Bioflavonoid, Bioflavonoid Complex, Bioflavonoid Concentrate, Bioflavonoid Extract, Bioflavonoïde, Bioflavonoïdes d'Agrumes, Citrus Bioflavones, Citrus Bioflavonoid, Citrus Bioflavonoids, Citrus Bioflavonoid Extract, Citrus Flavones, Citrus Flavonoids, Complexe de Bioflavonoïdes, Concentré de Bioflavonoïde, Eldrin, Extrait de Bioflavonoïde, Flavonoid, Flavonoïde, Flavonoïdes d'Agrumes, Oxerutin, Quercetin-3-rhamnoglucoside, Quercetin-3-rutinoside, Quercétine-3-rutinoside, Rutina, Rutine, Rutinum, Rutosid, Rutoside, Rutosidum, Sclerutin, Sophorin.<br/><br/>


Overview Information

Rutin is a plant pigment (flavonoid) that is found in certain fruits and vegetables. Rutin is used to make medicine. The major sources of rutin for medical use include buckwheat, Japanese pagoda tree, and Eucalyptus macrorhyncha. Other sources of rutin include the leaves of several species of eucalyptus, lime tree flowers, elder flowers, hawthorn leaves and flowers, rue, St. John's Wort, Ginkgo biloba, apples, and other fruits and vegetables.

Some people believe that rutin can strengthen blood vessels, so they use it for varicose veins, internal bleeding, hemorrhoids, and to prevent strokes due to broken veins or arteries (hemorrhagic strokes). Rutin is also used to prevent a side effect of cancer treatment called mucositis. This is a painful condition marked by swelling and ulcer formation in the mouth or lining of the digestive tract.

In combination with the proteins trypsin and bromelain, rutin is also used for osteoarthritis.

Rutin is sometimes used on the skin to reduce wrinkles.

How does it work?

Rutin has chemicals that might have antioxidant and anti-inflammatory effects. These chemicals might offer some protection against cancer and other diseases.


Uses & Effectiveness?

Possibly Effective for

  • Osteoarthritis. Taking rutin by mouth in combination with trypsin and bromelain (Wobenzym PS) seems to be about as effective as the medication diclofenac (Voltaren) in relieving pain and improving knee function in people with osteoarthritis.
  • Swelling in the arm after breast surgery (post-surgical lymphedema). Some early research suggests that taking a specific product (Wobenzym N) containing rutin, pancreatin, papain, trypsin, and chymotrypsin daily for 7 weeks reduces swelling in the arm due to breast removal surgery.

Insufficient Evidence for

  • Aging skin. Early research suggests applying a cream containing rutin to the skin twice a day reduces the size and number of wrinkles and 'crow's feet' under the eyes.
  • Blood vessel disease.
  • Varicose veins.
  • Prevention of mouth ulcers associated with cancer treatments.
  • Bleeding.
  • Hemorrhoids.
More evidence is needed to rate the effectiveness of rutin for these uses.

Side Effects

Side Effects & Safety

Rutin is LIKELY SAFE when taken by mouth in amounts found in fruits and vegetables. Rutin is POSSIBLY SAFE when taken by mouth appropriately in medicinal amounts for a short period of time or when applied on the skin. It can cause some side effects including headache, flushing, rashes, or stomach upset.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking rutin if you are pregnant or breast feeding. Stay on the safe side and avoid use.



We currently have no information for RUTIN Interactions.



The following doses have been studied in scientific research:


  • For osteoarthritis: A combination product (Wobenzym PS), providing 600 mg of rutin, 288 mg of trypsin, and 540 mg of bromelain in divided doses has been used.
  • For swelling in the arm after breast surgery (post-surgical lymphedema): A specific product (Wobenzym N) containing rutin, pancreatin, papain, bromelain, trypsin, and chymotrypsin daily for 7 weeks has been used.

View References


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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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