AGARICUS MUSHROOM

OTHER NAME(S):

Agaric, Agaricus, Agaricus blazei, Agarikusutake, Brazil Mushroom, Brazilian Mushroom, Brazilian Sun-Mushroom, Callampa Agaricus, Champignon Agaric, Champignon Brésilien, Champignon du Brésil, Cogumelo do Sol, Kawariharatake, Himematsutake, Mushroom, Sun Mushroom.

Overview

Overview Information

Agaricus mushroom is a fungus. It originated in Brazil, but is now grown in China, Japan, Brazil, and the US. Solutions containing chemicals that are taken from the plant are used as medicine.

Agaricus mushroom is used for various types of cancer, and for the side effects of cancer treatments, but there is no strong evidence supporting any uses.

How does it work?

Some developing research suggests agaricus mushroom might strengthen the immune system, fight tumor development, and work as an antioxidant.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Side effects of cancer drug treatment. Early research shows that taking agaricus mushroom extract might reduce some of the side effects of chemotherapy, including weakness and loss of appetite.
  • A type of inflammatory bowel disease (Crohn disease). Early research shows that taking agaricus mushroom extract does not reduce fatigue or improve symptoms in people with Crohn disease.
  • Diabetes. Early research shows that some diabetes medications work better when they are given with agaricus mushroom extract.
  • Swelling (inflammation) of the liver caused by hepatitis B virus (hepatitis B). Early research shows that taking agaricus mushroom extract might help reduce liver damage in people with hepatitis B infection.
  • Cancer of white blood cells called plasma cells (multiple myeloma). Early research shows that taking agaricus mushroom extract during treatment for multiple myeloma does not improve the response to treatment.
  • A type of inflammatory bowel disease (ulcerative colitis). Early research shows that taking agaricus mushroom extract helps reduce fatigue and improve symptoms in people with ulcerative colitis.
  • Cancer.
  • Hardening of the arteries (atherosclerosis).
  • Hay fever.
  • Heart failure.
  • High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia).
  • Weak and brittle bones (osteoporosis).
  • Stomach ulcers.
  • Other conditions.
More evidence is needed to rate the effectiveness of agaricus mushroom for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Agaricus mushroom is POSSIBLY SAFE for most people when taken for up to 12 months. Agaricus mushroom can cause blood sugar to go too low (hypoglycemia) in some people with diabetes. It can also cause nausea, diarrhea and upset stomach.

A few people who took agaricus mushroom during treatment for cancer have developed severe liver damage, and a few have had allergic reactions.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if agaricus mushroom is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Liver disease: There is some concern that agaricus mushroom might cause liver disease or make it worse. Don't use it if you have liver disease.

Surgery: Agaricus mushroom might lower blood sugar. There is some concern that it might interfere with blood sugar control during surgery. Stop using agaricus mushroom at least 2 weeks before a scheduled surgery.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Medications used for diabetes (Antidiabetes drugs) interacts with AGARICUS MUSHROOM

    Agaricus mushroom might decrease blood sugar in people with type 2 diabetes. Diabetes medications are also used to lower blood sugar. Taking agaricus mushroom along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
    Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Dosing

Dosing

The appropriate dose of agaricus mushroom depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for agaricus mushroom. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Ahn WS, Kim DJ, Chae GT, et al. Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. Int J Gynecol Cancer 2004;14:589-94. View abstract.
  • Barbisan LF, Miyamoto M, Scolastici C, et al. Influence of aqueous extract of Agaricus blazei on rat liver toxicity induced by different doses of diethylnitrosamine. J Ethnopharmacol 2002;83:25-32. View abstract.
  • Bernardshaw S, Johnson E, Hetland G. An extract of the mushroom Agaricus blazei Murill administered orally protects against systemic Streptococcus pneumoniae infection in mice. Scand J Immunol 2005;62:393-8. View abstract.
  • Chen L, Shao H. Extract from Agaricus blazei Murill can enhance immune responses elicited by DNA vaccine against foot-and-mouth disease. Vet Immunol Immunopathol 2006;109:177-82. View abstract.
  • Delmanto RD, de Lima PL, Sugui MM, et al. Antimutagenic effect of Agaricus blazei Murrill mushroom on the genotoxicity induced by cyclophosphamide. Mutat Res 2001;496:15-21. View abstract.
  • Guterrez ZR, Mantovani MS, Eira AF, et al. Variation of the antimutagenicity effects of water extracts of Agaricus blazei Murrill in vitro. Toxicol In Vitro 2004;18:301-9. View abstract.
  • Hashimoto T, Nonaka Y, Minato K, et al. Suppressive effect of polysaccharides from the edible and medicinal mushrooms, Lentinus edodes and Agaricus blazei, on the expression of cytochrome P450s in mice. Biosci Biotechnol Biochem 2002;66:1610-4. View abstract.
  • Hsu CH, Hwang KC, Chiang YH, Chou P. The mushroom Agaricus blazei Murill extract normalizes liver function in patients with chronic hepatitis B. J Altern Complement Med 2008;14(3):299-301. View abstract.
  • Hsu CH, Liao YL, Lin SC, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med 2007;13:97-102. View abstract.
  • Kaneno R, Fontanari LM, Santos SA, et al. Effects of extracts from Brazilian sun-mushroom (Agaricus blazei) on the NK activity and lymphoproliferative responsiveness of Ehrlich tumor-bearing mice. Food Chem Toxicol 2004;42:909-16. View abstract.
  • Kasai H, He LM, Kawamura M, et al. IL-12 Production induced by Agaricus blazei fraction H (ABH) involves toll-like receptor (TLR). Evid Based Complement Alternat Med 2004;1:259-67. View abstract.
  • Ker YB, Chen KC, Chyau CC, et al. Antioxidant capability of polysaccharides fractionated from submerge-cultured Agaricus blazei mycelia. J Agric Food Chem 2005;53:7052-8. View abstract.
  • Kim YW, Kim KH, Choi HJ, Lee DS. Anti-diabetic activity of beta-glucans and their enzymatically hydrolyzed oligosaccharides from Agaricus blazei. Biotechnol Lett 2005;27:483-7. View abstract.
  • Kimura Y, Kido T, Takaku T, et al. Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions. Cancer Sci 2004;95:758-64. View abstract.
  • Kobayashi H, Yoshida R, Kanada Y, et al. Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis in mouse model. J Cancer Res Clin Oncol 2005;131:527-38. View abstract.
  • Konishi H, Yamanaka K, Mizutani H. Possible case for false-positive reaction in serum 5-S-cysteinyldopa levels in a patient with malignant melanoma by ingestion of Agaricus blazei Murrill extract. J Dermatol 2010;37(8):773-5. View abstract.
  • Kozuka M, Oyama M, Tokuda H, Nishino H, Lee KH. Cancer preventive agents 3. Antitumor promoting effects of Agaricus blazei. Pharm Biol 2005;43(6):568-72.
  • Kuroiwa Y, Nishikawa A, Imazawa T, et al. Lack of subchronic toxicity of an aqueous extract of Agaricus blazei Murrill in F344 rats. Food Chem Toxicol 2005;43:1047-53. View abstract.
  • Lee YL, Kim HJ, Lee MS, et al. Oral administration of Agaricus blazei (H1 strain) inhibited tumor growth in a sarcoma 180 inoculation model. Exp Anim 2003;52:371-5. View abstract.
  • Lima CU, Souza VC, Morita MC, Chiarello MD, Karnikowski MG. Agaricus blazei Murrill and inflammatory mediators in elderly women: a randomized clinical trial. Scand J Immunol 2012;75(3):336-41. View abstract.
  • Mahmood F, Hetland G, Nentwich I, Mirlashari MR, Ghiasvand R, Nissen-Meyer LSH. Agaricus blazei-based mushroom extract supplementation to birch allergic blood donors: a randomized clinical trial. Nutrients 2019;11(10):2339. doi: 10.3390/nu11102339. View abstract.
  • Martins de Oliveira J, Jordao BQ, Ribeiro LR, et al. Anti-genotoxic effect of aqueous extracts of sun mushroom (Agaricus blazei Murill lineage 99/26) in mammalian cells in vitro. Food Chem Toxicol 2002;40:1775-80. View abstract.
  • Menoli RC, Mantovani MS, Ribeiro LR, et al. Antimutagenic effects of the mushroom Agaricus blazei Murrill extracts on V79 cells. Mutat Res 2001;496:5-13. View abstract.
  • Mukai H, Watanabe T, Ando M, Katsumata N. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn J Clin Oncol 2006;36:808-10. View abstract.
  • Nakajima A, Ishida T, Koga M, et al. Effect of hot water extract from Agaricus blazei Murill on antibody-producing cells in mice. Int Immunopharmacol 2002;2:1205-11. View abstract.
  • Ohno N, Furukawa M, Miura NN, et al. Antitumor beta glucan from the cultured fruit body of Agaricus blazei. Biol Pharm Bull 2001;24:820-8. View abstract.
  • Ohno S, Sumiyoshi Y, Hashine K, et al. Phase I clinical study of the dietary supplement, Agaricus blazei Murill, in cancer patients in remission. Evid Based Complement Alternat Med 2011, doi 10.1155/2011/192381. View abstract.
  • Shimizu S, Kitada H, Yokota H, et al. Activation of the alternative complement pathway by Agaricus blazei Murill. Phytomedicine 2002;9:536-45. View abstract.
  • Suehiro M, Katoh N, Kishimoto S. Chelitis due to Agaricus blazei Murill mushroom extract. Contact Dermatitis 2007;56(5):293-4. View abstract.
  • Takaku T, Kimura Y, Okuda H. Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action. J Nutr 2001;131:1409-13. View abstract.
  • Tangen JM, Tierens A, Caers J, et al. Immunomodulatory effects of the Agaricus blazei Murrill-based mushroom extract AndroSan in patients with multiple myeloma undergoing high dose chemotherapy and autologous stem cell transplantation: a randomized, double blinded clinical study. Biomed Res Int 2015;2015:718539. View abstract.
  • Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E. Cytokine levels after consumption of a medicinal Agaricus blazei Murill-based mushroom extract, AndoSan, in patients with Crohn's disease and ulcerative colitis in a randomized single-blinded placebo-controlled study. Scand J Immunol 2016;84(6):323-331. View abstract.
  • Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E. Effect of a medicinal Agaricus blazei Murill-based mushroom extract, AndroSan, on symptoms, fatigue and quality of life in patients with ulcerative colitis in a randomized single-blinded placebo controlled study. PLoS One 2016;11(3):e0150191. View abstract.
  • Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E. Effect of the medicinal Agaricus blazei Murill-based mushroom extract, AndoSan, on symptoms, fatigue and quality of life in patients with Crohn's disease in a randomized single-blinded placebo controlled study. PLoS One 2016;11(7):e0159288. View abstract.
  • Vincent M, Philippe E, Everard A, et al. Dietary supplementation with Agaricus blazei Murill extract prevents diet-induced obesity and insulin resistance in rats. Obesity (Silver Spring) 2013;21(3):553-61. View abstract.
  • Wei Q, Zhan Y, Chen B, et al. Assessment of antioxidant and antidiabetic properties of Agaricus blazei Murill extracts. Food Sci Nutr 2019;8(1):332-9. doi: 10.1002/fsn3.1310. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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