PHOSPHATIDYLCHOLINE

OTHER NAME(S):

1,2-diacyl-sn-glycero-3-phosphocholine, Fosfatidilcolina, Lipodissolve, Lipolight, Lipolyse, Lipothérapie, Lipotherapy, Phosphatidyl Choline, Phospholipid, Phospholipide, Phospholipon, Polyenylphosphatidylcholine, Polyénylphosphatidylcholine, PtdCho.

Overview

Overview Information

Phosphatidylcholine is a chemical contained in eggs, soybeans, mustard, sunflower, and other foods. It is found naturally in the body in all cells. Phosphatidylcholine is also a source of choline in the body.

Phosphatidylcholine is used for ulcerative colitis. There is some scientific research that supports this use.

Phosphatidylcholine is also used for memory loss, Alzheimer disease, and liver disease, but there is no good scientific evidence to support these uses.

Phosphatidylcholine is also used in cosmetic injections for "dissolving" fat, but these are considered unapproved drugs by the U.S. Food and Drug Administration (FDA).

How does it work?

The body makes a chemical called acetylcholine from phosphatidylcholine. Acetylcholine is important for memory and other functions in the body. Phosphatidylcholine might help to protect the wall of the large intestine in people with a type of inflammatory bowel disease (ulcerative colitis).

Uses

Uses & Effectiveness?

Possibly Effective for

  • A type of inflammatory bowel disease (ulcerative colitis). Research suggests that taking various types of phosphatidylcholine daily for up to 3 months improves symptoms in people with ulcerative colitis.

Possibly Ineffective for

  • Swelling (inflammation) of the liver caused by the hepatitis A virus (hepatitis A). Taking phosphatidylcholine by mouth does not seem to improve liver function in people with hepatitis A.
  • Infant development. Taking phosphatidylcholine during pregnancy does not seem to improve the brain development of the infant.
  • Improving a medical procedure called peritoneal dialysis. Taking phosphatidylcholine by mouth does not seem to improve a medical procedure called peritoneal dialysis.
  • A movement disorder often caused by antipsychotic drugs (tardive dyskinesia). Taking phosphatidylcholine by mouth does not seem to improve tardive dyskinesia.

Insufficient Evidence for

  • Acne. Early research suggests that applying a cream containing 4% niacinamide and phosphatidylcholine to the skin seems to improve acne in some people.
  • Liver disease in people who drink alcohol. Early research suggests that taking phosphatidylcholine daily for 24 months does not increase survival in people with liver disease who drink alcohol.
  • Reducing fat deposits. Early research suggests that injections of phosphatidylcholine under the skin may make fatty deposits on the chin, thigh, hips, abdomen, back, neck, and elsewhere look smaller to some people. Improvements appear to last for 2-3 years or longer. In one study, 80% of patients reported improvements in facial fat that lasted for up to 3 years. However, these results have been questioned because the studies were not well designed.
  • Reduced brain function in people with advanced liver disease (hepatic encephalopathy). Research suggests that taking phosphatidylcholine daily for 6-8 weeks does not improve declining brain function in people with liver disease or liver failure.
  • Swelling (inflammation) of the liver caused by the hepatitis B virus (hepatitis B). Studies of phosphatidylcholine for hepatitis B show conflicting results. It is not clear if phosphatidylcholine is beneficial.
  • Swelling (inflammation) of the liver caused by the hepatitis C virus (hepatitis C). Early research suggests that taking phosphatidylcholine by mouth, together with interferon, seems to improve liver function in people with hepatitis C.
  • High levels of lipoproteins in the blood (hyperlipoproteinemia). Early research suggests that taking phosphatidylcholine does not reduce lipoprotein levels in people with hyperlipoproteinemia.
  • Non-cancerous fatty tumors (lipomas). There is one report that injecting a phosphatidylcholine solution directly into a lipoma can shrink the tumor by about 35%. However, this treatment might cause an unwanted reaction in the lipoma.
  • Build up of fat in the liver in people who drink little or no alcohol (nonalcoholic fatty liver disease or NAFLD). Early research suggests that taking phosphatidylcholine might improve liver function in people with NAFLD.
  • Memory. There is early evidence that taking a single 25 mg dose of phosphatidylcholine can improve some measures of memory in healthy college students.
  • Eyelid fat. There is some evidence that injecting a phosphatidylcholine solution reduces bulging lower eyelid fat pads in some people.
  • Aging.
  • Diseases, such as Alzheimer disease, that interfere with thinking (dementia).
  • Chest pain (angina).
  • Anxiety.
  • Hardening of the arteries (atherosclerosis).
  • Eczema (atopic dermatitis).
  • Bipolar disorder.
  • Gallbladder disease.
  • High cholesterol.
  • Narrowing of blood vessels that causes poor blood flow to the limbs (peripheral arterial disease).
  • High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia).
  • Premenstrual syndrome (PMS).
  • Other conditions.
More evidence is needed to rate the effectiveness of phosphatidylcholine for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Phosphatidylcholine is POSSIBLY SAFE when taken by mouth, in a dose up to 30 grams per day for 6 weeks, or up to 6 grams per day for 2 years. When phosphatidylcholine is taken by mouth, it can sometimes cause excessive sweating, stomach upset, and diarrhea.

When given as a shot: Phosphatidylcholine is POSSIBLY SAFE when given as an injection under the skin for up to 5 doses spread 2-4 weeks apart. The injections can cause irritation, swelling, redness, itching, burning, bruising, and pain at the injection site. These side effects usually go away over a period of several days. Sometimes, phosphatidylcholine might cause gastrointestinal upset, like bloating, diarrhea, and nausea.

If phosphatidylcholine is injected directly into a non-cancerous fatty tumor (lipoma), it might cause a reaction that could make the tumor more fibrous, needing surgery to remove it.

When applied to the skin: Phosphatidylcholine is POSSIBLY SAFE when applied to the skin for up to 12 weeks.

Special Precautions & Warnings:

Pregnancy: Phosphatidylcholine is POSSIBLY SAFE when taken by mouth.

Breast-feeding: There isn't enough reliable information to know if phosphatidylcholine is safe to use when breast-feeding. Stay on the safe side and avoid use.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Drying medications (Anticholinergic drugs) interacts with PHOSPHATIDYLCHOLINE

    Some drying medications are called anticholinergic drugs. Phosphatidylcholine might increase chemicals that can decrease the effects of these drying medications.

    Some drying medications include atropine, scopolamine, and some medications used for allergies (antihistamines) and for depression (antidepressants).

  • Medications for Alzheimer's disease (Acetylcholinesterase (AChE) inhibitors) interacts with PHOSPHATIDYLCHOLINE

    Phosphatidylcholine might increase a chemical in the body called acetylcholine. Medications for Alzheimer's called acetylcholinesterase inhibitors also increase the chemical acetylcholine. Taking phosphatidylcholine along with medications for Alzheimer's disease might increase effects and side effects of medications for Alzheimer's disease.

    Some medications called acetylcholinesterase inhibitors include donepezil (Aricept), tacrine (Cognex), rivastigmine (Exelon), and galantamine (Reminyl, Razadyne).

  • Various medications used for glaucoma, Alzheimer's disease, and other conditions (Cholinergic drugs) interacts with PHOSPHATIDYLCHOLINE

    Phosphatidylcholine might increase a chemical in the body called acetylcholine. This chemical is similar to some medications used for glaucoma, Alzheimer's disease, and other conditions. Taking phosphatidylcholine with these medications might increase the chance of side effects.

    Some of these medications used for glaucoma, Alzheimer's disease, and other conditions include pilocarpine (Pilocar and others), and others.

Dosing

Dosing

The following doses have been studied in scientific research:

ADULTS

BY MOUTH:

  • A type of inflammatory bowel disease (ulcerative colitis): 1-6 grams daily taken in divided doses.

View References

REFERENCES:

  • Bartsch, G. G. and Gerber, G. B. Influence of phospholipids on liver damage. II. Changes in lipid content and synthesis after liver damage with carbontetrachloride and other agents. Acta Hepatogastroenterol.(Stuttg) 1975;22(4):228-236. View abstract.
  • Fabia, R., Ar'Rajab, A., Willen, R., Andersson, R., Ahren, B., Larsson, K., and Bengmark, S. Effects of phosphatidylcholine and phosphatidylinositol on acetic-acid-induced colitis in the rat. Digestion 1992;53(1-2):35-44. View abstract.
  • Holecek, M., Mraz, J., Koldova, P., and Skopec, F. Effect of polyunsaturated phosphatidylcholine on liver regeneration onset after hepatectomy in the rat. Arzneimittelforschung. 1992;42(3):337-339. View abstract.
  • Neuberger, J., Hegarty, J. E., Eddleston, A. L., and Williams, R. Effect of polyunsaturated phosphatidylcholine on immune mediated hepatocyte damage. Gut 1983;24(8):751-755. View abstract.
  • Panos, J. M., Palson, R., Johnson, R., Portmann, B., and Williams, R. Polyunsaturated phosphatidylcholine for acute alcoholic hepatitis: a double blind randomized placebo controlled trial. Eur.J.Gastroenterol 1990;2:351-355.
  • Romagosa, R., Saap, L., Givens, M., Salvarrey, A., He, J. L., Hsia, S. L., and Taylor, J. R. A pilot study to evaluate the treatment of basal cell carcinoma with 5-fluorouracil using phosphatidyl choline as a transepidermal carrier. Dermatol.Surg. 2000;26(4):338-340. View abstract.
  • Schneider, J., Muller, R., Buberl, W., Kaffarnik, H., Schubotz, R., Hausmann, L., Muhlfellner, G., and Muhlfellner, O. Effect of polyenyl phosphatidyl choline on clofibrate-induced increase in LDL cholesterol. Eur.J.Clin.Pharmacol. 2-19-1979;15(1):15-19. View abstract.
  • Singh, N. K. and Prasad, R. C. A pilot study of polyunsaturated phosphatidyl choline in fulminant and subacute hepatic failure. J Assoc.Physicians India 1998;46(6):530-532. View abstract.
  • Stremmel, W., Merle, U., Zahn, A., Autschbach, F., Hinz, U., and Ehehalt, R. Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis. Gut 2005;54(7):966-971. View abstract.
  • Zierenberg, O. and Grundy, S. M. Intestinal absorption of polyenephosphatidylcholine in man. J Lipid Res 1982;23(8):1136-1142. View abstract.
  • Ablon G, Rotunda AM. Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review. Dermatol Surg 2004;30:422-7. View abstract.
  • Aronson PJ, Lorincz AL. Promotion of palmar sweating with oral phosphatidylcholine. Acta Derm Venereol 1985;65:19-24. View abstract.
  • Chan PC, Tam SC, Robinson JD, et al. Effect of phosphatidylcholine on ultrafiltration in patients on continuous ambulatory peritoneal dialysis. Nephron 1991;59:100-3. View abstract.
  • Cheatham CL, Goldman BD, Fischer LM, da Costa KA, Reznick JS, Zeisel SH. Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 2012;96(6):1465-72. View abstract.
  • Chung SY, Moriyama T, Uezu E, et al. Administration of phosphatidylcholine increases brain acetylcholine concentration and improves memory in mice with dementia. J Nutr. 1995 Jun;125(6):1484-9. View abstract.
  • Domino EF, Mathews BN, Tait SK, Ortiz A. Effects of oral phosphatidylcholine on mouse brain choline and acetylcholine. Arch Int Pharmacodyn Ther. 1983;265(1):49-54. View abstract.
  • Domino EF, May WW, Demetriou S, et al. Lack of clinically significant improvement of patients with tardive dyskinesia following phosphatidylcholine therapy. Biol Psychiatry 1985;20:1189-96. View abstract.
  • Food and Drug Administration. Warning Letter to Ayoula Dublin regarding Lipostabil. July 22, 2003.
  • Guan R, Ho KY, Kang JY, et al. The effect of polyunsaturated phosphatidyl choline in the treatment of acute viral hepatitis. Aliment Pharmacol Ther 1995;9:699-703. View abstract.
  • Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. Cosmet Dermatol 2005;4:308-13. View abstract.
  • Hexsel D, Serra M, Mazzuco R, et al. Phosphatidylcholine in the treatment of localized fat. J Drugs Dermatol 2003;2:511-8. View abstract.
  • Hexsel DM, Serra M, de Oliveira Dal'Forno T, et al. Cosmetic uses of injectable phosphatidylcholine on the face. Otolaryngol Clin North Am 2005;38:1119-29. View abstract.
  • Jenkins PJ, Portmann BP, Eddleston AL, Williams R. Use of polyunsaturated phosphatidyl choline in HBsAg negative chronic active hepatitis: results of prospective double-blind controlled trial. Liver 1982;2:77-81. View abstract.
  • Jope RS. Effects of phosphatidylcholine administration to rats on choline in blood and choline and acetylcholine in brain. J Pharmacol Exp Ther. 1982;220(2):322-8. View abstract.
  • Karner M, Kocjan A, Stein J, et al. First multicenter study of modified release phosphatidylcholine "LT-02" in ulcerative colitis: a randomized, placebo-controlled trial in mesalazine-refractory courses. Am J Gastroenterol 2014;109(7):1041-51. View abstract.
  • Koo SI, Noh SK. Phosphatidylcholine inhibits and lysophosphatidylcholine enhances the lymphatic absorption of alpha-tocopherol in adult rats. J Nutr 2001;131:717-22.. View abstract.
  • Kopera D, Binder B, Toplak H, et al. Histopathologic changes after intralesional application of phosphatidylcholine for lipoma reduction: report of a case. Am J Dermatopathol 2006;28:331-3. View abstract.
  • Ladd SL, Sommer SA, LaBerge S, Toscano W. Effect of phosphatidylcholine on explicit memory. Clin Neuropharmacol 1993;16:540-9. View abstract.
  • Lieber CS, Leo MA, Aleynik S, et al. Increased circulating level of dilinoleoylphosphatidylcholine is associated with protection against alcohol induced oxidative stress and liver fibrosis in man. Hepatology 2000;32:386A.
  • Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. View abstract.
  • Maev IV, Samsonov AA, Palgova LK, et al. Effectiveness of phosphatidylcholine as adjunctive therapy in improving liver function tests in patients with non-alcoholic fatty liver disease and metabolic comorbidities: real-life observational study from Russia. BMJ Open Gastroenterol. 2020;7(1):e000368. View abstract.
  • Maev IV, Samsonov AA, Palgova LK, et al. Effectiveness of phosphatidylcholine in alleviating steatosis in patients with non-alcoholic fatty liver disease and cardiometabolic comorbidities (MANPOWER study). BMJ Open Gastroenterol. 2020;7(1):e000341. View abstract.
  • Merin JP, Matsuyama M, Kira T, et al. Alpha-lipoic acid blocks HIV-1 LTR-dependent expression of hygromycin resistance in THP-1 stable transformants. FEBS Lett 1996;394:9-13. View abstract.
  • Morganti P, Berardesca E, Guarneri B, et al. Topical clindamycin 1% vs. linoleic acid-rich phosphatidylcholine and nicotinamide 4% in the treatment of acne: a multicentre-randomized trial. Int J Cosmet Sci 2011;33(5):467-76. View abstract.
  • Niederau C, Strohmeyer G, Heintges T, et al. Polyunsaturated phosphatidyl-choline and interferon alpha for treatment of chronic hepatitis B and C: a multi-center, randomized, double-blind, placebo-controlled trial. Leich Study Group. Hepatogastroenterology 1998;45:797-804. View abstract.
  • Phosphatidylcholine. Altern Med Rev 2002;7(2):150-4. View abstract.
  • Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003;27:315-8. View abstract.
  • Rittes PG. The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads. Dermatol Surg 2001;27:391-2. View abstract.
  • Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg 2006;32:465-80. View abstract.
  • Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol 2010;44(5):e101-7. View abstract.
  • Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. View abstract.
  • Symons C, Fortune F, Greenbaum RA, Dandona P. Cardiac hypertrophy, hypertrophic cardiomyopathy, and hyperparathyroidism-an association. Br Heart J 1985;54:539-42. View abstract.
  • Wade A, Weller PJ, eds. Handbook of Pharmaceutical Excipients. 2nd ed. Washington, DC: Am Pharmaceutical Assn, 1994.
  • Ylilauri MPT, Voutilainen S, Lönnroos E, et al. Associations of dietary choline intake with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr. 2019;110(6):1416-23. View abstract.

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