QUILLAIA
Arbre à Savon, Bois de Panama, China Bark, Murillo Bark, Panama Bark, Quillaja, Quillaja saponaria, Quillay, Savonnier, Soap Tree, Soap Tree Bark, Soapbark.
Uses & Effectiveness
Insufficient Evidence for
- High cholesterol.
- A lung disease that makes it harder to breath (chronic obstructive pulmonary disease or COPD).
- Asthma.
- Athlete's foot (Tinea pedis).
- Bed sores (pressure ulcers.
- Common cold.
- Cough.
- Dandruff.
- Foot sores in people with diabetes.
- Leg sores caused by weak blood circulation (venous leg ulcer).
- Rough, scaly skin on the scalp and face (seborrheic dermatitis).
- Short-term swelling (inflammation) of the airways in the lungs (acute bronchitis).
- Other conditions.
Side Effects & Safety
When taken by mouth: Quillaia is LIKELY SAFE when taken by mouth in food amounts. But it is POSSIBLY UNSAFE when taken by mouth in medicinal doses. Plants such as quillaia that contain high amounts of tannins can cause stomach and intestinal disturbances, as well as kidney and liver damage. Quillaia also contains chemicals called oxalates that can lower blood calcium levels and cause kidney stones. Quillaia use can also cause diarrhea, stomach pain, serious breathing problems, convulsions, coma, red blood cell destruction, and kidney failure. Quillaia can also irritate and damage the lining of the mouth, throat, and digestive tract.When applied to the skin: There isn't enough reliable information to know if quillaia is safe or what the side effects might be.
When inhaled: There isn't enough reliable information to know if quillaia is safe. The powder can cause sneezing when inhaled.
When applied into the vagina: There isn't enough reliable information to know if quillaia is safe or what the side effects might be.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Quillaia is POSSIBLY UNSAFE for both mother and infant. Avoid use.Stomach and intestinal (gastrointestinal, GI) problems: Quillaia can irritate the GI tract. Don't use it if you have a stomach or intestinal disorder.
Kidney disease: The oxalate in quillaia can cause kidney stones. Don't use it if you have kidney disease or a history of kidney stones.
Interactions
Moderate Interaction
Be cautious with this combination
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Medications taken by mouth (Oral drugs) interacts with QUILLAIA
Quillaia contains a large amount of chemicals called tannins. Tannins absorb substances in the stomach and intestines. Taking quillaia along with medications taken by mouth can decrease how much medicine your body absorbs, and decrease the effectiveness of your medicine. To prevent this interaction, take quillaia at least one hour after medications you take by mouth.
-
Metformin (Glucophage) interacts with QUILLAIA
Metformin (Glucophage) is used to help decrease blood sugar. Quillaia might decrease how much metformin (Glucophage) the body absorbs. Taking quillaia along with metformin (Glucophage) might decrease the effectiveness of metformin (Glucophage) for lowering blood sugar. Monitor your blood sugar closely. The dose of your metformin (Glucophage) might need to be changed.
Dosing
The appropriate dose of quillaia depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for quillaia. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
REFERENCES:
- Adamczyk B, Simon J, Kitunen V, Adamczyk S, Smolander A. Tannins and their complex interaction with different organic nitrogen compounds and enzymes: old paradigms versus recent advances. ChemistryOpen. 2017;6(5):610-614. View abstract.
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Fleck JD, Betti AH, da Silva FP, et al. Saponins from Quillaja saponaria and Quillaja brasiliensis: particular chemical characteristics and biological activities. Molecules 2019;24(1). pii: E171. View abstract.
- Kim SW, Park SK, Kang SI, et al. Hypocholesterolemic property of Yucca schidigera and Quillaja saponaria extracts in human body. Arch Pharm Res 2003;26(12):1042-6. View abstract.
- McRae JM, Kennedy JA. Wine and grape tannin interactions with salivary proteins and their impact on astringency: a review of current research. Molecules. 2011;16(3):2348-64. View abstract.
- Pillion DJ, Amsden JA, Kensil CR, et al. Structure-function relationship among Quillaja saponins serving as excipients for nasal and ocular delivery of insulin. J Pharm Sci 1996;85:518-24. View abstract.
- Recchia J, Lurantos MH, Amsden JA, et al. A semisynthetic Quillajasaponin as a drug delivery agent for aminoglycoside antibiotics. Pharm Res 1995;12:1917-23. View abstract.
- Roner MR, Tam KI, Kiesling-Barrager M. Prevention of rotavirus infections in vitro with aqueous extracts of Quillaja Saponaria Molina. Future Med Chem 2010;2(7):1083-97. View abstract.
- Sidhu GS, Oakenfull DG. A mechanism for the hypocholesterolaemic activity of saponins. Br J Nutr 1986;55:643-9. View abstract.
- Tam KI, Roner MR. Characterization of in vivo anti-rotavirus activities of saponin extracts from Quillaja saponaria Molina. Antiviral Res 2011;90(3):231-41. View abstract.
- Wu JY, Gardner BH, Murphy CI, et al. Saponin adjuvant enhancement of antigen-specific immune responses to an experimental HIV-1 vaccine. J Immunol 1992;148:1519-25. View abstract.
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