Abrojo, Abrojos, Al-Gutub, Baijili, Bindii, Bulgarian Tribulus Terrestris, Caltrop, Cat's-Head, Ci Ji Li, Common Dubbletjie, Croix-de-Malte, Devil's-Thorn, Devil's-Weed, Épine du Diable, Escarbot, Espigón, German Tribulus Terrestris, Goathead, Gokantaka, Gokhru, Gokshur, Gokshura, Nature's Viagra, Puncture Vine, Puncture Weed, Qutiba, Small Caltrops, Tribule, Tribule Terrestre, Tribulis, Tribulis Terrestris, Tribulus, Tribulus terrestris.<br/><br/>
Overview InformationTribulus is a plant that produces fruit covered with spines. Rumor has it that tribulus is also known as puncture vine because the spines are so sharp they can flatten bicycle tires. People use the fruit, leaf, and root as medicine.
People use tribulus for conditions such as chest pain, eczema, enlarged prostate, sexual disorders, infertility, and many others, but there is no good scientific evidence to support these uses.
How does it work?Tribulus has chemicals that might increase levels of some hormones. However, it doesn't appear to increase male hormones (testosterone) in humans.
Uses & Effectiveness
Possibly Ineffective for
- Enhancing athletic performance. Taking tribulus by mouth, alone or with other herbs and supplements, doesn't seem to enhance body composition or exercise performance in athletes.
Insufficient Evidence for
- Chest pain (angina pectoris). Early research shows that taking tribulus extract by mouth might reduce symptoms of angina.
- Eczema (atopic dermatitis). Taking tribulus by mouth in combination with 9 other herbs might reduce redness and skin outbreaks in adults and children with a certain type of eczema. However, some research shows no benefit.
- Enlarged prostate (Benign prostatic hyperplasia; BPH). Early research shows that taking a supplement containing tribulus and curry leaf (Murraya koenigii) for 12 weeks improves symptoms similar to the prescription drug tamsulosin in men with an enlarged prostate. Other early research shows that taking a supplement containing tribulus, brown algae, chitosan, and saw palmetto for 2 months improves symptoms and quality of life in men with lower urinary tract symptoms, with or without BPH.
- Erectile dysfunction (ED). Some early research shows that taking tribulus for 3 months improves erections in men with a condition called partial androgen deficiency. Men with this condition often have ED. Other early research shows that taking a supplement containing tribulus, brown algae, and chitosan for 3 months improves sexual satisfaction, desire, ability to ejaculate, and sexual quality of life in men with ED. However, other research shows that taking tribulus for 30 days does not improve erections in men with ED.
- Infertility. Research on tribulus for infertility is conflicting. Some early research shows that taking tribulus for 60 days does not improve sperm count in men with low sperm count. However, other research shows that taking a specific tribulus product for 30 days improves ejaculate volume, sperm concentration, and sperm movement in men with low sperm count and defective sperm movement. Other research shows that taking the same tribulus product for 1-2 months may increase sexual desire and erections in some men with infertility due to low levels of testosterone.
- Sexual problems in women. Early research shows that taking tribulus for 4 weeks improves sexual desire, arousal, satisfaction, orgasm, pain, and lubrication in women with low sexual desire. Other early research shows that taking tribulus for 90 days improves sexual desire, arousal, sensation, lubrication, ability to reach orgasm, and sexual comfort in postmenopausal women with sexual problems.
- "Tired blood" (anemia).
- Intestinal gas (flatulence).
- Other conditions.
Side Effects & SafetyTribulus supplements are POSSIBLY SAFEfor most people when taken by mouth for a short period of time. Tribulus has been used safely in research studies lasting up to 90 days. Side effects are usually mild and uncommon but might include stomach pain, cramping, diarrhea, nausea, vomiting, constipation, excitation, difficulty sleeping, or heavy menstrual bleeding. In rare cases, reports of kidney damage have been linked to taking tribulus. The long-term safety of tribulus is unknown.
Eat the spine-covered fruit of tribulus is LIKELY UNSAFE. There has been a report of a serious lung problem linked to eating the fruit.
Special Precautions & Warnings:Pregnancy and breast-feeding: Taking tribulus during pregnancy is POSSIBLY UNSAFE. Animal research suggests that tribulus might harm fetal development. Not enough is known about the safety of using tribulus during breast-feeding. It's best not to use tribulus if you are pregnant or nursing.
Diabetes. Tribulus might decrease blood sugar levels. Dose of diabetes medications might need to be adjusted by your healthcare provider.
Surgery: Tribulus might affect blood sugar levels and blood pressure. This might interfere with blood sugar and blood pressure control during and after surgery. Stop using tribulus at least 2 weeks before a scheduled surgery.
Be cautious with this combination
Lithium interacts with TRIBULUS
Tribulus might have an effect like a water pill or "diuretic." Taking tribulus might decrease how well the body gets rid of lithium. This could increase how much lithium is in the body and result in serious side effects. Talk with your healthcare provider before using this product if you are taking lithium. Your lithium dose might need to be changed.
Medications for diabetes (Antidiabetes drugs) interacts with TRIBULUS
Tribulus might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking tribulus along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.<br/><br/> Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
The appropriate dose of tribulus depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for tribulus. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
- Pedersen, A., Marckmann, P., and Sandstrom, B. Postprandial lipoprotein, glucose and insulin responses after two consecutive meals containing rapeseed oil, sunflower oil or palm oil with or without glucose at the first meal. Br J Nutr 1999;82(2):97-104. View abstract.
- Perez-Jimenez, F., Espino, A., Lopez-Segura, F., Blanco, J., Ruiz-Gutierrez, V., Prada, J. L., Lopez-Miranda, J., Jimenez-Pereperez, J., and Ordovas, J. M. Lipoprotein concentrations in normolipidemic males consuming oleic acid-rich diets from two different sources: olive oil and oleic acid-rich sunflower oil. Am.J.Clin.Nutr. 1995;62(4):769-775. View abstract.
- Perona, J. S., Canizares, J., Montero, E., Sanchez-Dominguez, J. M., Catala, A., and Ruiz-Gutierrez, V. Virgin olive oil reduces blood pressure in hypertensive elderly subjects. Clin.Nutr. 2004;23(5):1113-1121. View abstract.
- Ruiz-Gutierrez, V., Perona, J. S., Pacheco, Y. M., Muriana, F. J., and Villar, J. Incorporation of dietary triacylglycerols from olive oil and high-oleic sunflower oil into VLDL triacylglycerols of hypertensive patients. Eur.J.Clin.Nutr. 1999;53(9):687-693. View abstract.
- Sakr, S. W., Attia, N., Haourigui, M., Paul, J. L., Soni, T., Vacher, D., and Girard-Globa, A. Fatty acid composition of an oral load affects chylomicron size in human subjects. Br.J.Nutr. 1997;77(1):19-31. View abstract.
- Sanchez-Muniz, F. J., Merinero, M. C., Rodriguez-Gil, S., Ordovas, J. M., Rodenas, S., and Cuesta, C. Dietary fat saturation affects apolipoprotein AII levels and HDL composition in postmenopausal women. J.Nutr. 2002;132(1):50-54. View abstract.
- Sanders, T. A., Oakley, F. R., Cooper, J. A., and Miller, G. J. Influence of a stearic acid-rich structured triacylglycerol on postprandial lipemia, factor VII concentrations, and fibrinolytic activity in healthy subjects. Am J Clin Nutr 2001;73(4):715-721. View abstract.
- Serrano, Paz P., Gonzalez, Bueno, V, Diego, Estevez M., Medrano, J., Ballesta, M. C., Martinez-Victoria, E., Calpena, R., Mataix, J., and Yago, M. D. [Postoperative enteral nutrition with a high content of mono- and polyunsaturated fatty acids]. Nutr.Hosp. 1995;10(4):223-227. View abstract.
- Adimoelja, A. Phytochemicals and the breakthrough of traditional herbs in the management of sexual dysfunctions. Int J Androl 2000;23 Suppl 2:82-84. View abstract.
- Kohut, M. L., Thompson, J. R., Campbell, J., Brown, G. A., Vukovich, M. D., Jackson, D. A., and King, D. S. Ingestion of a dietary supplement containing dehydroepiandrosterone (DHEA) and androstenedione has minimal effect on immune function in middle-aged men. J Am Coll Nutr 2003;22(5):363-371. View abstract.
- Adaikan, P. G., Gauthaman, K., Prasad, R. N., and Ng, S. C. Proerectile pharmacological effects of Tribulus terrestris extract on the rabbit corpus cavernosum. Ann Acad.Med Singapore 2000;29(1):22-26. View abstract.
- Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. View abstract.
- Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. View abstract.
- Antonio J, Uelmen J, Rodriguez R, Earnest C. The effects of Tribulus terrestris on body composition and exercise performance in resistance-trained males. Int J Sport Nutr Exerc Metab 2000;10:208-15. View abstract.
- Bedir, E. and Khan, I. A. New steroidal glycosides from the fruits of Tribulus terrestris. J Nat Prod 2000;63(12):1699-1701. View abstract.
- Bedir, E., Khan, I. A., and Walker, L. A. Biologically active steroidal glycosides from Tribulus terrestris. Pharmazie 2002;57(7):491-493. View abstract.
- Bourke, C. A., Stevens, G. R., and Carrigan, M. J. Locomotor effects in sheep of alkaloids identified in Australian Tribulus terrestris. Aust.Vet.J 1992;69(7):163-165. View abstract.
- Brown GA, Vukovich MD, Martini ER, et al. Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30- to 59-year-old men. Int J Vitam Nutr Res 2001;71:293-301. View abstract.
- Brown GA, Vukovich MD, Martini ER, et al. Endocrine and lipid responses to chronic androstenediol-herbal supplementation in 30 to 58 year old men. J Am Coll Nutr 2001;20:520-8. View abstract.
- Brown GA, Vukovich MD, Reifenrath TA, et al. Effects of anabolic precursors on serum testosterone concentrations and adaptations to resistance training in young men. Int J Sport Nutr Exerc Metab 2000;10:340-59. View abstract.
- Campanelli M, De Thomasis R, Tenaglia RL. Priapism caused by 'Tribulus terrestris'. Int J Impot Res 2016;28(1):39-40. View abstract.
- Conrad, J., Dinchev, D., Klaiber, I., Mika, S., Kostova, I., and Kraus, W. A novel furostanol saponin from Tribulus terrestris of Bulgarian origin. Fitoterapia 2004;75(2):117-122. View abstract.
- De Combarieu E, Fuzzati N, Lovati M, Mercalli E. Furostanol saponins from Tribulus terrestris. Fitoterapia 2003;74:583-91. View abstract.
- Deepak M, Dipankar G, Prashanth D, et al. Tribulosin and beta-sitosterol-D-glucoside, the anthelmintic principles of Tribulus terrestris. Phytomedicine 2002;9:753-6. View abstract.
- Deng, Y., Yang, L., and An, S. L. [Effect of Tribulus terrestris L decoction of different concentrations on tyrosinase activity and the proliferation of melanocytes]. Di Yi.Jun.Yi.Da.Xue.Xue.Bao. 2002;22(11):1017-1019. View abstract.
- Dudley JP. Bilateral pneumothorax resulting from the bronchoscopic removal of a puncture vine fruit. Ann Otol Rhinol Laryngol 1983;92:396-7. View abstract.
- Fung AY, Look PC, Chong LY, et al. A controlled trial of traditional Chinese herbal medicine in Chinese patients with recalcitrant atopic dermatitis. Int J Dermatol 1999;38:387-92 . View abstract.
- Gauthaman K, Adaikan PG, Prasad RN. Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats. Life Sci 2002;71:1385-96. View abstract.
- Gauthaman K, Adaikan PG. Effect of Tribulus terrestris on nicotinamide adenine dinucleotide phosphate-diaphorase activity and androgen receptors in rat brain. J Ethnopharmacol 2005;96:127-32. View abstract.
- Gauthaman K, Ganesan AP. The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction-an evaluation using primates, rabbit and rat. Phytomedicine 2008;15(1-2):44-54. View abstract.
- Glastonbury, J. R., Doughty, F. R., Whitaker, S. J., and Sergeant, E. A syndrome of hepatogenous photosensitisation, resembling geeldikkop, in sheep grazing Tribulus terrestris. Aust Vet J 1984;61(10):314-316. View abstract.
- Hong CH, Hur SK, Oh OJ, et al. Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. J Ethnopharmacol 2002;83:153-9. View abstract.
- Huang, J. W., Tan, C. H., Jiang, S. H., and Zhu, D. Y. Terrestrinins A and B, two new steroid saponins from Tribulus terrestris. J Asian Nat Prod Res 2003;5(4):285-290. View abstract.
- Iacono F, Prezioso D, Illiano E, et al. Observational study: daily treatment with a new compound "Tradamixina" plus serenoa repens for two months improved the lower urinary tract symptoms. BMC Surg 2012;12 Suppl 1:S22. View abstract.
- Jacob, R. H. and Peet, R. L. Poisoning of sheep and goats by Tribulis terrestris (caltrop). Aust Vet J 1987;64(9):288-289. View abstract.
- Jameel, J. K., Kneeshaw, P. J., Rao, V. S., and Drew, P. J. Gynaecomastia and the plant product "Tribulis terrestris". Breast 2004;13(5):428-430. View abstract.
- Kumanov F, Bozadzhieva E, Platonova M, and et al. [Clinical testing of Tribestan]. Savr Med 1982;4:211-215.
- Li M, Qu W, Wang Y, et al. [Hypoglycemic effect of saponin from Tribulus terrestris] Zhong Yao Cai 2002;25:420-2. View abstract.
- Neychev, V. K. and Mitev, V. I. The aphrodisiac herb Tribulus terrestris does not influence the androgen production in young men. J Ethnopharmacol. 2005; Oct 3;101(1-3):319-23 View abstract.
- Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. View abstract.
- Protich, M., Tsvetkov, D., Nalbanski, B., Stanislavov, R., and Katsarova, M. [Clinical trial of a tribestan preparation in infertile men]. Akush.Ginekol.(Sofiia) 1983;22(4):326-329. View abstract.
- Raos, M., Bumber, Z., and Kovac, K. [A bronchial polyp and foreign body in an adolescent]. Lijec.Vjesn. 2001;123(7-8):177-178. View abstract.
- Roaiah MF, El Khayat YI, GamalEl Din SF, Abd El Salam MA. Pilot study on the effect of botanical medicine (Tribulus terrestris) on serum testosterone level and erectile function in aging males with partial androgen deficiency (PADAM). J Sex Marital Ther 2016;42(4):297-301. View abstract.
- Rogerson S, Riches CJ, Jennings C, et al. The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players. J Strength Cond Res 2007;21(2):348-53. View abstract.
- Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. View abstract.
- Sansalone S, Leonardi R, Antonini G, et al. Alga Ecklonia bicyclis, Tribulus terrestris, and glucosamine oligosaccharide improve erectile function, sexual quality of life, and ejaculation function in patients with moderate mild-moderate erectile dysfunction: a prospective, randomized, placebo-controlled, single-blinded study. Biomed Res Int. 2014;2014:121396. View abstract.
- Santos CA Jr, Reis LO, Destro-Saade R, et al. Tribulus terrestris versus placebo in the treatment of erectile dysfunction: a prospective randomized, double blind study. Actas Urol Esp 2014;38(4):244-8. View abstract.
- Sellandi TM, Thakar AB, Baghel MS. Clinical study of Tribulus terrestris Linn. in oligozoospermia: a double blind study. Ayu 2012;33(3):356-64. View abstract.
- Sengupta G, Hazra A, Kundu A, Ghosh A. Comparison of Murraya koenigii - and Tribulus terrestris-based oral formulation versus tamsulosin in the treatment of benign prostatic hyperplasia in men aged >50 years: a double-blind, double-dummy, randomized controlled trial. Clin Ther 2011;33(12):1943-52. View abstract.
- Seth, S. D. and Jagadeesh, G. Cardiac action of Tribulus terrestris. Indian J Med Res 1976;64(12):1821-1825. View abstract.
- Seth, S. D. and Prabhakar, M. C. Preliminary pharmacological investigations of Tribulus terrestris, Linn. (Gokhru) part 1. Indian J Med Sci 1974;28(9):377-380. View abstract.