MASTIC

OTHER NAME(S):

Arabic Gum, Arbre à Mastic, Arbre au Mastic, Chios Mastic, Lentisco, Lentisk, Mastic Gum, Mastich, Mastiha, Mastika, Mastix, Mata Charneca, Pistacia lentiscus, Pistachier Lentisque.

Overview

Overview Information

Mastic is a tree. People use the sap (resin) from the trunk to make medicine.

Mastic is used for conditions such as stomach and intestinal ulcers, long-term swelling (inflammation) in the digestive tract (inflammatory bowel disease or IBD), infections, and wound healing, but there is no good scientific evidence to support these uses.

In manufacturing, mastic resin is used in the food and drink industries and in the production of chewing gum.

How does it work?

Mastic might help reduce stomach acid and may protect the lining of the stomach and intestine. Mastic also contains a fragrant oil which could kill bacteria and freshen the breath. In a test tube, mastic seems to fight bacteria and fungi.

Uses

Uses & Effectiveness?

Possibly Effective for

  • Indigestion (dyspepsia). Taking mastic gum by mouth for 3 weeks seems to improve symptoms of indigestion, including stomach pain, upper abdominal pain, and heartburn.
  • Stomach ulcers. Taking mastic powder by mouth for 2 weeks seems to reduce symptoms and improve healing in people with intestinal ulcers. Also, early research suggests that taking mastic powder by mouth for 4 weeks improves these outcomes in people with stomach ulcers.

Insufficient Evidence for

  • A type of inflammatory bowel disease (Crohn disease). Early research suggests that taking mastic by mouth for 4 weeks improves symptoms in people with Crohn disease.
  • A digestive tract infection that can lead to ulcers (Helicobacter pylori or H. pylori). Early research suggests that taking mastic gum for 2 weeks helps eliminate H. pylori infections in some, but not all, people 5 weeks after finishing treatment. However, taking mastic gum seems to be less effective at eliminating H. pylori infections compared to taking a combination of the drugs pantoprazole, amoxicillin, and clarithromycin.
  • Long-term swelling (inflammation) in the digestive tract (inflammatory bowel disease or IBD). Some research shows that taking mastic doesn't help with quality of life in people with IBD.
  • A serious gum infection (periodontitis). Early research suggests that brushing with mastic essential oil-containing toothpaste using a sonic toothbrush for 12 weeks reduces plaque buildup, as well as swelling, redness, and bleeding of the gums, in people with gum disease better than using a sonic toothbrush alone.
  • Breathing problems.
  • Muscle aches.
  • Bacterial and fungal infections.
  • Repelling insects.
  • Improving blood circulation.
  • Cuts, when applied to the skin.
  • Other conditions.
More evidence is needed to rate the effectiveness of mastic for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Mastic is POSSIBLY SAFE for most people when taken appropriately for up to 3 months.

When applied to the skin: There isn't enough reliable information to know if mastic is safe or what the side effects might be.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if mastic is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Allergy to Schinus terebinthifolious and other Pistacia species: People who are allergic to these plants might also be allergic to mastic tree.

Interactions

Interactions?

We currently have no information for MASTIC Interactions.

Dosing

Dosing

The following doses have been studied in scientific research:

BY MOUTH:

  • For indigestion (dyspepsia): 350 mg of mastic gum has been taken three times daily for 3 weeks.
  • For stomach ulcers: 1-2 grams of mastic gum has been taken every day for 2-4 weeks.

View References

REFERENCES:

  • Takahashi, K., Fukazawa, M., Motohira, H., Ochiai, K., Nishikawa, H., and Miyata, T. A pilot study on antiplaque effects of mastic chewing gum in the oral cavity. J Periodontol. 2003;74(4):501-505. View abstract.
  • Triantafyllou, A., Chaviaras, N., Sergentanis, T. N., Protopapa, E., and Tsaknis, J. Chios mastic gum modulates serum biochemical parameters in a human population. J Ethnopharmacol. 4-20-2007;111(1):43-49. View abstract.
  • Watanabe, H., Hagiwara, S., Fukuda, M., Yuichi, I., Tamura, N., Suzuki, M., and Kawasaki, D. Double blind randomized control test for the usefulness of mastic compound dentifrice against periodontitis under using sonic toothbrush 2010. Yakuri to chiryo 2010;38(10):915-925.
  • Al-Said MS, Ageel AM, Parmar NS, Tariq M. Evaluation of mastic, a crude drug obtained from Pistacia lentiscus for gastric and duodenal anti-ulcer activity. J Ethnopharmacol 1986;15:271-8. View abstract.
  • Iauk L, Ragusa S, Rapisarda A, et al. In vitro antimicrobial activity of Pistacia lentiscus L. extracts: preliminary report. J Chemother 1996;8:207-9. View abstract.
  • Keynan N, Tamir R, Waisel Y, et al. Allergenicity of the pollen of Pistacia. Allergy 1997;52:323-30. View abstract.
  • Papada E, Forbes A, Amerikanou C, et al. Antioxidative efficacy of a Pistacia lentiscus supplement and its effect on the plasma amino acid profile in inflammatory bowel disease: A randomised, double-blind, placebo-controlled trial. Nutrients. 2018;10(11). pii: E1779. View abstract.
  • Papada E, Gioxari A, Amerikanou C, et al. Regulation of faecal biomarkers in inflammatory bowel disease patients treated with oral mastiha (Pistacia lentiscus) supplement: A double-blind and placebo-controlled randomised trial. Phytother Res. 2019;33(2):360-369. View abstract.
  • Papada E, Gioxari A, Brieudes V, et al. Bioavailability of terpenes and postprandial effect on human antioxidant potential. An open-label study in healthy subjects. Mol Nutr Food Res. 2018;62(3). View abstract.
  • Kaliora, A. C., Stathopoulou, M. G., Triantafillidis, J. K., Dedoussis, G. V., and Andrikopoulos, N. K. Chios mastic treatment of patients with active Crohn's disease. World J Gastroenterol. 2-7-2007;13(5):748-753. View abstract.
  • Kang, J. S., Wanibuchi, H., Salim, E. I., Kinoshita, A., and Fukushima, S. Evaluation of the toxicity of mastic gum with 13 weeks dietary administration to F344 rats. Food Chem Toxicol. 2007;45(3):494-501. View abstract.
  • Koutsoudaki, C., Krsek, M., and Rodger, A. Chemical composition and antibacterial activity of the essential oil and the gum of Pistacia lentiscus Var. chia. J Agric.Food Chem 10-5-2005;53(20):7681-7685. View abstract.
  • Loutrari, H., Magkouta, S., Pyriochou, A., Koika, V., Kolisis, F. N., Papapetropoulos, A., and Roussos, C. Mastic oil from Pistacia lentiscus var. chia inhibits growth and survival of human K562 leukemia cells and attenuates angiogenesis. Nutr Cancer 2006;55(1):86-93. View abstract.
  • Magkouta, S., Stathopoulos, G. T., Psallidas, I., Papapetropoulos, A., Kolisis, F. N., Roussos, C., and Loutrari, H. Protective effects of mastic oil from Pistacia lentiscus variation chia against experimental growth of lewis lung carcinoma. Nutr Cancer 2009;61(5):640-648. View abstract.
  • Mahmoudi, M., Ebrahimzadeh, M. A., Nabavi, S. F., Hafezi, S., Nabavi, S. M., and Eslami, Sh. Antiinflammatory and antioxidant activities of gum mastic. Eur.Rev.Med Pharmacol.Sci 2010;14(9):765-769. View abstract.
  • Moulos, P., Papadodima, O., Chatziioannou, A., Loutrari, H., Roussos, C., and Kolisis, F. N. A transcriptomic computational analysis of mastic oil-treated Lewis lung carcinomas reveals molecular mechanisms targeting tumor cell growth and survival. BMC.Med Genomics 2009;2:68. View abstract.
  • Paraschos, S., Magiatis, P., Mitakou, S., Petraki, K., Kalliaropoulos, A., Maragkoudakis, P., Mentis, A., Sgouras, D., and Skaltsounis, A. L. In vitro and in vivo activities of Chios mastic gum extracts and constituents against Helicobacter pylori. Antimicrob.Agents Chemother. 2007;51(2):551-559. View abstract.
  • Sterer, N. Antimicrobial effect of mastic gum methanolic extract against Porphyromonas gingivalis. J Med Food 2006;9(2):290-292. View abstract.
  • Sterer, N., Nuas, S., Mizrahi, B., Goldenberg, C., Weiss, E. I., Domb, A., and Davidi, M. P. Oral malodor reduction by a palatal mucoadhesive tablet containing herbal formulation. J Dent. 2008;36(7):535-539. View abstract.
  • Aksoy, A., Duran, N., and Koksal, F. In vitro and in vivo antimicrobial effects of mastic chewing gum against Streptococcus mutans and mutans streptococci. Arch Oral Biol 12-15-2005; View abstract.
  • Al Habbal, M. J., Al Habbal, Z., and Huwez, F. U. A double-blind controlled clinical trial of mastic and placebo in the treatment of duodenal ulcer. Clin Exp Pharmacol.Physiol 1984;11(5):541-544. View abstract.
  • Ali-Shtayeh, M. S. and Abu Ghdeib, S. I. Antifungal activity of plant extracts against dermatophytes. Mycoses 1999;42(11-12):665-672. View abstract.
  • Balan, K. V., Prince, J., Han, Z., Dimas, K., Cladaras, M., Wyche, J. H., Sitaras, N. M., and Pantazis, P. Antiproliferative activity and induction of apoptosis in human colon cancer cells treated in vitro with constituents of a product derived from Pistacia lentiscus L. var. chia. Phytomedicine. 2007;14(4):263-272. View abstract.
  • Barra, A., Coroneo, V., Dessi, S., Cabras, P., and Angioni, A. Characterization of the volatile constituents in the essential oil of Pistacia lentiscus L. from different origins and its antifungal and antioxidant activity. J Agric.Food Chem 8-22-2007;55(17):7093-7098. View abstract.
  • Dabos, K. J., Sfika, E., Vlatta, L. J., and Giannikopoulos, G. The effect of mastic gum on Helicobacter pylori: a randomized pilot study. Phytomedicine. 2010;17(3-4):296-299. View abstract.
  • Dabos, K. J., Sfika, E., Vlatta, L. J., Frantzi, D., Amygdalos, G. I., and Giannikopoulos, G. Is Chios mastic gum effective in the treatment of functional dyspepsia? A prospective randomised double-blind placebo controlled trial. J Ethnopharmacol. 2-3-2010;127(2):205-209. View abstract.
  • Dimas, K., Hatziantoniou, S., Wyche, J. H., and Pantazis, P. A mastic gum extract induces suppression of growth of human colorectal tumor xenografts in immunodeficient mice. In Vivo 2009;23(1):63-68. View abstract.
  • Doi, K., Wei, M., Kitano, M., Uematsu, N., Inoue, M., and Wanibuchi, H. Enhancement of preneoplastic lesion yield by Chios Mastic Gum in a rat liver medium-term carcinogenesis bioassay. Toxicol.Appl.Pharmacol. 1-1-2009;234(1):135-142. View abstract.
  • He, M. L., Chen, W. W., Zhang, P. J., Jiang, A. L., Fan, W., Yuan, H. Q., Liu, W. W., and Zhang, J. Y. Gum mastic increases maspin expression in prostate cancer cells. Acta Pharmacol.Sin. 2007;28(4):567-572. View abstract.
  • Huang, X. Y., Wang, H. C., Yuan, Z., Li, A., He, M. L., Ai, K. X., Zheng, Q., and Qin, H. L. Gemcitabine combined with gum mastic causes potent growth inhibition and apoptosis of pancreatic cancer cells. Acta Pharmacol.Sin. 2010;31(6):741-745. View abstract.
  • Huwez, F. U. and Al Habbal, M. J. Mastic in treatment of benign gastric ulcers. Gastroenterol.Jpn. 1986;21(3):273-274. View abstract.
  • Huwez, F. U., Thirlwell, D., Cockayne, A., and Ala'Aldeen, D. A. Mastic gum kills Helicobacter pylori. N.Engl.J Med 12-24-1998;339(26):1946. View abstract.
  • Kaliora, A. C., Stathopoulou, M. G., Triantafillidis, J. K., Dedoussis, G. V., and Andrikopoulos, N. K. Alterations in the function of circulating mononuclear cells derived from patients with Crohn's disease treated with mastic. World J Gastroenterol. 12-7-2007;13(45):6031-6036. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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© Therapeutic Research Faculty 2018.