Avenasterol, B-sitosterol 3-B-D-glucoside, B-Sitosterolin, B-Sitosterols, Beta Sitosterin, Bêta-sitostérine, Beta Sitosterol, Bêta-Sitostérol, Beta-sitosterol glucoside, Beta-sitosterol glycoside, Betasitosterol, Brassicasterol, Campest-5-en-3beta-ol, Campesterol, Campestérol,Cinchol, Cupreol, Dihydro-beta-sitosterol, Ester de Stérol Végétal, Esters de Phytostérol, Esters de Stérol Dérivés d'huile Végétale, Glucoside de Bêta-Sitostérol, Phytosterol, Phytostérol, Phytosterol Esters, Phytosterols, Phytostérols, Plant Phytosterols, Plant Sterol Esters, Plant Sterolins, Quebrachol, Rhamnol, Sitosterin, Sitosterol, Sitosterolins, Sitosterols, Sterinol, Stérolines, Stérolines Végétales, Sterolins, Stérols Végétaux, Stigmasterin, Stigmasterol, Stigmastérol, Vegetable Oil Sterol Esters, Vegetable Sterol Esters, 5,22-Stigmastadien-3beta-ol, 3-beta, 3-beta-stigmast-5-en-3-ol, 22,23-dihydrostigmasterol, 24-beta-ethyl-delta-5-cholesten-3beta-ol, 24-ethyl-cholesterol.<br/><br/>
Overview InformationPlant sterols are a group of substances made in plants. Plant sterols are found in the highest amounts in foods like vegetable oils, nuts, and seeds. Plant sterols are used as medicine.
Plant sterols are taken by mouth to lower cholesterol levels and help prevent heart disease and heart attacks. Plant sterols are also used for some cancers such as stomach cancer, colon cancer, and rectal cancer. Plant sterols are also used for weight loss.
In foods, plant sterols are added to some types of margarine. The federal Food and Drug Administration (FDA) allows manufacturers to claim that foods containing plant sterol esters can help reduce the risk of coronary heart disease (CHD). This rule is based on the FDA's conclusion that plant sterol esters may reduce the risk of CHD by lowering blood cholesterol levels. There is plenty of evidence that plant sterols do lower cholesterol levels. But there is no proof that long-term use actually lowers the risk of developing CHD.
Don't confuse plant sterols with beta-sitosterol. Beta-sitosterol is one type of plant sterol. However, it also has its own uses. Also don't confuse plant sterols with sitostanol. Sitostanol is a plant stanol.
How does it work?Plant sterols are a group of plant substances that resemble cholesterol. They might help reduce cholesterol levels by limiting the amount of cholesterol that is able to enter the body. Some plant sterols might also reduce how much cholesterol is made in the body.
Uses & Effectiveness
Likely Effective for
- Reducing cholesterol levels in people with an inherited tendency toward high cholesterol (familial hypercholesterolemia). Plant sterols are effective for reducing cholesterol levels in children and adults with high cholesterol levels due to familial hypercholesterolemia. When taken in people who are also following a low-fat or cholesterol-lowering diet, plant sterols can reduce total and "bad" low-density lipoprotein (LDL) cholesterol more than the diet alone. Plant sterols don't decrease blood fats called triglycerides or increase "good" high-density lipoprotein (HDL) cholesterol levels.
- High cholesterol. Taking plant sterols lowers total and low-density lipoprotein (LDL or "bad") cholesterol levels by about 3% to 15% in people with high cholesterol who are following a cholesterol-lowering diet. When added to a cholesterol-lowering prescription medication, such as certain "statins", plant sterols reduce total cholesterol by an additional 12-22 mg/dL and LDL cholesterol by another 11-16 mg/dL.
Plant sterols can be incorporated in margarines, dairy products, and breads and cereals, or taken in pill form. Research suggests a dose of about 2-3 grams daily lowers cholesterol the most. But plant sterols may stop working as well when taken for more than 2-3 months. Plant sterols don't raise "good" high-density lipoprotein (HDL) cholesterol levels.
Insufficient Evidence for
- Colon and rectal cancer. People who eat more plant sterols as part of their diet don't have a lower risk of colon cancer compared to people who eat less plant sterols. Also women who eat more plant sterols don't have a lower risk of rectal cancer compared to women who eat less plant sterols. But men who eat more plant sterols might have a lower risk of rectal cancer compared to men who eat less plant sterols.
- Cancer of the stomach. People who eat at least 82.5 mg of plant sterols daily as part of their diet seem to have a lower risk of gastric cancer compared to people who eat less than 45.5 mg daily.
- Metabolic syndrome. Metabolic syndrome is a group of conditions that increase the risk of having heart disease, stroke, and diabetes. These conditions include high cholesterol, high blood pressure, high blood sugar, and excess fat. Some research shows that taking 2 grams of plant sterols twice daily reduces cholesterol levels in people with metabolic syndrome. But other research shows that taking 2 grams of plant sterols once daily does not lower cholesterol levels in people with metabolic syndrome.
- Heart attack. Men who eat more plant sterols as part of their diet have a 29% lower risk of having a heart attack compared to men who eat less. But women who eat more plant sterols don't seem to have a lower risk of having a heart attack compared to women who eat less.
- Obesity. Early research shows that eating a snack bar containing 1.8 grams of plant sterols lowers total cholesterol levels by about 10% compared to eating the snack bar alone in people who are obese and trying to lose weight. But eating the snack bar containing plant sterols doesn't increase weight loss, reduce "bad" low-density lipoprotein (LDL) cholesterol levels, or improve blood sugar levels compared to eating a snack bar that doesn't contain plant sterols.
- Heart disease.
- Other conditions.
Side Effects & SafetyPlant sterols are LIKELY SAFE for most people when taken by mouth. They can cause some side effects, such as diarrhea or fat in the stool.
Special Precautions & Warnings:Pregnancy and breast-feeding: Not enough is known about the use of plant sterols during pregnancy and breast-feeding. Stay on the safe side and avoid use.
Sitosterolemia, a rare inherited fat storage disease: Plant sterols can build up in the blood and tissue of people with this condition. This build-up can make these people prone to early heart disease. Taking plant sterols might make this condition worse. Don't take plant sterols if you have sitosterolemia.
Short bowel syndrome, a condition related to removal of part of the gut: Worsening of liver function has been reported for a person with short bowel syndrome who was given nutrients containing plant sterols. Liver function improved when the plant sterols were removed from the nutrients. It's not clear if the plant sterols were responsible. Until more is known, don't take plant sterols if you have short bowel syndrome.
We currently have no information for PLANT STEROLS Interactions.
The following doses have been studied in scientific research:
- For reducing cholesterol levels in adults with an inherited tendency toward high cholesterol (familial hypercholesterolemia): 1.6-1.8 grams of plant sterols per day for 8-26 weeks have been used.
- For high cholesterol: Doses of about 2-3 grams daily seem to work the best.
- For reducing cholesterol levels in children with an inherited tendency toward high cholesterol (familial hypercholesterolemia): 1.6-2.3 grams of plant sterols per day have been used in children 6-16 years-old.
- Amundsen, A. L., Ntanios, F., Put, N., and Ose, L. Long-term compliance and changes in plasma lipids, plant sterols and carotenoids in children and parents with FH consuming plant sterol ester-enriched spread. Eur.J Clin.Nutr. 2004;58(12):1612-1620. View abstract.
- Clifton, P. M., Noakes, M., Sullivan, D., Erichsen, N., Ross, D., Annison, G., Fassoulakis, A., Cehun, M., and Nestel, P. Cholesterol-lowering effects of plant sterol esters differ in milk, yoghurt, bread and cereal. Eur.J Clin.Nutr. 2004;58(3):503-509. View abstract.
- De Stefani, E., Boffetta, P., Ronco, A. L., Brennan, P., Deneo-Pellegrini, H., Carzoglio, J. C., and Mendilaharsu, M. Plant sterols and risk of stomach cancer: a case-control study in Uruguay. Nutr.Cancer 2000;37(2):140-144. View abstract.
- Demonty, I., Chan, Y. M., Pelled, D., and Jones, P. J. Fish-oil esters of plant sterols improve the lipid profile of dyslipidemic subjects more than do fish-oil or sunflower oil esters of plant sterols. Am J Clin Nutr 2006;84(6):1534-1542. View abstract.
- Fernandez, C., Suarez, Y., Ferruelo, A. J., Gomez-Coronado, D., and Lasuncion, M. A. Inhibition of cholesterol biosynthesis by Delta22-unsaturated phytosterols via competitive inhibition of sterol Delta24-reductase in mammalian cells. Biochem.J 8-15-2002;366(Pt 1):109-119. View abstract.
- Grundy, S. M., Ahrens, E. H., Jr., and Salen, G. Dietary beta-sitosterol as an internal standard to correct for cholesterol losses in sterol balance studies. J Lipid Res 1968;9(3):374-387. View abstract.
- Guardamagna, O., Abello, F., Baracco, V., Federici, G., Bertucci, P., Mozzi, A., Mannucci, L., Gnasso, A., and Cortese, C. Primary hyperlipidemias in children: effect of plant sterol supplementation on plasma lipids and markers of cholesterol synthesis and absorption. Acta Diabetol. 2011;48(2):127-133. View abstract.
- Hallikainen, M., Huikko, L., Kontra, K., Nissinen, M., Piironen, V., Miettinen, T., and Gylling, H. Effect of parenteral serum plant sterols on liver enzymes and cholesterol metabolism in a patient with short bowel syndrome. Nutr Clin Pract. 2008;23(4):429-435. View abstract.
- Hendriks, H. F., Brink, E. J., Meijer, G. W., Princen, H. M., and Ntanios, F. Y. Safety of long-term consumption of plant sterol esters-enriched spread. Eur.J Clin.Nutr. 2003;57(5):681-692. View abstract.
- Normen, A. L., Brants, H. A., Voorrips, L. E., Andersson, H. A., van den Brandt, P. A., and Goldbohm, R. A. Plant sterol intakes and colorectal cancer risk in the Netherlands Cohort Study on Diet and Cancer. Am J Clin.Nutr. 2001;74(1):141-148. View abstract.
- Relas, H., Gylling, H., and Miettinen, T. A. Fate of intravenously administered squalene and plant sterols in human subjects. J.Lipid Res. 2001;42(6):988-994. View abstract.
- Tuomilehto, J., Tikkanen, M. J., Hogstrom, P., Keinanen-Kiukaanniemi, S., Piironen, V., Toivo, J., Salonen, J. T., Nyyssonen, K., Stenman, U. H., Alfthan, H., and Karppanen, H. Safety assessment of common foods enriched with natural nonesterified plant sterols. Eur J Clin Nutr 2009;63(5):684-691. View abstract.
- Acuff RV, Cai DJ, Dong ZP, Bell D. The lipid lowering effect of plant sterol ester capsules in hypercholesterolemic subjects. Lipids Health Dis. 2007 Apr 9;6:11. View abstract.
- Amir Shaghaghi M, Abumweis SS, Jones PJ. Cholesterol-lowering efficacy of plant sterols/stanols provided in capsule and tablet formats: results of a systematic review and meta-analysis. J Acad Nutr Diet. 2013 Nov;113(11):1494-503. View abstract.
- Anon. FDA authorizes new coronary heart disease health claim for plant sterol and plant stanol esters. FDA. 2000. Available at: <a href="http://www3.scienceblog.com/community/older/archives/M/1/fda0642.htm" target="_blank">http://www3.scienceblog.com/community/older/archives/M/1/fda0642.htm</a>. (Accessed 26 May 2016).
- Baumgartner S, Ras RT, Trautwein EA, Mensink RP, Plat J. Plasma fat-soluble vitamin and carotenoid concentrations after plant sterol and plant stanol consumption: a meta-analysis of randomized controlled trials. Eur J Nutr. 2017;56(3):909-923. View abstract.
- Berendschot TT, Plat J, de Jong A, Mensink RP. Long-term plant stanol and sterol ester-enriched functional food consumption, serum lutein/zeaxanthin concentration and macular pigment optical density. Br J Nutr. 2009 Jun;101(11):1607-10. View abstract.
- Casas-Agustench P, Serra M, Pérez-Heras A, Cofán M, Pintó X, Trautwein EA, Ros E. Effects of plant sterol esters in skimmed milk and vegetable-fat-enriched milk on serum lipids and non-cholesterol sterols in hypercholesterolaemic subjects: a randomised, placebo-controlled, crossover study. Br J Nutr. 2012 Jun;107(12):1766-75. View abstract.
- Chen JT, Wesley R, Shamburek RD, et al. Meta-Analysis of natural therapies for hyperlipidemia: plant sterols and stanols versus policosanol. Pharmacotherapy 2005;25:171-83. View abstract.
- Demonty I, Ras RT, van der Knaap HC, Meijer L, Zock PL, Geleijnse JM, Trautwein EA. The effect of plant sterols on serum triglyceride concentrations is dependent on baseline concentrations: a pooled analysis of 12 randomised controlled trials. Eur J Nutr. 2013 Feb;52(1):153-60. View abstract.
- Doornbos AM, Meynen EM, Duchateau GS, van der Knaap HC, Trautwein EA. Intake occasion affects the serum cholesterol lowering of a plant sterol-enriched single-dose yoghurt drink in mildly hypercholesterolaemic subjects. Eur J Clin Nutr. 2006 Mar;60(3):325-33. View abstract.
- Eady S, Wallace A, Willis J, Scott R, Frampton C. Consumption of a plant sterol-based spread derived from rice bran oil is effective at reducing plasma lipid levels in mildly hypercholesterolaemic individuals. Br J Nutr. 2011 Jun 28;105(12):1808-18. View abstract.
- Gomes GB, Zazula AD, Shigueoka LS, et al. A randomized open-label trial to assess the effect of plant sterols associated with ezetimibe in low-density lipoprotein levels in patients with coronary artery disease on statin therapy. J Med Food. 2017;20(1):30-36. View abstract.
- Hallikainen MA, Sarkkinen ES, Gylling H, et al. Comparison of the effects of plant sterol ester and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low-fat diet. Eur J Clin Nutr 2000;54:715-25. View abstract.
- Haque Hussain SS, Weir J, Roberts N. Severe dermatitis secondary to plant sterol supplements. Clin Exp Dermatol. 2009 Oct;34(7):e276-7. View abstract.
- Heinemann T, Kullak-Ublick GA, Pietruck B, von Bergmann K. Mechanisms of action of plant sterols on inhibition of cholesterol absorption. Comparison of sitosterol and sitostanol. Eur J Clin Pharmacol 1991;40 Suppl 1:S59-63. View abstract.
- Hidaka H, Kojima H, Kawabata T, et al. Effects of an HMG-CoA reductase inhibitor, pravastatin, and bile sequestering resin, cholestyramine, on plasma plant sterol levels in hypercholesterolemic subjects. J Atheroscler Thromb 1995;2:60-5. View abstract.
- Hongu N, Kitts DD, Zawistowski J, Dossett CM, Kopec A, Pope BT, Buchowski MS. Pigmented rice bran and plant sterol combination reduces serum lipids in overweight and obese adults. J Am Coll Nutr. 2014;33(3):231-8. View abstract.
- Jones PJ, Demonty I, Chan YM, Herzog Y, Pelled D. Fish-oil esters of plant sterols differ from vegetable-oil sterol esters in triglycerides lowering, carotenoid bioavailability and impact on plasminogen activator inhibitor-1 (PAI-1) concentrations in hypercholesterolemic subjects. Lipids Health Dis. 2007 Oct 25;6:28. View abstract.
- Jones PJ, Ntanios FY, Raeini-Sarjaz M, et al. Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. Am J Clin Nutr 1999;69:1144-50. View abstract.
- Jones PJ, Raeini-Sarjaz M, Ntanios FY, et al. Modulation of plasma lipid levels and cholesterol kinetics by phytosterol versus phytostanol esters. J Lipid Res 2000;41:697-705. View abstract.
- Klingberg S, Ellegård L, Johansson I, Jansson JH, Hallmans G, Winkvist A. Dietary intake of naturally occurring plant sterols is related to a lower risk of a first myocardial infarction in men but not in women in northern Sweden. J Nutr. 2013 Oct;143(10):1630-5. View abstract.
- Korpela R, Tuomilehto J, Högström P, Seppo L, Piironen V, Salo-Väänänen P, Toivo J, Lamberg-Allardt C, Kärkkäinen M, Outila T, Sundvall J, Vilkkilä S, Tikkanen MJ. Safety aspects and cholesterol-lowering efficacy of low fat dairy products containing plant sterols. Eur J Clin Nutr. 2006 May;60(5):633-42. View abstract.
- Law M. Plant sterol and stanol margarines and health. BMJ 2000;320:861-4. View abstract.
- Lichtenstein AH, Deckelbaum RJ. Stanol/sterol ester-containing foods and blood cholesterol levels: a statement for healthcare professionals from Nutrition Committee, Council on Nutrition, Physical Activity, Metabolism of American Heart Association. Circulation 2001;103:1177-9. View abstract.
- Mackay DS, Gebauer SK, Eck PK, Baer DJ, Jones PJ. Lathosterol-to-cholesterol ratio in serum predicts cholesterol-lowering response to plant sterol consumption in a dual-center, randomized, single-blind placebo-controlled trial. Am J Clin Nutr. 2015 Mar;101(3):432-9. View abstract.
- Maki KC, Lawless AL, Reeves MS, Dicklin MR, Jenks BH, Shneyvas E, Brooks JR. Lipid-altering effects of a dietary supplement tablet containing free plant sterols and stanols in men and women with primary hypercholesterolaemia: a randomized, placebo-controlled crossover trial. Int J Food Sci Nutr. 2012 Jun;63(4):476-82. View abstract.
- Maki KC, Lawless AL, Reeves MS, Kelley KM, Dicklin MR, Jenks BH, Shneyvas E, Brooks JR. Lipid effects of a dietary supplement softgel capsule containing plant sterols/stanols in primary hypercholesterolemia. Nutrition. 2013 Jan;29(1):96-100. View abstract.
- Malhotra A, Shafiq N, Arora A, Singh M, Kumar R, Malhotra S. Dietary interventions (plant sterols, stanols, omega-3 fatty acids, soy protein and dietary fibers) for familial hypercholesterolaemia. Cochrane Database Syst Rev. 2014 Jun 10;6:CD001918. View abstract.
- McKenney JM, Jenks BH, Shneyvas E, Brooks JR, Shenoy SF, Cook CM, Maki KC. A softgel dietary supplement containing esterified plant sterols and stanols improves the blood lipid profile of adults with primary hypercholesterolemia: a randomized, double-blind, placebo-controlled replication study. J Acad Nutr Diet. 2014 Feb;114(2):244-9. View abstract.
- Musa-Veloso K, Poon TH, Elliot JA, Chung C. A comparison of the LDL-cholesterol lowering efficacy of plant stanols and plant sterols over a continuous dose range: results of a meta-analysis of randomized, placebo-controlled trials. Prostaglandins Leukot Essent Fatty Acids. 2011 Jul;85(1):9-28. View abstract.
- Nguyen LB, Shefer S, Salen G, et al. Competitive inhibition of hepatic sterol 27-hydroxylase by sitosterol: decreased activity in sitosterolemia. Proc Assoc Am Physicians 1998;110:32-9. View abstract.
- O'Neill FH, Sanders TA, Thompson GR. Comparison of efficacy of plant stanol ester and sterol ester: short-term and longer-term studies. Am J Cardiol. 2005 Jul 4;96(1A):29D-36D. View abstract.
- Ooi EM, Watts GF, Barrett PH, Chan DC, Clifton PM, Ji J, Nestel PJ. Dietary plant sterols supplementation does not alter lipoprotein kinetics in men with the metabolic syndrome. Asia Pac J Clin Nutr. 2007;16(4):624-31. View abstract.
- Patel SB, Honda A, Salen G. Sitosterolemia: exclusion of genes involved in reduced cholesterol biosynthesis. J Lipid Res 1998;39:1055-61. View abstract.
- Raeini-Sarjaz M, Ntanios FY, Vanstone CA, Jones PJ. No changes in serum fat-soluble vitamin and carotenoid concentrations with the intake of plant sterol/stanol esters in the context of a controlled diet. Metabolism. 2002 May;51(5):652-6. View abstract.
- Ras RT, Geleijnse JM, Trautwein EA. LDL-cholesterol-lowering effect of plant sterols and stanols across different dose ranges: a meta-analysis of randomised controlled studies. Br J Nutr. 2014 Jul 28;112(2):214-9. View abstract.
- Ras RT, Koppenol WP, Garczarek U, et al. Increases in plasma plant sterols stabilize within four weeks of plant sterol intake and are independent of cholesterol metabolism. Nutr Metab Cardiovasc Dis. 2016;26(4):302-9. View abstract.
- Richelle M, Enslen M, Hager C, et al. Both free and esterified plant sterols reduce cholesterol absorption and the bioavailability of beta-carotene and alpha-tocopherol in normocholesterolemic humans. Am J Clin Nutr 2004;80:171-7. View abstract.
- Salen G, Shefer S, Nguyen L, et al. Sisterolemia. J Lipid Res 1992;33:945-55. View abstract.
- Salen G, Shore V, Tint GS, et al. Increased sitosterol absorption, decreased removal, and expanded body pools compensate for reduced cholesterol synthesis in sitosterolemia with xanthomatosis. J Lipid Res 1989;30:1319-30. View abstract.
- Scholle JM, Baker WL, Talati R, Coleman CI. The effect of adding plant sterols or stanols to statin therapy in hypercholesterolemic patients: systematic review and meta-analysis. J Am Coll Nutr. 2009 Oct;28(5):517-24. View abstract.
- Sialvera TE, Pounis GD, Koutelidakis AE, Richter DJ, Yfanti G, Kapsokefalou M, Goumas G, Chiotinis N, Diamantopoulos E, Zampelas A. Phytosterols supplementation decreases plasma small and dense LDL levels in metabolic syndrome patients on a westernized type diet. Nutr Metab Cardiovasc Dis. 2012 Oct;22(10):843-8. View abstract.
- Stalenhoef AF, Hectors M, Demacker PN. Effect of plant sterol-enriched margarine on plasma lipids and sterols in subjects heterozygous for phytosterolaemia. J Intern Med 2001;249:163-6.. View abstract.
- Stalenhoef AF. Images in clinical medicine. Phytosterolemia and xanthomatosis. N Engl J Med 2003;349:51.. View abstract.
- Talati R, Sobieraj DM, Makanji SS, Phung OJ, Coleman CI. The comparative efficacy of plant sterols and stanols on serum lipids: a systematic review and meta-analysis. J Am Diet Assoc. 2010 May;110(5):719-26. View abstract.
- Vásquez-Trespalacios EM, Romero-Palacio J. Efficacy of yogurt drink with added plant stanol esters (Benecol®, Colanta) in reducing total and LDL cholesterol in subjects with moderate hypercholesterolemia: a randomized placebo-controlled crossover trial NCT01461798. Lipids Health Dis. 2014 Aug 6;13:125. View abstract.
- Weststrate JA, Meijer GW. Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr 1998;52:334-43. View abstract.
- Yang W, Gage H, Jackson D, Raats M. The effectiveness and cost-effectiveness of plant sterol or stanol-enriched functional foods as a primary prevention strategy for people with cardiovascular disease risk in England: a modeling study. Eur J Health Econ 2018;19(7):909-22. doi: 10.1007/s10198-017-0934-2. View abstract.
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