TRIBULUS

OTHER NAME(S):

Abrojo, Abrojos, Al-Gutub, Baijili, Bindii, Bulgarian Tribulus Terrestris, Caltrop, Cat's-Head, Ci Ji Li, Common Dubbletjie, Croix-de-Malte, Devil's-Thorn, Devil's-Weed, Épine du Diable, Escarbot, Espigón, German Tribulus Terrestris, Goathead, Gokantaka, Gokhru, Gokshur, Gokshura, Nature's Viagra, Puncture Vine, Puncture Weed, Qutiba, Small Caltrops, Tribule, Tribule Terrestre, Tribulis, Tribulis Terrestris, Tribulus, Tribulus terrestris.<br/><br/>

Overview

Overview Information

Tribulus is a plant that produces fruit covered with spines. Rumor has it that tribulus is also known as puncture vine because the spines are so sharp they can flatten bicycle tires. People use the fruit, leaf, and root as medicine.

People use tribulus for conditions such as chest pain, eczema, enlarged prostate, sexual disorders, infertility, and many others, but there is no good scientific evidence to support these uses.

How does it work?

Tribulus has chemicals that might increase levels of some hormones. However, it doesn't appear to increase male hormones (testosterone) in humans.

Uses

Uses & Effectiveness?

Possibly Ineffective for

  • Enhancing athletic performance. Taking tribulus by mouth, alone or with other herbs and supplements, doesn't seem to enhance body composition or exercise performance in athletes.

Insufficient Evidence for

  • Chest pain (angina pectoris). Early research shows that taking tribulus extract by mouth might reduce symptoms of angina.
  • Eczema (atopic dermatitis). Taking tribulus by mouth in combination with 9 other herbs might reduce redness and skin outbreaks in adults and children with a certain type of eczema. However, some research shows no benefit.
  • Enlarged prostate (Benign prostatic hyperplasia; BPH). Early research shows that taking a supplement containing tribulus and curry leaf (Murraya koenigii) for 12 weeks improves symptoms similar to the prescription drug tamsulosin in men with an enlarged prostate. Other early research shows that taking a supplement containing tribulus, brown algae, chitosan, and saw palmetto for 2 months improves symptoms and quality of life in men with lower urinary tract symptoms, with or without BPH.
  • Erectile dysfunction (ED). Some early research shows that taking tribulus for 3 months improves erections in men with a condition called partial androgen deficiency. Men with this condition often have ED. Other early research shows that taking a supplement containing tribulus, brown algae, and chitosan for 3 months improves sexual satisfaction, desire, ability to ejaculate, and sexual quality of life in men with ED. However, other research shows that taking tribulus for 30 days does not improve erections in men with ED.
  • Infertility. Research on tribulus for infertility is conflicting. Some early research shows that taking tribulus for 60 days does not improve sperm count in men with low sperm count. However, other research shows that taking a specific tribulus product for 30 days improves ejaculate volume, sperm concentration, and sperm movement in men with low sperm count and defective sperm movement. Other research shows that taking the same tribulus product for 1-2 months may increase sexual desire and erections in some men with infertility due to low levels of testosterone.
  • Sexual problems in women. Early research shows that taking tribulus for 4 weeks improves sexual desire, arousal, satisfaction, orgasm, pain, and lubrication in women with low sexual desire. Other early research shows that taking tribulus for 90 days improves sexual desire, arousal, sensation, lubrication, ability to reach orgasm, and sexual comfort in postmenopausal women with sexual problems.
  • "Tired blood" (anemia).
  • Cancer.
  • Coughs.
  • Intestinal gas (flatulence).
  • Other conditions.
More evidence is needed to rate the effectiveness of tribulus for these uses.

Side Effects

Side Effects & Safety

Tribulus supplements are POSSIBLY SAFEfor most people when taken by mouth for a short period of time. Tribulus has been used safely in research studies lasting up to 90 days. Side effects are usually mild and uncommon but might include stomach pain, cramping, diarrhea, nausea, vomiting, constipation, excitation, difficulty sleeping, or heavy menstrual bleeding. In rare cases, reports of kidney damage have been linked to taking tribulus. The long-term safety of tribulus is unknown.

Eat the spine-covered fruit of tribulus is LIKELY UNSAFE. There has been a report of a serious lung problem linked to eating the fruit.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Taking tribulus during pregnancy is POSSIBLY UNSAFE. Animal research suggests that tribulus might harm fetal development. Not enough is known about the safety of using tribulus during breast-feeding. It's best not to use tribulus if you are pregnant or nursing.

Diabetes. Tribulus might decrease blood sugar levels. Dose of diabetes medications might need to be adjusted by your healthcare provider.

Surgery: Tribulus might affect blood sugar levels and blood pressure. This might interfere with blood sugar and blood pressure control during and after surgery. Stop using tribulus at least 2 weeks before a scheduled surgery.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Lithium interacts with TRIBULUS

    Tribulus might have an effect like a water pill or "diuretic." Taking tribulus might decrease how well the body gets rid of lithium. This could increase how much lithium is in the body and result in serious side effects. Talk with your healthcare provider before using this product if you are taking lithium. Your lithium dose might need to be changed.

  • Medications for diabetes (Antidiabetes drugs) interacts with TRIBULUS

    Tribulus might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking tribulus along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.<br/><br/> Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Dosing

Dosing

The appropriate dose of tribulus depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for tribulus. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Deepak M, Dipankar G, Prashanth D, et al. Tribulosin and beta-sitosterol-D-glucoside, the anthelmintic principles of Tribulus terrestris. Phytomedicine 2002;9:753-6. View abstract.
  • Deng, Y., Yang, L., and An, S. L. [Effect of Tribulus terrestris L decoction of different concentrations on tyrosinase activity and the proliferation of melanocytes]. Di Yi.Jun.Yi.Da.Xue.Xue.Bao. 2002;22(11):1017-1019. View abstract.
  • Dudley JP. Bilateral pneumothorax resulting from the bronchoscopic removal of a puncture vine fruit. Ann Otol Rhinol Laryngol 1983;92:396-7. View abstract.
  • Fung AY, Look PC, Chong LY, et al. A controlled trial of traditional Chinese herbal medicine in Chinese patients with recalcitrant atopic dermatitis. Int J Dermatol 1999;38:387-92 . View abstract.
  • Gauthaman K, Adaikan PG, Prasad RN. Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats. Life Sci 2002;71:1385-96. View abstract.
  • Gauthaman K, Adaikan PG. Effect of Tribulus terrestris on nicotinamide adenine dinucleotide phosphate-diaphorase activity and androgen receptors in rat brain. J Ethnopharmacol 2005;96:127-32. View abstract.
  • Gauthaman K, Ganesan AP. The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction-an evaluation using primates, rabbit and rat. Phytomedicine 2008;15(1-2):44-54. View abstract.
  • Glastonbury, J. R., Doughty, F. R., Whitaker, S. J., and Sergeant, E. A syndrome of hepatogenous photosensitisation, resembling geeldikkop, in sheep grazing Tribulus terrestris. Aust Vet J 1984;61(10):314-316. View abstract.
  • Hong CH, Hur SK, Oh OJ, et al. Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. J Ethnopharmacol 2002;83:153-9. View abstract.
  • Huang, J. W., Tan, C. H., Jiang, S. H., and Zhu, D. Y. Terrestrinins A and B, two new steroid saponins from Tribulus terrestris. J Asian Nat Prod Res 2003;5(4):285-290. View abstract.
  • Iacono F, Prezioso D, Illiano E, et al. Observational study: daily treatment with a new compound "Tradamixina" plus serenoa repens for two months improved the lower urinary tract symptoms. BMC Surg 2012;12 Suppl 1:S22. View abstract.
  • Jacob, R. H. and Peet, R. L. Poisoning of sheep and goats by Tribulis terrestris (caltrop). Aust Vet J 1987;64(9):288-289. View abstract.
  • Jameel, J. K., Kneeshaw, P. J., Rao, V. S., and Drew, P. J. Gynaecomastia and the plant product "Tribulis terrestris". Breast 2004;13(5):428-430. View abstract.
  • Kumanov F, Bozadzhieva E, Platonova M, and et al. [Clinical testing of Tribestan]. Savr Med 1982;4:211-215.
  • Li M, Qu W, Wang Y, et al. [Hypoglycemic effect of saponin from Tribulus terrestris] Zhong Yao Cai 2002;25:420-2. View abstract.
  • Neychev, V. K. and Mitev, V. I. The aphrodisiac herb Tribulus terrestris does not influence the androgen production in young men. J Ethnopharmacol. 2005; Oct 3;101(1-3):319-23 View abstract.
  • Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. View abstract.
  • Protich, M., Tsvetkov, D., Nalbanski, B., Stanislavov, R., and Katsarova, M. [Clinical trial of a tribestan preparation in infertile men]. Akush.Ginekol.(Sofiia) 1983;22(4):326-329. View abstract.
  • Raos, M., Bumber, Z., and Kovac, K. [A bronchial polyp and foreign body in an adolescent]. Lijec.Vjesn. 2001;123(7-8):177-178. View abstract.
  • Roaiah MF, El Khayat YI, GamalEl Din SF, Abd El Salam MA. Pilot study on the effect of botanical medicine (Tribulus terrestris) on serum testosterone level and erectile function in aging males with partial androgen deficiency (PADAM). J Sex Marital Ther 2016;42(4):297-301. View abstract.
  • Rogerson S, Riches CJ, Jennings C, et al. The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players. J Strength Cond Res 2007;21(2):348-53. View abstract.
  • Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. View abstract.
  • Sansalone S, Leonardi R, Antonini G, et al. Alga Ecklonia bicyclis, Tribulus terrestris, and glucosamine oligosaccharide improve erectile function, sexual quality of life, and ejaculation function in patients with moderate mild-moderate erectile dysfunction: a prospective, randomized, placebo-controlled, single-blinded study. Biomed Res Int. 2014;2014:121396. View abstract.
  • Santos CA Jr, Reis LO, Destro-Saade R, et al. Tribulus terrestris versus placebo in the treatment of erectile dysfunction: a prospective randomized, double blind study. Actas Urol Esp 2014;38(4):244-8. View abstract.
  • Sellandi TM, Thakar AB, Baghel MS. Clinical study of Tribulus terrestris Linn. in oligozoospermia: a double blind study. Ayu 2012;33(3):356-64. View abstract.
  • Sengupta G, Hazra A, Kundu A, Ghosh A. Comparison of Murraya koenigii - and Tribulus terrestris-based oral formulation versus tamsulosin in the treatment of benign prostatic hyperplasia in men aged >50 years: a double-blind, double-dummy, randomized controlled trial. Clin Ther 2011;33(12):1943-52. View abstract.
  • Seth, S. D. and Jagadeesh, G. Cardiac action of Tribulus terrestris. Indian J Med Res 1976;64(12):1821-1825. View abstract.
  • AbuMweis, S. S., Vanstone, C. A., Ebine, N., Kassis, A., Ausman, L. M., Jones, P. J., and Lichtenstein, A. H. Intake of a single morning dose of standard and novel plant sterol preparations for 4 weeks does not dramatically affect plasma lipid concentrations in humans. J Nutr. 2006;136(4):1012-1016. View abstract.
  • Aguilera, C. M., Mesa, M. D., Ramirez-Tortosa, M. C., Nestares, M. T., Ros, E., and Gil, A. Sunflower oil does not protect against LDL oxidation as virgin olive oil does in patients with peripheral vascular disease. Clin.Nutr. 2004;23(4):673-681. View abstract.
  • Albers, R., van der Wielen, R. P., Brink, E. J., Hendriks, H. F., Dorovska-Taran, V. N., and Mohede, I. C. Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men. Eur J Clin Nutr 2003;57(4):595-603. View abstract.
  • Allman-Farinelli, M. A., Gomes, K., Favaloro, E. J., and Petocz, P. A diet rich in high-oleic-acid sunflower oil favorably alters low-density lipoprotein cholesterol, triglycerides, and factor VII coagulant activity. J.Am.Diet.Assoc. 2005;105(7):1071-1079. View abstract.
  • Almallah, Y. Z., Ewen, S. W., El-Tahir, A., Mowat, N. A., Brunt, P. W., Sinclair, T. S., Heys, S. D., and Eremin, O. Distal proctocolitis and n-3 polyunsaturated fatty acids (n-3 PUFAs): the mucosal effect in situ. J Clin Immunol. 2000;20(1):68-76. View abstract.
  • Almallah, Y. Z., Richardson, S., O'Hanrahan, T., Mowat, N. A., Brunt, P. W., Sinclair, T. S., Ewen, S., Heys, S. D., and Eremin, O. Distal procto-colitis, natural cytotoxicity, and essential fatty acids. Am.J.Gastroenterol. 1998;93(5):804-809. View abstract.
  • Bechoua, S., Dubois, M., Vericel, E., Chapuy, P., Lagarde, M., and Prigent, A. F. Influence of very low dietary intake of marine oil on some functional aspects of immune cells in healthy elderly people. Br.J.Nutr. 2003;89(4):523-531. View abstract.
  • Binkoski, A. E., Kris-Etherton, P. M., Wilson, T. A., Mountain, M. L., and Nicolosi, R. J. Balance of unsaturated fatty acids is important to a cholesterol-lowering diet: comparison of mid-oleic sunflower oil and olive oil on cardiovascular disease risk factors. J.Am.Diet.Assoc. 2005;105(7):1080-1086. View abstract.
  • Seth, S. D. and Prabhakar, M. C. Preliminary pharmacological investigations of Tribulus terrestris, Linn. (Gokhru) part 1. Indian J Med Sci 1974;28(9):377-380. View abstract.
  • Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. View abstract.
  • Sheehan M, Rustin MHA, Atherton DJ, et al. Efficacy of traditional Chinese herbal therapy in adult atopic dermatitis. Lancet 1992;340:13-17. View abstract.
  • Sheehan MP, Atherton DJ. A controlled trial of traditional Chinese medicinal plants in widespread non-exudative atopic eczema. Br J Dermatol 1992;126:179-84. View abstract.
  • Sun, B., Qu, W. J., Zhang, X. L., Yang, H. J., Zhuang, X. Y., and Zhang, P. [Investigation on inhibitory and apoptosis-inducing effects of saponins from Tribulus terrestris on hepatoma cell line BEL-7402]. Zhongguo Zhong.Yao Za Zhi. 2004;29(7):681-684. View abstract.
  • Sun, B., Qu, W., and Bai, Z. [The inhibitory effect of saponins from Tribulus terrestris on Bcap-37 breast cancer cell line in vitro]. Zhong.Yao Cai. 2003;26(2):104-106. View abstract.
  • Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  • Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. View abstract.
  • Twaij HA, Elisha EE, Khalid RM, and et al. Analgesic studies on some Iraqi medicinal plants. International Journal of Crude Drug Research 1987;25(4):251-254.
  • Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. View abstract.
  • Wang B, Ma L, Liu T. 406 cases of angina pectoris in coronary heart disease treated with saponin of Tribulus terrestris. Chung Hsi I Chieh Ho Tsa Chih 1990;10:85-7. View abstract.
  • Wilkins AL, et al. Photosensitivity in South Africa. IX. Structure elucidation of a beta-glucosidase-treated saponin from Tribulus terrestis, and the identification of saponin chemotypes of South African T. terrestis. Onderstepoort Journal Veterinary Res 1996; 63:327-34. View abstract.
  • Zarkova S. [Steroid saponins of Tribulus terrestris L. have a stimulant effect on the sexual function]. Rev Port Ciencias Vet 1984;79(470):117-126.
  • Zhang W, Leonard T, Bath-Hextall F, et al. Chinese herbal medicine for atopic eczema. Cochrane Database Syst Rev 2004;4:CD002291. View abstract.

More Resources for TRIBULUS

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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