Bois d’Artois, Bois Béni, Bois Ordinaire, Boj, Boje, Boxwood Extract, Buis, Buis Commun, Buis Toujours Vert, Bujo, Bush Tree, Buxaceae, Buxus, Buxus colchica, Buxus hyrcana, Buxus sempervirens, Dudgeon, Extrait de Buis, SPV 30.<br/><br/>


Overview Information

Boxwood is a plant. People take chemicals from the leaf to make medicine (boxwood extract). The leaf itself should not be used for medicine. It can cause serious harm, including death.

Boxwood extract is used to treat HIV/AIDS and to boost immunity. Boxwood extract (SPV 30) is not usually found on store shelves. Most users get it through internet sources or AIDS buyers' clubs.

Boxwood is also used for arthritis and as a “blood-detoxifying agent.”

How does it work?

Boxwood might stop viruses from reproducing, but there isn't enough scientific evidence to support this theory.


Uses & Effectiveness?

Insufficient Evidence for

  • Treating HIV/AIDS. There is early evidence that 990 mg per day of a specific boxwood leaf extract (SPV 30) might delay disease progression in HIV-infected people. It seems to delay decreases in CD4 cell counts, increases in viral load, and/or progression to AIDS in HIV-infected people who have no AIDS symptoms. A higher dose of 1980 mg per day does not seem to be effective.
  • Stimulating the immune system.
  • Arthritis.
  • Detoxifying the blood.
  • Other conditions.
More evidence is needed to rate the effectiveness of boxwood for these uses.

Side Effects

Side Effects & Safety

Boxwood extract (SPV 30) is POSSIBLY SAFE for most people when taken by mouth for up to 16 months. It sometimes causes diarrhea or stomachcramps.

It’s LIKELY UNSAFE to use whole boxwood leaf. It has serious side effects that the leaf extract doesn't seem to have. Whole boxwood leaf can cause poisoning, including life-threatening side effects such as seizures and paralysis. It can also cause death.

Special Precautions & Warnings:

Pregnancy and breast-feeding: It’s LIKELY UNSAFE to use whole boxwood leaf, whether or not you are pregnant or breast-feeding. Not enough is known about the safety of using boxwood extract during pregnancy or breast-feeding. Stay on the safe side and avoid use until more is known.

Slow heart rate (bradycardia): Boxwood extract might slow down the heart rate. This could be a problem in people who already have a slow heart rate.

Gastrointestinal tract blockage: Boxwood extract might cause “congestion” in the intestines. This might cause problems in people who have a blockage in their intestines.

Ulcers: Boxwood extract might increase secretions in the stomach and intestines. There is concern that this could worsen ulcers.

Lung conditions: Boxwood extract might increase fluid secretions in the lung. There is concern that this could worsen lung conditions such as asthma or emphysema.

Seizures: There is concern that boxwood extract might increase the risk of seizures.

Urinary tract obstruction: Boxwood extract might increase secretions in the urinary tract. There is concern that this could worsen urinary obstruction.



We currently have no information for BOXWOOD Interactions.



The appropriate dose of boxwood depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for boxwood. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Ahmed, D., Choudhary, M. I., Turkoz, S., and Sener, B. Chemical Constituents of Buxus sempervirens. Planta Med 1988;54(2):173-174. View abstract.
  • Ata, A., Naz, S., Choudhary, M. I., Atta, ur Rahman, Sener, B., and Turkoz, S. New triterpenoidal alkaloids from Buxus sempervirens. Z Naturforsch.[C.] 2002;57(1-2):21-28. View abstract.
  • Boxwood. Treat.Rev. 1995;(no 17):7. View abstract.
  • Dopke, W. and Muller, B. [Buxaltin and buxiramine, 2 new alkaloids from Buxus sempervirens L]. Pharmazie 1969;24(10):649. View abstract.
  • Durant, J., Chantre, P. H., Gonzalez, G., Vandermander, J., Halfon, P. H., Rousse, B., Guedon, D., Rahelinirina, V., Chamaret, S., Montagnier, L., and Dellamonica, P. Efficacy and safety of
  • Ernst, E. [How "ethics arguments" hinder research. With Buxus sempervirens against AIDS?]. Fortschr.Med. 5-20-1998;116(14):6-7. View abstract.
  • Gollub, M. J., Gerdes, H., and Bains, M. S. Radiographic appearances of esophageal stents. Radiographics 1997;17(5):1169-1182. View abstract.
  • Grodeck, B. SPV-30: where's the proof? Posit.Aware. 1995;7. View abstract.
  • Kuller, K. Happiness reigns in the drug marketplace. GMHC.Treat.Issues 1997;11(4/5):6-8. View abstract.
  • Kupchan, S. M., Kennedy, R. M., Schleigh, W. R., and Ohta, G. Buxus alkaloids. XII. Benzamide alkaloids from Buxus sempervirens L. Tetrahedron 1967;23(12):4563-4586. View abstract.
  • Kvaltinova, Z., Lukovic, L., Machova, J., and Fatranska, M. Effect of the steroidal alkaloid buxaminol-E on blood pressure, acetylcholinesterase activity and (3H)quinuclidinyl benzilate binding in cerebral cortex. Pharmacology 1991;43(1):20-25. View abstract.
  • Liu, J. P., Manheimer, E., and Yang, M. Herbal medicines for treating HIV infection and AIDS. Cochrane.Database.Syst.Rev. 2005;(3):CD003937. View abstract.
  • Loru, F., Duval, D., Aumelas, A., Akeb, F., Guedon, D., and Guedj, R. Four steroidal alkaloids from the leaves of Buxus sempervirens. Phytochemistry 2000;54(8):951-957. View abstract.
  • Orhan, I., Sener, B., Choudhary, M. I., and Khalid, A. Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plants. J Ethnopharmacol 2004;91(1):57-60. View abstract.
  • Promising results for SPV-30. AIDS Patient.Care 1995;9(5):259. View abstract.
  • SPV-30 may offer CD4 increase. Posit.Aware. 1995;7. View abstract.
  • SPV-30 shows encouraging results. AIDS Patient.Care STDS. 1996;10(3):186-187. View abstract.
  • Stokes, D. No claims of SPV-30 success. [letter]. Posit.Aware. 1995;4. View abstract.
  • Tominaga, T., Guimbertau, G., and Dubourdieu, D. Contribution of benzenemethanethiol to smoky aroma of certain Vitis vinifera L. wines. J Agric.Food Chem 2-26-2003;51(5):1373-1376. View abstract.
  • van Neer, F. J. and van Ginkel, C. J. Allergic contact dermatitis from a boxwood recorder. Contact Dermatitis 1997;36(6):305. View abstract.
  • Atta-ur-Rahman Au, Ata A, Naz S, et al. New steroidal alkaloids from the roots of buxus sempervirens. J Nat Prod 1999;62:665-9. View abstract.
  • Durant J, Chantre P, Gonzalez G, et al. Efficacy and safety of Buxus sempervirens L. preparations (SPV30) in HIV-infected asymptomatic patients: a multicentre, randomized, double-blind, placebo-controlled trial. Phytomedicine 1998;5:1-10.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.