Almeida, A. A., Farah, A., Silva, D. A., Nunan, E. A., and Gloria, M. B. Antibacterial activity of coffee extracts and selected coffee chemical compounds against enterobacteria. J Agric.Food Chem 11-15-2006;54(23):8738-8743. View abstract.
Arion, W. J., Canfield, W. K., Ramos, F. C., Schindler, P. W., Burger, H. J., Hemmerle, H., Schubert, G., Below, P., and Herling, A. W. Chlorogenic acid and hydroxynitrobenzaldehyde: new inhibitors of hepatic glucose 6-phosphatase. Arch.Biochem.Biophys. 3-15-1997;339(2):315-322. View abstract.
Bassoli, B. K., Cassolla, P., Borba-Murad, G. R., Constantin, J., Salgueiro-Pagadigorria, C. L., Bazotte, R. B., da Silva, R. S., and de Souza, H. M. Chlorogenic acid reduces the plasma glucose peak in the oral glucose tolerance test: effects on hepatic glucose release and glycaemia. Cell Biochem.Funct. 2008;26(3):320-328. View abstract.
Blum, J., Lemaire, B., and Lafay, S. Effect of a green decaffeinated coffee extract on glycaemia: a pilot prospective study. Nutrafoods 2007;6(3):13-17.
Clifford, M. N., Marks, S., Knight, S., and Kuhnert, N. Characterization by LC-MS(n) of four new classes of p-coumaric acid-containing diacyl chlorogenic acids in green coffee beans. J.Agric.Food Chem. 6-14-2006;54(12):4095-4101. View abstract.
Couteau, D., McCartney, A. L., Gibson, G. R., Williamson, G., and Faulds, C. B. Isolation and characterization of human colonic bacteria able to hydrolyse chlorogenic acid. J.Appl.Microbiol. 2001;90(6):873-881. View abstract.
Daglia, M., Papetti, A., Gregotti, C., Berte, F., and Gazzani, G. In vitro antioxidant and ex vivo protective activities of green and roasted coffee. J.Agric.Food Chem. 2000;48(5):1449-1454. View abstract.
Daglia, M., Tarsi, R., Papetti, A., Grisoli, P., Dacarro, C., Pruzzo, C., and Gazzani, G. Antiadhesive effect of green and roasted coffee on Streptococcus mutans' adhesive properties on saliva-coated hydroxyapatite beads. J.Agric.Food Chem. 2-27-2002;50(5):1225-1229. View abstract.
Franzke, C., Grunert, K. S., Hildebrandt, U., and Griehl, H. [On the theobromine and theophylline content of raw coffee and tea]. Pharmazie 9-9-1968;23(9):502-503. View abstract.
Glei, M., Kirmse, A., Habermann, N., Persin, C., and Pool-Zobel, B. L. Bread enriched with green coffee extract has chemoprotective and antigenotoxic activities in human cells. Nutr.Cancer 2006;56(2):182-192. View abstract.
Gonthier, M. P., Verny, M. A., Besson, C., Remesy, C., and Scalbert, A. Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats. J.Nutr. 2003;133(6):1853-1859. View abstract.
Greenberg, J. A., Boozer, C. N., and Geliebter, A. Coffee, diabetes, and weight control. Am.J.Clin.Nutr. 2006;84(4):682-693. View abstract.
Herling, A. W., Burger, H., Schubert, G., Hemmerle, H., Schaefer, H., and Kramer, W. Alterations of carbohydrate and lipid intermediary metabolism during inhibition of glucose-6-phosphatase in rats. Eur.J.Pharmacol. 12-10-1999;386(1):75-82. View abstract.
Higdon, J. V. and Frei, B. Coffee and health: a review of recent human research. Crit Rev.Food Sci.Nutr. 2006;46(2):101-123. View abstract.
Monteiro, M., Farah, A., Perrone, D., Trugo, L. C., and Donangelo, C. Chlorogenic acid compounds from coffee are differentially absorbed and metabolized in humans. J.Nutr. 2007;137(10):2196-2201. View abstract.
Moridani, M. Y., Scobie, H., and O'Brien, P. J. Metabolism of caffeic acid by isolated rat hepatocytes and subcellular fractions. Toxicol.Lett. 7-21-2002;133(2-3):141-151. View abstract.
Oka, K. [Pharmacological bases of coffee nutrients for diabetes prevention]. Yakugaku Zasshi 2007;127(11):1825-1836. View abstract.
Olthof, M. R., Hollman, P. C., Buijsman, M. N., van Amelsvoort, J. M., and Katan, M. B. Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans. J.Nutr. 2003;133(6):1806-1814. View abstract.
Ramalakshmi, K., Kubra, I. R., and Rao, L. J. Physicochemical characteristics of green coffee: comparison of graded and defective beans. J.Food Sci. 2007;72(5):S333-S337. View abstract.
Richelle, M., Tavazzi, I., and Offord, E. Comparison of the antioxidant activity of commonly consumed polyphenolic beverages (coffee, cocoa, and tea) prepared per cup serving. J.Agric.Food Chem. 2001;49(7):3438-3442. View abstract.
Saito, T., Tsuchida, T., Watanabe, T., Arai, Y., Mitsui, Y., Okawa, W., and Kajihara, Y. Effect of coffee bean extract in essential hypertension. Jpn J Med Pharm Sci 2002;47:67-74.
Selmar, D., Bytof, G., and Knopp, S. E. The storage of green coffee (Coffea arabica): decrease of viability and changes of potential aroma precursors. Ann.Bot. 2008;101(1):31-38. View abstract.
Suzuki, A., Fujii, A., Jokura, H., Tokimitsu, I., Hase, T., and Saito, I. Hydroxyhydroquinone interferes with the chlorogenic acid-induced restoration of endothelial function in spontaneously hypertensive rats. Am.J.Hypertens. 2008;21(1):23-27. View abstract.
Suzuki, A., Fujii, A., Yamamoto, N., Yamamoto, M., Ohminami, H., Kameyama, A., Shibuya, Y., Nishizawa, Y., Tokimitsu, I., and Saito, I. Improvement of hypertension and vascular dysfunction by hydroxyhydroquinone-free coffee in a genetic model of hypertension. FEBS Lett. 4-17-2006;580(9):2317-2322. View abstract.
Takahama, U., Ryu, K., and Hirota, S. Chlorogenic acid in coffee can prevent the formation of dinitrogen trioxide by scavenging nitrogen dioxide generated in the human oral cavity. J.Agric.Food Chem. 10-31-2007;55(22):9251-9258. View abstract.
Uragoda, C. G. Acute symptoms in coffee workers. J.Trop.Med.Hyg. 1988;91(3):169-172. View abstract.
van Dam, R. M. Coffee and type 2 diabetes: from beans to beta-cells. Nutr Metab Cardiovasc.Dis. 2006;16(1):69-77. View abstract.
Zuskin, E., Kanceljak, B., Skuric, Z., and Butkovic, D. Bronchial reactivity in green coffee exposure. Br.J.Ind.Med. 1985;42(6):415-420. View abstract.
- Jackson, L. S. and Lee, K. Chemical forms of iron, calcium, magnesium and zinc in coffee and rat diets containing coffee. J-Food-Prot.Ames, Iowa : International Association of Milk, Food, and Environmental Sanitarians 1988;51(11):883-886.
Abernethy DR, Todd EL. Impairment of caffeine clearance by chronic use of low-dose oestrogen-containing oral contraceptives. Eur J Clin Pharmacol 1985;28:425-8. View abstract.
Ali M, Afzal M. A potent inhibitor of thrombin stimulated platelet thromboxane formation from unprocessed tea. Prostaglandins Leukot Med 1987;27:9-13. View abstract.
Alonso-Salces RM, Serra F, Reniero F, Héberger K. Botanical and geographical characterization of green coffee (Coffea arabica and Coffea canephora): chemometric evaluation of phenolic and methylxanthine contents. J Agric Food Chem 2009;57:4224-35. View abstract.
Aqel RA, Zoghbi GJ, Trimm JR, et al. Effect of caffeine administered intravenously on intracoronary-administered adenosine-induced coronary hemodynamics in patients with coronary artery disease. Am J Cardiol 2004;93:343-6. View abstract.
Ardlie NG, Glew G, Schultz BG, Schwartz CJ. Inhibition and reversal of platelet aggregation by methyl xanthines. Thromb Diath Haemorrh 1967;18:670-3. View abstract.
Avisar R, Avisar E, Weinberger D. Effect of coffee consumption on intraocular pressure. Ann Pharmacother 2002;36:992-5.. View abstract.
Bara AI, Barley EA. Caffeine for asthma. Cochrane Database Syst Rev 2001;4:CD001112.. View abstract.
Beach CA, Mays DC, Guiler RC, et al. Inhibition of elimination of caffeine by disulfiram in normal subjects and recovering alcoholics. Clin Pharmacol Ther 1986;39:265-70. View abstract.
Bell DG, Jacobs I, Ellerington K. Effect of caffeine and ephedrine ingestion on anaerobic exercise performance. Med Sci Sports Exerc 2001;33:1399-403. View abstract.
Benowitz NL, Osterloh J, Goldschlager N, et al. Massive catecholamine release from caffeine poisoning. JAMA 1982;248:1097-8. View abstract.
Blum J, Lemaire B, and Lafay S. Effect of a green decaffeinated coffee extract on glycaemia: a pilot prospective study. Nutrafoods 2007;6(3):13-17.
Brown NJ, Ryder D, Branch RA. A pharmacodynamic interaction between caffeine and phenylpropanolamine. Clin Pharmacol Ther 1991;50:363-71. View abstract.
Carbo M, Segura J, De la Torre R, et al. Effect of quinolones on caffeine disposition. Clin Pharmacol Ther 1989;45:234-40. View abstract.
Carrillo JA, Benitez J. Clinically significant pharmacokinetic interactions between dietary caffeine and medications. Clin Pharmacokinet 2000;39:127-53. View abstract.
Chiu KM. Efficacy of calcium supplements on bone mass in postmenopausal women. J Gerontol A Biol Sci Med Sci 1999;54:M275-80. View abstract.
Dellalibera O, Lemaire B, Lafay S. Svetol, green coffee extract, induces weight loss and increases the lean to fat mass ratio in volunteers with overweight problem. Phytotherapie 2006;4:194-7.
Dellalibera, O., Lemaire, B., and Lafay, S. Svetol®, green coffee extract, induces weight loss and increases the lean to fat mass ratio in volunteers with overweight problem. Phytotherapie 2006;4:1-4.
Dews PB, Curtis GL, Hanford KJ, O'Brien CP. The frequency of caffeine withdrawal in a population-based survey and in a controlled, blinded pilot experiment. J Clin Pharmacol 1999;39:1221-32. View abstract.
Dews PB, O'Brien CP, Bergman J. Caffeine: behavioral effects of withdrawal and related issues. Food Chem Toxicol 2002;40:1257-61. View abstract.
Duncan L. The green coffee bean that burns fat fast. The Dr. Oz Show, April 25, 2012. Available at: https://www.doctoroz.com/blog/lindsey-duncan-nd-cn/green-coffee-bean-burns-fat-fast.
Durrant KL. Known and hidden sources of caffeine in drug, food, and natural products. J Am Pharm Assoc 2002;42:625-37. View abstract.
Farah A, Donangelo CM. Phenolic compounds in coffee. Braz J Plant Physiol 2006;18:23-36.
Farah A, Monteiro M, Donangelo CM, Lafay S. Chlorogenic acids from green coffee extract are highly bioavailable in humans. J Nutr 2008;138:2309-15. View abstract.
Federal Trade Commission Press Release. Green coffee bean manufacturer settles FTC charges of pushing its product based on results of "seriously flawed" weight loss study. Available at: www.ftc.gov/news-events/press-releases/2014/09/green-coffee-bean-manufacturer-settles-ftc-charges-pushing-its (accessed July 5, 2015).
Federal Trade Commission Press Release. Marketer who promoted a green coffee bean weight-loss supplement agrees to settle FTC charges. Available at: www.ftc.gov/news-events/press-releases/2015/01/marketer-who-promoted-green-coffee-bean-weight-loss-supplement (accessed July 5, 2015).
Ferrini RL, Barrett-Connor E. Caffeine intake and endogenous sex steroid levels in postmenopausal women. The Rancho Bernardo Study. Am J Epidemiol 1996:144:642-4. View abstract.
Forrest WH Jr, Bellville JW, Brown BW Jr. The interaction of caffeine with pentobarbital as a nighttime hypnotic. Anesthesiology 1972;36:37-41. View abstract.
Gertz BJ, Holland SD, Kline WF, et al. Studies of the oral bioavailability of alendronate. Clin Pharmacol Ther 1995;58:288-98. View abstract.
Greer F, Hudson R, Ross R, et al. Caffeine ingestion decreases glucose disposal during a hyperinsulinemic-euglycemic clamp in sedentary humans. Diabetes. 2001 Oct;50:2349-54. View abstract.
Hagg S, Spigset O, Mjorndal T, Dahlqvist R. Effect of caffeine on clozapine pharmacokinetics in healthy volunteers. Br J Clin Pharmacol 2000;49:59-63. View abstract.
Haller CA, Benowitz NL, Jacob P 3rd. Hemodynamic effects of ephedra-free weight-loss supplements in humans. Am J Med 2005;118:998-1003.. View abstract.
Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000;343:1833-8. View abstract.
Harder S, Fuhr U, Staib AH, Wolff T. Ciprofloxacin-caffeine: a drug interaction established using in vivo and in vitro investigations. Am J Med 1989;87:89S-91S. View abstract.
Healy DP, Polk RE, Kanawati L, et al. Interaction between oral ciprofloxacin and caffeine in normal volunteers. Antimicrob Agents Chemother 1989;33:474-8. View abstract.
Hodgson JM, Puddey IB, Burke V, et al. Effects on blood pressure of drinking green and black tea. J Hypertens 1999;17:457-63. View abstract.
Holmgren P, Norden-Pettersson L, Ahlner J. Caffeine fatalities--four case reports. Forensic Sci Int 2004;139:71-3. View abstract.
Horner NK, Lampe JW. Potential mechanisms of diet therapy for fibrocystic breast conditions show inadequate evidence of effectiveness. J Am Diet Assoc 2000;100:1368-80. View abstract.
Hurrell RF, Reddy M, Cook JD. Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages. Br J Nutr 1999;81:289-95. View abstract.
Infante S, Baeza ML, Calvo M, et al. Anaphylaxis due to caffeine. Allergy 2003;58:681-2. View abstract.
Institute of Medicine. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. Washington, DC: National Academy Press, 2001. Available at: https://books.nap.edu/books/0309082587/html/index.html.
Irwin PL, King G, Hicks KB. Polymerized cyclomaltoheptaose (beta-cyclodextrin, beta-CDn) inclusion complex formation with chlorogenic acid: solvent effects on thermochemistry and enthalpy-entropy compensation. Carbohydr Res. 1996 Feb 28;282:65-79. View abstract.
Irwin PL, Pfeffer PE, Doner LW, et al. Binding geometry, stoichiometry, and thermodynamics of cyclomalto-oligosaccharide (cyclodextrin) inclusion complex formation with chlorogenic acid, the major substrate of apple polyphenol oxidase. Carbohydr Res. 1994 Mar 18;256:13-27. View abstract.
Jefferson JW. Lithium tremor and caffeine intake: two cases of drinking less and shaking more. J Clin Psychiatry 1988;49:72-3. View abstract.
Joeres R, Klinker H, Heusler H, et al. Influence of mexiletine on caffeine elimination. Pharmacol Ther 1987;33:163-9. View abstract.
Johnston KL, Clifford MN, Morgan LM. Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine. Am J Clin Nutr. 2003 Oct;78:728-33. View abstract.
Juliano LM, Griffiths RR. A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features. Psychopharmacology (Berl) 2004;176:1-29. View abstract.
Keijzers GB, De Galan BE, Tack CJ, et al. Caffeine can decrease insulin sensitivity in humans. Diabetes Care. 2002 Feb;25:364-9. View abstract.
Klag MJ, Wang NY, Meoni LA, et al. Coffee intake and risk of hypertension: The John Hopkins precursors study. Arch Intern Med 2002;162:657-62. View abstract.
Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. View abstract.
Kozuma K, Tsuchiya S, Kohori J, et al. Antihypertensive effect of green coffee bean extract on mildly hypertensive subjects. Hypertens Res. 2005 Sep;28(9):711-8. View abstract.
Kynast-Gales SA, Massey LK. Effect of caffeine on circadian excretion of urinary calcium and magnesium. J Am Coll Nutr. 1994;13:467-72. View abstract.
Lake CR, Rosenberg DB, Gallant S, et al. Phenylpropanolamine increases plasma caffeine levels. Clin Pharmacol Ther 1990;47:675-85. View abstract.
Leson CL, McGuigan MA, Bryson SM. Caffeine overdose in an adolescent male. J Toxicol Clin Toxicol 1988;26:407-15. View abstract.
Lloyd T, Johnson-Rollings N, Eggli DF, et al. Bone status among postmenopausal women with different habitual caffeine intakes: a longitudinal investigation. J Am Coll Nutr 2000;19:256-61. View abstract.
Massey LK, Whiting SJ. Caffeine, urinary calcium, calcium metabolism and bone. J Nutr 1993;123:1611-4. View abstract.
Massey LK. Is caffeine a risk factor for bone loss in the elderly? Am J Clin Nutr 2001;74:569-70. View abstract.
May DC, Jarboe CH, VanBakel AB, Williams WM. Effects of cimetidine on caffeine disposition in smokers and nonsmokers. Clin Pharmacol Ther 1982;31:656-61. View abstract.
Mester R, Toren P, Mizrachi I, et al. Caffeine withdrawal increases lithium blood levels. Biol Psychiatry 1995;37:348-50. View abstract.
Moreira DP, Monteiro MC, Ribeiro-Alves M, et al. Contribution of chlorogenic acids to the iron-reducing activity of coffee beverages. J Agric Food Chem. 2005 Mar 9;53:1399-402. View abstract.
Nix D, Zelenitsky S, Symonds W, et al. The effect of fluconazole on the pharmacokinetics of caffeine in young and elderly subjects. Clin Pharmacol Ther 1992;51:183.
Nurminen ML, Niittynen L, Korpela R, Vapaatalo H. Coffee, caffeine and blood pressure: a critical review. Eur J Clin Nutr 1999;53:831-9. View abstract.
Ochiai R, Jokura H, Suzuki A, et al. Green coffee bean extract improves human vasoreactivity. Hypertens Res 2004;27:731-7. View abstract.
Olthof MR, Hollman PC, Zock PL, Katan MB. Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans. Am J Clin Nutr 2001;73:532-8. View abstract.
Olthol MR, Hollman PCH, Katan MB. Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr 2001;131:66-71. View abstract.
Onakpoya I, Terry R, Ernst E. The use of green coffee extract as a weight loss supplement: a systematic review and meta-analysis of randomised clinical trials. Gastroenterol Res Pract 2011;2011. pii: 382852. Epub 2010 Aug 31. View abstract.
Pereira MA, Parker ED, and Folsom AR. Coffee consumption and risk of type 2 diabetes mellitus: an 11-year prospective study of 28 812 postmenopausal women. Arch Intern Med. 2006 Jun 26;166:1311-6. View abstract.
Pollock BG, Wylie M, Stack JA, et al. Inhibition of caffeine metabolism by estrogen replacement therapy in postmenopausal women. J Clin Pharmacol 1999;39:936-40. View abstract.
Raaska K, Raitasuo V, Laitila J, Neuvonen PJ. Effect of caffeine-containing versus decaffeinated coffee on serum clozapine concentrations in hospitalised patients. Basic Clin Pharmacol Toxicol 2004;94:13-8. View abstract.
Rapuri PB, Gallagher JC, Kinyamu HK, Ryschon KL. Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes. Am J Clin Nutr 2001;74:694-700. View abstract.
Samarrae WA, Truswell AS. Short-term effect of coffee on blood fibrinolytic activity in healthy adults. Atherosclerosis 1977;26:255-60. View abstract.
Sanderink GJ, Bournique B, Stevens J, et al. Involvement of human CYP1A isoenzymes in the metabolism and drug interactions of riluzole in vitro. Pharmacol Exp Ther 1997;282:1465-72. View abstract.
Shimoda H, Seki E, Aitani M. Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC Complement Altern Med 2006;6:9. View abstract.
Sinclair CJ, Geiger JD. Caffeine use in sports. A pharmacological review. J Sports Med Phys Fitness 2000;40:71-9. View abstract.
Smith A. Effects of caffeine on human behavior. Food Chem Toxicol 2002;40:1243-55. View abstract.
Stanek EJ, Melko GP, Charland SL. Xanthine interference with dipyridamole-thallium-201 myocardial imaging. Pharmacother 1995;29:425-7. View abstract.
Suzuki A, Kagawa D, Ochiai R, et al. Green coffee bean extract and its metabolites have a hypotensive effect in spontaneously hypertensive rats. Hypertens Res. 2002 Jan;25:99-107. View abstract.
Svetol Product Information Pack. Naturex, Avignon, France. March 2013. Available at: https://greencoffee.gr/wp-content/uploads/2013/12/GA501071_PRODUCT-INFO-PACK_04-06-2013.pdf (accessed July 6, 2015).
Thom E. The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people. J Int Med Res 2007;35:900-8. View abstract.
Thong FS and Graham TE. Caffeine-induced impairment of glucose tolerance is abolished by beta-adrenergic receptor blockade in humans. J Appl Physiol (1985). 2002 Jun;92:2347-52. View abstract.
Underwood DA. Which medications should be held before a pharmacologic or exercise stress test? Cleve Clin J Med 2002;69:449-50. View abstract.
Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3. View abstract.
Vinson J, Burnham B. Retraction: Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects. Diabetes Metab Syndr Obes 2014;7:467. Available at: www.ncbi.nlm.nih.gov/pmc/articles/PMC4206203/.
Vinson JA, Burnham BR, Nagendran MV. Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects. Diabetes Metab Syndr Obes 2012;5:21-7. View abstract.
Wahllander A, Paumgartner G. Effect of ketoconazole and terbinafine on the pharmacokinetics of caffeine in healthy volunteers. Eur J Clin Pharmacol 1989;37:279-83. View abstract.
Wakabayashi K, Kono S, Shinchi K, et al. Habitual coffee consumption and blood pressure: A study of self-defense officials in Japan. Eur J Epidemiol 1998;14:669-73. View abstract.
Wallach J. Interpretation of Diagnostic Tests. A synopsis of Laboratory Medicine. Fifth ed; Boston, MA: Little Brown, 1992.
Watanabe T, Arai Y, Mitsui Y, et al. The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension. Clin Exp Hypertens 2006;28:439-49. View abstract.
Watson JM, Jenkins EJ, Hamilton P, et al. Influence of caffeine on the frequency and perception of hypoglycemia in free-living patients with type 1 diabetes. Diabetes Care 2000;23:455-9. View abstract.
Watson JM, Sherwin RS, Deary IJ, et al. Dissociation of augmented physiological, hormonal and cognitive responses to hypoglycaemia with sustained caffeine use. Clin Sci (Lond) 2003;104:447-54. View abstract.
Winkelmayer WC, Stampfer MJ, Willett WC, Curhan GC. Habitual caffeine intake and the risk of hypertension in women. JAMA 2005;294:2330-5. View abstract.
Yamaguchi T, Chikama A, Mori K, et al. Hydroxyhydroquinone-free coffee: a double-blind, randomized controlled dose-response study of blood pressure. Nutr Metab Cardiovasc Dis. 2008 Jul;18:408-14. View abstract.
Zheng XM, Williams RC. Serum caffeine levels after 24-hour abstention: clinical implications on dipyridamole (201)Tl myocardial perfusion imaging. J Nucl Med Technol 2002;30:123-7. View abstract.
Almeida, A. A., Farah, A., Silva, D. A., Nunan, E. A., and Gloria, M. B. Antibacterial activity of coffee extracts and selected coffee chemical compounds against enterobacteria. J Agric.Food Chem 11-15-2006;54(23):8738-8743. View abstract.
Alstott, R. L., Miller, A. J., and Forney, R. B. Report of a human fatality due to caffeine. J.Forensic Sci. 1973;18(2):135-137. View abstract.
Arion, W. J., Canfield, W. K., Ramos, F. C., Schindler, P. W., Burger, H. J., Hemmerle, H., Schubert, G., Below, P., and Herling, A. W. Chlorogenic acid and hydroxynitrobenzaldehyde: new inhibitors of hepatic glucose 6-phosphatase. Arch.Biochem.Biophys. 3-15-1997;339(2):315-322. View abstract.
Arya, L. A., Myers, D. L., and Jackson, N. D. Dietary caffeine intake and the risk for detrusor instability: a case-control study. Obstet.Gynecol. 2000;96(1):85-89. View abstract.
Banko, L. T., Haq, S. A., Rainaldi, D. A., Klem, I., Siegler, J., Fogel, J., Sacchi, T. J., and Heitner, J. F. Incidence of caffeine in serum of patients undergoing dipyridamole myocardial perfusion stress test by an intensive versus routine caffeine history screening. Am.J Cardiol. 5-15-2010;105(10):1474-1479. View abstract.
Bassoli, B. K., Cassolla, P., Borba-Murad, G. R., Constantin, J., Salgueiro-Pagadigorria, C. L., Bazotte, R. B., da Silva, R. S., and de Souza, H. M. Chlorogenic acid reduces the plasma glucose peak in the oral glucose tolerance test: effects on hepatic glucose release and glycaemia. Cell Biochem.Funct. 2008;26(3):320-328. View abstract.
Blum, J., Lemaire, B., and Lafay, S. Effect of a green decaffeinated coffee extract on glycaemia: a pilot prospective study. Nutrafoods 2007;6(3):13-17.
Bryant, C. M., Dowell, C. J., and Fairbrother, G. Caffeine reduction education to improve urinary symptoms. Br.J.Nurs. 4-25-2002;11(8):560-565. View abstract.
Buscemi, S., Verga, S., Batsis, J. A., Donatelli, M., Tranchina, M. R., Belmonte, S., Mattina, A., Re, A., and Cerasola, G. Acute effects of coffee on endothelial function in healthy subjects. Eur.J Clin Nutr. 2010;64(5):483-489. View abstract.
Clausen, T. Hormonal and pharmacological modification of plasma potassium homeostasis. Fundam.Clin Pharmacol 2010;24(5):595-605. View abstract.
Couteau, D., McCartney, A. L., Gibson, G. R., Williamson, G., and Faulds, C. B. Isolation and characterization of human colonic bacteria able to hydrolyse chlorogenic acid. J.Appl.Microbiol. 2001;90(6):873-881. View abstract.
Daglia, M., Papetti, A., Gregotti, C., Berte, F., and Gazzani, G. In vitro antioxidant and ex vivo protective activities of green and roasted coffee. J.Agric.Food Chem. 2000;48(5):1449-1454. View abstract.
Daglia, M., Tarsi, R., Papetti, A., Grisoli, P., Dacarro, C., Pruzzo, C., and Gazzani, G. Antiadhesive effect of green and roasted coffee on Streptococcus mutans' adhesive properties on saliva-coated hydroxyapatite beads. J.Agric.Food Chem. 2-27-2002;50(5):1225-1229. View abstract.
Dimaio, V. J. and Garriott, J. C. Lethal caffeine poisoning in a child. Forensic Sci. 1974;3(3):275-278. View abstract.
Ernest, D., Chia, M., and Corallo, C. E. Profound hypokalaemia due to Nurofen Plus and Red Bull misuse. Crit Care Resusc. 2010;12(2):109-110. View abstract.
Franzke, C., Grunert, K. S., Hildebrandt, U., and Griehl, H. [On the theobromine and theophylline content of raw coffee and tea]. Pharmazie 9-9-1968;23(9):502-503. View abstract.
Glauser, T., Bircher, A., and Wuthrich, B. [Allergic rhinoconjunctivitis caused by the dust of green coffee beans]. Schweiz.Med.Wochenschr. 8-29-1992;122(35):1279-1281. View abstract.
Glei, M., Kirmse, A., Habermann, N., Persin, C., and Pool-Zobel, B. L. Bread enriched with green coffee extract has chemoprotective and antigenotoxic activities in human cells. Nutr.Cancer 2006;56(2):182-192. View abstract.
Gonthier, M. P., Verny, M. A., Besson, C., Remesy, C., and Scalbert, A. Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats. J.Nutr. 2003;133(6):1853-1859. View abstract.
Greenberg, J. A., Boozer, C. N., and Geliebter, A. Coffee, diabetes, and weight control. Am.J.Clin.Nutr. 2006;84(4):682-693. View abstract.
Herling, A. W., Burger, H., Schubert, G., Hemmerle, H., Schaefer, H., and Kramer, W. Alterations of carbohydrate and lipid intermediary metabolism during inhibition of glucose-6-phosphatase in rats. Eur.J.Pharmacol. 12-10-1999;386(1):75-82. View abstract.
Higdon, J. V. and Frei, B. Coffee and health: a review of recent human research. Crit Rev.Food Sci.Nutr. 2006;46(2):101-123. View abstract.
Jeppesen, U., Loft, S., Poulsen, H. E., and Brsen, K. A fluvoxamine-caffeine interaction study. Pharmacogenetics 1996;6(3):213-222. View abstract.
Johansen, J. P. and Viskum, S. [Asthma associated with the handling of green coffee beans]. Ugeskr.Laeger 10-12-1987;149(42):2853. View abstract.
MacKenzie, T., Comi, R., Sluss, P., Keisari, R., Manwar, S., Kim, J., Larson, R., and Baron, J. A. Metabolic and hormonal effects of caffeine: randomized, double-blind, placebo-controlled crossover trial. Metabolism 2007;56(12):1694-1698. View abstract.
Mairesse, M., Casel, S., and Ledent, C. [Asthma to green coffee of environmental origin]. Rev.Mal Respir. 1996;13(3):308-309. View abstract.
Moisey, L. L., Robinson, L. E., and Graham, T. E. Consumption of caffeinated coffee and a high carbohydrate meal affects postprandial metabolism of a subsequent oral glucose tolerance test in young, healthy males. Br.J Nutr. 2010;103(6):833-841. View abstract.
Monteiro, M., Farah, A., Perrone, D., Trugo, L. C., and Donangelo, C. Chlorogenic acid compounds from coffee are differentially absorbed and metabolized in humans. J.Nutr. 2007;137(10):2196-2201. View abstract.
Moridani, M. Y., Scobie, H., and O'Brien, P. J. Metabolism of caffeic acid by isolated rat hepatocytes and subcellular fractions. Toxicol.Lett. 7-21-2002;133(2-3):141-151. View abstract.
Oka, K. [Pharmacological bases of coffee nutrients for diabetes prevention]. Yakugaku Zasshi 2007;127(11):1825-1836. View abstract.
Olthof, M. R., Hollman, P. C., Buijsman, M. N., van Amelsvoort, J. M., and Katan, M. B. Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans. J.Nutr. 2003;133(6):1806-1814. View abstract.
Orozco-Gregorio, H., Mota-Rojas, D., Bonilla-Jaime, H., Trujillo-Ortega, M. E., Becerril-Herrera, M., Hernandez-Gonzalez, R., and Villanueva-Garcia, D. Effects of administration of caffeine on metabolic variables in neonatal pigs with peripartum asphyxia. Am.J Vet.Res. 2010;71(10):1214-1219. View abstract.
Peyresblanques, J. [Conjunctival allergy to green coffee]. Bull.Soc.Ophtalmol.Fr. 1984;84(10):1097-1098. View abstract.
Richelle, M., Tavazzi, I., and Offord, E. Comparison of the antioxidant activity of commonly consumed polyphenolic beverages (coffee, cocoa, and tea) prepared per cup serving. J.Agric.Food Chem. 2001;49(7):3438-3442. View abstract.
Rigato, I., Blarasin, L., and Kette, F. Severe hypokalemia in 2 young bicycle riders due to massive caffeine intake. Clin J Sport Med. 2010;20(2):128-130. View abstract.
Rudolph, T. and Knudsen, K. A case of fatal caffeine poisoning. Acta Anaesthesiol.Scand 2010;54(4):521-523. View abstract.
Saito, T., Tsuchida, T., Watanabe, T., Arai, Y., Mitsui, Y., Okawa, W., and Kajihara, Y. Effect of coffee bean extract in essential hypertension. Jpn J Med Pharm Sci 2002;47:67-74.
Selmar, D., Bytof, G., and Knopp, S. E. The storage of green coffee (Coffea arabica): decrease of viability and changes of potential aroma precursors. Ann.Bot. 2008;101(1):31-38. View abstract.
Simmonds, M. J., Minahan, C. L., and Sabapathy, S. Caffeine improves supramaximal cycling but not the rate of anaerobic energy release. Eur.J Appl Physiol 2010;109(2):287-295. View abstract.
Smits, P., Corstens, F. H., Aengevaeren, W. R., Wackers, F. J., and Thien, T. False-negative dipyridamole-thallium-201 myocardial imaging after caffeine infusion. J Nucl.Med. 1991;32(8):1538-1541. View abstract.
Smits, P., Temme, L., and Thien, T. The cardiovascular interaction between caffeine and nicotine in humans. Clin Pharmacol Ther 1993;54(2):194-204. View abstract.
Suzuki, A., Fujii, A., Jokura, H., Tokimitsu, I., Hase, T., and Saito, I. Hydroxyhydroquinone interferes with the chlorogenic acid-induced restoration of endothelial function in spontaneously hypertensive rats. Am.J.Hypertens. 2008;21(1):23-27. View abstract.
Suzuki, A., Fujii, A., Yamamoto, N., Yamamoto, M., Ohminami, H., Kameyama, A., Shibuya, Y., Nishizawa, Y., Tokimitsu, I., and Saito, I. Improvement of hypertension and vascular dysfunction by hydroxyhydroquinone-free coffee in a genetic model of hypertension. FEBS Lett. 4-17-2006;580(9):2317-2322. View abstract.
Takahama, U., Ryu, K., and Hirota, S. Chlorogenic acid in coffee can prevent the formation of dinitrogen trioxide by scavenging nitrogen dioxide generated in the human oral cavity. J.Agric.Food Chem. 10-31-2007;55(22):9251-9258. View abstract.
Thelander, G., Jonsson, A. K., Personne, M., Forsberg, G. S., Lundqvist, K. M., and Ahlner, J. Caffeine fatalities--do sales restrictions prevent intentional intoxications? Clin Toxicol.(Phila) 2010;48(4):354-358. View abstract.
Thomas, K. E., Trigg, C. J., Baxter, P. J., Topping, M., Lacey, J., Crook, B., Whitehead, P., Bennett, J. B., and Davies, R. J. Factors relating to the development of respiratory symptoms in coffee process workers. Br.J.Ind.Med. 1991;48(5):314-322. View abstract.
Uragoda, C. G. Acute symptoms in coffee workers. J.Trop.Med.Hyg. 1988;91(3):169-172. View abstract.
van Dam, R. M. Coffee and type 2 diabetes: from beans to beta-cells. Nutr Metab Cardiovasc.Dis. 2006;16(1):69-77. View abstract.
Zuskin, E., Dreshaj, I., Jakupi, M., and Haxhiu, M. A. Effect of exposure to green coffee dust extract on airway reactivity. Arh.Hig.Rada Toksikol. 1986;37(2):205-216. View abstract.
Zuskin, E., Kanceljak, B., Mataija, M., and Tonkovic-Lojovic, M. [Specific bronchial reactivity in unripe coffee processing workers]. Arh.Hig.Rada Toksikol. 1989;40(1):3-8. View abstract.
Zuskin, E., Kanceljak, B., Skuric, Z., and Butkovic, D. Bronchial reactivity in green coffee exposure. Br.J.Ind.Med. 1985;42(6):415-420. View abstract.
- Jackson, L. S. and Lee, K. Chemical forms of iron, calcium, magnesium and zinc in coffee and rat diets containing coffee. J-Food-Prot.Ames, Iowa : International Association of Milk, Food, and Environmental Sanitarians 1988;51(11):883-886.
Abernethy DR, Todd EL. Impairment of caffeine clearance by chronic use of low-dose oestrogen-containing oral contraceptives. Eur J Clin Pharmacol 1985;28:425-8. View abstract.
Ali M, Afzal M. A potent inhibitor of thrombin stimulated platelet thromboxane formation from unprocessed tea. Prostaglandins Leukot Med 1987;27:9-13. View abstract.
Alonso-Salces RM, Serra F, Reniero F, Héberger K. Botanical and geographical characterization of green coffee (Coffea arabica and Coffea canephora): chemometric evaluation of phenolic and methylxanthine contents. J Agric Food Chem 2009;57:4224-35. View abstract.
Alshabi AM, Alkahtani SA, Shaikh IA, Habeeb MS. Caffeine modulates pharmacokinetic and pharmacodynamic profiles of pioglitazone in diabetic rats: Impact on therapeutics. Saudi Med J 2021;42(2):151-160. View abstract.
Anderson BJ, Gunn TR, Holford NH, Johnson R. Caffeine overdose in a premature infant: clinical course and pharmacokinetics. Anaesth Intensive Care 1999;27:307-11. View abstract.
Aqel RA, Zoghbi GJ, Trimm JR, et al. Effect of caffeine administered intravenously on intracoronary-administered adenosine-induced coronary hemodynamics in patients with coronary artery disease. Am J Cardiol 2004;93:343-6. View abstract.
Ardlie NG, Glew G, Schultz BG, Schwartz CJ. Inhibition and reversal of platelet aggregation by methyl xanthines. Thromb Diath Haemorrh 1967;18:670-3. View abstract.
Asbaghi O, Kashkooli S, Mardani M, et al. Effect of green coffee bean extract supplementation on liver function and inflammatory biomarkers: A meta-analysis of randomized clinical trials. Complement Ther Clin Pract 2021;43:101349. View abstract.
Asbaghi O, Sadeghian M, Rahmani S, et al. The effect of green coffee extract supplementation on anthropometric measures in adults: A comprehensive systematic review and dose-response meta-analysis of randomized clinical trials. Complement Ther Med. 2020;51:102424. View abstract.
Avisar R, Avisar E, Weinberger D. Effect of coffee consumption on intraocular pressure. Ann Pharmacother 2002;36:992-5.. View abstract.
Azcona O, Barbanoi MJ, Torrent J, Jane F. Evaluation of the central effects of alcohol and caffeine interaction. Br J Clin Pharmacol 1995;40:393-400. View abstract.
Bahmannia M, Azizzade M, Heydari S, et al. Effects of decaffeinated green coffee extract supplementation on anthropometric indices, blood glucose, leptin, adiponectin and neuropeptide Y (NPY) in breast cancer survivors: a randomized clinical trial. Food Funct 2022;13(19):10347-10356. View abstract.
Bara AI, Barley EA. Caffeine for asthma. Cochrane Database Syst Rev 2001;4:CD001112.. View abstract.
Beach CA, Mays DC, Guiler RC, et al. Inhibition of elimination of caffeine by disulfiram in normal subjects and recovering alcoholics. Clin Pharmacol Ther 1986;39:265-70. View abstract.
Beaudoin MS, Allen B, Mazzetti G, Sullivan PJ, Graham TE. Caffeine ingestion impairs insulin sensitivity in a dose-dependent manner in both men and women. Appl Physiol Nutr Metab. 2013;38(2):140-7. doi: 10.1139/apnm-2012-0201. Epub 2012 9. View abstract.
Bell DG, Jacobs I, Ellerington K. Effect of caffeine and ephedrine ingestion on anaerobic exercise performance. Med Sci Sports Exerc 2001;33:1399-403. View abstract.
Benowitz NL, Osterloh J, Goldschlager N, et al. Massive catecholamine release from caffeine poisoning. JAMA 1982;248:1097-8. View abstract.
Blum J, Lemaire B, and Lafay S. Effect of a green decaffeinated coffee extract on glycaemia: a pilot prospective study. Nutrafoods 2007;6(3):13-17.
Bonsignore A, Sblano S, Pozzi F, Ventura F, Dell'Erba A, Palmiere C. A case of suicide by ingestion of caffeine. Forensic Sci Med Pathol. 2014 Sep;10(3):448-51. doi: 10.1007/s12024-014-9571-6. Epub 2014 27. View abstract.
Boozer CN, Nasser JA, Heymsfield SB, et al. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. Int J Obes Relat Metab Disord 2001;25:316-24. View abstract.
Broughton LJ, Rogers HJ. Decreased systemic clearance of caffeine due to cimetidine. Br J Clin Pharmacol 1981;12:155-9. View abstract.
Brown NJ, Ryder D, Branch RA. A pharmacodynamic interaction between caffeine and phenylpropanolamine. Clin Pharmacol Ther 1991;50:363-71. View abstract.
Cappelletti S, Piacentino D, Fineschi V, Frati P, Cipollini L, Aromatario M. Caffeine-related deaths: manner of deaths and categories of risk. Nutrients. 2018 May 14;10(5). pii: E611. View abstract.
Carbo M, Segura J, De la Torre R, et al. Effect of quinolones on caffeine disposition. Clin Pharmacol Ther 1989;45:234-40. View abstract.
Carrillo JA, Benitez J. Clinically significant pharmacokinetic interactions between dietary caffeine and medications. Clin Pharmacokinet 2000;39:127-53. View abstract.
Cesana M, Broccali G, Imbimbo BP, Crema A. Effect of single doses of rufloxacin on the disposition of theophylline and caffeine after single administration. Int J Clin Pharmacol Ther Toxicol 1991:29:133-8. View abstract.
Chen H, Huang W, Huang X, et al. Effects of green coffee bean extract on C-reactive protein levels: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med. 2020;52:102498. View abstract.
Chen Y, Zhao Y, Wang Y, et al. The influence of green coffee bean extract supplementation on blood glucose levels: A systematic review and dose-response meta-analysis of randomized controlled trials. Phytother Res. 2020;34(9):2159-2169. View abstract.
Chen, Y., Xiao, C. Q., He, Y. J., Chen, B. L., Wang, G., Zhou, G., Zhang, W., Tan, Z. R., Cao, S., Wang, L. P., and Zhou, H. H. Genistein alters caffeine exposure in healthy female volunteers. Eur.J Clin.Pharmacol. 2011;67(4):347-353. View abstract.
Chiu KM. Efficacy of calcium supplements on bone mass in postmenopausal women. J Gerontol A Biol Sci Med Sci 1999;54:M275-80. View abstract.
Chroscinska-Krawczyk, M., Jargiello-Baszak, M., Walek, M., Tylus, B., and Czuczwar, S. J. Caffeine and the anticonvulsant potency of antiepileptic drugs: experimental and clinical data. Pharmacol.Rep. 2011;63(1):12-18. View abstract.
Cozma-Petrut A, Loghin F, Miere D, Dumitrascu DL.Diet in irritable bowel syndrome: What to recommend, not what to forbid to patients! World J Gastroenterol. 2017;23(21):3771-3783. View abstract.
Daniel, W. A., Syrek, M., Rylko, Z., and Kot, M. Effects of phenothiazine neuroleptics on the rate of caffeine demethylation and hydroxylation in the rat liver. Pol.J Pharmacol 2001;53(6):615-621. View abstract.
Dellalibera O, Lemaire B, Lafay S. Svetol, green coffee extract, induces weight loss and increases the lean to fat mass ratio in volunteers with overweight problem. Phytotherapie 2006;4:194-7.
Dellalibera, O., Lemaire, B., and Lafay, S. Svetol®, green coffee extract, induces weight loss and increases the lean to fat mass ratio in volunteers with overweight problem. Phytotherapie 2006;4:1-4.
Dews PB, Curtis GL, Hanford KJ, O'Brien CP. The frequency of caffeine withdrawal in a population-based survey and in a controlled, blinded pilot experiment. J Clin Pharmacol 1999;39:1221-32. View abstract.
Dews PB, O'Brien CP, Bergman J. Caffeine: behavioral effects of withdrawal and related issues. Food Chem Toxicol 2002;40:1257-61. View abstract.
Ding F, Ma B, Nazary-Vannani A, et al. The effects of green coffee bean extract supplementation on lipid profile in humans: A systematic review and meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis. 2020;30(1):1-10. View abstract.
Duncan L. The green coffee bean that burns fat fast. The Dr. Oz Show, April 25, 2012. Available at: https://www.doctoroz.com/blog/lindsey-duncan-nd-cn/green-coffee-bean-burns-fat-fast.
Durrant KL. Known and hidden sources of caffeine in drug, food, and natural products. J Am Pharm Assoc 2002;42:625-37. View abstract.
Farah A, Donangelo CM. Phenolic compounds in coffee. Braz J Plant Physiol 2006;18:23-36.
Farah A, Monteiro M, Donangelo CM, Lafay S. Chlorogenic acids from green coffee extract are highly bioavailable in humans. J Nutr 2008;138:2309-15. View abstract.
Federal Trade Commission Press Release. Green coffee bean manufacturer settles FTC charges of pushing its product based on results of "seriously flawed" weight loss study. Available at: www.ftc.gov/news-events/press-releases/2014/09/green-coffee-bean-manufacturer-settles-ftc-charges-pushing-its (accessed July 5, 2015).
Ferrini RL, Barrett-Connor E. Caffeine intake and endogenous sex steroid levels in postmenopausal women. The Rancho Bernardo Study. Am J Epidemiol 1996:144:642-4. View abstract.
Forrest WH Jr, Bellville JW, Brown BW Jr. The interaction of caffeine with pentobarbital as a nighttime hypnotic. Anesthesiology 1972;36:37-41. View abstract.
Fuhr, U., Strobl, G., Manaut, F., Anders, E. M., Sorgel, F., Lopez-de-Brinas, E., Chu, D. T., Pernet, A. G., Mahr, G., Sanz, F., and . Quinolone antibacterial agents: relationship between structure and in vitro inhibition of the human cytochrome P450 isoform CYP1A2. Mol.Pharmacol. 1993;43(2):191-199. View abstract.
García-Cordero J, Sierra-Cinos JL, Seguido MA, et al. Regular consumption of green coffee phenol, oat ß-glucan and green coffee phenol/oat ß-glucan supplements does not change body composition in subjects with overweight and obesity. Foods 2022;11(5):679. View abstract.
Gasior, M., Borowicz, K., Buszewicz, G., Kleinrok, Z., and Czuczwar, S. J. Anticonvulsant activity of phenobarbital and valproate against maximal electroshock in mice during chronic treatment with caffeine and caffeine discontinuation. Epilepsia 1996;37(3):262-268. View abstract.
Gasior, M., Swiader, M., Przybylko, M., Borowicz, K., Turski, W. A., Kleinrok, Z., and Czuczwar, S. J. Felbamate demonstrates low propensity for interaction with methylxanthines and Ca2+ channel modulators against experimental seizures in mice. Eur.J Pharmacol 7-10-1998;352(2-3):207-214. View abstract.
Gertz BJ, Holland SD, Kline WF, et al. Studies of the oral bioavailability of alendronate. Clin Pharmacol Ther 1995;58:288-98. View abstract.
Gorski, J. C., Huang, S. M., Pinto, A., Hamman, M. A., Hilligoss, J. K., Zaheer, N. A., Desai, M., Miller, M., and Hall, S. D. The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo. Clin Pharmacol Ther. 2004;75(1):89-100. View abstract.
Greer F, Hudson R, Ross R, et al. Caffeine ingestion decreases glucose disposal during a hyperinsulinemic-euglycemic clamp in sedentary humans. Diabetes. 2001 Oct;50:2349-54. View abstract.
Hagg S, Spigset O, Mjorndal T, Dahlqvist R. Effect of caffeine on clozapine pharmacokinetics in healthy volunteers. Br J Clin Pharmacol 2000;49:59-63. View abstract.
Haller CA, Benowitz NL, Jacob P 3rd. Hemodynamic effects of ephedra-free weight-loss supplements in humans. Am J Med 2005;118:998-1003.. View abstract.
Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000;343:1833-8. View abstract.
Harder S, Fuhr U, Staib AH, Wolff T. Ciprofloxacin-caffeine: a drug interaction established using in vivo and in vitro investigations. Am J Med 1989;87:89S-91S. View abstract.
Harder S, Staib AH, Beer C, et al. 4-quinolones inhibit biotransformation of caffeine. Eur J Clin Pharmacol 1988;35:651-6. View abstract.
Hartter, S., Nordmark, A., Rose, D. M., Bertilsson, L., Tybring, G., and Laine, K. Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity. Br.J.Clin.Pharmacol. 2003;56(6):679-682. View abstract.
Healy DP, Polk RE, Kanawati L, et al. Interaction between oral ciprofloxacin and caffeine in normal volunteers. Antimicrob Agents Chemother 1989;33:474-8. View abstract.
Hodgson JM, Puddey IB, Burke V, et al. Effects on blood pressure of drinking green and black tea. J Hypertens 1999;17:457-63. View abstract.
Holmgren P, Norden-Pettersson L, Ahlner J. Caffeine fatalities--four case reports. Forensic Sci Int 2004;139:71-3. View abstract.
Horner NK, Lampe JW. Potential mechanisms of diet therapy for fibrocystic breast conditions show inadequate evidence of effectiveness. J Am Diet Assoc 2000;100:1368-80. View abstract.
Hurrell RF, Reddy M, Cook JD. Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages. Br J Nutr 1999;81:289-95. View abstract.
Infante S, Baeza ML, Calvo M, et al. Anaphylaxis due to caffeine. Allergy 2003;58:681-2. View abstract.
Institute of Medicine. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. Washington, DC: National Academy Press, 2001. Available at: https://books.nap.edu/books/0309082587/html/index.html.
Irwin PL, King G, Hicks KB. Polymerized cyclomaltoheptaose (beta-cyclodextrin, beta-CDn) inclusion complex formation with chlorogenic acid: solvent effects on thermochemistry and enthalpy-entropy compensation. Carbohydr Res. 1996 Feb 28;282:65-79. View abstract.
Irwin PL, Pfeffer PE, Doner LW, et al. Binding geometry, stoichiometry, and thermodynamics of cyclomalto-oligosaccharide (cyclodextrin) inclusion complex formation with chlorogenic acid, the major substrate of apple polyphenol oxidase. Carbohydr Res. 1994 Mar 18;256:13-27. View abstract.
Jabbar SB, Hanly MG. Fatal caffeine overdose: a case report and review of literature. Am J Forensic Med Pathol. 2013;34(4):321-4. doi: 10.1097/PAF.0000000000000058. Review. View abstract.
Jankiewicz, K., Chroscinska-Krawczyk, M., Blaszczyk, B., and Czuczwar, S. J. [Caffeine and antiepileptic drugs: experimental and clinical data]. Przegl.Lek. 2007;64(11):965-967. View abstract.
Jefferson JW. Lithium tremor and caffeine intake: two cases of drinking less and shaking more. J Clin Psychiatry 1988;49:72-3. View abstract.
Jia H, Xu A, Yuan J, et al. Experimental study on cytochrome P450 enzymes after receiving ferment powder caterpillar fungus. Zhongguo Zhong Yao Za Zhi 2009;34:2079-82. View abstract.
Joeres R, Klinker H, Heusler H, et al. Influence of mexiletine on caffeine elimination. Pharmacol Ther 1987;33:163-9. View abstract.
Joeres R, Richter E. Mexiletine and caffeine elimination. N Engl J Med 1987;317:117. View abstract.
Johnston KL, Clifford MN, Morgan LM. Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine. Am J Clin Nutr. 2003 Oct;78:728-33. View abstract.
Juliano LM, Griffiths RR. A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features. Psychopharmacology (Berl) 2004;176:1-29. View abstract.
Keijzers GB, De Galan BE, Tack CJ, et al. Caffeine can decrease insulin sensitivity in humans. Diabetes Care. 2002 Feb;25:364-9. View abstract.
Khaneghah AM, Fakhri Y, Abdi L, Coppa CFSC, Franco LT, de Oliveira CAF. The concentration and prevalence of ochratoxin A in coffee and coffee-based products: A global systematic review, meta-analysis and meta-regression. Fungal Biol. 2019;123(8):611-617. View abstract.
Klag MJ, Wang NY, Meoni LA, et al. Coffee intake and risk of hypertension: The John Hopkins precursors study. Arch Intern Med 2002;162:657-62. View abstract.
Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. View abstract.
Kozuma K, Tsuchiya S, Kohori J, et al. Antihypertensive effect of green coffee bean extract on mildly hypertensive subjects. Hypertens Res. 2005 Sep;28(9):711-8. View abstract.
Kunitake Y, Mizoguchi Y, Sogawa R, et al. Effect of excessive coffee consumption on the clinical course of a patient with bipolar disorder: a case report and literature review.
Clin Neuropharmacol. 2017 Jul/Aug;40(4):160-162.
doi: 10.1097/WNF.0000000000000222.
View abstract.
Kynast-Gales SA, Massey LK. Effect of caffeine on circadian excretion of urinary calcium and magnesium. J Am Coll Nutr. 1994;13:467-72. View abstract.
Lake CR, Rosenberg DB, Gallant S, et al. Phenylpropanolamine increases plasma caffeine levels. Clin Pharmacol Ther 1990;47:675-85. View abstract.
Lane JD, Barkauskas CE, Surwit RS, Feinglos MN. Caffeine impairs glucose metabolism in type 2 diabetes. Diabetes Care 2004;27:2047-8. View abstract.
Lee DR, Lee J, Rota M, et al. Coffee consumption and risk of fractures: a systematic review and dose-response meta-analysis. Bone. 2014;63:20-8. View abstract.
Leson CL, McGuigan MA, Bryson SM. Caffeine overdose in an adolescent male. J Toxicol Clin Toxicol 1988;26:407-15. View abstract.
Li S, Dai Z, Wu Q. Effect of coffee intake on hip fracture: a meta-analysis of prospective cohort studies. Nutr J. 2015;14:38. View abstract.
Liu, T. T. and Liau, J. Caffeine increases the linearity of the visual BOLD response. Neuroimage. 2-1-2010;49(3):2311-2317. View abstract.
Lloyd T, Johnson-Rollings N, Eggli DF, et al. Bone status among postmenopausal women with different habitual caffeine intakes: a longitudinal investigation. J Am Coll Nutr 2000;19:256-61. View abstract.
Luszczki, J. J., Zuchora, M., Sawicka, K. M., Kozinska, J., and Czuczwar, S. J. Acute exposure to caffeine decreases the anticonvulsant action of ethosuximide, but not that of clonazepam, phenobarbital and valproate against pentetrazole-induced seizures in mice. Pharmacol Rep. 2006;58(5):652-659. View abstract.
Magdalan J, Zawadzki M, Skowronek R, et al. Nonfatal and fata intoxications with pure caffeine - report of three different cases. Forensic Sci Med Pathol. 2017 Sep;13(3):355-58. View abstract.
Martínez-López S, Sarriá B, Mateos R, Bravo-Clemente L. Moderate consumption of a soluble green/roasted coffee rich in caffeoylquinic acids reduces cardiovascular risk markers: results from a randomized, cross-over, controlled trial in healthy and hypercholesterolemic subjects. Eur J Nutr. 2019;58(2):865-878. View abstract.
Massey LK, Whiting SJ. Caffeine, urinary calcium, calcium metabolism and bone. J Nutr 1993;123:1611-4. View abstract.
Massey LK. Is caffeine a risk factor for bone loss in the elderly? Am J Clin Nutr 2001;74:569-70. View abstract.
May DC, Jarboe CH, VanBakel AB, Williams WM. Effects of cimetidine on caffeine disposition in smokers and nonsmokers. Clin Pharmacol Ther 1982;31:656-61. View abstract.
Meshkani M, Saedisomeolia A, Yekaninejad M, Mousavi SA, Ildarabadi A, Vahid-Dastjerdi M. The effect of green coffee supplementation on lipid profile, glycemic indices, inflammatory biomarkers and anthropometric indices in Iranian women with polycystic ovary syndrome: A randomized clinical trial. Clin Nutr Res 2022;11(4):241-254. View abstract.
Mester R, Toren P, Mizrachi I, et al. Caffeine withdrawal increases lithium blood levels. Biol Psychiatry 1995;37:348-50. View abstract.
Moreira DP, Monteiro MC, Ribeiro-Alves M, et al. Contribution of chlorogenic acids to the iron-reducing activity of coffee beverages. J Agric Food Chem. 2005 Mar 9;53:1399-402. View abstract.
Nawrot P, Jordan S, Eastwood J, et al. Effects of caffeine on human health. Food Addit Contam 2003;20:1-30. View abstract.
Nikpayam O, Najafi M, Ghaffari S, Jafarabadi MA, Sohrab G, Roshanravan N. Effects of green coffee extract on fasting blood glucose, insulin concentration and homeostatic model assessment of insulin resistance (HOMA-IR): a systematic review and meta-analysis of interventional studies. Diabetol Metab Syndr. 2019;11:91. View abstract.
Nix D, Zelenitsky S, Symonds W, et al. The effect of fluconazole on the pharmacokinetics of caffeine in young and elderly subjects. Clin Pharmacol Ther 1992;51:183.
Norager, C. B., Jensen, M. B., Weimann, A., and Madsen, M. R. Metabolic effects of caffeine ingestion and physical work in 75-year old citizens. A randomized, double-blind, placebo-controlled, cross-over study. Clin Endocrinol (Oxf) 2006;65(2):223-228. View abstract.
Nurminen ML, Niittynen L, Korpela R, Vapaatalo H. Coffee, caffeine and blood pressure: a critical review. Eur J Clin Nutr 1999;53:831-9. View abstract.
Ochiai R, Jokura H, Suzuki A, et al. Green coffee bean extract improves human vasoreactivity. Hypertens Res 2004;27:731-7. View abstract.
Olthof MR, Hollman PC, Zock PL, Katan MB. Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans. Am J Clin Nutr 2001;73:532-8. View abstract.
Olthol MR, Hollman PCH, Katan MB. Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr 2001;131:66-71. View abstract.
Onakpoya I, Terry R, Ernst E. The use of green coffee extract as a weight loss supplement: a systematic review and meta-analysis of randomised clinical trials. Gastroenterol Res Pract 2011;2011. pii: 382852. Epub 2010 Aug 31. View abstract.
Pereira MA, Parker ED, and Folsom AR. Coffee consumption and risk of type 2 diabetes mellitus: an 11-year prospective study of 28 812 postmenopausal women. Arch Intern Med. 2006 Jun 26;166:1311-6. View abstract.
Petrie HJ, Chown SE, Belfie LM, et al. Caffeine ingestion increases the insulin response to an oral-glucose-tolerance test in obese men before and after weight loss. Am J Clin Nutr 2004;80:22-8. View abstract.
Pollock BG, Wylie M, Stack JA, et al. Inhibition of caffeine metabolism by estrogen replacement therapy in postmenopausal women. J Clin Pharmacol 1999;39:936-40. View abstract.
Pourmasoumi M, Hadi A, Marx W, Najafgholizadeh A, Kaur S, Sahebkar A. The Effect of Green Coffee Bean Extract on Cardiovascular Risk Factors: A Systematic Review and Meta-analysis. Adv Exp Med Biol 2021;1328:323-345. View abstract.
Poussel M, Kimmoun A, Levy B, Gambier N, Dudek F, Puskarczyk E, Poussel JF, Chenuel B. Fatal cardiac arrhythmia following voluntary caffeine overdose in an amateur body-builder athlete. Int J Cardiol. 2013 1;166(3):e41-2. doi: 10.1016/j.ijcard.2013.01.238. Epub 2013 7. No abstract available. View abstract.
Raaska K, Raitasuo V, Laitila J, Neuvonen PJ. Effect of caffeine-containing versus decaffeinated coffee on serum clozapine concentrations in hospitalised patients. Basic Clin Pharmacol Toxicol 2004;94:13-8. View abstract.
Rao SS. Current and emerging treatment options for fecal incontinence. J Clin Gastroenterol. 2014;48(9):752-64.
View abstract.
Rapuri PB, Gallagher JC, Kinyamu HK, Ryschon KL. Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes. Am J Clin Nutr 2001;74:694-700. View abstract.
Roshan H, Nikpayam O, Sedaghat M, Sohrab G. Effects of green coffee extract supplementation on anthropometric indices, glycaemic control, blood pressure, lipid profile, insulin resistance and appetite in patients with the metabolic syndrome: a randomised clinical trial. Br J Nutr. 2018;119(3):250-258. View abstract.
Samarrae WA, Truswell AS. Short-term effect of coffee on blood fibrinolytic activity in healthy adults. Atherosclerosis 1977;26:255-60. View abstract.
Sanderink GJ, Bournique B, Stevens J, et al. Involvement of human CYP1A isoenzymes in the metabolism and drug interactions of riluzole in vitro. Pharmacol Exp Ther 1997;282:1465-72. View abstract.
Shekelle PG, Hardy ML, Morton SC, et al. Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis. JAMA 2003;289:1537-45.. View abstract.
Shimoda H, Seki E, Aitani M. Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC Complement Altern Med 2006;6:9. View abstract.
Sinclair CJ, Geiger JD. Caffeine use in sports. A pharmacological review. J Sports Med Phys Fitness 2000;40:71-9. View abstract.
Smith A. Effects of caffeine on human behavior. Food Chem Toxicol 2002;40:1243-55. View abstract.
Smits P, Straatman C, Pijpers E, Thien T. Dose-dependent inhibition of the hemodynamic response to dipyridamole by caffeine. Clin Pharmacol Ther 1991;50:529-37. View abstract.
Staib, A. H., Stille, W., Dietlein, G., Shah, P. M., Harder, S., Mieke, S., and Beer, C. Interaction between quinolones and caffeine. Drugs 1987;34 Suppl 1:170-174. View abstract.
Stanek EJ, Melko GP, Charland SL. Xanthine interference with dipyridamole-thallium-201 myocardial imaging. Pharmacother 1995;29:425-7. View abstract.
Stille, W., Harder, S., Mieke, S., Beer, C., Shah, P. M., Frech, K., and Staib, A. H. Decrease of caffeine elimination in man during co-administration of 4-quinolones. J.Antimicrob.Chemother. 1987;20(5):729-734. View abstract.
Suzuki A, Kagawa D, Ochiai R, et al. Green coffee bean extract and its metabolites have a hypotensive effect in spontaneously hypertensive rats. Hypertens Res. 2002 Jan;25:99-107. View abstract.
Svetol Product Information Pack. Naturex, Avignon, France. March 2013. Available at: https://greencoffee.gr/wp-content/uploads/2013/12/GA501071_PRODUCT-INFO-PACK_04-06-2013.pdf (accessed July 6, 2015).
Tejani FH, Thompson RC, Kristy R, Bukofzer S. Effect of caffeine on SPECT myocardial perfusion imaging during regadenoson pharmacologic stress: a prospective, randomized, multicenter study. Int J Cardiovasc Imaging. 2014 Jun;30(5):979-89. doi: 10.1007/s10554-014-0419-7. Epub 2014 17. View abstract.
Thom E. The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people. J Int Med Res 2007;35:900-8. View abstract.
Thong FS and Graham TE. Caffeine-induced impairment of glucose tolerance is abolished by beta-adrenergic receptor blockade in humans. J Appl Physiol (1985). 2002 Jun;92:2347-52. View abstract.
Twaruzek M, Kosicki R, Kwiatkowska-Gizynska J, Grajewski J, Altyn I. Ochratoxin A and citrinin in green coffee and dietary supplements with green coffee extract. Toxicon. 2020;188:172-177. View abstract.
Underwood DA. Which medications should be held before a pharmacologic or exercise stress test? Cleve Clin J Med 2002;69:449-50. View abstract.
Ursing, C., Wikner, J., Brismar, K., and Rojdmark, S. Caffeine raises the serum melatonin level in healthy subjects: an indication of melatonin metabolism by cytochrome P450(CYP)1A2. J.Endocrinol.Invest 2003;26(5):403-406. View abstract.
Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3. View abstract.
van Rooij J, van der Stegen GH, Schoemaker RC, et al. A placebo-controlled parallel study of the effect of two types of coffee oil on serum lipids and transaminases: identification of chemical substances involved in the cholesterol-raising effect of coffee. Am J Clin Nutr. 1995 Jun;61:1277-83. View abstract.
Vandeberghe K, Gillis N, Van Leemputte M, et al. Caffeine counteracts the ergogenic action of muscle creatine loading. J Appl Physiol 1996;80:452-7. View abstract.
Vaz, J., Kulkarni, C., David, J., and Joseph, T. Influence of caffeine on pharmacokinetic profile of sodium valproate and carbamazepine in normal human volunteers. Indian J.Exp.Biol. 1998;36(1):112-114. View abstract.
Vinson J, Burnham B. Retraction: Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects. Diabetes Metab Syndr Obes 2014;7:467. Available at: www.ncbi.nlm.nih.gov/pmc/articles/PMC4206203/.
Vinson JA, Burnham BR, Nagendran MV. Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects. Diabetes Metab Syndr Obes 2012;5:21-7. [RETRACTED]. View abstract.
Wahllander A, Paumgartner G. Effect of ketoconazole and terbinafine on the pharmacokinetics of caffeine in healthy volunteers. Eur J Clin Pharmacol 1989;37:279-83. View abstract.
Wakabayashi K, Kono S, Shinchi K, et al. Habitual coffee consumption and blood pressure: A study of self-defense officials in Japan. Eur J Epidemiol 1998;14:669-73. View abstract.
Wallach J. Interpretation of Diagnostic Tests. A synopsis of Laboratory Medicine. Fifth ed; Boston, MA: Little Brown, 1992.
Wang S, Li X, Yang Y, et al. Does coffee, tea and caffeine consumption reduce the risk of incident breast cancer? A systematic review and network meta-analysis. Public Health Nutr 2021;24(18):6377-6389. View abstract.
Watanabe T, Arai Y, Mitsui Y, et al. The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension. Clin Exp Hypertens 2006;28:439-49. View abstract.
Watson JM, Jenkins EJ, Hamilton P, et al. Influence of caffeine on the frequency and perception of hypoglycemia in free-living patients with type 1 diabetes. Diabetes Care 2000;23:455-9. View abstract.
Watson JM, Sherwin RS, Deary IJ, et al. Dissociation of augmented physiological, hormonal and cognitive responses to hypoglycaemia with sustained caffeine use. Clin Sci (Lond) 2003;104:447-54. View abstract.
Weerakoon WNMTDN, Anjali NVP, Jayathilaka N, Seneviratne KN. Soybean oil and coconut oil enhance the absorption of chlorogenic acid in humans. J Food Biochem 2021;e13823. View abstract.
Wikoff D, Welsh BT, Henderson R, et al. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food Chem Toxicol 2017;109:585-648. View abstract.
Williams MH, Branch JD. Creatine supplementation and exercise performance: an update. J Am Coll Nutr 1998;17:216-34. View abstract.
Winkelmayer WC, Stampfer MJ, Willett WC, Curhan GC. Habitual caffeine intake and the risk of hypertension in women. JAMA 2005;294:2330-5. View abstract.
Wojcikowski, J. and Daniel, W. A. Perazine at therapeutic drug concentrations inhibits human cytochrome P450 isoenzyme 1A2 (CYP1A2) and caffeine metabolism--an in vitro study. Pharmacol Rep. 2009;61(5):851-858. View abstract.
Yamaguchi T, Chikama A, Mori K, et al. Hydroxyhydroquinone-free coffee: a double-blind, randomized controlled dose-response study of blood pressure. Nutr Metab Cardiovasc Dis. 2008 Jul;18:408-14. View abstract.
Zelenitsky SA, Norman A, Nix DE. The effects of fluconazole on the pharmacokinetics of caffeine in young and elderly subjects. J Infect Dis Pharmacother 1995;1:1-11.
Zhang LL, Zhang JR, Guo K, et al. Effects of fluoroquinolones on CYP4501A and 3A in male broilers. Res Vet Sci 2011;90:99-105. View abstract.
Zheng KH, Zhu K, Wactawski-Wende J, et al. Caffeine intake from coffee and tea and invasive breast cancer incidence among postmenopausal women in the Women's Health Initiative. Int J Cancer 2021;149(12):2032-2044. View abstract.
Zheng XM, Williams RC. Serum caffeine levels after 24-hour abstention: clinical implications on dipyridamole (201)Tl myocardial perfusion imaging. J Nucl Med Technol 2002;30:123-7. View abstract.
Zheng, J., Chen, B., Jiang, B., Zeng, L., Tang, Z. R., Fan, L., and Zhou, H. H. The effects of puerarin on CYP2D6 and CYP1A2 activities in vivo. Arch Pharm Res 2010;33(2):243-246. View abstract.