Anis, Anís, Anis Vert, Aniseed, Anise Essential Oil, Anise Oil, Anisi Fructus, Dohn-e-Anisoon, Graine d'Anis Vert, Green Anise, Huile Essentielle d'Anis, Phytoestrogen, Phyto-Œstrogène, Pimpinella anisum, Pinella, Semen Anisi, Shatpushpa, Sweet Cumin, Velaiti Saunf.
Overview InformationAnise is an herb. The seed and oil are used to make medicine. Less commonly, the root and leaf are used to make medicine as well. Do not confuse anise with other herbs called star anise or fennel. These are sometimes called anise.
Anise is most commonly used for indigestion (dyspepsia) and a long-term disorder of the large intestines that causes stomach pain (irritable bowel syndrome or IBS). It is also used for many other conditions, but there is no good scientific evidence to support most of these uses.
In foods, anise is used as a flavoring agent. It has a sweet, aromatic taste that resembles the taste of black licorice. It is commonly used in alcohols and liqueurs, such as anisette and ouzo. Anise is also used in dairy products, gelatins, meats, candies, and breath fresheners.
In manufacturing, anise is often used as a fragrance in soap, creams, perfumes, and sachets.
How does it work?There are chemicals in anise that may have estrogen-like effects. Chemicals in anise may also act as insecticides and decrease swelling or inflammation.
Uses & Effectiveness
Possibly Effective for
- Indigestion (dyspepsia). Some research shows that taking anise powder daily for 4 weeks reduces stomach discomfort, bloating, and pain following a meal in people who have indigestion after eating.
- A long-term disorder of the large intestines that causes stomach pain (irritable bowel syndrome or IBS). Some research shows that taking a capsule containing anise oil daily reduces pain and bloating in people with IBS.
Insufficient Evidence for
- Asthma. Early research shows that drinking one cup of a tea containing anise and multiple other ingredients reduces coughing and sleep discomfort in people with allergic asthma.
- Constipation. Early research shows that drinking an herbal tea containing anise, fennel, elderberry, and senna daily for 5 days improves constipation in some people.
- Depression. Some research shows that taking a capsule containing anise oil daily for 4 weeks improves feelings of depression in people with irritable bowel syndrome (IBS).
- Diabetes. Early research shows that taking anise seed powder daily for 2 months lowers blood sugar levels in people with diabetes.
- Lice. Early research shows that applying a spray containing anise oil, coconut oil, and ylang ylang oil to the scalp helps to get rid of head lice. The effect of this combination spray appears to be comparable to a spray containing the chemicals permethrin, malathion, piperonyl, butoxide, and isododecane.
- Symptoms of menopause. Early research shows that taking anise seed extract daily for 4 weeks reduces how often menopausal women get hot flashes.
- Migraine. Some early evidence shows that applying a cream containing anise oil to the forehead area at the start of a migraine might improve the headache by a small amount. But people in this study could smell the anise cream. It is not clear if this effect is due to applying the cream to the forehead, to the smell of the cream, or to a "placebo effect."
- Starting menstrual periods.
- Increasing breast milk.
- Increasing sex drive.
- Other conditions.
Side Effects & SafetyWhen taken by mouth: Anise is LIKELY SAFE for most adults when taken in amounts typically found in foods. Anise powder and oil are POSSIBLY SAFE when taken as medicine for up to 4 weeks.
Special Precautions & Warnings:Pregnancy and breast-feeding: Anise is LIKELY SAFE for pregnant and breast-feeding women when used as part of a normal diet. There isn't enough reliable information to know if anise is safe to use in larger medicinal amounts when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.
Children: Anise is LIKELY SAFE for most children when taken by mouth in amounts typically found in foods. There isn't enough reliable information to know if anise is safe for children to use in medicinal amounts.
Allergies: Anise might cause allergic reactions in some people who are allergic to other plants that are similar to anise. Plants that are similar to anise include asparagus, caraway, celery, coriander, cumin, dill, and fennel.
Diabetes: Anise might lower blood sugar. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use anise.
Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Anise might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use anise.
Surgery: Anise might lower blood sugar levels. There is some concern that it might interfere with blood sugar control during and after surgery. Stop using anise at least 2 weeks before a scheduled surgery.
Be cautious with this combination
Birth control pills (Contraceptive drugs) interacts with ANISE
Some birth control pills contain estrogen. Anise might have some of the same effects as estrogen. But anise isn't as strong as the estrogen in birth control pills. Taking anise along with birth control pills might decrease the effectiveness of birth control pills. If you take birth control pills along with anise, use an additional form of birth control such as a condom.
Some birth control pills include ethinyl estradiol and levonorgestrel (Triphasil), ethinyl estradiol and norethindrone (Ortho-Novum 1/35, Ortho-Novum 7/7/7), and others.
Estrogens interacts with ANISE
Large amounts of anise might have some of the same effects as estrogen. But large amounts of anise aren't as strong as estrogen pills. Taking anise along with estrogen pills might decrease the effects of estrogen pills.
Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.
Tamoxifen (Nolvadex) interacts with ANISE
Some types of cancer are affected by hormones in the body. Estrogen-sensitive cancers are cancers that are affected by estrogen levels in the body. Tamoxifen (Nolvadex) is used to help treat and prevent these types of cancer. Anise seems to also affect estrogen levels in the body. By affecting estrogen in the body, anise might decrease the effectiveness of tamoxifen (Nolvadex). Do not take anise if you are taking tamoxifen (Nolvadex).
The following doses have been studied in scientific research:
- For indigestion (dyspepsia): 9 grams of anise powder daily for 4 weeks.
- For a long-term disorder of the large intestines that causes stomach pain (irritable bowel syndrome or IBS): 200 mg of anise oil in a special, coated capsule, taken three times daily for 4 weeks.
- Rodrigues VM, Rosa PT, Marques MO, et al. Supercritical extraction of essential oil from aniseed (Pimpinella anisum L) using CO2: solubility, kinetics, and composition data. J Agric Food Chem 2003;51:1518-23. View abstract.
- Sahraei H, Ghoshooni H, Hossein Salimi S, et al. The effects of fruit essential oil of the Pimpinella anisum on acquisition and expression of morphine induced conditioned place preference in mice. J Ethnopharmacol 2002;80:43-7. View abstract.
- Samojlik I, Mijatovic V, Petkovic S, et al. The influence of essential oil of aniseed (Pimpinella anisum, L.) on drug effects on the central nervous system. Fitoterapia 2012;83:1466-73. View abstract.
- Samojlik I, Petkovic S, Stilinovic N, et al. Pharmacokinetic herb-drug interaction between essential oil of aniseed (Pimpinella anisum L., Apiaceae) and acetaminophen and caffeine: A potential risk for clinical practice. Phytother Res 2016;30:253-9. View abstract.
- Shojaii A, Abdollahi Fard M. Review of pharmacological properties and chemical constituents of Pimpinella anisum. ISRN Pharm 2012;2012:510795. View abstract.
- Stager, J., Wuthrich, B., and Johansson, S. G. Spice allergy in celery-sensitive patients. Allergy 1991;46(6):475-478. View abstract.
- Tabanca N, Khan SI, Bedir E, et al. Estrogenic activity of isolated compounds and essential oils of Pimpinella species from Turkey, evaluated using a recombinant yeast screen. Planta Med 2004;70:728-35. View abstract.
- Twaij HA, Elisha EE, Khalid RM, Paul NJ. Analgesic studies on some Iraqi medicinal plants. Int J Crude Drug Res 1987;25:251-54.
- Wuthrich, B. and Dietschi, R. [The celery-carrot-mugwort-condiment syndrome: skin test and RAST results]. Schweiz.Med Wochenschr. 3-16-1985;115(11):258-264. View abstract.
- Wuthrich, B. and Hofer, T. [Food allergy: the celery-mugwort-spice syndrome. Association with mango allergy?]. Dtsch.Med Wochenschr 6-22-1984;109(25):981-986. View abstract.
- Poon, T. S. and Freeman, S. Cheilitis caused by contact allergy to anethole in spearmint flavoured toothpaste. Australas.J Dermatol. 2006;47(4):300-301. View abstract.
- Prajapati, V., Tripathi, A. K., Aggarwal, K. K., and Khanuja, S. P. Insecticidal, repellent and oviposition-deterrent activity of selected essential oils against Anopheles stephensi, Aedes aegypti and Culex quinquefasciatus. Bioresour.Technol. 2005;96(16):1749-1757. View abstract.
- Reichling, J., Merkel, B., and Hofmeister, P. Studies on the biological activities of rare phenylpropanoids of the genus Pimpinella. J Nat.Prod. 1991;54(5):1416-1418. View abstract.
- Soliman, K. M. and Badeaa, R. I. Effect of oil extracted from some medicinal plants on different mycotoxigenic fungi. Food Chem.Toxicol 2002;40(11):1669-1675. View abstract.
- Yu, L., Guo, N., Yang, Y., Wu, X., Meng, R., Fan, J., Ge, F., Wang, X., Liu, J., and Deng, X. Microarray analysis of p-anisaldehyde-induced transcriptome of Saccharomyces cerevisiae. J Ind Microbiol.Biotechnol. 2010;37(3):313-322. View abstract.
- Boskabady MH, Ramazani-Assari M. Relaxant effect of Pimpinella anisum on isolated guinea pig tracheal chains and its possible mechanism(s). J Ethnopharmacol 2001;74:83-8. View abstract.
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Garcia-Gonzalez JJ, Bartolome-Zavala B, Fernandez-Melendez S, et al. Occupational rhinoconjunctivitis and food allergy because of aniseed sensitization. Ann Allergy Asthma Immunol 2002;88:518-22. . View abstract.
- Ghoshegir SA, Mazaheri M, Ghannadi A, et al. Pimpinella anisum in modifying the quality of life in patients with functional dyspepsia: A double-blind randomized clinical trial. J Res Med Sci 2014;19:1118-23. View abstract.
- Ghoshegir SA, Mazaheri M, Ghannadi A, et al. Pimpinella anisum in the treatment of functional dyspepsia: A double-blind, randomized clinical trial. J Res Med Sci 2015;20:13-21. View abstract.
- Hallstrom H, Thuvander A. Toxicological evaluation of myristicin. Nat Toxins 1997;5:186-92. View abstract.
- Haqqaq EG, Abou-Moustafa MA, Boucher W, Theoharides TC. The effect of a herbal water-extract on histamine release from mast cells and on allergic asthma. J Herb Pharmacother 2003;3:41-54. View abstract.
- Ishikawa T, Fujimatu E, Kitajima J. Water-soluble constituents of anise: new glucosides of anethole glycol and its related compounds. Chem Pharm Bull (Tokyo) 2002;50:1460-6. View abstract.
- Kassi E, Papoutsi Z, Fokialakis N, et al. Greek plant extracts exhibit selective estrogen receptor modulator (SERM)-like properties. J Agric Food Chem 2004;52:6956-61. View abstract.
- Kreydiyyeh SI, Usta J, Knio K, et al. Aniseed oil increases glucose absorption and reduces urine output in the rat. Life Sci 2003;74:663-73. View abstract.
- Lee HS. p-Anisaldehyde: acaricidal component of Pimpinella anisum seed oil against the house dust mites Dermatophagoides farinae and Dermatophagoides pteronyssinus. Planta Med 2004;70:279-81. View abstract.
- Mosaffa-Jahromi M, Lankarani KB, Pasalar M, et al. Efficacy and safety of enteric coated capsules of anise oil to treat irritable bowel syndrome. J Ethnopharmacol 2016;194:937-946. View abstract.
- Mosaffa-Jahromi M, Tamaddon AM, Afsharypuor S, et al. Effectiveness of anise oil for treatment of mild to moderate depression in patients with irritable bowel syndrome: A randomized active and placebo-controlled clinical trial. J Evid Based Complementary Altern Med 2017;22:41-46. View abstract.
- Mosavat SH, Jaberi AR, Sobhani Z, Mosaffa-Jahromi M, Iraji A, Moayedfard A. Efficacy of anise (Pimpinella anisum L.) oil for migraine headache: A pilot randomized placebo-controlled clinical trial. J Ethnopharmacol. 2019;236:155-160. View abstract.
- Muller M, Byres M, Jaspars M. et al. 2D NMR spectroscopic analyses of archangelicin from the seeds of Angelica archangelica. Acta Pharm 2004;54:277-85. View abstract.
- Mumcuoglu KY, Miller J, Zamir C, et al. The in vivo pediculicidal efficacy of a natural remedy. Isr Med Assoc J 2002;4:790-3. View abstract.
- Nahid K, Fariborz M, Ataolah G, Solokian S. The effect of an Iranian herbal drug on primary dysmenorrhea: a clinical controlled trial. J Midwifery Womens Health 2009;54:401-4. View abstract.
- Nahidi F, Kariman N, Simbar M, Mojab F. The study on the effects of Pimpinella anisum on relief and recurrence of menopausal hot flashes. Iran J Pharm Res 2012;11:1079-85. View abstract.
- Pourgholami MH, Majzoob S, Javadi M, et al. The fruit essential oil of Pimpinella anisum exerts anticonvulsant effects in mice. J Ethnopharmacol 1999;66:211-5. View abstract.
- Rajeshwari U, Shobha I, Andallu B. Comparison of aniseeds and coriander seeds for antidiabetic, hypolipidemic and antioxidant activities. Spatula DD-Peer Reviewed Journal on Complementary Medicine and Drug Discovery 2011;1:9-16.
- Abdel-Fatah MK and et al. Antimicrobial activities of some local medicinal plants. Journal of Drug Research (Egypt) 2002;24:179-186.
- Al Mofleh, I. A., Alhaider, A. A., Mossa, J. S., Al Soohaibani, M. O., and Rafatullah, S. Aqueous suspension of anise "Pimpinella anisum" protects rats against chemically induced gastric ulcers. World J Gastroenterol. 2-21-2007;13(7):1112-1118. View abstract.
- Andersen, K. E. Contact allergy to toothpaste flavors. Contact Dermatitis 1978;4(4):195-198. View abstract.
- Anliker, M. D., Borelli, S., and Wuthrich, B. Occupational protein contact dermatitis from spices in a butcher: a new presentation of the mugwort-spice syndrome. Contact Dermatitis 2002;46(2):72-74. View abstract.
- Astani, A., Reichling, J., and Schnitzler, P. Screening for Antiviral Activities of Isolated Compounds from Essential Oils. Evid.Based Complement Alternat.Med 12-15-2009; View abstract.
- Atapour M and et al. In vitro susceptibility of the Gram-negative bacterium Helicobacter pylori to extracts of Iranian medicinal plants. Pharmaceutical Biology 2009;47(1):77-80.
- Aviles, H., O'Donnell, P., Orshal, J., Fujii, H., Sun, B., and Sonnenfeld, G. Active hexose correlated compound activates immune function to decrease bacterial load in a murine model of intramuscular infection. Am J Surg. 2008;195(4):537-545. View abstract.
- Chainy, G. B., Manna, S. K., Chaturvedi, M. M., and Aggarwal, B. B. Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis. Oncogene 6-8-2000;19(25):2943-2950. View abstract.
- De Martino, L., De, Feo, V, Fratianni, F., and Nazzaro, F. Chemistry, antioxidant, antibacterial and antifungal activities of volatile oils and their components. Nat.Prod.Commun. 2009;4(12):1741-1750. View abstract.
- Fitzgerald, D. J., Stratford, M., Gasson, M. J., and Narbad, A. Structure-function analysis of the vanillin molecule and its antifungal properties. J Agric.Food Chem. 3-9-2005;53(5):1769-1775. View abstract.
- Gonzalez-Gutierrez, M. L., Sanchez-Fernandez, C., Esteban-Lopez, M. I., Sempere-Ortells, J. M., and Diaz-Alperi, P. Allergy to anis. Allergy 2000;55(2):195-196. View abstract.
- Karapinar, M. Inhibitory effects of anethole and eugenol on the growth and toxin production of Aspergillus parasiticus. Int J Food Microbiol. 1990;10(3-4):193-199. View abstract.
- Koch, C., Reichling, J., Kehm, R., Sharaf, M. M., Zentgraf, H., Schneele, J., and Schnitzler, P. Efficacy of anise oil, dwarf-pine oil and chamomile oil against thymidine-kinase-positive and thymidine-kinase-negative herpesviruses. J Pharm.Pharmacol. 2008;60(11):1545-1550. View abstract.
- Koch, C., Reichling, J., Schneele, J., and Schnitzler, P. Inhibitory effect of essential oils against herpes simplex virus type 2. Phytomedicine 2008;15(1-2):71-78. View abstract.
- Kosalec, I., Pepeljnjak, S., and Kustrak, D. Antifungal activity of fluid extract and essential oil from anise fruits (Pimpinella anisum L., Apiaceae). Acta Pharm 2005;55(4):377-385. View abstract.
- Lachowicz, K. J., Jones, G. P., Briggs, D. R., Bienvenu, F. E., Wan, J., Wilcock, A., and Coventry, M. J. The synergistic preservative effects of the essential oils of sweet basil (Ocimum basilicum L.) against acid-tolerant food microflora. Lett.Appl.Microbiol. 1998;26(3):209-214. View abstract.
- Lee, H. S. Food protective effect of acaricidal components isolated from anise seeds against the stored food mite, Tyrophagus putrescentiae (Schrank). J Food Prot. 2005;68(6):1208-1210. View abstract.
- Narasimha BGV and et al. In vitro antimicrobial efficiency of some essential oils. Flavour Ind. 1970;1:725-729.
- Ozcan, M. Effect of spice hydrosols on the growth of Aspergillus parasiticus NRRL 2999 strain. J Med.Food 2005;8(2):275-278. View abstract.
- Picon, P. D., Picon, R. V., Costa, A. F., Sander, G. B., Amaral, K. M., Aboy, A. L., and Henriques, A. T. Randomized clinical trial of a phytotherapic compound containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifolia for chronic constipation. BMC.Complement Altern.Med. 2010;10:17. View abstract.
Have you ever purchased ANISE?
Did you or will you purchase this product in-store or online?
Where did you or where do you plan to purchase this product?
Where did you or where do you plan to purchase this product?
What factors influenced or will influence your purchase? (check all that apply)
Where did you or where do you plan to purchase this product?
Do you buy vitamins online or instore?
What factors are most important to you? (check all that apply)