Anise contains chemicals that might have estrogen-like effects, decrease swelling, and help fight off insects.
People use anise for indigestion, constipation, migraine, menopausal symptoms, and many other puproses, but there is no good scientific evidence to support these uses.
Don't confuse anise with star anise. These are not the same.
Uses & Effectiveness ?
We currently have no information for ANISE overview.
Special Precautions and Warnings
Pregnancy and breast-feeding: Anise is commonly consumed in foods. But there isn't enough reliable information to know if anise is safe to use in larger amounts as medicine while pregnant or breast-feeding. Stay on the safe side and stick to food amounts.
Children: Anise is commonly consumed in foods. But there isn't enough reliable information to know if anise is safe for children to use as medicine.
Allergies: Anise might cause allergic reactions in some people who are allergic to other plants that are similar to anise. Plants that are similar to anise include asparagus, caraway, celery, coriander, cumin, dill, and fennel.
Hormone-sensitive conditions: Anise might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use anise. This includes breast cancer, uterine cancer, ovarian cancer, endometriosis, and others.
Surgery: Anise might lower blood sugar levels. This might interfere with blood sugar control during and after surgery. Stop using anise at least 2 weeks before a scheduled surgery.
Birth control pills (Contraceptive drugs) interacts with ANISE
Some birth control pills contain estrogen. Taking anise along with birth control pills might decrease the effects of birth control pills. If you take birth control pills along with anise, use an additional form of birth control such as a condom.
Estrogens interacts with ANISE
Large amounts of anise might have some of the same effects as estrogen. Taking anise along with estrogen pills might increase or decrease the effects of estrogen pills.
Tamoxifen (Nolvadex) interacts with ANISE
Tamoxifen is used to help treat and prevent estrogen-sensitive cancers. Anise seems to affect estrogen levels in the body. By affecting estrogen in the body, anise might decrease the effects of tamoxifen.
Medications for diabetes (Antidiabetes drugs) interacts with ANISE
Anise might lower blood sugar levels. Taking anise along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Caffeine interacts with ANISE
Taking anise oil with caffeine might reduce the levels of caffeine in the blood. This might decrease the effects of caffeine.
Codeine interacts with ANISE
Codeine is changed into morphine by the liver. Taking anise oil with codeine might increase the effects and side effects of codeine.
Diazepam (Valium) interacts with ANISE
The body breaks down diazepam to get rid of it. Taking anise oil with diazepam might slow down how quickly the body breaks down diazepam. This might increase the effects and side effects of diazepam.
Fluoxetine (Prozac) interacts with ANISE
Taking anise oil with fluoxetine might reduce how well fluoxetine works.
Imipramine (Tofranil) interacts with ANISE
Taking anise oil with imipramine might reduce how well imipramine works.
Midazolam (Versed) interacts with ANISE
The body breaks down midazolam to get rid of it. Anise oil might slow down how quickly the body breaks down midazolam. This might increase the effects and side effects of midazolam.
Be cautious with this combination
Acetaminophen (Tylenol, others) interacts with ANISE
Taking anise oil with acetaminophen might reduce the levels of acetaminophen in the blood. This might reduce how well acetaminophen works.
Be watchful with this combination
As medicine, anise seed powder has most often been used by adults in doses of 5 grams by mouth daily for up to 2 months. Anise oil has most often been in doses of 200 mg by mouth three times daily for up to 4 weeks. Anise extract has most often been used in doses of 110-330 mg by mouth daily for up to 4 weeks. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.
Abdel-Fatah MK and et al. Antimicrobial activities of some local medicinal plants. Journal of Drug Research (Egypt) 2002;24:179-186.
Al Mofleh, I. A., Alhaider, A. A., Mossa, J. S., Al Soohaibani, M. O., and Rafatullah, S. Aqueous suspension of anise "Pimpinella anisum" protects rats against chemically induced gastric ulcers. World J Gastroenterol. 2-21-2007;13(7):1112-1118. View abstract.
Andersen, K. E. Contact allergy to toothpaste flavors. Contact Dermatitis 1978;4(4):195-198. View abstract.
Anliker, M. D., Borelli, S., and Wuthrich, B. Occupational protein contact dermatitis from spices in a butcher: a new presentation of the mugwort-spice syndrome. Contact Dermatitis 2002;46(2):72-74. View abstract.
Astani, A., Reichling, J., and Schnitzler, P. Screening for Antiviral Activities of Isolated Compounds from Essential Oils. Evid.Based Complement Alternat.Med 12-15-2009; View abstract.
Atapour M and et al. In vitro susceptibility of the Gram-negative bacterium Helicobacter pylori to extracts of Iranian medicinal plants. Pharmaceutical Biology 2009;47(1):77-80.
Aviles, H., O'Donnell, P., Orshal, J., Fujii, H., Sun, B., and Sonnenfeld, G. Active hexose correlated compound activates immune function to decrease bacterial load in a murine model of intramuscular infection. Am J Surg. 2008;195(4):537-545. View abstract.
Chainy, G. B., Manna, S. K., Chaturvedi, M. M., and Aggarwal, B. B. Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis. Oncogene 6-8-2000;19(25):2943-2950. View abstract.
De Martino, L., De, Feo, V, Fratianni, F., and Nazzaro, F. Chemistry, antioxidant, antibacterial and antifungal activities of volatile oils and their components. Nat.Prod.Commun. 2009;4(12):1741-1750. View abstract.
Fitzgerald, D. J., Stratford, M., Gasson, M. J., and Narbad, A. Structure-function analysis of the vanillin molecule and its antifungal properties. J Agric.Food Chem. 3-9-2005;53(5):1769-1775. View abstract.
Gonzalez-Gutierrez, M. L., Sanchez-Fernandez, C., Esteban-Lopez, M. I., Sempere-Ortells, J. M., and Diaz-Alperi, P. Allergy to anis. Allergy 2000;55(2):195-196. View abstract.
Karapinar, M. Inhibitory effects of anethole and eugenol on the growth and toxin production of Aspergillus parasiticus. Int J Food Microbiol. 1990;10(3-4):193-199. View abstract.
Koch, C., Reichling, J., Kehm, R., Sharaf, M. M., Zentgraf, H., Schneele, J., and Schnitzler, P. Efficacy of anise oil, dwarf-pine oil and chamomile oil against thymidine-kinase-positive and thymidine-kinase-negative herpesviruses. J Pharm.Pharmacol. 2008;60(11):1545-1550. View abstract.
Koch, C., Reichling, J., Schneele, J., and Schnitzler, P. Inhibitory effect of essential oils against herpes simplex virus type 2. Phytomedicine 2008;15(1-2):71-78. View abstract.
Kosalec, I., Pepeljnjak, S., and Kustrak, D. Antifungal activity of fluid extract and essential oil from anise fruits (Pimpinella anisum L., Apiaceae). Acta Pharm 2005;55(4):377-385. View abstract.
Lachowicz, K. J., Jones, G. P., Briggs, D. R., Bienvenu, F. E., Wan, J., Wilcock, A., and Coventry, M. J. The synergistic preservative effects of the essential oils of sweet basil (Ocimum basilicum L.) against acid-tolerant food microflora. Lett.Appl.Microbiol. 1998;26(3):209-214. View abstract.
Lee, H. S. Food protective effect of acaricidal components isolated from anise seeds against the stored food mite, Tyrophagus putrescentiae (Schrank). J Food Prot. 2005;68(6):1208-1210. View abstract.
Narasimha BGV and et al. In vitro antimicrobial efficiency of some essential oils. Flavour Ind. 1970;1:725-729.
Ozcan, M. Effect of spice hydrosols on the growth of Aspergillus parasiticus NRRL 2999 strain. J Med.Food 2005;8(2):275-278. View abstract.
Picon, P. D., Picon, R. V., Costa, A. F., Sander, G. B., Amaral, K. M., Aboy, A. L., and Henriques, A. T. Randomized clinical trial of a phytotherapic compound containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifolia for chronic constipation. BMC.Complement Altern.Med. 2010;10:17. View abstract.
Poon, T. S. and Freeman, S. Cheilitis caused by contact allergy to anethole in spearmint flavoured toothpaste. Australas.J Dermatol. 2006;47(4):300-301. View abstract.
Prajapati, V., Tripathi, A. K., Aggarwal, K. K., and Khanuja, S. P. Insecticidal, repellent and oviposition-deterrent activity of selected essential oils against Anopheles stephensi, Aedes aegypti and Culex quinquefasciatus. Bioresour.Technol. 2005;96(16):1749-1757. View abstract.
Reichling, J., Merkel, B., and Hofmeister, P. Studies on the biological activities of rare phenylpropanoids of the genus Pimpinella. J Nat.Prod. 1991;54(5):1416-1418. View abstract.
Soliman, K. M. and Badeaa, R. I. Effect of oil extracted from some medicinal plants on different mycotoxigenic fungi. Food Chem.Toxicol 2002;40(11):1669-1675. View abstract.
Yu, L., Guo, N., Yang, Y., Wu, X., Meng, R., Fan, J., Ge, F., Wang, X., Liu, J., and Deng, X. Microarray analysis of p-anisaldehyde-induced transcriptome of Saccharomyces cerevisiae. J Ind Microbiol.Biotechnol. 2010;37(3):313-322. View abstract.
Boskabady MH, Ramazani-Assari M. Relaxant effect of Pimpinella anisum on isolated guinea pig tracheal chains and its possible mechanism(s). J Ethnopharmacol 2001;74:83-8. View abstract.
Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
Es-Safi I, Mechchate H, Amaghnouje A, et al. Assessment of antidepressant-like, anxiolytic effects and impact on memory of Pimpinella anisum L. total extract on Swiss albino mice. Plants (Basel) 2021;10(8):1573. View abstract.
Farahmand M, Khalili D, Ramezani Tehrani F, Amin G, Negarandeh R. Could anise decrease the intensity of premenstrual syndrome symptoms in comparison to placebo? A double-blind randomized clinical trial. J Complement Integr Med 2020. Online ahead of print. View abstract.
Garcia-Gonzalez JJ, Bartolome-Zavala B, Fernandez-Melendez S, et al. Occupational rhinoconjunctivitis and food allergy because of aniseed sensitization. Ann Allergy Asthma Immunol 2002;88:518-22. . View abstract.
Ghoshegir SA, Mazaheri M, Ghannadi A, et al. Pimpinella anisum in modifying the quality of life in patients with functional dyspepsia: A double-blind randomized clinical trial. J Res Med Sci 2014;19:1118-23. View abstract.
Ghoshegir SA, Mazaheri M, Ghannadi A, et al. Pimpinella anisum in the treatment of functional dyspepsia: A double-blind, randomized clinical trial. J Res Med Sci 2015;20:13-21. View abstract.
Hallstrom H, Thuvander A. Toxicological evaluation of myristicin. Nat Toxins 1997;5:186-92. View abstract.
Haqqaq EG, Abou-Moustafa MA, Boucher W, Theoharides TC. The effect of a herbal water-extract on histamine release from mast cells and on allergic asthma. J Herb Pharmacother 2003;3:41-54. View abstract.
Hashemnia M, Nikousefat Z, Mohammadalipour A, Zangeneh MM, Zangeneh A. Wound healing activity of Pimpinella anisum methanolic extract in streptozotocin-induced diabetic rats. J Wound Care 2019;28(Sup10):S26-S36. View abstract.
Ishikawa T, Fujimatu E, Kitajima J. Water-soluble constituents of anise: new glucosides of anethole glycol and its related compounds. Chem Pharm Bull (Tokyo) 2002;50:1460-6. View abstract.
Kassi E, Papoutsi Z, Fokialakis N, et al. Greek plant extracts exhibit selective estrogen receptor modulator (SERM)-like properties. J Agric Food Chem 2004;52:6956-61. View abstract.
Kreydiyyeh SI, Usta J, Knio K, et al. Aniseed oil increases glucose absorption and reduces urine output in the rat. Life Sci 2003;74:663-73. View abstract.
Lee HS. p-Anisaldehyde: acaricidal component of Pimpinella anisum seed oil against the house dust mites Dermatophagoides farinae and Dermatophagoides pteronyssinus. Planta Med 2004;70:279-81. View abstract.
Mosaffa-Jahromi M, Lankarani KB, Pasalar M, et al. Efficacy and safety of enteric coated capsules of anise oil to treat irritable bowel syndrome. J Ethnopharmacol 2016;194:937-946. View abstract.
Mosaffa-Jahromi M, Tamaddon AM, Afsharypuor S, et al. Effectiveness of anise oil for treatment of mild to moderate depression in patients with irritable bowel syndrome: A randomized active and placebo-controlled clinical trial. J Evid Based Complementary Altern Med 2017;22:41-46. View abstract.
Mosavat SH, Jaberi AR, Sobhani Z, Mosaffa-Jahromi M, Iraji A, Moayedfard A. Efficacy of anise (Pimpinella anisum L.) oil for migraine headache: A pilot randomized placebo-controlled clinical trial. J Ethnopharmacol. 2019;236:155-160. View abstract.
Muller M, Byres M, Jaspars M. et al. 2D NMR spectroscopic analyses of archangelicin from the seeds of Angelica archangelica. Acta Pharm 2004;54:277-85. View abstract.
Mumcuoglu KY, Miller J, Zamir C, et al. The in vivo pediculicidal efficacy of a natural remedy. Isr Med Assoc J 2002;4:790-3. View abstract.
Nahid K, Fariborz M, Ataolah G, Solokian S. The effect of an Iranian herbal drug on primary dysmenorrhea: a clinical controlled trial. J Midwifery Womens Health 2009;54:401-4. View abstract.
Nahidi F, Kariman N, Simbar M, Mojab F. The study on the effects of Pimpinella anisum on relief and recurrence of menopausal hot flashes. Iran J Pharm Res 2012;11:1079-85. View abstract.
Pourgholami MH, Majzoob S, Javadi M, et al. The fruit essential oil of Pimpinella anisum exerts anticonvulsant effects in mice. J Ethnopharmacol 1999;66:211-5. View abstract.
Rajeshwari U, Shobha I, Andallu B. Comparison of aniseeds and coriander seeds for antidiabetic, hypolipidemic and antioxidant activities. Spatula DD-Peer Reviewed Journal on Complementary Medicine and Drug Discovery 2011;1:9-16.
Rodrigues VM, Rosa PT, Marques MO, et al. Supercritical extraction of essential oil from aniseed (Pimpinella anisum L) using CO2: solubility, kinetics, and composition data. J Agric Food Chem 2003;51:1518-23. View abstract.
Sahraei H, Ghoshooni H, Hossein Salimi S, et al. The effects of fruit essential oil of the Pimpinella anisum on acquisition and expression of morphine induced conditioned place preference in mice. J Ethnopharmacol 2002;80:43-7. View abstract.
Samojlik I, Mijatovic V, Petkovic S, et al. The influence of essential oil of aniseed (Pimpinella anisum, L.) on drug effects on the central nervous system. Fitoterapia 2012;83:1466-73. View abstract.
Samojlik I, Petkovic S, Stilinovic N, et al. Pharmacokinetic herb-drug interaction between essential oil of aniseed (Pimpinella anisum L., Apiaceae) and acetaminophen and caffeine: A potential risk for clinical practice. Phytother Res 2016;30:253-9. View abstract.
Shojaii A, Abdollahi Fard M. Review of pharmacological properties and chemical constituents of Pimpinella anisum. ISRN Pharm 2012;2012:510795. View abstract.
Stager, J., Wuthrich, B., and Johansson, S. G. Spice allergy in celery-sensitive patients. Allergy 1991;46(6):475-478. View abstract.
Tabanca N, Khan SI, Bedir E, et al. Estrogenic activity of isolated compounds and essential oils of Pimpinella species from Turkey, evaluated using a recombinant yeast screen. Planta Med 2004;70:728-35. View abstract.
Twaij HA, Elisha EE, Khalid RM, Paul NJ. Analgesic studies on some Iraqi medicinal plants. Int J Crude Drug Res 1987;25:251-54.
Wuthrich, B. and Dietschi, R. [The celery-carrot-mugwort-condiment syndrome: skin test and RAST results]. Schweiz.Med Wochenschr. 3-16-1985;115(11):258-264. View abstract.
Wuthrich, B. and Hofer, T. [Food allergy: the celery-mugwort-spice syndrome. Association with mango allergy?]. Dtsch.Med Wochenschr 6-22-1984;109(25):981-986. View abstract.
You Might Also Like
CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.
This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.