ARSENIC

OTHER NAME(S):

Arsenate, Arsenic Pentoxide, Arsenic Trichloride, Arsenic Trioxide, Arsénico, Arsenicum Album, Arsenicum Iodatum, Arsenite, Arsénite, Arsénite de Sodium, As, Atomic Number 33, Fowler's Solution, Numéro Atomique 33, Pentoxyde d'Arsenic, Sodium Arsenite, Solution de Fowler, Trichlorure d'Arsenic.<br/><br/>

Overview

Overview Information

Arsenic is a trace element. It is found in several foods including seafood, poultry, grains (especially rice), bread, cereal products, mushrooms, and dairy products. Some forms of arsenic are used as medicine. Some forms of arsenic (inorganic arsenic) can have serious side effects.

Healthcare providers sometimes give arsenic trioxide intravenously (by IV) to treat a type of blood cancer called acute promyelocytic leukemia. This arsenic product is available by prescription only.

Arsenic is also used for asthma, cough, pain, swelling (inflammation), and other conditions, but there is no good scientific evidence to support these uses. Using arsenic can also be unsafe.

How does it work?

Arsenic is a trace element that occurs naturally in very small amounts in the diet. Its exact functions are not known. The estimated adult daily intake of arsenic from a typical diet is 12-50 mcg. A dietary requirement of 12-25 mcg/day has been suggested.

In leukemia, arsenic trioxide increases death of cancer cells.

Uses

Uses & Effectiveness?

Effective for

  • Cancer of the white blood cells (leukemia). A specific, prescription-only form of arsenic (arsenic trioxide, Trisenox) is given by IV for the treatment of a specific cancer of the white blood cells known as acute promyelocytic leukemia.

Insufficient Evidence for

  • Asthma.
  • Cancer.
  • Cough.
  • Hemorrhoids.
  • Itching.
  • Rheumatoid arthritis (RA).
  • Scaly, itchy skin (psoriasis).
  • Other conditions.
More evidence is needed to rate the effectiveness of arsenic for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Arsenic is LIKELY SAFE when eaten in normal food amounts. The form of arsenic found naturally in foods (organic arsenic) does not seem to cause any harm. Other forms of arsenic (inorganic arsenic) are LIKELY UNSAFE when taken by mouth, especially when used long-term or in high doses. These forms can be very poisonous. Don't take arsenic supplements. Taking 10 mcg/kg daily over time can produce symptoms of arsenic poisoning. Taking high doses of arsenic, 5 mg or sometimes less, short-term can cause digestive tract symptoms. Higher doses can also cause severe poisoning and death. Inorganic arsenic is classified as a cancer-causing agent in humans. Drinking water contaminated with inorganic arsenic has been linked to cancer, heart problems, and diabetes.

When given by IV: Arsenic trioxide (Trisenox) is LIKELY SAFE when given intravenously (by IV) to adults by a healthcare provider. It is an FDA-approved prescription drug.

Special Precautions & Warnings:

Children: Arsenic is LIKELY SAFE when eaten by children in normal food amounts. The form of arsenic found naturally in foods (organic arsenic) does not seem to cause any harm. Other forms of arsenic (inorganic arsenic) are LIKELY UNSAFE for children when taken by mouth, especially when used long-term or in high doses. Over time, drinking water contaminated with inorganic arsenic may lead to problems with memory, attention, and intelligence in children.

Pregnancy and breast-feeding: Arsenic is LIKELY SAFE when eaten in normal food amounts by women who are pregnant or breast-feeding. However, other forms of arsenic (inorganic arsenic) are LIKELY UNSAFE when taken by mouth by women who are pregnant or breast-feeding, especially when used long-term or in high doses. Inorganic arsenic has been linked to miscarriages, stillbirths, and, in some cases, death of the newborn infant. Do not take arsenic supplements and avoid water contaminated with inorganic arsenic if you are pregnant or breast-feeding.

Low levels of folic acid (folic acid deficiency): There is some evidence that folic acid deficiency changes the way the body processes and removes arsenic and may contribute to higher arsenic levels.

Heart problems: The prescription form of arsenic (arsenic trioxide, Trisenox) can affect heart rhythm in some patients.

Interactions

Interactions?

Major Interaction

Do not take this combination

!
  • Medications that can cause an irregular heartbeat (QT interval-prolonging drugs) interacts with ARSENIC

    Some forms of arsenic might cause an abnormal heart beat. Taking arsenic along with other medications that can cause an irregular heartbeat might cause serious side effects including heart arrhythmias.<br /> Some medications that can cause an irregular heartbeat include amiodarone (Cordarone), disopyramide (Norpace), dofetilide (Tikosyn), ibutilide (Corvert), procainamide (Pronestyl), quinidine, sotalol (Betapace), thioridazine (Mellaril), and many others.

Dosing

Dosing

The following doses have been studied in scientific research:

BY IV:

  • For cancer of the white blood cells (leukemia): Healthcare providers give prescription-only arsenic intravenously (by IV) for a certain type of white blood cell cancer known as acute promyelocytic leukemia.

View References

REFERENCES:

  • Belon, P., Banerjee, P., Choudhury, S. C., Banerjee, A., Biswas, S. J., Karmakar, S. R., Pathak, S., Guha, B., Chatterjee, S., Bhattacharjee, N., Das, J. K., and Khuda-Bukhsh, A. R. Can administration of potentized homeopathic remedy, Arsenicum album, alter antinuclear antibody (ANA) titer in people living in high-risk arsenic contaminated areas? I. A correlation with certain hematological parameters. Evid Based Complement Alternat.Med 2006;3(1):99-107. View abstract.
  • Datta, S., Mallick, P., and Bukhsh, A. R. Efficacy of a potentized homoeopathic drug (Arsenicum Album-30) in reducing genotoxic effects produced by arsenic trioxide in mice: comparative studies of pre-, post- and combined pre- and post-oral administration and comparative efficacy of two microdoses. Complement Ther.Med. 1999;7(2):62-75. View abstract.
  • Khuda-Bukhsh, A. R., Pathak, S., Guha, B., Karmakar, S. R., Das, J. K., Banerjee, P., Biswas, S. J., Mukherjee, P., Bhattacharjee, N., Choudhury, S. C., Banerjee, A., Bhadra, S., Mallick, P., Chakrabarti, J., and Mandal, B. Can homeopathic arsenic remedy combat arsenic poisoning in humans exposed to groundwater arsenic contamination?: a preliminary report on first human trial. Evid Based Complement Alternat.Med 2005;2(4):537-548. View abstract.
  • Kundu, S. N., Mitra, K., and Bukhsh, A. R. Efficacy of a potentized homoeopathic drug (Arsenicum-album-30) in reducing cytotoxic effects produced by arsenic trioxide in mice: III. Enzymatic changes and recovery of tissue damage in liver. Complement Ther.Med. 2000;8(2):76-81. View abstract.
  • Kundu, S. N., Mitra, K., and Khuda Bukhsh, A. R. Efficacy of a potentized homeopathic drug (Arsenicum-Aalbum-30) in reducing cytotoxic effects produced by arsenic trioxide in mice: IV. Pathological changes, protein profiles, and content of DNA and RNA. Complement Ther.Med. 2000;8(3):157-165. View abstract.
  • Mallick, P., Mallick, J. C., Guha, B., and Khuda-Bukhsh, A. R. Ameliorating effect of microdoses of a potentized homeopathic drug, Arsenicum Album, on arsenic-induced toxicity in mice. BMC.Complement Altern.Med. 10-22-2003;3(1):7. View abstract.
  • Mitra, K., Kundu, S. N., and Khuda Bukhsh, A. R. Efficacy of a potentized homoeopathic drug (Arsenicum Album-30) in reducing toxic effects produced by arsenic trioxide in mice: II. On alterations in body weight, tissue weight and total protein. Complement Ther.Med. 1999;7(1):24-34. View abstract.
  • Oberbaum, M., Schreiber, R., Rosenthal, C., and Itzchaki, M. Homeopathic treatment in emergency medicine: a case series. Homeopathy. 2003;92(1):44-47. View abstract.
  • Amster E, Tiwary A, Schenker MB. Case report: potential arsenic toxicosis secondary to herbal kelp supplement. Environ Health Perspect 2007;115:606-8. View abstract.
  • Chakraborti D, Mukherjee SC, Saha KC, et al. Arsenic toxicity from homeopathic treatment. J Toxicol Clin Toxicol 2003;41:963-7. View abstract.
  • Chiou HY, Huang WI, Su CL, et al. Dose-response relationship between prevalence of cerebrovascular disease and ingested inorganic arsenic. Stroke 1997;28:1717-23. View abstract.
  • Eckhert CD. Other trace elements. In: Shils ME, Shike M, Ross AC, et al (eds). Modern Nutrition in Health and Disease. 10th ed. Philadelphia, PA: Lippincott Williams & Wilkins, 2006.
  • Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002. Available at: www.nap.edu/books/0309072794/html/.
  • Gamble MV, Liu X, Slavkovich V, et al. Folic acid supplementation lowers blood arsenic. Am J Clin Nutr 2007;86:1202-9. View abstract.
  • Kim M. Mercury, cadmium and arsenic contents of calcium dietary supplements. Food Addit Contam 2004;21:763-7. View abstract.
  • Nielsen FH. Nutritional requirements for boron, silicon, vanadium, nickel, and arsenic: current knowledge and speculation. FASEB J 1991;5:2661-7. View abstract.
  • Ratnaike RN. Acute and chronic arsenic toxicity. Postgrad Med J 2003;79:391-6. View abstract.
  • US Department of Health and Human Services. Agency for Toxic Substances and Disease Registry. Public Health Statement: Arsenic. August 2007. Available at: www.atsdr.cdc.gov/toxprofiles/tp2-c1-b.pdf (Accessed 14 April 2008).
  • Uthus EO, Seaborn CD. Deliberations and evaluations of the approaches, endpoints and paradigms for dietary recommendations of the other trace elements. J Nutr 1996;126:2452s-2459s. View abstract.
  • Wasserman GA, Liu X, Parvez F, et al. Water arsenic exposure and children's intellectual function in Araihazar, Bangladesh. Environ Health Perspect 2004;112:1329-33. View abstract.
  • Belon, P., Banerjee, P., Choudhury, S. C., Banerjee, A., Biswas, S. J., Karmakar, S. R., Pathak, S., Guha, B., Chatterjee, S., Bhattacharjee, N., Das, J. K., and Khuda-Bukhsh, A. R. Can administration of potentized homeopathic remedy, Arsenicum album, alter antinuclear antibody (ANA) titer in people living in high-risk arsenic contaminated areas? I. A correlation with certain hematological parameters. Evid Based Complement Alternat.Med 2006;3(1):99-107. View abstract.
  • Khuda-Bukhsh, A. R., Pathak, S., Guha, B., Karmakar, S. R., Das, J. K., Banerjee, P., Biswas, S. J., Mukherjee, P., Bhattacharjee, N., Choudhury, S. C., Banerjee, A., Bhadra, S., Mallick, P., Chakrabarti, J., and Mandal, B. Can homeopathic arsenic remedy combat arsenic poisoning in humans exposed to groundwater arsenic contamination?: a preliminary report on first human trial. Evid Based Complement Alternat.Med 2005;2(4):537-548. View abstract.
  • Mallick, P., Mallick, J. C., Guha, B., and Khuda-Bukhsh, A. R. Ameliorating effect of microdoses of a potentized homeopathic drug, Arsenicum Album, on arsenic-induced toxicity in mice. BMC.Complement Altern.Med. 10-22-2003;3(1):7. View abstract.
  • Mitra, K., Kundu, S. N., and Khuda Bukhsh, A. R. Efficacy of a potentized homoeopathic drug (Arsenicum Album-30) in reducing toxic effects produced by arsenic trioxide in mice: II. On alterations in body weight, tissue weight and total protein. Complement Ther.Med. 1999;7(1):24-34. View abstract.
  • Oberbaum, M., Schreiber, R., Rosenthal, C., and Itzchaki, M. Homeopathic treatment in emergency medicine: a case series. Homeopathy. 2003;92(1):44-47. View abstract.
  • Amster E, Tiwary A, Schenker MB. Case report: potential arsenic toxicosis secondary to herbal kelp supplement. Environ Health Perspect 2007;115:606-8. View abstract.
  • Chakraborti D, Mukherjee SC, Saha KC, et al. Arsenic toxicity from homeopathic treatment. J Toxicol Clin Toxicol 2003;41:963-7. View abstract.
  • Chiou HY, Huang WI, Su CL, et al. Dose-response relationship between prevalence of cerebrovascular disease and ingested inorganic arsenic. Stroke 1997;28:1717-23. View abstract.
  • Dong J, Su SY. The association between arsenic and children's intelligence: a meta-analysis. Biol Trace Elem Res 2009;129(1-3):88-93. View abstract.
  • Eckhert CD. Other trace elements. In: Shils ME, Shike M, Ross AC, et al (eds). Modern Nutrition in Health and Disease. 10th ed. Philadelphia, PA: Lippincott Williams & Wilkins, 2006.
  • Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002. Available at: www.nap.edu/books/0309072794/html/.
  • Gamble MV, Liu X, Slavkovich V, et al. Folic acid supplementation lowers blood arsenic. Am J Clin Nutr 2007;86:1202-9. View abstract.
  • Hsueh YM, Chen WJ, Lee CY, et al. Association of arsenic methylation capacity with developmental delays and health status in children: a prospective case-control trial. Sci Rep 2016;6:37287. View abstract.
  • Karagas MR, Punshon T, Sayarath V, Jackson BP, Folt CL, Cottingham KL. Association of rice and rice-product consumption with arsenic exposure early in life. JAMA Pediatr 2016;170(6):609-16. View abstract.
  • Kim M. Mercury, cadmium and arsenic contents of calcium dietary supplements. Food Addit Contam 2004;21:763-7. View abstract.
  • Lamm SH, Ferdosi H, Dissen EK, Li J, Ahn J. A systematic review and meta-regression analysis of lung cancer risk and inorganic arsenic in drinking water. Int J Environ Res Public Health 2015;12(12):15498-515. View abstract.
  • Moon KA, Oberoi S, Barchowsky A, et al. A dose-response meta-analysis of chronic arsenic exposure and incident cardiovascular disease. Int J Epidemiol 2017;46(6):1924-39. View abstract.
  • Nielsen FH. Nutritional requirements for boron, silicon, vanadium, nickel, and arsenic: current knowledge and speculation. FASEB J 1991;5:2661-7. View abstract.
  • Nong Q, Zhang Y, Guallar E, Zhong Q. Arsenic exposure and predicted 10-year atherosclerotic cardiovascular risk using the pooled cohort equations in U.S. hypertensive adults. Int J Environ Res Public Health 2016;13(11). pii: E1093. View abstract.
  • Pichler G, Grau-Perez M, Tellez-Plaza M, et al. Association of arsenic exposure with cardiac geometry and left ventricular function in young adults. Circ Cardiovasc Imaging 2019;12(5):e009018. View abstract.
  • Quansah R, Armah FA, Essumang DK, et al. Association of arsenic with adverse pregnancy outcomes/infant mortality: a systematic review and meta-analysis. Environ Health Perspect 2015;123(5):412-21. View abstract.
  • Ratnaike RN. Acute and chronic arsenic toxicity. Postgrad Med J 2003;79:391-6. View abstract.
  • Rodríguez-Barranco M, Lacasaña M, Aguilar-Garduño C, et al. Association of arsenic, cadmium and manganese exposure with neurodevelopment and behavioural disorders in children: a systematic review and meta-analysis. Sci Total Environ 2013;454-455:562-77. View abstract.
  • Saint-Jacques N, Parker L, Brown P, Dummer TJ. Arsenic in drinking water and urinary tract cancers: a systematic review of 30 years of epidemiological evidence. Environ Health 2014;13:44. View abstract.
  • Sung TC, Huang JW, Guo HR. Association between arsenic exposure and diabetes: a meta-analysis. Biomed Res Int 2015;2015:368087. View abstract.
  • Tsinovoi CL, Xun P, McClure LA, et al. Arsenic exposure in relation to ischemic stroke: the reasons for geographic and racial differences in stroke study. Stroke 2018;49(1):19-26. View abstract.
  • US Department of Health and Human Services. Agency for Toxic Substances and Disease Registry. Public Health Statement: Arsenic. August 2007. Available at: www.atsdr.cdc.gov/toxprofiles/tp2-c1-b.pdf (Accessed 14 April 2008).
  • Uthus EO, Seaborn CD. Deliberations and evaluations of the approaches, endpoints and paradigms for dietary recommendations of the other trace elements. J Nutr 1996;126:2452s-2459s. View abstract.
  • Wang W, Xie Z, Lin Y, Zhang D. Association of inorganic arsenic exposure with type 2 diabetes mellitus: a meta-analysis. J Epidemiol Community Health 2014;68(2):176-84. View abstract.
  • Wasserman GA, Liu X, Parvez F, et al. Water arsenic exposure and children's intellectual function in Araihazar, Bangladesh. Environ Health Perspect 2004;112:1329-33. View abstract.

Vitamins Survey

Have you ever purchased ARSENIC?

Did you or will you purchase this product in-store or online?

Where did you or where do you plan to purchase this product?

Where did you or where do you plan to purchase this product?

What factors influenced or will influence your purchase? (check all that apply)

Vitamins Survey

Where did you or where do you plan to purchase this product?

Do you buy vitamins online or instore?

What factors are most important to you? (check all that apply)

This survey is being conducted by the WebMD marketing sciences department.Read More

More Resources for ARSENIC

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.