, et al. Absolute stereostructure of potent alpha-glucosidase inhibitor, Salacinol, with unique thiosugar sulfonium sulfate inner salt structure from Salacia reticulata. Bioorg Med Chem. 2002 May;10(5):1547-54. View abstract.
  • Yoshikawa M, Ninomiya K, Shimoda H, et al. Hepatoprotective and antioxidative properties of Salacia reticulata: preventive effects of phenolic constituents on CCl4-induced liver injury in mice. Biol Pharm Bull 2002;25:72-6. View abstract.
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  • Yoshikawa M1, Pongpiriyadacha Y, Kishi A, et al. [Biological activities of Salacia chinensis originating in Thailand: the quality evaluation guided by alpha-glucosidase inhibitory activity]. Yakugaku Zasshi. 2003 Oct;123(10):871-80. View abstract.
  • Yoshikawa M1, Zhang Y, Wang T, et al. New triterpene constituents, foliasalacins A(1)-A(4), B(1)-B(3), and C, from the leaves of Salacia chinensis. Chem Pharm Bull (Tokyo). 2008 Jul;56(7):915-20. View abstract.
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  • Zhang Y1, Nakamura S, Pongpiriyadacha Y, et al. Absolute structures of new megastigmane glycosides, foliasalaciosides E(1), E(2), E(3), F, G, H, and I from the leaves of Salacia chinensis. Chem Pharm Bull (Tokyo). 2008 Apr;56(4):547-53. View abstract.

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