POLYDEXTROSE

OTHER NAME(S):

(2S,3R ,4S,5S,6R)-6-[[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxane-2,3,4,5-tetrol.<br/><br/>

Overview

Overview Information

Polydextrose is a type of carbohydrate. It's made in laboratories.

Polydextrose is taken by mouth for constipation, prediabetes, and diabetes. It is also used as a prebiotic.

In foods, polydextrose is used as a sweetener and to improve the texture of foods.

How does it work?

Polydextrose passes undigested into the colon where it can increase bowel mass and possibly promote growth of certain bacteria that are thought to be beneficial.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Constipation. Early research shows that taking polydextrose might increase bowel movements in people with constipation related to dialysis. But other research shows that polydextrose doesn't increase bowel movements in people with long-term constipation.
  • Diabetes. Early research shows that drinking a beverage containing polydextrose twice daily for 12 weeks does not improve blood sugar control in people with diabetes.
  • Prediabetes. Early research shows that drinking a beverage containing polydextrose twice daily for 12 weeks does not improve blood sugar control in people with prediabetes.
  • Other conditions.
More evidence is needed to rate the effectiveness of polydextrose for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Polydextrose is LIKELY SAFE when used as a food additive in amounts of less than 15 grams. Polydextrose is POSSIBLY SAFE when used as a medicine in doses up to 90 grams per day or up to 50 grams as a single dose. In some people, this amount of polydextrose might cause gas, bloating, or loose stools. Polydextrose is POSSIBLY UNSAFE when used as medicine higher amounts. Taking more than 90 grams of polydextrose per day, or more than 50 grams as a single dose, might cause severe diarrhea in some people.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if polydextrose is safe to use as a medicine when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.

Children: Polydextrose is POSSIBLY SAFE for infants when added to formula at concentrations of 2-4 grams per liter of formula.

Interactions

Interactions?

We currently have no information for POLYDEXTROSE Interactions.

Dosing

Dosing

The appropriate dose of polydextrose depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for polydextrose. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Schwab, U., Louheranta, A., Torronen, A., and Uusitupa, M. Impact of sugar beet pectin and polydextrose on fasting and postprandial glycemia and fasting concentrations of serum total and lipoprotein lipids in middle-aged subjects with abnormal glucose metabolism. Eur J Clin Nutr 2006;60(9):1073-1080. View abstract.
  • Achour L, Flourie B, Briet F, et al. Gastrointestinal effects and energy value of polydextrose in healthy nonobese men. Am J Clin Nutr 1994;59(6):1362-1368. View abstract.
  • Auerbach MH, Craig SA, Howlett JF, Hayes KC. Caloric availability of polydextrose. Nutr Rev 2007;65(12 Pt 1):544-549. View abstract.
  • Burdock GA, Flamm WG. A review of the studies of the safety of polydextrose in food. Food Chem Toxicol 1999;37(2-3):233-264. View abstract.
  • Craig SAS, Holden JF, Troup JP, Auerbach MH, Frier HI. Polydextrose as soluble fiber: Physiological and analytical aspects. Cereal Foods World 1998;43(5):370-376.
  • Flood MT, Auerbach MH, Craig SA. A review of the clinical toleration studies of polydextrose in food. Food Chem Toxicol 2004;42(9):1531-1542. View abstract.
  • Food Additive Status List. Available at: http://www.fda.gov/food/ingredientspackaginglabeling/foodadditivesingredients/ucm091048.htm#abb.
  • Hengst C, Ptok S, Roessler A, Fechner A, Jahreis G. Effects of polydextrose supplementation on different faecal parameters in healthy volunteers. Int J Food Sci Nutr 2009;60 Suppl 5:96-105. View abstract.
  • Hyvonen L, Linna M, Tuorila H, Dijksterhuis G. Perception of melting and flavor release of ice cream containing different types and contents of fat. J Dairy Sci 2003;86(4):1130-1138. View abstract.
  • Jie Z, Bang-Yao L, Ming-Jie X, et al. Studies on the effects of polydextrose intake on physiologic functions in Chinese people. Am J Clin Nutr 2000;72(6):1503-1509. View abstract.
  • Kimura Y, Nagata Y, Bryant CW, Buddington RK. Nondigestible oligosaccharides do not increase accumulation of lipid soluble environmental contaminants by mice. J Nutr 2002;132(1):80-87. View abstract.
  • Kimura Y, Nagata Y, Buddington RK. Some dietary fibers increase elimination of orally administered polychlorinated biphenyls but not that of retinol in mice. J Nutr 2004;134(1):135-142. View abstract.
  • King NA, Craig SA, Pepper T, Blundell JE. Evaluation of the independent and combined effects of xylitol and polydextrose consumed as a snack on hunger and energy intake over 10 d. Br J Nutr 2005;93(6):911-915. View abstract.
  • Kumemura M, Shimizu S, Tanizaki M, et al. The early phase of colon tumorigenesis induced by dimethylhydrazine in ICR mice. Oncol Rep 1998;5(3):621-624. View abstract.
  • Makivuokko H, Nurmi J, Nurminen P, Stowell J, Rautonen N. In vitro effects on polydextrose by colonic bacteria and caco-2 cell cyclooxygenase gene expression. Nutr Cancer 2005;52(1):94-104. View abstract.
  • Mitchell HL. "The role of the bulking agent polydextrose in fat replacement." Handbook of Fat Replacers. Ed. Roller S, Jones SA. Boca Raton, FL: CRC Press LLC, 1996.
  • Mudgil D, Barak S. Composition, properties and health benefits of indigestible carbohydrate polymers as dietary fiber: a review. Int J Biol Macromol 2013;61:1-6. View abstract.
  • Nakamura N, Gaskins HR, Collier CT, et al. Molecular ecological analysis of fecal bacterial populations from term infants fed formula supplemented with selected blends of prebiotics. Appl Environ Microbiol 2009;75(4):1121-1128. View abstract.
  • Newberne PM, Conner MW, Estes P. The influence of food additives and related materials on lower bowel structure and function. Toxicol Pathol 1988;16(2):184-197. View abstract.
  • Ogata S, Fujimoto K, Iwakiri R, et al. Effect of polydextrose on absorption of triglyceride and cholesterol in mesenteric lymph-fistula rats. Proc Soc Exp Biol Med 1997;215(1):53-58. View abstract.
  • Saku K, Yoshinaga K, Okura Y, et al. Effects of polydextrose on serum lipids, lipoproteins, and apolipoproteins in healthy subjects. Clin Ther 1991;13(2):254-258. View abstract.
  • Satoh H, Hara T, Murakawa D, Matsuura M, Takata K. Soluble dietary fiber protects against nonsteroidal anti-inflammatory drug-induced damage to the small intestine in cats. Dig Dis Sci 2010;55(5):1264-1271. View abstract.
  • Setser CS, Racette WL. Macromolecule replacers in food products. Crit Rev Food Sci Nutr 1992;32(3):275-297. View abstract.
  • Setsu E. [Cariogenicity of polydextrose and refined polydextrose as a substrate]. Nichidai Koko Kagaku 1989;15(1):1-11. View abstract.
  • Shimomura, Y., Maeda, K., Nagasaki, M., Matsuo, Y., Murakami, T., Bajotto, G., Sato, J., Seino, T., Kamiwaki, T., and Suzuki, M. Attenuated response of the serum triglyceride concentration to ingestion of a chocolate containing polydextrose and lactitol in place of sugar. Biosci Biotechnol Biochem 2005;69(10):1819-1823. View abstract.
  • Tomlin J, Read NW. A comparative study of the effects on colon function caused by feeding ispaghula husk and polydextrose. Aliment Pharmacol Ther 1988;2(6):513-519. View abstract.
  • Willis, H. J., Eldridge, A. L., Beiseigel, J., Thomas, W., and Slavin, J. L. Greater satiety response with resistant starch and corn bran in human subjects. Nutr Res 2009;29(2):100-105. View abstract.
  • Ziegler E, Vanderhoof JA, Petschow B, et al. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr 2007;44(3):359-364. View abstract.
  • Schwab, U., Louheranta, A., Torronen, A., and Uusitupa, M. Impact of sugar beet pectin and polydextrose on fasting and postprandial glycemia and fasting concentrations of serum total and lipoprotein lipids in middle-aged subjects with abnormal glucose metabolism. Eur J Clin Nutr 2006;60(9):1073-1080. View abstract.
  • Achour L, Flourie B, Briet F, et al. Gastrointestinal effects and energy value of polydextrose in healthy nonobese men. Am J Clin Nutr 1994;59(6):1362-1368. View abstract.
  • Auerbach MH, Craig SA, Howlett JF, Hayes KC. Caloric availability of polydextrose. Nutr Rev 2007;65(12 Pt 1):544-549. View abstract.
  • Burdock GA, Flamm WG. A review of the studies of the safety of polydextrose in food. Food Chem Toxicol 1999;37(2-3):233-264. View abstract.
  • Craig SAS, Holden JF, Troup JP, Auerbach MH, Frier HI. Polydextrose as soluble fiber: Physiological and analytical aspects. Cereal Foods World 1998;43(5):370-376.
  • Duncan PI, Enters-Weijnen CF, Emami N, et al. Short-term daily intake of polydextrose fiber does not shorten intestinal transit time in constipated adults: A randomized controlled trial. Nutrients. 2018;10(7). pii: E920. View abstract.
  • Flood MT, Auerbach MH, Craig SA. A review of the clinical toleration studies of polydextrose in food. Food Chem Toxicol 2004;42(9):1531-1542. View abstract.
  • Food Additive Status List. Available at: http://www.fda.gov/food/ingredientspackaginglabeling/foodadditivesingredients/ucm091048.htm#abb.
  • Hyvonen L, Linna M, Tuorila H, Dijksterhuis G. Perception of melting and flavor release of ice cream containing different types and contents of fat. J Dairy Sci 2003;86(4):1130-1138. View abstract.
  • Ibarra A, Astbury NM, Olli K, Alhoniemi E, Tiihonen K. Effects of polydextrose on different levels of energy intake. A systematic review and meta-analysis. Appetite. 2015;87:30-7. View abstract.
  • Ibarra A, Olli K, Pasman W, et al. Effects of polydextrose with breakfast or with a midmorning preload on food intake and other appetite-related parameters in healthy normal-weight and overweight females: An acute, randomized, double-blind, placebo-controlled, and crossover study. Appetite. 2017;110:15-24. View abstract.
  • Jie Z, Bang-Yao L, Ming-Jie X, et al. Studies on the effects of polydextrose intake on physiologic functions in Chinese people. Am J Clin Nutr 2000;72(6):1503-1509. View abstract.
  • King NA, Craig SA, Pepper T, Blundell JE. Evaluation of the independent and combined effects of xylitol and polydextrose consumed as a snack on hunger and energy intake over 10 d. Br J Nutr 2005;93(6):911-915. View abstract.
  • Magro DO, de Oliveira LM, Bernasconi I, Ruela Mde S, Credidio L, Barcelos IK, Leal RF, Ayrizono Mde L, Fagundes JJ, Teixeira Lde B, Ouwehand AC, Coy CS. Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation. Nutr J. 2014 24;13:75. View abstract.
  • Martinelli M, Hick E, Walz F, Drago SR. Effects of cereal bar containing polydextrose on subjective feelings of appetite and energy intake in overweight adults over 15 d. Int J Food Sci Nutr. 2018;69(7):892-899. View abstract.
  • Mitchell HL. "The role of the bulking agent polydextrose in fat replacement." Handbook of Fat Replacers. Ed. Roller S, Jones SA. Boca Raton, FL: CRC Press LLC, 1996.
  • Mudgil D, Barak S. Composition, properties and health benefits of indigestible carbohydrate polymers as dietary fiber: a review. Int J Biol Macromol 2013;61:1-6. View abstract.
  • Nakamura N, Gaskins HR, Collier CT, et al. Molecular ecological analysis of fecal bacterial populations from term infants fed formula supplemented with selected blends of prebiotics. Appl Environ Microbiol 2009;75(4):1121-1128. View abstract.
  • Ogata S, Fujimoto K, Iwakiri R, et al. Effect of polydextrose on absorption of triglyceride and cholesterol in mesenteric lymph-fistula rats. Proc Soc Exp Biol Med 1997;215(1):53-58. View abstract.
  • Olli K, Salli K, Alhoniemi E, et al. Postprandial effects of polydextrose on satiety hormone responses and subjective feelings of appetite in obese participants. Nutr J. 2015;14:2. View abstract.
  • Saku K, Yoshinaga K, Okura Y, et al. Effects of polydextrose on serum lipids, lipoproteins, and apolipoproteins in healthy subjects. Clin Ther 1991;13(2):254-258. View abstract.
  • Setser CS, Racette WL. Macromolecule replacers in food products. Crit Rev Food Sci Nutr 1992;32(3):275-297. View abstract.
  • Setsu E. [Cariogenicity of polydextrose and refined polydextrose as a substrate]. Nichidai Koko Kagaku 1989;15(1):1-11. View abstract.
  • Shimada M, Nagano N, Goto S, et al. Effect of polydextrose intake on constipation in Japanese dialysis patients: A triple-blind, randomized, controlled trial. J Nutr Sci Vitaminol (Tokyo). 2015;61(4):345-53. View abstract.
  • Shimomura, Y., Maeda, K., Nagasaki, M., Matsuo, Y., Murakami, T., Bajotto, G., Sato, J., Seino, T., Kamiwaki, T., and Suzuki, M. Attenuated response of the serum triglyceride concentration to ingestion of a chocolate containing polydextrose and lactitol in place of sugar. Biosci Biotechnol Biochem 2005;69(10):1819-1823. View abstract.
  • Tiihonen K, Rautonen N, Alhoniemi E, Ahotupa M, Stowell J, Vasankari T. Postprandial triglyceride response in normolipidemic, hyperlipidemic and obese subjects - the influence of polydextrose, a non-digestible carbohydrate. Nutr J. 2015;14:23. View abstract.
  • Tomlin J, Read NW. A comparative study of the effects on colon function caused by feeding ispaghula husk and polydextrose. Aliment Pharmacol Ther 1988;2(6):513-519. View abstract.
  • Willis, H. J., Eldridge, A. L., Beiseigel, J., Thomas, W., and Slavin, J. L. Greater satiety response with resistant starch and corn bran in human subjects. Nutr Res 2009;29(2):100-105. View abstract.
  • Ziegler E, Vanderhoof JA, Petschow B, et al. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr 2007;44(3):359-364. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.