HORSERADISH

OTHER NAME(S):

Amoraciae Rusticanae Radix, Armoracia lopathifolia, Armoracia rusticana, Cochlearia armoracia, Cran de Bretagne, Cranson, Grand Raifort, Great Raifort, Meerrettich, Mountain Radish, Moutarde des Allemands, Moutarde des Capucins, Moutardelle, Nasturtium armoracia, Pepperrot, Rábano Picante, Rábano Rústico, Radis de Cheval, Raifort, Raifort Sauvage, Red Cole, Rorippa armoracia.<br/><br/>

Overview

Overview Information

Horseradish is a plant. It is frequently prepared as a condiment, but the roots are also used as medicine.

Horseradish is used for urinary tract infections, kidney stones, fluid retention, cough, bronchitis, achy joints (rheumatism), gallbladder disorders, sciatic nerve pain, gout, colic, and intestinal worms in children.

Some people apply horseradish directly to the skin for painful and swollen joints or tissues and for minor muscle aches.

How does it work?

Horseradish might help fight bacteria and stop spasms.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Bronchitis. Early research shows that taking a specific product (Angocin Anti-Infekt N) containing horseradish root and nasturtium by mouth for about 7-14 days reduces symptoms of acute bronchitis as effectively as antibiotics.
  • Nasal swelling (sinusitis). Early research shows that taking a specific product (Angocin Anti-Infekt N) containing horseradish root and nasturtium by mouth for about 7-14 days reduces symptoms of acute sinusitis as effectively as antibiotics.
  • Urinary tract infections (UTIs). Early research shows that taking a specific product (Angocin Anti-Infekt N) containing horseradish root and nasturtium by mouth for about 7-14 days is less effective than antibiotics for reducing symptoms of UTIs.
  • Fluid retention (edema).
  • Cough.
  • Achy joints and muscles.
  • Gout.
  • Gallbladder disorders.
  • Sciatic nerve pain.
  • Colic.
  • Intestinal worms.
  • Other conditions.
More evidence is needed to rate the effectiveness of horseradish for these uses.

Side Effects

Side Effects & Safety

Horseradish root is LIKELY SAFE when taken by mouth in food amounts. It is POSSIBLY SAFE for most people when taken by mouth in medicinal amounts. However, it contains mustard oil, which is extremely irritating to the lining of the mouth, throat, nose, digestive system, and urinary tract. Horseradish can cause side effects including stomach upset, bloody vomiting, and diarrhea. It may also slow down the activity of the thyroid gland.

When used on the skin, horseradish is POSSIBLY SAFE when preparations containing 2% mustard oil or less are used, but it can cause skin irritation and allergic reactions.

Special Precautions & Warnings:

Children less than 4 years old: Horseradish is LIKELY UNSAFE in young children when taken by mouth because it can cause digestive tract problems.

Pregnancy and breast-feeding: It’s LIKELY UNSAFE to take horseradish by mouth in large amounts if you are pregnant or breast-feeding. Horseradish contains mustard oil, which can be toxic and irritating. Horseradish tincture is also LIKELY UNSAFE when used regularly or in large amounts because it might cause a miscarriage.

Stomach or intestinal ulcers, inflammatory bowel disease, infections or other digestive tract conditions: Horseradish can irritate the digestive tract. Don’t use horseradish if you have any of these conditions.

Underactive thyroid gland (hypothyroidism): There is concern that using horseradish might make this condition worse.

Kidney problems: There is concern that horseradish might increase urine flow. This could be a problem for people with kidney disorders. Avoid using horseradish if you have kidney problems.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Levothyroxine interacts with HORSERADISH

    Levothyroxine is used for low thyroid function. Horseradish seems to decrease the thyroid. Taking horseradish along with levothyroxine might decrease the effects of levothyroxine.<br /><nb>Some brands that contain levothyroxine include Armour Thyroid, Eltroxin, Estre, Euthyrox, Levo-T, Levothroid, Levoxyl, Synthroid, Unithroid, and others.

Dosing

Dosing

The appropriate dose of horseradish depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for horseradish. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Agabeili, R. A. and Kasimova, T. E. [Antimutagenic activity of Armoracia rusticana, Zea mays and Ficus carica plant extracts and their mixture]. Tsitol.Genet. 2005;39(3):75-79. View abstract.
  • Agabeili, R. A., Kasimova, T. E., and Alekperov, U. K. [Antimutagenic activity of plant extracts from Armoracia rusticana, Ficus carica and Zea mays and peroxidase in eukaryotic cells]. Tsitol.Genet. 2004;38(2):40-45. View abstract.
  • Bartonek-Roxa, E., Eriksson, H., and Mattiasson, B. The cDNA sequence of a neutral horseradish peroxidase. Biochim.Biophys Acta 2-16-1991;1088(2):245-250. View abstract.
  • Deimann, W., Taugner, R., and Fahimi, H. D. Arterial hypotension induced by horseradish peroxidase in various rat strains. J Histochem.Cytochem. 1976;24(12):1213-1217. View abstract.
  • Deme, D., Virion, A., Michot, J. L., and Pommier, J. Thyroid hormone synthesis and thyroglobulin iodination related to the peroxidase localization of oxidizing equivalents: studies with cytochrome c peroxidase and horseradish peroxidase. Arch Biochem Biophys 2-1-1985;236(2):559-566. View abstract.
  • Goos, K. H., Albrecht, U., and Schneider, B. [Efficacy and safety profile of a herbal drug containing nasturtium herb and horseradish root in acute sinusitis, acute bronchitis and acute urinary tract infection in comparison with other treatments in the daily practice/results of a prospective cohort study]. Arzneimittelforschung 2006;56(3):249-257. View abstract.
  • Govere, E. M., Tonegawa, M., Bruns, M. A., Wheeler, E. F., Kephart, K. B., Voigt, J. W., and Dec, J. Using minced horseradish roots and peroxides for the deodorization of swine manure: a pilot scale study. Bioresour.Technol 2007;98(6):1191-1198. View abstract.
  • Greco, O. and Dachs, G. U. Gene directed enzyme/prodrug therapy of cancer: historical appraisal and future prospectives. J Cell Physiol 2001;187(1):22-36. View abstract.
  • Greco, O., Folkes, L. K., Wardman, P., Tozer, G. M., and Dachs, G. U. Development of a novel enzyme/prodrug combination for gene therapy of cancer: horseradish peroxidase/indole-3-acetic acid. Cancer Gene Therapy 2000;7(11):1414-1420.
  • HALBEISEN, T. [Antibiotic substance obtained from Cochlearia armoracia L.]. Arzneimittelforschung 1957;7(5):321-324. View abstract.
  • Kawaoka, A., Matsunaga, E., Endo, S., Kondo, S., Yoshida, K., Shinmyo, A., and Ebinuma, H. Ectopic expression of a horseradish peroxidase enhances growth rate and increases oxidative stress resistance in hybrid aspen. Plant Physiol 2003;132(3):1177-1185. View abstract.
  • KIENHOLZ, M. [Studies of antibacterial substances from horseradish (Cochlearia armoracia), nasturtium (Tropaeolum maius) and garden peppergrass (Lepidium sativum).]. Arch Hyg Bakteriol. 1957;141(3):182-197. View abstract.
  • Kinae, N., Masuda, H., Shin, Il S., Furugori, M., and Shimoi, K. Functional properties of wasabi and horseradish. Biofactors 2000;13(1-4):265-269.
  • Li, X. and Kushad, M. M. Purification and characterization of myrosinase from horseradish (Armoracia rusticana) roots. Plant Physiol Biochem 2005;43(6):503-511. View abstract.
  • Luczaj, L. and Szymanski, W. M. Wild vascular plants gathered for consumption in the Polish countryside: a review. J.Ethnobiol.Ethnomed. 2007;3:17. View abstract.
  • MATTHES, T. and SCHMIDT, K. [Carcinolytic effect of Cochlearia armoracia in Ehrlich's ascites cancer in mouse, in Jensen sarcoma in rat and in cancer of the skin in humans.]. Arztl.Forsch 8-10-1955;9(8):I/358-I/363. View abstract.
  • Panter, K. E. and James, L. F. Natural plant toxicants in milk: a review. J Anim Sci 1990;68(3):892-904. View abstract.
  • Park, I. K., Choi, K. S., Kim, D. H., Choi, I. H., Kim, L. S., Bak, W. C., Choi, J. W., and Shin, S. C. Fumigant activity of plant essential oils and components from horseradish (Armoracia rusticana), anise (Pimpinella anisum) and garlic (Allium sativum) oils against Lycoriella ingenua (Diptera: Sciaridae). Pest.Manag.Sci 2006;62(8):723-728. View abstract.
  • Patterson, A. V., Saunders, M. P., and Greco, O. Prodrugs in genetic chemoradiotherapy. Curr Pharm Des 2003;9(26):2131-2154. View abstract.
  • Sakuyama, H., Endo, Y., Fujimoto, K., and Hatana, Y. Oxidative degradation of alkylphenols by horseradish peroxidase. J Biosci.Bioeng. 2003;96(3):227-231. View abstract.
  • SCHINDLER, E., ZIPP, H., and MARTH, I. [Comparative clinical studies on non-specific urinary tract infections with an enzyme-glycoside mixture obtained from horseradish roots (Cochlearia armoracia L.)]. Arzneimittelforschung 1960;10:919-921. View abstract.
  • Sjaastad, O. V., Blom, A. K., and Haye, R. Hypotensive effects in cats caused by horseradish peroxidase mediated by metabolites of arachidonic acid. J Histochem.Cytochem. 1984;32(12):1328-1330. View abstract.
  • Tonegawa, M., Dec, J., and Bollag, J. M. Use of additives to enhance the removal of phenols from water treated with horseradish and hydrogen peroxide. J Environ.Qual. 2003;32(4):1222-1227. View abstract.
  • Tupper, J., Tozer, G. M., and Dachs, G. U. Use of horseradish peroxidase for gene-directed enzyme prodrug therapy with paracetamol. British Journal of Cancer 2004;90(9):1858-1862.
  • van der Want, J. J., Klooster, J., Cardozo, B. N., de Weerd, H., and Liem, R. S. Tract-tracing in the nervous system of vertebrates using horseradish peroxidase and its conjugates: tracers, chromogens and stabilization for light and electron microscopy. Brain Res Brain Res Protoc. 1997;1(3):269-279. View abstract.
  • Veitch, N. C. Horseradish peroxidase: a modern view of a classic enzyme. Phytochemistry 2004;65(3):249-259. View abstract.
  • Wardman, P. Indole-3-acetic acids and horseradish peroxidase: a new prodrug/enzyme combination for targeted cancer therapy. Curr Pharm Des 2002;8(15):1363-1374. View abstract.
  • WECHSELBERG, K. [In vitro studies on the effect of oily plant extracts from Tropaeolum maius, Cochlearia armoracia and Allium sativum on growth of tubercle bacteria.]. Z Hyg Infektionskr 1958;145(4):380-394. View abstract.
  • Weil, M. J., Zhang, Y., and Nair, M. G. Colon cancer proliferating desulfosinigrin in wasabi (Wasabia japonica). Nutr Cancer 2004;48(2):207-213. View abstract.
  • Conaway, C. C., Yang, Y. M., and Chung, F. L. Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans. Curr Drug Metab 2002;3(3):233-255. View abstract.
  • Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  • Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
  • Weil, M. J., Zhang, Y., and Nair, M. G. Tumor cell proliferation and cyclooxygenase inhibitory constituents in horseradish (Armoracia rusticana) and Wasabi (Wasabia japonica). J Agric Food Chem 2005;53(5):1440-1444. View abstract.

More Resources for HORSERADISH

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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