Tribulus has chemicals that might increase levels of some hormones. But it doesn't appear to increase male hormones (testosterone) in humans. Tribulus is also known as puncture vine because its sharp spines can flatten bicycle tires.
People use tribulus for sexual disorders, infertility, chest pain, enlarged prostate, and many other conditions, but there is no good scientific evidence to support most of these uses.
Uses & Effectiveness ?
Possibly Effective for
Possibly Ineffective for
Eating the spine-covered fruit of tribulus is likely unsafe. There have been reports of serious lung problems due to eating the fruit.
Special Precautions and Warnings
Eating the spine-covered fruit of tribulus is likely unsafe. There have been reports of serious lung problems due to eating the fruit. Pregnancy: Taking tribulus during pregnancy is possibly unsafe. Animal research suggests that tribulus might harm development of the fetus.
Breast-feeding. There isn't enough reliable information to know if tribulus is safe to use when breast-feeding. Stay on the safe side and avoid use.
Surgery: Tribulus might affect blood sugar levels and blood pressure. This might interfere with blood sugar and blood pressure control during and after surgery. Stop using tribulus at least 2 weeks before a scheduled surgery.
Lithium interacts with TRIBULUS
Tribulus might have an effect like a "water pill" or diuretic. Taking tribulus might decrease how well the body gets rid of lithium. This could increase how much lithium is in the body and result in serious side effects. Talk with your healthcare provider before using this product if you are taking lithium. Your lithium dose might need to be changed.
Medications for diabetes (Antidiabetes drugs) interacts with TRIBULUS
Tribulus might lower blood sugar levels. Taking Tribulus along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Medications for high blood pressure (Antihypertensive drugs) interacts with TRIBULUS
Tribulus might lower blood pressure. Taking Tribulus along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.
Be cautious with this combination
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Sengupta G, Hazra A, Kundu A, Ghosh A. Comparison of Murraya koenigii - and Tribulus terrestris-based oral formulation versus tamsulosin in the treatment of benign prostatic hyperplasia in men aged >50 years: a double-blind, double-dummy, randomized controlled trial. Clin Ther 2011;33(12):1943-52. View abstract.
Seth, S. D. and Jagadeesh, G. Cardiac action of Tribulus terrestris. Indian J Med Res 1976;64(12):1821-1825. View abstract.
Dudley JP. Bilateral pneumothorax resulting from the bronchoscopic removal of a puncture vine fruit. Ann Otol Rhinol Laryngol 1983;92:396-7. View abstract.
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Gauthaman K, Adaikan PG, Prasad RN. Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats. Life Sci 2002;71:1385-96. View abstract.
Gauthaman K, Adaikan PG. Effect of Tribulus terrestris on nicotinamide adenine dinucleotide phosphate-diaphorase activity and androgen receptors in rat brain. J Ethnopharmacol 2005;96:127-32. View abstract.
Gauthaman K, Ganesan AP. The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction-an evaluation using primates, rabbit and rat. Phytomedicine 2008;15(1-2):44-54. View abstract.
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Huang, J. W., Tan, C. H., Jiang, S. H., and Zhu, D. Y. Terrestrinins A and B, two new steroid saponins from Tribulus terrestris. J Asian Nat Prod Res 2003;5(4):285-290. View abstract.
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Kamenov Z, Fileva S, Kalinov K, Jannini EA. Evaluation of the efficacy and safety of Tribulus terrestris in male sexual dysfunction-A prospective, randomized, double-blind, placebo-controlled clinical trial. Maturitas. 2017 May;99:20-26. doi: 10.1016/j.maturitas.2017.01.011. View abstract.
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Marques MAA, Lourenço BHLB, Reis MP, et al. Osteoprotective Effects of Tribulus terrestris L.: Relationship Between Dehydroepiandrosterone Levels and Ca2+-Sparing Effect. J Med Food. 2019 Mar;22(3):241-247. View abstract.
Deng, Y., Yang, L., and An, S. L. [Effect of Tribulus terrestris L decoction of different concentrations on tyrosinase activity and the proliferation of melanocytes]. Di Yi.Jun.Yi.Da.Xue.Xue.Bao. 2002;22(11):1017-1019. View abstract.
Adimoelja, A. Phytochemicals and the breakthrough of traditional herbs in the management of sexual dysfunctions. Int J Androl 2000;23 Suppl 2:82-84. View abstract.
Adaikan, P. G., Gauthaman, K., Prasad, R. N., and Ng, S. C. Proerectile pharmacological effects of Tribulus terrestris extract on the rabbit corpus cavernosum. Ann Acad.Med Singapore 2000;29(1):22-26. View abstract.
Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. View abstract.
Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. View abstract.
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Bedir, E., Khan, I. A., and Walker, L. A. Biologically active steroidal glycosides from Tribulus terrestris. Pharmazie 2002;57(7):491-493. View abstract.
Bourke, C. A., Stevens, G. R., and Carrigan, M. J. Locomotor effects in sheep of alkaloids identified in Australian Tribulus terrestris. Aust.Vet.J 1992;69(7):163-165. View abstract.
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Conrad, J., Dinchev, D., Klaiber, I., Mika, S., Kostova, I., and Kraus, W. A novel furostanol saponin from Tribulus terrestris of Bulgarian origin. Fitoterapia 2004;75(2):117-122. View abstract.
De Combarieu E, Fuzzati N, Lovati M, Mercalli E. Furostanol saponins from Tribulus terrestris. Fitoterapia 2003;74:583-91. View abstract.
de Souza KZ, Vale FB, Geber S. Efficacy of Tribulus terrestris for the treatment of hypoactive sexual desire disorder in postmenopausal women: a randomized, double-blinded, placebo-controlled trial. Menopause. 2016 Nov;23(11):1252-1256. doi: 10.1080/09513590.2017.1409711 View abstract.
Deepak M, Dipankar G, Prashanth D, et al. Tribulosin and beta-sitosterol-D-glucoside, the anthelmintic principles of Tribulus terrestris. Phytomedicine 2002;9:753-6. View abstract.
Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
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Talemi MNPE, Ardakani SMP, Roozbeh B. Tribulus terrestris may decrease muscle damage markers following a high-intensity resistance exercise: a pilot study. Int J Vitam Nutr Res. 2020:1-7. Online ahead of print. View abstract.
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Vale FBC, Zanolla Dias de Souza K, Rezende CR, Geber S. Efficacy of Tribulus Terrestris for the treatment of premenopausal women with hypoactive sexual desire disorder: a randomized double-blinded, placebo-controlled trial. Gynecol Endocrinol. 2018 May;34(5):442-445. doi: 10.1080/09513590.2017.1409711. View abstract.
Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. View abstract.
Wang B, Ma L, Liu T. 406 cases of angina pectoris in coronary heart disease treated with saponin of Tribulus terrestris. Chung Hsi I Chieh Ho Tsa Chih 1990;10:85-7. View abstract.
Wilkins AL, et al. Photosensitivity in South Africa. IX. Structure elucidation of a beta-glucosidase-treated saponin from Tribulus terrestis, and the identification of saponin chemotypes of South African T. terrestis. Onderstepoort Journal Veterinary Res 1996; 63:327-34. View abstract.
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