Champignon Dansant, Champignon des Fous Dansants, Champignon Maitake, Dancing Mushroom, Grifola, Grifola frondosa, Hen of the Woods, Hongo Maitake, King of Mushrooms, Maitake, Monkey's Bench, Mushroom, Ram's Head, Roi des Champignons, Sheep's Head, Shelf Fungi.<br/><br/>
Overview InformationMaitake is a type of mushroom. People use it to make medicine.
Some people take maitake mushroom by mouth for infertility due to a hormonal disorder that causes enlarged ovaries with cysts (polycystic ovary syndrome or PCOS), diabetes, and many other conditions, but there is no good scientific evidence to support these uses.
How does it work?Maitake mushroom contains chemicals which might help fight tumors, stimulate the immune system, and lower blood sugar and lipid levels.
Uses & Effectiveness
Insufficient Evidence for
- Diabetes. Early research shows that taking maitake mushroom polysaccharides (MMP) by mouth may lower blood sugar in people with diabetes.
- A hormonal disorder that causes enlarged ovaries with cysts (polycystic ovary syndrome or PCOS). Early research shows that taking a specific dietary supplement containing maitake mushroom extract can improve ovulation in women whose periods have stopped due to PCOS. Maitake mushroom does not appear to be as effective as the drug clomiphene for PCOS, but the combination of these two agents may be more effective than either one alone for improving ovulation.
- Chronic fatigue syndrome (CFS).
- Hay fever.
- High blood pressure.
- High cholesterol.
- Weight loss or control.
- Chemotherapy support.
- Other conditions.
Side Effects & SafetyWhen taken by mouth: Maitake mushroom is POSSIBLY SAFE for most people when taken by mouth as medicine, but there isn't much information about the potential side effects. Some people have reported nausea after taking maitake mushroom.
Special Precautions & Warnings:Pregnancy and breast-feeding: There isn't enough reliable information to know if maitake mushroom is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Diabetes: Maitake mushroom might lower blood sugar levels. Your diabetes medications might need to be adjusted by your healthcare provider.
Low blood pressure: Maitake mushroom can lower blood pressure. In theory, taking maitake mushroom might make blood pressure become too low in people with low blood pressure.
Surgery: Maitake mushroom might affect blood sugar levels, making blood sugar control difficult during and after surgery. Stop using maitake mushroom at least 2 weeks before a scheduled surgery.
Be cautious with this combination
Medications for diabetes (Antidiabetes drugs) interacts with MAITAKE MUSHROOM
Maitake mushroom might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking maitake mushroom along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.<br/><br/> Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
The appropriate dose of maitake mushroom depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for maitake mushroom. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
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- Bae, J. T., Sim, G. S., Lee, D. H., Lee, B. C., Pyo, H. B., Choe, T. B., and Yun, J. W. Production of exopolysaccharide from mycelial culture of Grifola frondosa and its inhibitory effect on matrix metalloproteinase-1 expression in UV-irradiated human dermal fibroblasts. FEMS Microbiol.Lett 10-15-2005;251(2):347-354. View abstract.
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- Cui, F. J., Li, Y., Xu, Y. Y., Liu, Z. Q., Huang, D. M., Zhang, Z. C., and Tao, W. Y. Induction of apoptosis in SGC-7901 cells by polysaccharide-peptide GFPS1b from the cultured mycelia of Grifola frondosa GF9801. Toxicol In Vitro 2007;21(3):417-427. View abstract.
- Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects. J.Cancer Res.Clin.Oncol. 2009;135(9):1215-1221. View abstract.
- Fukushima, M., Ohashi, T., Fujiwara, Y., Sonoyama, K., and Nakano, M. Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, shiitake (Lentinus edodes) fiber, and enokitake (Flammulina velutipes) fiber in rats. Exp Biol Med (Maywood.) 2001;226(8):758-765. View abstract.
- Fullerton, S. A., Samadi, A. A., Tortorelis, D. G., Choudhury, M. S., Mallouh, C., Tazaki, H., and Konno, S. Induction of apoptosis in human prostatic cancer cells with beta-glucan (Maitake mushroom polysaccharide). Mol Urol 2000;4(1):7-13. View abstract.
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- Hong, L., Xun, M., and Wutong, W. Anti-diabetic effect of an alpha-glucan from fruit body of maitake (Grifola frondosa) on KK-Ay mice. J Pharm Pharmacol 2007;59(4):575-582. View abstract.
- Horio, H. and Ohtsuru, M. Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats. J Nutr Sci Vitaminol.(Tokyo) 2001;47(1):57-63. View abstract.
- Inoue, A., Kodama, N., and Nanba, H. Effect of maitake (grifolafrondosa) D-fraction on the control of the T lymph node Th-1/Th-2 proportion. Biol Pharm Bull 2002;25(4):536-540. View abstract.
- Ishibashi, K., Miura, N. N., Adachi, Y., Ohno, N., and Yadomae, T. Relationship between solubility of grifolan, a fungal 1,3-beta-D- glucan, and production of tumor necrosis factor by macrophages in vitro. Biosci Biotechnol Biochem 2001;65(9):1993-2000. View abstract.
- Kidd, P. M. The use of mushroom glucans and proteoglycans in cancer treatment. Altern.Med Rev. 2000;5(1):4-27. View abstract.
- Kodama, N., Komuta, K., and Nanba, H. Can maitake MD-fraction aid cancer patients? Altern.Med Rev 2002;7(3):236-239. View abstract.
- Kurashige, S., Akuzawa, Y., and Endo, F. Effects of Lentinus edodes, Grifola frondosa and Pleurotus ostreatus administration on cancer outbreak, and activities of macrophages and lymphocytes in mice treated with a carcinogen, N-butyl-N- butanolnitrosoamine. Immunopharmacol.Immunotoxicol. 1997;19(2):175-183. View abstract.
- Li, X., Rong, J., Wu, M., and Zeng, X. [Anti-tumor effect of polysaccharide from Grifola frondosa and its influence on immunological function]. Zhong.Yao Cai. 2003;26(1):31-32. View abstract.
- Lin, J. T. and Liu, W. H. o-Orsellinaldehyde from the submerged culture of the edible mushroom Grifola frondosa exhibits selective cytotoxic effect against Hep 3B cells through apoptosis. J Agric Food Chem 10-4-2006;54(20):7564-7569. View abstract.
- Manohar, V., Talpur, N. A., Echard, B. W., Lieberman, S., and Preuss, H. G. Effects of a water-soluble extract of maitake mushroom on circulating glucose/insulin concentrations in KK mice. Diabetes Obes.Metab 2002;4(1):43-48. View abstract.
- Matsui, K., Kodama, N., and Nanba, H. Effects of maitake (Grifola frondosa) D-Fraction on the carcinoma angiogenesis. Cancer Lett 10-30-2001;172(2):193-198. View abstract.
- Mayell, M. Maitake extracts and their therapeutic potential. Altern Med Rev 2001;6(1):48-60. View abstract.
- Miura, N. N., Ohno, N., Aketagawa, J., Tamura, H., Tanaka, S., and Yadomae, T. Blood clearance of (1-->3)-beta-D-glucan in MRL lpr/lpr mice. FEMS Immunol Med Microbiol 1996;13(1):51-57. View abstract.
- Nanba, H. Maitake D-fraction: Healing and preventing potentials for cancer. Townsend Letter for Doctors & Patients 1996;151/152:84-85.
- Ohno, N., Egawa, Y., Hashimoto, T., Adachi, Y., and Yadomae, T. Effect of beta-glucans on the nitric oxide synthesis by peritoneal macrophage in mice. Biol Pharm Bull 1996;19(4):608-612. View abstract.
- Okazaki, M., Adachi, Y., Ohno, N., and Yadomae, T. Structure-activity relationship of (1-->3)-beta-D-glucans in the induction of cytokine production from macrophages, in vitro. Biol Pharm Bull 1995;18(10):1320-1327. View abstract.
- Preuss, H. G., Echard, B., Bagchi, D., Perricone, N. V., and Zhuang, C. Enhanced insulin-hypoglycemic activity in rats consuming a specific glycoprotein extracted from maitake mushroom. Mol.Cell Biochem 2007;306(1-2):105-113. View abstract.
- Sanzen, I., Imanishi, N., Takamatsu, N., Konosu, S., Mantani, N., Terasawa, K., Tazawa, K., Odaira, Y., Watanabe, M., Takeyama, M., and Ochiai, H. Nitric oxide-mediated antitumor activity induced by the extract from Grifola frondosa (Maitake mushroom) in a macrophage cell line, RAW264.7. J Exp Clin Cancer Res 2001;20(4):591-597. View abstract.
- Sliva, D. Cellular and physiological effects of Ganoderma lucidum (Reishi). Mini.Rev.Med Chem. 2004;4(8):873-879. View abstract.
- Spelman, K., Burns, J., Nichols, D., Winters, N., Ottersberg, S., and Tenborg, M. Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Altern.Med.Rev. 2006;11(2):128-150. View abstract.
- Suzuki, I., Hashimoto, K., Oikawa, S., Sato, K., Osawa, M., and Yadomae, T. Antitumor and immunomodulating activities of a beta-glucan obtained from liquid-cultured Grifola frondosa. Chem Pharm Bull (Tokyo) 1989;37(2):410-413. View abstract.
- Suzuki, I., Itani, T., Ohno, N., Oikawa, S., Sato, K., Miyazaki, T., and Yadomae, T. Antitumor activity of a polysaccharide fraction extracted from cultured fruiting bodies of Grifola frondosa. J Pharmacobiodyn. 1984;7(7):492-500. View abstract.
- Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. View abstract.
- Tanaka, H., Tsunematsu, K., Nakamura, N., Suzuki, K., Tanaka, N., Takeya, I., Saikai, T., and Abe, S. Successful treatment of hypersensitivity pneumonitis caused by Grifola frondosa (Maitake) mushroom using a HFA-BDP extra-fine aerosol. Intern.Med. 2004;43(8):737-740. View abstract.
- Wu, M. J., Cheng, T. L., Cheng, S. Y., Lian, T. W., Wang, L., and Chiou, S. Y. Immunomodulatory properties of Grifola frondosa in submerged culture. J Agric.Food Chem 4-19-2006;54(8):2906-2914. View abstract.
- Yang, D., Li, S., Wang, H., Li, X., Liu, S., Han, W., Hao, J., and Zhang, H. [Prevention of postoperative recurrence of bladder cancer: a clinical study]. Zhonghua Wai Ke.Za Zhi. 1999;37(8):464-465. View abstract.
- Adachi K, Nanba H, Kuroda H. Potentiation of host-mediated antitumor activity in mice by beta-glucan obtained from Grifola frondosa (maitake). Chem Pharm Bull (Tokyo) 1987;35:262-70. View abstract.
- Aoki H, Hanayama M, Mori K, Sato R. Grifola frondosa (Maitake) extract activates PPARd and improves glucose intolerance in high-fat diet-induced obese mice. Biosci Biotechnol Biochem. 2018;82(9):1550-1559. View abstract.
- Borchers AT, Stern JS, Hackman RM, et al. Mushrooms, tumors, and immunity. Proc Soc Exp Biol Med 1999;221:281-293. View abstract.
- Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Complement Med 2010;16:1295-9. View abstract.
- Han C, Cui B. Pharmacological and pharmacokinetic studies with agaricoglycerides, extracted from Grifola frondosa, in animal models of pain and inflammation. Inflammation 2012;35(4):1269-75. View abstract.
- Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. View abstract.
- Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. View abstract.
- Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. View abstract.
- Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. View abstract.
- Kubo K, Aoki H, Nanba H. Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake). I. Biol Pharm Bull 1994;17:1106-10. View abstract.
- Kubo K, Nanba H. The effect of maitake mushrooms on liver and serum lipids. Alt Ther Health Med 1996;2:62-6. View abstract.
- Nanba H, Kubo K. Effect of Maitake D-fraction on cancer prevention. Ann N Y Acad Sci 1997;833:204-7. View abstract.
- Nanba H. Activity of maitake D-fraction to inhibit carcinogenesis and metastasis. Ann N Y Acad Sci 1995;768:243-5. View abstract.
- Pan YY, Zeng F, Guo WL, et al. Effect of Grifola frondosa 95% ethanol extract on lipid metabolism and gut microbiota composition in high-fat diet-fed rats. Food Funct. 2018;9(12):6268-6278. View abstract.
- Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. View abstract.
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