ASHITABA
Angelica, Angelica keiskei, Ashitaba du Japon, Herbe de la Longévité, Japanese Ashitaba, Kenso, Leaves of Tomorrow, Sinsuncho, Tomorrow Leaf.
Uses & Effectiveness
Insufficient Evidence for
- Liver disease in people who drink alcohol. Early research shows that taking ashitaba extract twice daily for 12 weeks doesn't improve fatigue or liver function in people who drink alcohol and have early signs of liver disease.
- Breast-feeding.
- Cancer.
- Constipation.
- Gout.
- Hay fever.
- High blood pressure.
- High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia).
- Persistent heartburn.
- Stomach ulcers.
- Other conditions.
Side Effects & Safety
When taken by mouth: Ashitaba is POSSIBLY SAFE when taken by mouth at a dose of up to 1000 mg daily, short-term. There isn't enough reliable information available to know if ashitaba is safe or what the side effects might be when taken for longer than 3 months.Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if ashitaba is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.Interactions
We currently have no information for ASHITABA Interactions.
Dosing
The appropriate dose of ashitaba depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for ashitaba. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
REFERENCES:
- Inamori Y, Baba K, Tsujibo H, et al. Antibacterial activity of two chalcones, xanthoangelol and 4-hydroxyderricin, isolated from the root of Angelica keiskei KOIDZUMI. Chem Pharm Bull (Tokyo) 1991;39:1604-5. View abstract.
- Kang MH, Park YK, Kim HY, Kim TS. Green vegetable drink consumption protects peripheral lymphocytes DNA damage in Korean smokers. Biofactors 2004;22:245-7. View abstract.
- Kwon D, Yoon S, Carter O, Bailey GS, Dashwood RH. Antioxidant and antigenotoxic activities of Angelica keiskei, Oenanthe javanica and Brassica oleracea in the Salmonella mutagenicity assay and in HCT116 human colon cancer cells. Biofactors. 2006;26(4):231-44. View abstract.
- Maronpot RR. Toxicological assessment of Ashitaba Chalcone. Food Chem Toxicol. 2015;77:111-9. View abstract.
- Murakami S, Kijima H, Isobe Y, et al. Inhibition of gastric H+, K(+)-ATPase by chalcone derivatives, xanthoangelol and 4-hydroxyderricin, from Angelica keiskei Koidzumi. J Pharm Pharmacol 1990;42:723-6. View abstract.
- Noh HM, Ahn EM, Yun JM, Cho BL, Paek YJ. Angelica keiskei Koidzumi extracts improve some markers of liver function in habitual alcohol drinkers: a randomized double-blind clinical trial. J Med Food. 2015;18(2):166-72. View abstract.
- Ogawa H, Nakashima S, Baba K. Effects of dietary Angelica keiskei on lipid metabolism in stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 2003;30:284-8. View abstract.
- Ogawa H, Ohno M, Baba K. Hypotensive and lipid regulatory actions of 4-hydroxyderricin, a chalcone from Angelica keiskei, in stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 2005;32:19-23. View abstract.
- Sugii M, Ohkita M, Taniguchi M, et al. Xanthoangelol D isolated from the roots of Angelica keiskei inhibits endothelin-1 production through the suppression of nuclear factor-kappaB. Biol Pharm Bull 2005;28:607-10. View abstract.
- Tabata K, Motani K, Takayanagi N, et al. Xanthoangelol, a major chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma and leukemia cells. Biol Pharm Bull 2005;28:1404-7. View abstract.
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