TINOSPORA CORDIFOLIA: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Tinospora cordifolia is a common climbing shrub that grows on other trees. It's native to India. Its root, stems, and leaves are used in Ayurvedic medicine.

Tinospora cordifolia contains many different chemicals that might affect the body. Some of these chemicals might have antioxidant and anti-inflammatory effects. Others might affect the immune system.

People use Tinospora cordifolia for hay fever, athletic performance, diabetes, high cholesterol, upset stomach, and many other conditions, but there is no good scientific evidence to support these uses.

Don't confuse Tinospora cordifolia with Andrachne, Arnica, Cha de Bugre, Cordyceps, Sida cordifolia, or Spearmint. These are not the same.

Interactions ?

Moderate Interaction

Be cautious with this combination

Medications for diabetes (Antidiabetes drugs) interacts with TINOSPORA CORDIFOLIA
Tinospora cordifolia might lower blood sugar levels. Taking Tinospora cordifolia along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Medications that decrease the immune system (Immunosuppressants) interacts with TINOSPORA CORDIFOLIA
Tinospora cordifolia can increase the activity of the immune system. Some medications, such as those used after a transplant, decrease the activity of the immune system. Taking Tinospora cordifolia along with these medications might decrease the effects of these medications.
Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with TINOSPORA CORDIFOLIA
Some medications are changed and broken down by the liver. Tinospora cordifolia might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates) interacts with TINOSPORA CORDIFOLIA
Some medications are changed and broken down by the liver. Tinospora cordifolia might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with TINOSPORA CORDIFOLIA
Some medications are changed and broken down by the liver. Tinospora cordifolia might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates) interacts with TINOSPORA CORDIFOLIA
Some medications are changed and broken down by the liver. Tinospora cordifolia might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

View References

REFERENCES:

Badar VA, Thawani VR, Wakode PT, et al. Efficacy of Tinospora cordifolia in allergic rhinitis. J Ethnopharmacol 2005;96:445-9. View abstract.

Castillo AL, Osi MO, Ramos JD, De Francia JL, Dujunco MU, Quilala PF. Efficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis-infected pediatric patients: A single blind, randomized controlled trial. J Pharmacol Pharmacother. 2013 Jan;4(1):39-46. View abstract.

Chopra A, Saluja M, Tillu G, Sarmukkaddam S, Venugopalan A, Narsimulu G, Handa R, Sumantran V, Raut A, Bichile L, Joshi K, Patwardhan B. Ayurvedic medicine offers a good alternative to glucosamine and celecoxib in the treatment of symptomatic knee osteoarthritis: a randomized, double-blind, controlled equivalence drug trial. Rheumatology (Oxford) 2013;52(8):1408-17. View abstract.

Goel HC, Prasad J, Singh S, et al. Radioprotective potential of an herbal extract of Tinospora cordifolia. Radiat Res (Tokyo) 2004;45:61-8. View abstract.

Grover JK, Vats V, Rathi SS. Anti-hyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. J Ethnopharmacol 2000;73:461-70. View abstract.

Hussain L, Akash MS, Ain NU, Rehman K, Ibrahim M. The Analgesic, Anti-Inflammatory and Anti-Pyretic Activities of Tinospora cordifolia. Adv Clin Exp Med. 2015 Nov-Dec;24(6):957-64. View abstract.

Jagetia GC, Nayak V, Vidyasagar MS. Evaluation of the antineoplastic activity of guduchi (Tinospora cordifolia) in cultured HeLa cells. Cancer Lett 1998;127:71-82. View abstract.

Jagetia GC, Rao SK. Evaluation of Cytotoxic Effects of Dichloromethane Extract of Guduchi (Tinospora cordifolia Miers ex Hook F & THOMS) on Cultured HeLa Cells. Evid Based Complement Alternat Med. 2006 Jun;3(2):267-72. View abstract.

Kapil A, Sharma S. Immunopotentiating compounds from Tinospora cordifolia. J Ethnopharmacol 1997;58:89-95. View abstract.

Kapur P, Jarry H, Wuttke W, Pereira BM, Seidlova-Wuttke D. Evaluation of the antiosteoporotic potential of Tinospora cordifolia in female rats. Maturitas. 2008 Apr 20;59(4):329-38. View abstract.

Kapur P, Pereira BM, Wuttke W, Jarry H. Androgenic action of Tinospora cordifolia ethanolic extract in prostate cancer cell line LNCaP. Phytomedicine. 2009 Jun;16(6-7):679-82. View abstract.

Leyon PV, Kuttan G. Effect of Tinospora cordifolia on the cytokine profile of angiogenesis-induced animals. Int Immunopharmacol 2004;4:1569-75. View abstract.

Manjrekar PN, Jolly CI, Narayanan S. Comparative studies of the immunomodulatory activity of Tinospora cordifolia and Tinospora sinensis. Fitoterapia 2000;71:254-7. View abstract.

Nair PK, Rodriguez S, Ramachandran R, et al. Immune stimulating properties of a novel polysaccharide from the medicinal plant Tinospora cordifolia. Int Immunopharmacol 2004;4:1645-59. View abstract.

Panchabhai TS, Kulkarni UP, Rege NN. Validation of therapeutic claims of Tinospora cordifolia: a review. Phytother Res. 2008 Apr;22(4):425-41. View abstract.

Patial V, Katoch S, Chhimwal J, Singh PP, Suresh PS, Padwad Y. Tinospora cordifolia activates PPAR? pathway and mitigates glomerular and tubular cell injury in diabetic kidney disease. Phytomedicine 2021;91:153663. View abstract.

Prince PS, Menon VP. Antioxidant activity of Tinospora cordifolia roots in experimental diabetes. J Ethnopharmacol 1999;65:277-81. View abstract.

Prince PS, Padmanabhan M, Menon VP, et al. Restoration of antioxidant defence by ethanolic Tinospora cordifolia root extract in alloxan-induced diabetic liver and kidney. Phytother Res 2004;18:785-7. View abstract.

Purandare H, Supe A. Immunomodulatory role of Tinospora cordifolia as an adjuvant in surgical treatment of diabetic foot ulcers: a prospective randomized controlled study. Indian J Med Sci. 2007 Jun;61(6):347-55. View abstract.

Rao SK, Rao PS, Rao BN. Preliminary investigation of the radiosensitizing activity of guduchi (Tinospora cordifolia) in tumor-bearing mice. Phytother Res. 2008 Nov;22(11):1482-9. View abstract.

Rawal A, Muddeshwar M, Biswas S. Effect of Rubia cordifolia, Fagonia cretica linn, and Tinospora cordifolia on free radical generation and lipid peroxidation during oxygen-glucose deprivation in rat hippocampal slices. Biochem Biophys Res Commun 2004;324:588-96. View abstract.

Rawal AK, Muddeshwar MG, Biswas SK. Rubia cordifolia, Fagonia cretica linn and Tinospora cordifolia exert neuroprotection by modulating the antioxidant system in rat hippocampal slices subjected to oxygen glucose deprivation. BMC Complement Altern Med 2004;4:11. View abstract.

Reddy SS, Ramatholisamma P, Karuna R, Saralakumari D. Preventive effect of Tinospora cordifolia against high-fructose diet-induced insulin resistance and oxidative stress in male Wistar rats. Food Chem Toxicol. 2009 Sep;47(9):2224-9. View abstract.

Sahu R, Ahmed T, Sangana R, Punde R, Subudhi BB. Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of glibenclamide in rat: an herb-drug interaction study. J Pharm Biomed Anal. 2018;151:310-6. doi: 10.1016/j.jpba.2018.01.010. View abstract.

Salve BA, Tripathi RK, Petare AU, Raut AA, Rege NN. Effect of Tinospora cordifolia on physical and cardiovascular performance induced by physical stress in healthy human volunteers. Ayu. 2015 Jul-Sep;36(3):265-70. View abstract.

Sannegowda KM, Venkatesha SH, Moudgil KD. Tinospora cordifolia inhibits autoimmune arthritis by regulating key immune mediators of inflammation and bone damage. Int J Immunopathol Pharmacol. 2015 Dec;28(4):521-31. View abstract.

Sharma B, Dabur R. Protective Effects of Tinospora cordifolia on Hepatic and Gastrointestinal Toxicity Induced by Chronic and Moderate Alcoholism. Alcohol Alcohol. 2016 Jan;51(1):1-10. View abstract.

Shirolkar A, Yadav A, Mandal TK, Dabur R. Intervention of Ayurvedic drug Tinospora cordifolia attenuates the metabolic alterations in hypertriglyceridemia: a pilot clinical trial. J Diabetes Metab Disord 2020;19(2):1367-79. View abstract.

Singh N, Singh SM, Shrivastava P. Immunomodulatory and antitumor actions of medicinal plant Tinospora cordifolia are mediated through activation of tumor-associated macrophages. Immunopharmacol Immunotoxicol 2004;26:145-62. View abstract.

Stanely Mainzen Prince P, Menon VP, Gunasekaran G. Hypolipidaemic action of Tinospora cordifolia roots in alloxan diabetic rats. J Ethnopharmacol 1999;64:53-7. View abstract.

Stanely Mainzen Prince P, Menon VP. Hypoglycaemic and hypolipidaemic action of alcohol extract of Tinospora cordifolia roots in chemical induced diabetes in rats. Phytother Res 2003;17:410-3. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

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TINOSPORA CORDIFOLIA - Uses, Side Effects, and More

Overview

Uses & Effectiveness ?

Side Effects

Special Precautions and Warnings

Interactions ?

Moderate Interaction

Medications for diabetes (Antidiabetes drugs) interacts with TINOSPORA CORDIFOLIA

Medications that decrease the immune system (Immunosuppressants) interacts with TINOSPORA CORDIFOLIA

Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with TINOSPORA CORDIFOLIA

Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates) interacts with TINOSPORA CORDIFOLIA

Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with TINOSPORA CORDIFOLIA

Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates) interacts with TINOSPORA CORDIFOLIA

Dosing

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