Bile Salt-Dependent Lipase, Bile Salt-Stimulated Lipase, Carboxyl Ester Lipase, Lipasa, Recombinant Bile Salt-Dependent Lipase, Triacylglycerol Lipase, Triglyceride Lipase.


Overview Information

Lipase is a compound involved in the break down of fats during digestion. It is found in many plants, animals, bacteria, and molds. Some people use lipase as a medicine.

Lipase is most commonly used for indigestion (dyspepsia), heartburn, and other gastrointestinal problems, but there is no good scientific evidence to support these uses.

Do not confuse lipase with pancreatic enzyme products. Pancreatic enzyme products contain multiple ingredients, including lipase. Some of these products are approved by the US FDA for digestion problems due to a disorder of the pancreas (pancreatic insufficiency).

How does it work?

Lipase seems to work by breaking down fat into smaller pieces, making digestion easier.


Uses & Effectiveness?

Insufficient Evidence for

  • Indigestion (dyspepsia). Some early evidence shows that taking lipase does not reduce stomach discomfort in people who have indigestion after eating a meal high in fat.
  • Growth and development in premature infants. Human breast milk contains lipase. But donated breast milk and infant formula do not contain lipase. Early research shows that adding lipase to these products does not help most premature infants grow faster. It might help to increase growth in the smallest infants. But side effects such as gas, colic, stomach pain, and bleeding might also be increased.
  • Celiac disease.
  • Crohn disease.
  • Heartburn.
  • Cystic fibrosis.
  • Other conditions.
More evidence is needed to rate the effectiveness of lipase for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: There isn't enough reliable information to know if lipase is safe or what the side effects might be.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if lipase is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Children: A specific form of lipase, called bile salt-stimulated lipase, is POSSIBLY UNSAFE in premature infants when added to formula. It might increase side effects in the gut. There isn't enough reliable information to know if other forms of lipase are safe in infants or children or what the side effects might be.



We currently have no information for LIPASE Interactions.



The appropriate dose of lipase depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for lipase. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. View abstract.
  • Levine ME, Koch SY, Koch KL. Lipase supplementation before a high-fat meal reduces perceptions of fullness in healthy subjects. Gut Liver. 2015;9(4):464-9. View abstract.
  • Owen G, Peters TJ, Dawson S, Goodchild MC. Pancreatic enzyme supplement dosage in cystic fibrosis. Lancet 1991;338:1153.
  • Stern RC, Eisenberg JD, Wagener JS, et al. A comparison of the efficacy and tolerance of pancrelipase and placebo in the treatment of steatorrhea in cystic fibrosis patients with clinical exocrine pancreatic insufficiency. Am J Gastroenterol 2000;95:1932-8. View abstract.
  • Thomson M, Clague A, Cleghorn GJ, Shepherd RW. Comparative in vitro and in vivo studies of enteric-coated pancrelipase preparations for pancreatic insufficiency. J Pediatr Gastroenterol Nutr 1993;17:407-13. View abstract.
  • Tursi JM, Phair PG, Barnes GL. Plant sources of acid stable lipases: potential therapy for cystic fibrosis. J Paediatr Child Health 1994;30:539-43. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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