ASPARTIC ACID: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Aspartic acid is a type of amino acid. Amino acids are used as building blocks to make protein in the body. One type of aspartic acid, called D-aspartic acid, is not used to make protein, but it is used in other body functions.

People use aspartic acid for fatigue, athletic performance, and muscle strength, but there is no good scientific evidence to support these uses.

How does it work ?

There isn't enough reliable information to know how L-aspartic acid might work.

Uses & Effectiveness ?

Insufficient Evidence for

Muscle strength. Taking D-aspartic acid does not seem to improve muscle strength in trained male athletes. The effect of D-aspartic acid in untrained athletes or women is not known.
Athletic performance.
Fatigue.
Increase absorption of minerals.
Withdrawal from heroin, morphine, and other opioid drugs.
Other conditions.

More evidence is needed to rate the effectiveness of aspartic acid for these uses.

Side Effects

Special Precautions and Warnings

When taken by mouth: Aspartic acid is LIKELY SAFE when consumed in food amounts. Aspartic acid is POSSIBLY SAFE when taken for a short time. There isn't enough reliable information to know if aspartic acid is safe when used long-term or what the side effects might be. Pregnancy and breast-feeding: Aspartic acid is LIKELY SAFE when consumed in food amounts. It is POSSIBLY UNSAFE when taken as a supplement during pregnancy or while breast-feeding. Aspartic acid supplements have been linked to possible brain defects in newborn infants in animal research. Don't use aspartic acid supplements if you are pregnant, trying to become pregnant, or breast-feeding.

Children: Aspartic acid is POSSIBLY UNSAFE when given by mouth to infants. It has been linked to possible brain defects in animal research. Don't give aspartic acid supplements to infants. There isn't enough reliable information to know if aspartic acid supplements are safe in older children and adolescents or what the side effects might be. Stay on the safe side and avoid use.

Interactions ?

We currently have no information for ASPARTIC ACID overview.

Dosing

The appropriate dose of aspartic acid depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for aspartic acid. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

Abel, T., Knechtle, B., Perret, C., Eser, P., von Arx, P., and Knecht, H. Influence of chronic supplementation of arginine aspartate in endurance athletes on performance and substrate metabolism - a randomized, double-blind, placebo-controlled study. Int J Sports Med 2005;26(5):344-349. View abstract.

Colombani, P. C., Bitzi, R., Frey-Rindova, P., Frey, W., Arnold, M., Langhans, W., and Wenk, C. Chronic arginine aspartate supplementation in runners reduces total plasma amino acid level at rest and during a marathon run. Eur J Nutr. 1999;38(6):263-270. View abstract.

Denis, C., Dormois, D., Linossier, M. T., Eychenne, J. L., Hauseux, P., and Lacour, J. R. Effect of arginine aspartate on the exercise-induced hyperammoniemia in humans: a two periods cross-over trial. Arch.Int Physiol Biochim.Biophys. 1991;99(1):123-127. View abstract.

FORMICA, P. E. The housewife syndrome. Treatment with the potassium and magnesium salts of aspartic acid. Curr.Ther.Res.Clin.Exp. 1962;4:98-106. View abstract.

HICKS, J. T. TREATMENT OF FATIGUE IN GENERAL PRACTICE: A DOUBLE BLIND STUDY. Clin.Med (Northfield.Il) 1964;71:85-90. View abstract.

NAGLE, F. J., BALKE, B., GANSLEN, R. V., and DAVIS, A. W., Jr. THE MITIGATION OF PHYSICAL FATIGUE WITH "SPARTASE". REP 63-12. Rep.Civ.Aeromed.Res.Inst.US. 1963;1-10. View abstract.

Ruddel, H., Werner, C., and Ising, H. Impact of magnesium supplementation on performance data in young swimmers. Magnes.Res 1990;3(2):103-107. View abstract.

SHAW, D. L., Jr., CHESNEY, M. A., TULLIS, I. F., and AGERSBORG, H. P. Management of fatigue: a physiologic approach. Am.J Med Sci. 1962;243:758-769. View abstract.

Trudeau, F. Aspartate and its ergogenic potential. Science & Sports 1996;11(4):223-232.

Tuttle, J. L., Potteiger, J. A., Evans, B. W., and Ozmun, J. C. Effect of acute potassium-magnesium aspartate supplementation on ammonia concentrations during and after resistance training. Int J Sport Nutr. 1995;5(2):102-109. View abstract.

Beltz SD, Doering PL. Efficacy of nutritional supplements used by athletes. Clin Pharm 1993;12:900-8. View abstract.

Firoz M, Graber M. Bioavailability of US commercial magnesium preparations. Magnes Res 2001;14:257-62.. View abstract.

Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: The National Academies Press, 2005. Available at: https://doi.org/10.17226/10490

Ichikawa S, Gohda T, Murakoshi M, et al. Aspartic acid supplementation ameliorates symptoms of diabetic kidney disease in mice. FEBS Open Bio. 2020;10(6):1122-34. View abstract.

Melville GW, Siegler JC, Marshall PWM. The effects of d-aspartic acid supplementation in resistance-trained men over a three month training period: A randomised controlled trial. PLoS One. 2017;12(8):e0182630. View abstract.

Ota N, Shi T, Sweedler JV. D-Aspartate acts as a signaling molecule in nervous and neuroendocrine systems. Amino Acids 2012;43:1873-86. View abstract.

Roshanzamir F, Safavi SM. The putative effects of D-Aspartic acid on blood testosterone levels: a systematic review. Int J Reprod Biomed (Yazd) 2017;15:1-10.View abstract.

Wagenmakers A. Muscle amino acid metabolism at rest and during exercise: role in human physiology and metabolism. Exerc Sport Sci Rev 1998;26:287-314. View abstract.

Willoughby DS, Leutholtz B. D-aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained men. Nutr Res 2013;33:803-10. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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ASPARTIC ACID - Uses, Side Effects, and More