D-MANNOSE

OTHER NAME(S):

Carubinose, D-Manosa, Mannose, Seminose.

Overview

Overview Information

D-mannose is a kind of sugar that is related to glucose.

D-mannose is used for an inherited disorder called carbohydrate-deficient glycoprotein syndrome type 1b. It is also used for infections of the kidney, bladder, or urethra (urinary tract infections or UTIs), but there is no good scientific evidence to support this use.

How does it work?

D-mannose might treat the deficiency caused by a genetic defect that causes abnormal breakdown and production of mannose. D-mannose might prevent certain kinds of bacteria from sticking to the walls of the urinary tract and causing infection.

Uses

Uses & Effectiveness?

Likely Effective for

  • An inherited disorder called carbohydrate-deficient glycoprotein syndrome type 1b. Taking d-mannose can improve digestive problems, low blood sugar, and blood clotting disorders in people with this disorder. D-mannose might also improve liver disease in some, but not all, people with this condition.

Insufficient Evidence for

  • Infections of the kidney, bladder, or urethra (urinary tract infections or UTIs). Early research shows that taking d-mannose for 13 days might reduce symptoms of UTIs, such as burning and increased urination. Early research also shows that taking d-mannose powder for 6 months after a UTI might help to prevent UTIs from occurring again.
  • Other conditions.
More evidence is needed to rate the effectiveness of d-mannose for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: D-mannose is POSSIBLY SAFE for most adults when taken in appropriate amounts for up to 6 months. It can cause diarrhea. In high doses, it might harm the kidneys. There isn't enough reliable information to know if d-mannose is safe or what the side effects might be when taken by mouth, long-term.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if d-mannose is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Children: D-mannose is POSSIBLY SAFE when taken by mouth in children with an inherited disorder called carbohydrate-deficient glycoprotein syndrome type 1b. It can cause diarrhea, loose stools, bloating, and nausea in these children. There isn't enough reliable information to know if d-mannose is safe to use in children who do not have this condition.

Diabetes: D-mannose might make blood sugar control more difficult in people with diabetes.

Interactions

Interactions?

We currently have no information for D-MANNOSE Interactions.

Dosing

Dosing

The following doses have been studied in scientific research:

CHILDREN

BY MOUTH:

  • For an inherited disorder called carbohydrate-deficient glycoprotein syndrome type 1b: 100-170 mg of d-mannose taken 3-6 times per day for a total daily dose of 300-1020 mg/kg has been used.

View References

REFERENCES:

  • . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. View abstract.
  • Alton G, Hasilik M, Niehues R, et al. Direct utilization of mannose for mammalian glycoprotein biosynthesis. Glycobiology 1998;8:285-95. View abstract.
  • Davis JA, Freeze HH. Studies of mannose metabolism and effects of long-term mannose ingestion in the mouse. Biochim Biophys Acta 2001;1528:116-26. View abstract.
  • de Lonlay P, Cuer M, Vuillaumier-Barrot S, et al. Hyperinsulinemic hypoglycemia as a presenting sign in phosphomannose isomerase deficiency: A new manifestation of carbohydrate-deficient glycoprotein syndrome treatable with mannose. J Pediatr 1999;135:379-83. View abstract.
  • de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. View abstract.
  • Domenici L, Monti M, Bracchi C, Giorgini M, Colagiovanni V, Muzii L, Benedetti Panici P. D-mannose: a promising support for acute urinary tract infections in women. A pilot study. Eur Rev Med Pharmacol Sci. 2016 Jul;20(13):2920-5. View abstract.
  • Freinkel N, Lewis NJ, Akazawa S, et al. The honeybee syndrome - implications of the teratogenicity of mannose in rat-embryo culture. N Engl J Med 1984;310:223-30. View abstract.
  • Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. View abstract.
  • Hendriksz CJ, McClean P, Henderson MJ, et al. Successful treatment of carbohydrate deficient glycoprotein syndrome type 1b with oral mannose. Arch Dis Child 2001;85:339-40. View abstract.
  • Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84. View abstract.
  • Marchiori D, Zanello PP. Efficacy of N-acetylcysteine, D-mannose and Morinda citrifolia to treat recurrent cystitis in breast cancer survivals. In Vivo. 2017 Sep-Oct;31(5):931-936. View abstract.
  • Mention K, Lacaille F, Valayannopoulos V, et al. Development of liver disease despite mannose treatment in two patients with CDG-Ib. Mol Genet Metab. 2008;93(1):40-3. View abstract.
  • Michaels EK, Chmiel JS, Plotkin BJ, Schaeffer AJ. Effect of D-mannose and D-glucose on Escherichia coli bacteriuria in rats. Urol Res 1983;11:97-102 . View abstract.
  • Niehues R, Hasilik M, Alton G, et al. Carbohydrate-deficient glycoprotein syndrome type Ib. Phosphomannose isomerase deficiency and mannose therapy. J Clin Invest 1998;101:1414-20. View abstract.
  • Ofek I, Goldhar J, Eshdat Y, Sharon N. The importance of mannose specific adhesins (lectins) in infections caused by Escherichia coli. Scand J Infect Dis Suppl 1982;33:61-7.
  • Ofek I, Mosek A, Sharon N. Mannose-specific adherence of Escherichia coli freshly excreted in the urine of patients with urinary tract infections, and of isolates subcultured from the infected urine. Infect Immun 1981;34:708-11. View abstract.
  • Penel-Capelle D, Dobbelaere D, Jaeken J, Klein A, Cartigny M, Weill J. Congenital disorder of glycosylation Ib (CDG-Ib) without gastrointestinal symptoms. J Inherit Metab Dis. 2003;26(1):83-5. View abstract.
  • Porru D, Parmigiani A, Tinelli C, et al. Oral D-mannose in recurrent urinary tract infections in women: a pilot study. Journal of Clinical Urology. 2014. 7(3):208-213.
  • Schaeffer AJ, Chmiel JS, Duncan JL, Falkowski WS. Mannose-sensitive adherence of Escherichia coli to epithelial cells from women with recurrent urinary tract infections. J Urol 1984;131:906-10. View abstract.
  • Venegas MF, Navas EL, Gaffney RA, et al. Binding of type 1-piliated Escherichia coli to vaginal mucus. Infect Immun 1995;63:416-22. View abstract.
  • Vicariotto F. Effectiveness of an association of a cranberry dry extract, D-mannose, and the two microorganisms Lactobacillus plantarum LP01 and Lactobacillus paracasei LPC09 in women affected by cystitis: a pilot study. J Clin Gastroenterol. 2014 Nov-Dec;48 Suppl 1:S96-101. View abstract.
  • Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. View abstract.

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