People use apples for conditions such as cancer, diabetes, obesity, and many others, but there is no good scientific evidence to support these uses.
How does it work ?
Uses & Effectiveness ?
We currently have no information for APPLE overview.
Special Precautions and Warnings
Children: Apples are LIKELY SAFE, as long as the seeds aren't eaten. Apple pectin is POSSIBLY SAFE for children when taken by mouth, short-term.
Allergy to apricot and related plants: Apple may cause an allergic reaction in people who are sensitive to the Rosaceae family. Members of this family include apricot, almond, plum, peach, pear, and strawberry. Apple might also cause an allergic reaction in people allergic to birch pollen. If you have allergies, be sure to check with your healthcare provider before taking apple.
Diabetes: Apple, especially apple juice, can increase blood sugar levels. Monitor your blood sugar carefully if you use apple products and have diabetes.
Atenolol (Tenormin) interacts with APPLE
Apple juice can decrease how much atenolol (Tenormin) your body absorbs. Drinking apple juice along with atenolol (Tenormin) might decrease the effectiveness of atenolol (Tenormin). To avoid this interaction, separate taking this medication from consuming apple juice by at least 4 hours.
Do not take this combination
Fexofenadine (Allegra) interacts with APPLE
Apple juice can decrease how much fexofenadine (Allegra) your body absorbs. Drinking apple juice along with fexofenadine (Allegra) might decrease the effectiveness of fexofenadine (Allegra). To avoid this interaction, separate taking this medication from consuming apple juice by at least 4 hours.
Medications moved by pumps in cells (Organic Anion-Transporting Polypeptide Substrates) interacts with APPLE
Some medications are moved by pumps in cells. Apple juice might change how these pumps work and decrease how much of some medications get absorbed by the body. This could make these medications less effective. To avoid this interaction, separate taking these medications from consuming apple juice by at least 4 hours.
Some of these medications that are moved by pumps in cells include bosentan (Tracleer), celiprolol (Celicard, others), etoposide (VePesid), fexofenadine (Allegra), fluoroquinolone antibiotics, glyburide (Micronase, Diabeta), irinotecan (Camptosar), methotrexate, paclitaxel (Taxol), saquinavir (Fortovase, Invirase), rifampin, statins, talinolol, torsemide (Demadex), troglitazone, and valsartan (Diovan).
Medications for diabetes (Antidiabetes drugs) interacts with APPLE
Consuming apples and drinking apple juice might increase blood sugar levels. Diabetes medications are used to lower blood sugar. Consuming apple or apple juice along with diabetes medications might interfere with blood sugar control. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Aliskiren (Tekturna, Rasilez) interacts with APPLE
Aliskiren (Tekturna, Rasilez) is moved by pumps in cells in the body. Apple juice might change how these pumps work and decrease how much aliskiren (Tekturna, Rasilez) gets absorbed by the body. This could make this medication less effective. To avoid this interaction, separate taking this medication from consuming apple by at least 4 hours
Be cautious with this combination
Medications for high blood pressure (Antihypertensive drugs) interacts with APPLE
Consuming apple and cherry juice might increase blood pressure in some people. Drinking apple juice while taking medications for lowering blood high blood pressure might interfere with blood pressure control. Monitor your blood pressure closely. The dose of your blood pressure medication might need to be changed.
Some medications used for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.
Be watchful with this combination
Akazome, Y. Characteristics and physiological functions of polyphenols from apples. Biofactors 2004;22(1-4):311-314. View abstract.
Anderson, J. W., Gustafson, N. J., Bryant, C. A., and Tietyen-Clark, J. Dietary fiber and diabetes: a comprehensive review and practical application. J Am Diet Assoc 1987;87(9):1189-1197. View abstract.
Asp, N. G., Agardh, C. D., Ahren, B., Dencker, I., Johansson, C. G., Lundquist, I., Nyman, M., Sartor, G., and Schersten, B. Dietary fibre in type II diabetes. Acta Med Scand Suppl 1981;656:47-50. View abstract.
Ballot, D., Baynes, R. D., Bothwell, T. H., Gillooly, M., MacFarlane, B. J., MacPhail, A. P., Lyons, G., Derman, D. P., Bezwoda, W. R., Torrance, J. D., and . The effects of fruit juices and fruits on the absorption of iron from a rice meal. Br J Nutr 1987;57(3):331-343. View abstract.
Bandazhevskaya, G. S., Nesterenko, V. B., Babenko, V. I., Yerkovich, T. V., and Bandazhevsky, Y. I. Relationship between caesium (137Cs) load, cardiovascular symptoms, and source of food in 'Chernobyl' children -- preliminary observations after intake of oral apple pectin. Swiss.Med Wkly. 12-18-2004;134(49-50):725-729. View abstract.
Bell, J. A. and Whiting, S. J. Effect of fruit on net acid and urinary calcium excretion in an acute feeding trial of women. Nutrition 2004;20(5):492-493. View abstract.
Campbell, G., Pickles, T., and D'yachkova, Y. A randomised trial of cranberry versus apple juice in the management of urinary symptoms during external beam radiation therapy for prostate cancer. Clin Oncol.(R.Coll Radiol.) 2003;15(6):322-328. View abstract.
Castillo-Zamora, C., Castillo-Peralta, L. A., and Nava-Ocampo, A. A. Randomized trial comparing overnight preoperative fasting period Vs oral administration of apple juice at 06:00-06:30 am in pediatric orthopedic surgical patients. Paediatr.Anaesth. 2005;15(8):638-642. View abstract.
Enomoto, T., Nagasako-Akazome, Y., Kanda, T., Ikeda, M., and Dake, Y. Clinical effects of apple polyphenols on persistent allergic rhinitis: A randomized double-blind placebo-controlled parallel arm study. J Investig.Allergol.Clin Immunol. 2006;16(5):283-289. View abstract.
Gallus, S., Talamini, R., Giacosa, A., Montella, M., Ramazzotti, V., Franceschi, S., Negri, E., and La, Vecchia C. Does an apple a day keep the oncologist away? Ann Oncol. 2005;16(11):1841-1844. View abstract.
Hoekstra, J. H., van den Aker, J. H., Ghoos, Y. F., Hartemink, R., and Kneepkens, C. M. Fluid intake and industrial processing in apple juice induced chronic non-specific diarrhoea. Arch Dis Child 1995;73(2):126-130. View abstract.
Howell, A. B., Reed, J. D., Krueger, C. G., Winterbottom, R., Cunningham, D. G., and Leahy, M. A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity. Phytochemistry 2005;66(18):2281-2291. View abstract.
Kamimura, A., Takahashi, T., and Watanabe, Y. Investigation of topical application of procyanidin B-2 from apple to identify its potential use as a hair growing agent. Phytomedicine. 2000;7(6):529-536. View abstract.
Kang, J. Y., Tay, H. H., Guan, R., Math, M. V., Yap, I., and Labrooy, S. J. Dietary supplementation with pectin in the maintenance treatment of duodenal ulcer. A controlled study. Scand J Gastroenterol 1988;23(1):95-99. View abstract.
Ko, S. H., Choi, S. W., Ye, S. K., Cho, B. L., Kim, H. S., and Chung, M. H. Comparison of the antioxidant activities of nine different fruits in human plasma. J Med Food 2005;8(1):41-46. View abstract.
Lazareva, E. B., Spiridonova, T. G., Chernega, E. N., Plesskaia, L. G., Grunenkova, I. V., Smirnov, S. V., and Men'shikov, D. D. [Topical pectins for the treatment of burn wounds]. Antibiot.Khimioter. 2002;47(9):9-13. View abstract.
Maekawa, N., Mikawa, K., Yaku, H., Nishina, K., and Obara, H. Effects of 2-, 4- and 12-hour fasting intervals on preoperative gastric fluid pH and volume, and plasma glucose and lipid homeostasis in children. Acta Anaesthesiol.Scand 1993;37(8):783-787. View abstract.
Mayer, B., Schumacher, M., Brandstatter, H., Wagner, F. S., and Hermetter, A. High-throughput fluorescence screening of antioxidative capacity in human serum. Anal.Biochem 10-15-2001;297(2):144-153. View abstract.
Mayne, P. D., McGill, A. R., Gormley, T. R., Tomkin, G. H., Julian, T. R., and O'Moore, R. R. The effect of apple fibre on diabetic control and plasma lipids. Ir J Med Sci 1982;151(2):36-41. View abstract.
Mee, K. A. and Gee, D. L. Apple fiber and gum arabic lowers total and low-density lipoprotein cholesterol levels in men with mild hypercholesterolemia. J Am Diet Assoc 1997;97(4):422-424. View abstract.
Naguib, M., Samarkandimb, A. H., Al-Hattab, Y., Turkistani, A., Delvi, M. B., Riad, W., and Attia, M. Metabolic, hormonal and gastric fluid and pH changes after different preoperative feeding regimens. Can J Anaesth. 2001;48(4):344-350. View abstract.
Nesterenko, V. B., Nesterenko, A. V., Babenko, V. I., Yerkovich, T. V., and Babenko, I. V. Reducing the 137Cs-load in the organism of "Chernobyl" children with apple-pectin. Swiss.Med Wkly. 1-10-2004;134(1-2):24-27. View abstract.
Paut, O. and Camboulives, J. [Perioperative fasting in children: current data]. Arch Pediatr 1995;2(8):774-782. View abstract.
Pirich, C., Schmid, P., Pidlich, J., and Sinzinger, H. [Lowering cholesterol with Anticholest--a high fiber guar-apple pectin drink]. Wien.Klin Wochenschr. 1992;104(11):314-316. View abstract.
Shah, M., Griffin, I. J., Lifschitz, C. H., and Abrams, S. A. Effect of orange and apple juices on iron absorption in children. Arch Pediatr Adolesc Med 2003;157(12):1232-1236. View abstract.
Sobolev, M. B., Khatskel', S. B., and Muradov, A. I. [Enterosorption by nonstarch polysaccharides as a method of treatment of children with mercury poisoning]. Vopr.Pitan. 1999;68(1):28-30. View abstract.
Splinter, W. M., Stewart, J. A., and Muir, J. G. Large volumes of apple juice preoperatively do not affect gastric pH and volume in children. Can J Anaesth. 1990;37(1):36-39. View abstract.
Splinter, W. M., Stewart, J. A., and Muir, J. G. The effect of preoperative apple juice on gastric contents, thirst, and hunger in children. Can J Anaesth. 1989;36(1):55-58. View abstract.
Takahashi, T., Kamimura, A., Yokoo, Y., Honda, S., and Watanabe, Y. The first clinical trial of topical application of procyanidin B-2 to investigate its potential as a hair growing agent. Phytother.Res 2001;15(4):331-336. View abstract.
Tanabe, T., Ebina, M., Ishihara, H., Matsuki, A., Oshima, S., and Fukushi, S. [Preanesthetic meals in elective surgical patients]. Masui 1997;46(6):788-792. View abstract.
Tanabe, T., Hashimoto, Y., Sugihara, K., Miyata, A., Maeda, A., Ishihara, H., and Matsuki, A. [The effect of preoperative oral fluid intake on the volume and pH of gastric contents in elective surgical patients--a comparison of tea with apple juice]. Masui 1996;45(8):967-970. View abstract.
Valenkevich, L. N. [Apple powder in the treatment of patients with chronic enteritis]. Vopr.Pitan. 1993;(3):24-27. View abstract.
Valois, S., Costa-Ribeiro, H., Jr., Mattos, A., Ribeiro, T. C., Mendes, C. M., and Lifshitz, F. Controlled, double-blind, randomized clinical trial to evaluate the impact of fruit juice consumption on the evolution of infants with acute diarrhea. Nutr J 2005;4:23. View abstract.
Visvanathan, R., Chen, R., Horowitz, M., and Chapman, I. Blood pressure responses in healthy older people to 50 g carbohydrate drinks with differing glycaemic effects. Br J Nutr 2004;92(2):335-340. View abstract.
Yaneva, M. P., Botushanova, A. D., Grigorov, L. A., Kokov, J. L., Todorova, E. P., and Krachanova, M. G. Evaluation of the immunomodulatory activity of Aronia in combination with apple pectin in patients with breast cancer undergoing postoperative radiation therapy. Folia Med (Plovdiv.) 2002;44(1-2):22-25. View abstract.
Young, J. F., Nielsen, S. E., Haraldsdottir, J., Daneshvar, B., Lauridsen, S. T., Knuthsen, P., Crozier, A., Sandstrom, B., and Dragsted, L. O. Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidative status. Am J Clin Nutr 1999;69(1):87-94. View abstract.
Akamine Y, Miura M, Komori H, et al. Effects of one-time apple juice ingestion on the pharmacokinetics of fexofenadine enantiomers. Eur J Clin Pharmacol. 2014 Sep;70(9):1087-95. View Abstract.
Bailey DG, Dresser GK, Munoz C, et al. Reduction of fexofenadine bioavailability by fruit juices. Clin Pharmacol Ther 2001;69:P21.
Bailey DG. Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol 2010;70:645-55. View abstract.
Balay, K. S., Hawthorne, K. M., Hicks, P. D., Griffin, I. J., Chen, Z., Westerman, M., and Abrams, S. A. Orange but not apple juice enhances ferrous fumarate absorption in small children. J Pediatr Gastroenterol Nutr 2010;50(5):545-550. View abstract.
Becker B, Kuhn U, Hardewig-Budny B. Double-blind, randomized evaluation of clinical efficacy and tolerability of an apple pectin-chamomile extract in children with unspecific diarrhea. Arzneimittelforschung 2006;56(6):387-393. View abstract.
Bondonno NP, Bondonno CP, Blekkenhorst LC, et al. Flavonoid-Rich Apple Improves Endothelial Function in Individuals at Risk for Cardiovascular Disease: A Randomized Controlled Clinical Trial. Mol Nutr Food Res. 2018;62(3). View abstract.
Brouns F, Theuwissen E, Adam A, Bell M, Berger A, Mensink RP. Cholesterol-lowering properties of different pectin types in mildly hyper-cholesterolemic men and women. Eur J Clin Nutr. 2012 May;66(5):591-9. View abstract.
Butland BK, Fehily AM, Elwood PC. Diet and lung function decline in a cohort of 2512 middle aged men. Thorax 2000;55:102-8. View abstract.
Castleman M. The healing herbs, the ultimate guide to the curative power of nature's medicines. 2nd ed. New York, NY: Bantam Books, 1995.
Chai SC, Hooshmand S, Saadat RL, Payton ME, Brummel-Smith K, Arjmandi BH. Daily apple versus dried plum: impact on cardiovascular disease risk factors in postmenopausal women. J Acad Nutr Diet. 2012 Aug;112(8):1158-68. View Abstract.
Conceição de Oliveira M, Sichieri R, Sanchez Moura A. Weight loss associated with a daily intake of three apples or three pears among overweight women. Nutrition 2003;19:253-6. View abstract.
Cummings, J. H., Branch, W., Jenkins, D. J., Southgate, D. A., Houston, H., and James, W. P. Colonic response to dietary fibre from carrot, cabbage, apple, bran. Lancet 1978;1(8054):5-9. View abstract.
Davidson MH, Dugan LD, Stocki J, et al. A low-viscosity soluble-fiber fruit juice supplement fails to lower cholesterol in hypercholesterolemic men and women. J Nutr 1998;128:1927-32. View abstract.
de la Motte S, Bose-O'Reilly S, Heinisch M, Harrison F. [Double-blind comparison of an apple pectin-chamomile extract preparation with placebo in children with diarrhea]. Arzneimittelforschung 1997;47(11):1247-1249. View abstract.
Dekkers R. Apple juice and the chemical-contact softening of gallstones. Lancet 1999;354:2171.
Francini A, Sebastiani L. Phenolic Compounds in Apple (Malus x domestica Borkh.): Compounds Characterization and Stability during Postharvest and after Processing. Antioxidants (Basel). 2013 Sep 18;2(3):181-93. View abstract.
Greenblatt DJ. Analysis of drug interactions involving fruit beverages and organic anion-transporting polypeptides. J Clin Pharmacol 2009;49:1403-7. View abstract.
Hollands WJ, Hart DJ, Dainty JR,et al. Bioavailability of epicatechin and effects on nitric oxide metabolites of an apple flavanol-rich extract supplemented beverage compared to a whole apple puree: a randomized, placebo-controlled, crossover trial. Mol Nutr Food Res. 2013 Jul;57(7):1209-17. View abstract.
Jeon H, Jang IJ, Lee S, et al. Apple juice greatly reduces systemic exposure to atenolol. Br J Clin Pharmacol 2012 May 11. doi: 10.1111/j.1365-2125.2012.04324.x. [Epub ahead of print]. View abstract.
Joy JM, Falcone PH, Vogel RM, Mosman MM, Kim MP, Moon JR. Supplementation with a proprietary blend of ancient peat and apple extract may improve body composition without affecting hematology in resistance-trained men. Appl Physiol Nutr Metab. 2015 Nov;40(11):1171-7. View abstract.
Joy JM, Vogel RM, Moon JR, et al.Ancient peat and apple extracts supplementation may improve strength and power adaptations in resistance trained men. BMC Complement Altern Med. 2016 Jul 18;16:224. View abstract.
Kamath AV, Yao M, Zhang Y, Chong S. Effect of fruit juices on the oral bioavailability of fexofenadine in rats. J Pharm Sci 2005;94:233-9. View abstract.
Kopac P, Rudin M, Gentinetta T, et al. Continuous apple consumption induces oral tolerance in birch-pollen-associated apple allergy. Allergy. 2012 Feb;67(2):280-5. View abstract.
Krishnasamy S, Lomer MCE, Marciani L, et al. Processing apples to puree or juice speeds gastric emptying and reduces postprandial intestinal volumes and satiety in healthy adults. J Nutr 2020;150(11):2890-9. View abstract.
Kunkel SD. Elmore CJ, Bongers KS, et al. Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease. PLoS One 2012;7:e39332. View abstract.
Le Marchand L, Murphy SP, Hankin JH, et al. Intake of flavonoids and lung cancer. J Natl Cancer Inst 2000;92:154-60. View abstract.
Luo J, Imai H, Ohyama T, et al. The Pharmacokinetic Exposure to Fexofenadine is Volume-Dependently Reduced in Healthy Subjects Following Oral Administration With Apple Juice. Clin Transl Sci. 2016 Aug;9(4):201-6. View abstract.
Lust J. The herb book. New York, NY: Bantam Books, 1999.
Mahalko JR, Sandstead HH, Johnson LK, et al. Effect of consuming fiber from corn bran, soy hulls, or apple powder on glucose tolerance and plasma lipids in type II diabetes. Am J Clin Nutr 1984;39:25-34. View abstract.
Rabbani GH, Teka T, Zaman B, et al. Clinical studies in persistent diarrhea: dietary management with green banana or pectin in Bangladeshi children. Gastroenterology 2001;121:554-60. View abstract.
Remington R, Chan A, Lepore A, Kotlya E, Shea TB. Apple juice improved behavioral but not cognitive symptoms in moderate-to-late stage Alzheimer's disease in an open-label pilot study. Am J Alzheimers Dis Other Demen. 2010 Jun;25(4):367-71. View abstract.
Rodriguez J, Crespo JF, Lopez-Rubio A, et al. Clinical cross-reactivity among foods of the Rosaceae family. J Allergy Clin Immunol 2000;106:183-189. View abstract.
Rubido S, García-Caballero L, Abeleira MT, Limeres J, García M, Diz P. Effect of chewing an apple on dental plaque removal and on salivary bacterial viability. PLoS One. 2018;13(7):e0199812. View abstract.
Sansone K, Kern M, Hong MY, Liu C, Hooshmand S. Acute Effects of Dried Apple Consumption on Metabolic and Cognitive Responses in Healthy Individuals. J Med Food. 2018;21(11):1158-1164. View abstract.
Soriano-Maldonado A, Hidalgo M, Arteaga P, de Pascual-Teresa S, Nova E. Effects of regular consumption of vitamin C-rich or polyphenol-rich apple juice on cardiometabolic markers in healthy adults: a randomized crossover trial. Eur J Nutr. 2014 Dec;53(8):1645-57. View abstract.
Tapaninen T, Neuvonen PJ, Niemi M. Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren. Br J Clin Pharmacol 2011;71:718-26. View abstract.
Tsiougkos N, Vovolis V. Repeated anaphylactic episodes to orange and apple. Eur Ann Allergy Clin Immunol. 2013 May;45(3):113-5. View abstract.
Wruss J, Lanzerstorfer P, Huemer S, et al. Differences in pharmacokinetics of apple polyphenols after standardized oral consumption of unprocessed apple juice. Nutr J. 2015 Apr 1;14:32. View abstract.
You Might Also Like
CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.
This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.