Rutin is most commonly used for swelling in the arms or legs caused by damage to the lymph system (lymphedema) and osteoarthritis. It is also used for autism, or on the skin for sun protection, but there is no good scientific evidence to support these uses.
How does it work ?
Uses & Effectiveness ?
Possibly Effective for
- Swelling in the arms or legs caused by damage to the lymph system (lymphedema). Some early research suggests that taking a specific product (Wobenzym N) containing rutin, pancreatin, papain, trypsin, and chymotrypsin daily for 7 weeks reduces swelling in the arm due to breast removal surgery.
- Osteoarthritis. Taking rutin by mouth in combination with trypsin and bromelain (Wobenzym PS) seems to be about as effective as the medicationdiclofenac (Voltaren) in relieving pain and improving knee function in people with osteoarthritis.
Insufficient Evidence for
- Aging skin. Early research suggests applying a cream containing rutin to the skin twice a day reduces the size and number of wrinkles and 'crow's feet' under the eyes.
- Autism. Early research suggests that taking a product containing rutin and chemicals called luteolin and quercetin might improve behavior and social functioning in children with autism.
- Airway infections caused by exercise. Early research shows that taking a product containing rutin, trypsin, and bromelain starting about one week before a marathon does not help to prevent upper airway infections after the race.
- Blood vessel disease.
- Prevention of mouth ulcers associated with cancer treatments.
- Varicose veins.
When applied to the skin: Rutin is POSSIBLY SAFE when applied to the skin as a cream.
Special Precautions and Warnings
We currently have no information for RUTIN overview.
- For osteoarthritis: A combination product (Wobenzym PS), providing 600 mg of rutin, 288 mg of trypsin, and 540 mg of bromelain in divided doses has been used.
- For swelling in the arms or legs caused by damage to the lymph system (lymphedema): A specific product (Wobenzym N) containing rutin, pancreatin, papain, bromelain, trypsin, and chymotrypsin daily for 7 weeks has been used.
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Cesarone MR, Belcaro G, Pellegrini L, et al. HR, 0-(beta-hydroxyethyl)-rutosides; (Venoruton): rapid relief of signs/symptoms in chronic venous insufficiency and microangiopathy: a prospective, controlled study. Angiology 2005;56(2):165-172. View abstract.
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Incandela L, Cesarone MR, DeSanctis MT, et al. Treatment of diabetic microangiopathy and edema with HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides): a prospective, placebo-controlled, randomized study. J Cardiovasc Pharmacol Ther 2002;7 Suppl 1:S11-S15. View abstract.
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