BOVINE CARTILAGE

OTHER NAME(S):

Antitumor Angiogenesis Factor (anti-TAF), Bovine Tracheal Cartilage (BTC), Cartilage Trachéal de Bovins, Cartílago Bovino, Catrix, Catrix-S, Collagen Bovine, Collagène Bovin, Glycosaminoglycan Polysulphuric Acid Complex, Processed Bovine Cartilage, Psoriacin, Psoriacin-T, Rumalon.<br/><br/>

Overview

Overview Information

Cartilage is a substance in the body that provides structural support. Bovine cartilage comes from cows (bovine). People sometimes use bovine cartilage as medicine.

Bovine cartilage is taken by mouth or injected under the skin (given subcutaneously) for rheumatoid arthritis (RA), osteoarthritis, ulcerative colitis, skin conditions such as scleroderma and psoriasis, herpes infection, brain cancer (glioblastoma multiforme), and other cancers.

It is also taken by mouth for allergic reactions caused by chemical toxins and is injected under the skin for inflammation of intestine (enteritis).

Bovine cartilage is applied directly to the skin (used topically) for wounds that won't heal; external hemorrhoids and rectal itching; and skin conditions such as acne, psoriasis, and dermatitis caused by poison oak or poison ivy. It is also used for "dry socket," a painful complication of tooth extraction.

Bovine cartilage is sometimes applied to the anus for internal hemorrhoids and anal tears.

Health providers sometimes give bovine cartilage as a shot (injection into the muscle) for osteoarthritis.

How does it work?

Bovine cartilage might work by providing chemicals needed for rebuilding cartilage in people with osteoarthritis. It might also help reduce swelling and help wounds heal more effectively.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Acne. Early research shows that applying bovine cartilage to the skin helps reduce acne in some people.
  • "Dry socket" after tooth extraction. Early research shows that applying bovine cartilage to the tooth socket after tooth extraction reduces pain in some people who develop a "dry socket."
  • Rectal tears. Early research shows that bovine cartilage helps reduce symptoms of rectal tears when applied internally as a suppository in rectum.
  • Anal itching. Early research shows that bovine cartilage helps reduce symptoms of anal itching when applied externally on the rectum.
  • Cancer. Early research shows that injections of bovine cartilage under the skin along with bovine cartilage capsules taken by mouth might help treat cancer in some people.
  • Inflammation of the intestine (enteritis). Early research shows that injecting bovine cartilage under the skin helps improve strength and weight and decreases the need for steroid drugs in people with inflammation of the intestine.
  • Hemorrhoids. Early research shows that bovine cartilage helps reduce itching when applied externally on the rectum in people with external hemorrhoids. Using a bovine cartilage suppository inside the rectum may also help reduce symptoms in people with hemorrhoids.
  • Osteoarthritis. Early research shows that injecting bovine cartilage under the skin may help decrease symptoms of osteoarthritis. Additionally, injecting a bovine cartilage-bone marrow combination into the muscle improves pain and other osteoarthritis symptoms in some people when taken for up to 3 years. But this effect does not seem to last longer than 3 years.
  • Skin reaction caused by poison oak and poison ivy. Early research shows that using bovine cartilage cream on the skin helps resolve skin reactions caused by poison oak and poison ivy within 1-2 weeks.
  • Psoriasis. Early research shows that applying bovine cartilage to the skin or injecting it under the skin for 6 weeks may improve symptoms of psoriasis.
  • Rheumatoid arthritis (RA). Early research shows that injecting bovine cartilage under the skin helps reduce symptoms of rheumatoid arthritis.
  • Ulcerative colitis. Early research shows that injecting bovine cartilage under the skin helps reduce the need for surgery in people with ulcerative colitis.
  • Wound healing. Early research shows that applying a specific ointment (Catrix 10) containing powdered bovine cartilage to the skin helps reduce skin redness, swelling, and erosion following a laser procedure on the face. Applying bovine cartilage from calves may actually help heal wounds faster than applying bovine cartilage from adult or unborn cows.
  • Other conditions.
More evidence is needed to rate the effectiveness of bovine cartilage for these uses.

Side Effects

Side Effects & Safety

Bovine cartilage is POSSIBLY SAFE for most people when taken by mouth, applied to the skin, or administered as a shot into the muscle or below the skin for medicinal purposes. It can cause side effects such as diarrhea, nausea, swelling, local redness, and itching.

There is some concern about the possibility of catching "mad cow disease" (bovine spongiform encephalitis, BSE) or other diseases from products that come from animals. "Mad cow disease" does not appear to be transmitted through cartilage products, but it is probably wise to avoid animal products from countries where mad cow disease has been found.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking bovine cartilage if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Interactions

Interactions?

We currently have no information for BOVINE CARTILAGE Interactions.

Dosing

Dosing

The appropriate dose of bovine cartilage depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for bovine cartilage. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Berg, P. A., Durk, H., Saal, J., and Hopf, G. Bovine cartilage and marrow extract. Lancet 6-3-1989;1(8649):1275. View abstract.
  • Brandt, R., Hedlof, E., Asman, I., Bucht, A., and Tengblad, A. A convenient radiometric assay for hyaluronan. Acta Otolaryngol.Suppl 1987;442:31-35. View abstract.
  • Bunning, R. A. D., Murphy, G., Kumar, S., Phillips, P., and Reynolds, J. Metalloproteinase inhibitors from bovine cartilage and body fluids. European Journal of Biochemistry 1984;139(1):75-80.
  • Durie, B. G., Soehnlen, B., and Prudden, J. F. Antitumor activity of bovine cartilage extract (Catrix-S) in the human tumor stem cell assay. J.Biol.Response Mod. 1985;4(6):590-595. View abstract.
  • Durk, H., Haase, K., Saal, J., Becker, W., and Berg, P. A. Nephrotic syndrome after injections of bovine cartilage and marrow extract. Lancet 3-18-1989;1(8638):614. View abstract.
  • Hiraki, Y., Kato, Y., Inoue, H., and Suzuki, F. Stimulation of DNA synthesis in quiescent rabbit chondrocytes in culture by limited exposure to somatomedin-like growth factors. European Journal of Biochemistry 1986;158(2):333-337.
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  • Liu, N., Lapcevich, R. K., Underhill, C. B., Han, Z., Gao, F., Swartz, G., Plum, S. M., Zhang, L., and Green, S. J. Metastatin: a hyaluronan-binding complex from cartilage that inhibits tumor growth. Cancer Res 2-1-2001;61(3):1022-1028. View abstract.
  • Saikawa, I., Hotokebuchi, T., Miyahara, H., Tokito, T., Maeda, T., Arita, C., and Sugioka, Y. High-density proteoglycan induces specific suppression of adjuvant-induced arthritis in rats. Clin Exp Immunol 1994;95(3):424-429. View abstract.
  • Schacht, E. and Roetz, R. Nephrotic syndrome after injections of bovine cartilage and marrow extract. Lancet 4-29-1989;1(8644):963. View abstract.
  • Shukunami, C., Oshima, Y., and Hiraki, Y. Chondromodulin-I and tenomodulin: a new class of tissue-specific angiogenesis inhibitors found in hypovascular connective tissues. Biochem Biophys Res Commun. 7-29-2005;333(2):299-307. View abstract.
  • Tanzi, E. L. and Perez, M. The effect of a mucopolysaccharide-cartilage complex healing ointment on Er:YAG laser resurfaced facial skin. Dermatol Surg 2002;28(4):305-308. View abstract.
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  • Durk H, Haase K, Saal J, et al. Nephrotic syndrome after injections of bovine cartilage and marrow extract. [letter] Lancet 1989;1:614.
  • Gramajo RJ, Cutroneo EJ, Fernandez DE, et al. A single-blind, placebo-controlled study of glycosaminoglycan-peptide complex ('Rumalon') in patients with osteoarthritis of the hip or knee. Curr Med Res Opin 1989;11(6):366-73. View abstract.
  • Houck JC, Jacob RA, Deangelo L, Vickers K. The inhibition of inflammation and the acceleration of tissue repair by cartilage powder. Surgery 1962;51:632-8. View abstract.
  • Katona G. A clinical trial of glycosaminoglycan-peptide complex ('Rumalon') in patients with osteoarthritis of the knee. Curr Med Res Opin 1987;10(9):625-33. View abstract.
  • Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
  • Paulette RE, Prudden JF. Studies on the acceleration of wound healing with cartilage. II. Histological observation. Surg Gynecol Obset 1959;108(4):406-8. View abstract.
  • Pavelka K, Gatterova J, Gollerova V, et al. A 5-year randomized controlled, double-blind study of a glycosaminoglycan polysulphuric acid complex (Rumalon) as a structure modifying therapy in osteoarthritis of the hip and knee. Osteoarthritis Cartilage 2000;8:335-42. View abstract.
  • Pavelka K, Gatterova J, Gollerova V, et al. A 5-year randomized controlled, double-blind study of glycosaminoglycan polysulphuric acid complex (Rumalon) as a structure modifying therapy in osteoarthritis of the hip and knee. Osteoarthritis Cartilage 2000;8(5):335-42. View abstract.
  • Prudden JF, Allen J. The clinical acceleration of healing with a cartilage preparation: a controlled study. JAMA 1965;192:352-6. View abstract.
  • Prudden JF, Balassa LL. The biological activity of bovine cartilage preparations. Clinical demonstration of their potent anti-inflammatory capacity with supplementary notes on certain relevant fundamental supportive studies. Semin Arthritis Rheum 1974;3:287-321.
  • Prudden JF, Inoue T, Ocampo L. Subcutaneous cartilage pellets. Their effect on wound tensile strength. Arch Surg 1962;85:245-6. View abstract.
  • Prudden JF, Migel P, Hanson P, et al. The discovery of a potent pure chemical wound-healing accelerator. Am J Surg 1970;119(5):560-4. View abstract.
  • Prudden JF, Nishihara G, Baker L. The acceleration of wound healing with cartilage. I. Surg Gynecol Obstet 1957;105(3):283-6. View abstract.
  • Prudden JF, Othmar G, Allen B. The acceleration of wound healing. Use of parenteral injections of a saline cartilage extract, with a note on the evaluations of electrophoretically separated fractions of the extract by tissue culture. Arch Surg 1963;86(1):157-61.
  • Prudden JF, Wolarsky ER, Balassa L. The acceleration of healing. Surg Gynecol Obstet 1969;128(6):1321-6. View abstract.
  • Prudden JF. The treatment of human cancer with agents prepared from bovine cartilage. J Biol Response Mod 1985;4:551-84. View abstract.
  • Prudden JF. Wound healing produced by cartilage preparations. The enhancement of acceleration, with a report on the use of a cartilage preparation in clinically chronic ulcers and in primarily closed human surgical incisions. Arch Surg 1964;89:1046-59. View abstract.
  • Sabo JC, Oberlander L, Enquist IF. Acceleration of open wound healing by cartilage. Arch Surg 1965;90:414-7. View abstract.
  • Schwartz MS, Gump F, Prudden JF. The influence of cartilage on the time course of wound healing. Surg Forum 1960;10:308-11. View abstract.

More Resources for BOVINE CARTILAGE

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.