Champignon Dansant, Champignon des Fous Dansants, Champignon Maitake, Dancing Mushroom, Grifola, Grifola frondosa, Hen of the Woods, Hongo Maitake, King of Mushrooms, Maitake, Monkey's Bench, Mushroom, Ram's Head, Roi des Champignons, Sheep's Head, Shelf Fungi.


Overview Information

Maitake is a type of mushroom. People use it to make medicine.

Some people take maitake mushroom by mouth for infertility due to a hormonal disorder that causes enlarged ovaries with cysts (polycystic ovary syndrome or PCOS), diabetes, and many other conditions, but there is no good scientific evidence to support these uses.

How does it work?

Maitake mushroom contains chemicals which might help fight tumors, stimulate the immune system, and lower blood sugar and lipid levels.


Uses & Effectiveness?

Insufficient Evidence for

More evidence is needed to rate maitake mushroom for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Maitake mushroom is POSSIBLY SAFE for most people when taken by mouth as medicine, but there isn't much information about the potential side effects. Some people have reported nausea after taking maitake mushroom.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if maitake mushroom is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Diabetes: Maitake mushroom might lower blood sugar levels. Your diabetes medications might need to be adjusted by your healthcare provider.

Low blood pressure: Maitake mushroom can lower blood pressure. In theory, taking maitake mushroom might make blood pressure become too low in people with low blood pressure.

Surgery: Maitake mushroom might affect blood sugar levels, making blood sugar control difficult during and after surgery. Stop using maitake mushroom at least 2 weeks before a scheduled surgery.



Moderate Interaction

Be cautious with this combination

  • Medications for diabetes (Antidiabetes drugs) interacts with MAITAKE MUSHROOM

    Maitake mushroom might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking maitake mushroom along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

    Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.



The appropriate dose of maitake mushroom depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for maitake mushroom. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


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  • Adachi, Y., Okazaki, M., Ohno, N., and Yadomae, T. Enhancement of cytokine production by macrophages stimulated with (1-- >3)-beta-D-glucan, grifolan (GRN), isolated from Grifola frondosa. Biol Pharm Bull 1994;17(12):1554-1560. View abstract.
  • Bae, J. T., Sim, G. S., Lee, D. H., Lee, B. C., Pyo, H. B., Choe, T. B., and Yun, J. W. Production of exopolysaccharide from mycelial culture of Grifola frondosa and its inhibitory effect on matrix metalloproteinase-1 expression in UV-irradiated human dermal fibroblasts. FEMS Microbiol.Lett 10-15-2005;251(2):347-354. View abstract.
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  • Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects. J.Cancer Res.Clin.Oncol. 2009;135(9):1215-1221. View abstract.
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  • Okazaki, M., Adachi, Y., Ohno, N., and Yadomae, T. Structure-activity relationship of (1-->3)-beta-D-glucans in the induction of cytokine production from macrophages, in vitro. Biol Pharm Bull 1995;18(10):1320-1327. View abstract.
  • Preuss, H. G., Echard, B., Bagchi, D., Perricone, N. V., and Zhuang, C. Enhanced insulin-hypoglycemic activity in rats consuming a specific glycoprotein extracted from maitake mushroom. Mol.Cell Biochem 2007;306(1-2):105-113. View abstract.
  • Sanzen, I., Imanishi, N., Takamatsu, N., Konosu, S., Mantani, N., Terasawa, K., Tazawa, K., Odaira, Y., Watanabe, M., Takeyama, M., and Ochiai, H. Nitric oxide-mediated antitumor activity induced by the extract from Grifola frondosa (Maitake mushroom) in a macrophage cell line, RAW264.7. J Exp Clin Cancer Res 2001;20(4):591-597. View abstract.
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  • Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. View abstract.
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  • Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Complement Med 2010;16:1295-9. View abstract.
  • Han C, Cui B. Pharmacological and pharmacokinetic studies with agaricoglycerides, extracted from Grifola frondosa, in animal models of pain and inflammation. Inflammation 2012;35(4):1269-75. View abstract.
  • Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. View abstract.
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  • Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. View abstract.
  • Kubo K, Aoki H, Nanba H. Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake). I. Biol Pharm Bull 1994;17:1106-10. View abstract.
  • Kubo K, Nanba H. The effect of maitake mushrooms on liver and serum lipids. Alt Ther Health Med 1996;2:62-6. View abstract.
  • Nanba H, Kubo K. Effect of Maitake D-fraction on cancer prevention. Ann N Y Acad Sci 1997;833:204-7. View abstract.
  • Nanba H. Activity of maitake D-fraction to inhibit carcinogenesis and metastasis. Ann N Y Acad Sci 1995;768:243-5. View abstract.
  • Pan YY, Zeng F, Guo WL, et al. Effect of Grifola frondosa 95% ethanol extract on lipid metabolism and gut microbiota composition in high-fat diet-fed rats. Food Funct. 2018;9(12):6268-6278. View abstract.
  • Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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