Brionia, Bryone, Bryone Blanche, Bryone Dioïque, Bryonia alba, Bryonia cretica, Bryonia dioca, Bryoniae Radix, Couleuvrée, Devil's Turnip, English Mandrake, Herbe de Feu, Ladies' Seal, Mandragore Grimpante, Navet du Diable, Rave de Serpent, Tamus, Tetterberry, Vigne Blanche, Vigne du Diable, White Bryony, Wild Hops, Wild Nep, Wild Vine, Wood Vine.


Overview Information

Bryonia is a plant. People use the root for medicine. The berries of the plant are poisonous.

Bryonia root is used as a laxative, to induce vomiting, for liver disease, infection, and many other conditions, but there is no good scientific evidence to support these uses. Using bryonia root is also likely unsafe.

How does it work?

Bryonia root contains chemicals that might reduce inflammation. Bryonia berries contain a toxic chemical that can be fatal.


Uses & Effectiveness?

Insufficient Evidence for

  • Stomach or intestinal diseases.
  • Lung diseases.
  • Arthritis.
  • Liver disease.
  • Metabolic disorders.
  • Fluid retention.
  • Preventing infections.
  • Causing vomiting.
  • Other conditions.
More evidence is needed to rate the effectiveness of bryonia for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Bryonia is LIKELY UNSAFE for anyone to use. Even in low doses, the root can cause many side effects, including dizziness, vomiting, convulsions, bloody diarrhea, nervous excitement, and kidney damage. Larger doses of the root may cause fatal poisoning. Eating the berries of the bryonia plant can cause death. As few as 40 berries can be fatal in an adult.

Special Precautions & Warnings:

It's LIKELY UNSAFE for anyone to take bryonia by mouth. But bryonia is especially dangerous for people with the following conditions:

Pregnancy: Bryonia is UNSAFE for pregnant women when taken by mouth. It can cause a miscarriage.

Breast-feeding: Bryonia is LIKELY UNSAFE for breast-feeding women when taken by mouth. It can cause serious health consequences.

Children: Bryonia is LIKELY UNSAFE for children when taken by mouth. The root can cause serious side effects. Eating as few as 15 berries can cause death.

Stomach and intestinal (gastrointestinal, GI) disorders: There are many reasons not to use bryonia. It can cause serious side effects and death. Additionally, it can irritate the stomach and intestines and can make GI problems worse.



We currently have no information for BRYONIA Interactions.



The appropriate dose of bryonia depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for bryonia. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Francisco, J. A., Gawlak, S. L., Miller, M., Bathe, J., Russell, D., Chace, D., Mixan, B., Zhao, L., Fell, H. P., and Siegall, C. B. Expression and characterization of bryodin 1 and a bryodin 1-based single-chain immunotoxin from tobacco cell culture. Bioconjug.Chem. 1997;8(5):708-713. View abstract.
  • Gawlak, S. L., Neubauer, M., Klei, H. E., Chang, C. Y., Einspahr, H. M., and Siegall, C. B. Molecular, biological, and preliminary structural analysis of recombinant bryodin 1, a ribosome-inactivating protein from the plant Bryonia dioica. Biochemistry 3-18-1997;36(11):3095-3103. View abstract.
  • Karageuzyan, K. G., Vartanyan, G. S., Agadjanov, M. I., Panossian, A. G., and Hoult, J. R. Restoration of the disordered glucose-fatty acid cycle in alloxan-diabetic rats by trihydroxyoctadecadienoic acids from Bryonia alba, a native Armenian medicinal plant. Planta Med. 1998;64(5):417-422. View abstract.
  • Karagezian, K. G., Vartanian, G. S., and Panosian, A. G. [Effect of an extract from the roots of bryony (Bryonia alba) on lipid peroxidation in the liver of rats with alloxan diabetes]. Biull.Eksp.Biol.Med. 1981;92(8):35-37. View abstract.
  • Merck, C. C., Sonnenwald, B., and Rollwage, H. [The administration of homeopathic drugs for the treatment of acute mastitis in cattle]. Berl Munch.Tierarztl.Wochenschr. 8-1-1989;102(8):266-272. View abstract.
  • Munoz, S. M., Salvarelli, S. M., Saiz, M. I., and Conde, F. P. A toxic protein from Bryonia dioica Jacq. fruits: the brydiofin. Biochem Biophys Res Commun 3-31-1992;183(3):1011-1018. View abstract.
  • Panosian, A. G. [Effect of Bryonia cucurbitacins on the biosynthesis of eicosanoids in human leukocytes]. Bioorg.Khim. 1985;11(2):264-269. View abstract.
  • Panosian, A. G., Dadaian, M. A., and Gabrielian, E. S. [Cucurbitacin R glycoside--a regulator of steroidogenesis and of the formation of prostaglandin E2--a specific modulator of the hypothalamus-hypophysis-adrenal cortex system]. Biull.Eksp.Biol.Med. 1987;104(10):456-457. View abstract.
  • Panossian, A. G., Avetissian, G. M., Mnatsakanian, V. A., Batrakov, S. G., Vartanian, S. A., Gabrielian, E. S., and Amroyan, E. A. Unsaturated polyhydroxy acids having prostaglandin-like activity from Bryonia alba II. Major components. Planta Med. 1983;47(1):17-25. View abstract.
  • Panossian, A. G., Oganessian, A. S., Ambartsumian, M., Gabrielian, E. S., Wagner, H., and Wikman, G. Effects of heavy physical exercise and adaptogens on nitric oxide content in human saliva. Phytomedicine. 1999;6(1):17-26. View abstract.
  • Panossian, A., Gabrielian, E., and Wagner, H. On the mechanism of action of plant adaptogens with particular reference to cucurbitacin R diglucoside. Phytomedicine. 1999;6(3):147-155. View abstract.
  • Siegall, C. B., Gawlak, S. L., Chace, D., Wolff, E. A., Mixan, B., and Marquardt, H. Characterization of ribosome-inactivating proteins isolated from Bryonia dioica and their utility as carcinoma-reactive immunoconjugates. Bioconjug.Chem. 1994;5(5):423-429. View abstract.
  • Suganda, A. G., Amoros, M., Girre, L., and Fauconnier, B. [Inhibitory effects of some crude and semi-purified extracts of indigenous French plants on the multiplication of human herpesvirus 1 and poliovirus 2 in cell culture]. J Nat Prod 1983;46(5):626-632. View abstract.
  • Ukiya, M., Akihisa, T., Yasukawa, K., Tokuda, H., Toriumi, M., Koike, K., Kimura, Y., Nikaido, T., Aoi, W., Nishino, H., and Takido, M. Anti-inflammatory and anti-tumor-promoting effects of cucurbitane glycosides from the roots of Bryonia dioica. J.Nat.Prod. 2002;65(2):179-183. View abstract.
  • Varshney, J. P. and Naresh, R. Comparative efficacy of homeopathic and allopathic systems of medicine in the management of clinical mastitis of Indian dairy cows. Homeopathy 2005;94(2):81-85. View abstract.
  • Varshney, J. P. and Naresh, R. Evaluation of a homeopathic complex in the clinical management of udder diseases of riverine buffaloes. Homeopathy 2004;93(1):17-20. View abstract.
  • Vartanian, G. S. and Karagezian, K. G. [Normalizing effect of Bryonia alba L. on blood phospholipids in alloxan diabetes]. Vopr.Med.Khim. 1981;27(2):179-181. View abstract.
  • Vartanian, G. S., Parsadanian, G. K., and Karagezian, K. G. [Effect of trihydroxyoctadecadiene acids from Bryonia alba L. on the activity of glycogen metabolism enzymes in alloxan diabetes]. Biull.Eksp.Biol.Med. 1984;97(3):295-297. View abstract.
  • Wachinger, M., Samtleben, R., Gerhauser, C., Wagner, H., and Erfle, V. Bryodin, a single-chain ribosome-inactivating protein, selectively inhibits the growth of HIV-1-infected cells and reduces HIV-1 production. Res.Exp.Med.(Berl) 1993;193(1):1-12. View abstract.
  • Whur, P. White bryony poisoning in a dog. Vet.Rec. 10-18-1986;119(16):411. View abstract.
  • Paris, A., Gonnet, N., Chaussard, C., Belon, P., Rocourt, F., Saragaglia, D., and Cracowski, J. L. Effect of homeopathy on analgesic intake following knee ligament reconstruction: a phase III monocentre randomized placebo controlled study. Br J Clin Pharmacol 2008;65(2):180-187. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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