SALACIA

OTHER NAME(S):

Chundan, Kathala Hibutu Tea, Ponkoranti, SO, S. oblonga, Salacia oblonga, Salacia reticulata.<br/><br/>

Overview

Overview Information

Salacia is an herb that is native to India and Sri Lanka. The root and stem are used to make medicine.

Salacia has a long history of use as a treatment for diabetes in Ayurveda, traditional Indian medicine. Mugs made from salacia wood are used by people with diabetes to drink water.

In addition to treating diabetes, salacia is used for treating gonorrhea, asthma, itchiness, joint pain (rheumatism), obesity, thirst, and menstrual problems.

How does it work?

Chemicals in salacia seem to prevent sugars in food from being absorbed by the body.

Uses

Uses & Effectiveness?

Possibly Effective for

  • Diabetes. Early research suggests that consuming salacia tea with each meal might lower hemoglobin A1C (HbA1C) levels in people with type 2 diabetes. HbA1C is a measure of blood sugar control. A single dose of salacia, in combination with a meal, also seems to reduce after-meal insulin levels and reduce after-meal blood sugar in healthy volunteers and in people with type 2 diabetes. These reductions indicate better blood sugar control. Other early research suggests that taking salacia with food for 6 weeks seems to reduce pre-meal blood sugar and HbA1C levels in patients with type 2 diabetes.

Insufficient Evidence for

More evidence is needed to rate the effectiveness of salacia for these uses.

Side Effects

Side Effects & Safety

Salacia is POSSIBLY SAFE when taken by mouth, short-term. Single doses of salacia can be consumed safely in doses up to 1000 mg. Consuming salacia tea with food seems to be safe for most people for up to three months. There isn't enough information to know if salacia is safe when used for long periods of time.

Salacia can cause uncomfortable side effects such as gas, belching, pain in the abdomen, nausea, and diarrhea in some people.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking salacia if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Diabetes: Salacia can decrease blood sugar levels. Your diabetes medications might need to be adjusted by your healthcare provider.

Surgery: Salacia might lower blood sugar levels. There is some concern that it might interfere with blood sugar control during and after surgery. Stop using salacia at least 2 weeks before a scheduled surgery.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!

  • Medications for diabetes (Antidiabetes drugs) interacts with SALACIA

    Salacia might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking salacia along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.<br><nb>Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Dosing

Dosing

The appropriate dose of salacia depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for salacia. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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View References

REFERENCES:

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  • Eskandari, R., Jones, K., Rose, D. R., and Pinto, B. M. Probing the active-site requirements of human intestinal N-terminal maltase glucoamylase: the effect of replacing the sulfate moiety by a methyl ether in ponkoranol, a naturally occurring alpha-glucosidase inhibitor. Bioorg.Med Chem.Lett. 10-1-2010;20(19):5686-5689. View abstract.
  • Eskandari, R., Kuntz, D. A., Rose, D. R., and Pinto, B. M. Potent glucosidase inhibitors: de-O-sulfonated ponkoranol and its stereoisomer. Org.Lett. 4-2-2010;12(7):1632-1635. View abstract.
  • Figueiredo, J. N., Raz, B., and Sequin, U. Novel quinone methides from View abstract.
  • Gallienne, E., Gefflaut, T., Bolte, J., and Lemaire, M. Synthesis of new nitrogen analogues of salacinol and deoxynojirimycin and their evaluation as glycosidase inhibitors. J Org.Chem. 2-3-2006;71(3):894-902. View abstract.
  • Gao, H. Y., Guo, Z. H., Cheng, P., Xu, X. M., and Wu, L. J. New triterpenes from View abstract.
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  • Ghavami, A., Chen, J. J., and Mario, Pinto B. Synthesis of a novel class of sulfonium ions as potential inhibitors of UDP-galactopyranose mutase. Carbohydr.Res. 1-22-2004;339(2):401-407. View abstract.
  • Ghavami, A., Johnston, B. D., and Pinto, B. M. A new class of glycosidase inhibitor: synthesis of salacinol and its stereoisomers. J Org.Chem. 4-6-2001;66(7):2312-2317. View abstract.
  • Ghavami, A., Johnston, B. D., Jensen, M. T., Svensson, B., and Pinto, B. M. Synthesis of nitrogen analogues of salacinol and their evaluation as glycosidase inhibitors. J Am.Chem.Soc. 7-4-2001;123(26):6268-6271. View abstract.
  • Ghavami, A., Johnston, B., and Maddess, M. Synthesis of 1,4-anhydro-D-xylitol heteroanalogues of the naturally occurring glycosidase inhibitor salacinol and their evaluation as glycosidase inhibitors. Canadian Journal of Chemistry 2002;80(8):937-942.
  • Giron, M. D., Sevillano, N., Salto, R., Haidour, A., Manzano, M., Jimenez, M. L., Rueda, R., and Lopez-Pedrosa, J. M. View abstract.
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  • Jayakanthan, K., Mohan, S., and Pinto, B. M. Structure proof and synthesis of kotalanol and de-O-sulfonated kotalanol, glycosidase inhibitors isolated from an herbal remedy for the treatment of type-2 diabetes. J Am.Chem.Soc. 4-22-2009;131(15):5621-5626. View abstract.
  • Johnson, M. A., Jensen, M. T., Svensson, B., and Pinto, B. M. Selection of a high-energy bioactive conformation of a sulfonium-ion glycosidase inhibitor by the enzyme glucoamylase G2. J Am.Chem.Soc. 5-14-2003;125(19):5663-5670. View abstract.
  • Johnston, B. D., Ghavami, A., Jensen, M. T., Svensson, B., and Pinto, B. M. Synthesis of selenium analogues of the naturally occurring glycosidase inhibitor salacinol and their evaluation as glycosidase inhibitors. J Am.Chem.Soc. 7-17-2002;124(28):8245-8250. View abstract.
  • Johnston, B. D., Jensen, H. H., and Pinto, B. M. Synthesis of sulfonium sulfate analogues of disaccharides and their conversion to chain-extended homologues of salacinol: new glycosidase inhibitors. J Org.Chem. 2-3-2006;71(3):1111-1118. View abstract.
  • Karunanayake, E. H. and Sirimanne, S. R. Mangiferin from the root bark of View abstract.
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  • Krishnakumar, K., Augusti, K. T., and Vijayammal, P. L. Anti-peroxidative and hypoglycaemic activity of View abstract.
  • Krishnan, V. and Rangaswami, S. Proanthocyanidins of View abstract.
  • Kumar, N. S. and Pinto, B. M. Synthesis of D-lyxitol and D-ribitol analogues of the naturally occurring glycosidase inhibitor salacinol. Carbohydr.Res. 12-12-2005;340(17):2612-2619. View abstract.
  • Liu, H. and Pinto, B. M. Efficient synthesis of the glucosidase inhibitor blintol, the selenium analogue of the naturally occurring glycosidase inhibitor salacinol. J Org.Chem. 1-21-2005;70(2):753-755. View abstract.
  • Liu, H., Nasi, R., Jayakanthan, K., Sim, L., Heipel, H., Rose, D. R., and Pinto, B. M. New synthetic routes to chain-extended selenium, sulfur, and nitrogen analogues of the naturally occurring glucosidase inhibitor salacinol and their inhibitory activities against recombinant human maltase glucoamylase. J Org.Chem. 8-17-2007;72(17):6562-6572. View abstract.
  • Liu, H., Sim, L., Rose, D. R., and Pinto, B. M. A new class of glucosidase inhibitor: analogues of the naturally occurring glucosidase inhibitor salacinol with different ring heteroatom substituents and acyclic chain extension. J Org.Chem. 4-14-2006;71(8):3007-3013. View abstract.

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