ANDROSTENEDIOL

OTHER NAME(S):

1-Androstene-3beta, 17beta-diol; 4-AD; 4-Androstenediol; 4-Androstènediol; 4-Androstene 3, 17-diol; 4-androstene-3beta,17beta-diol; 5-AD; 5-Androstenediol; 5-Androstènediol; 5-androstene-3beta,17beta-diol; Androdiol; Androstènediol.

Overview

Overview Information

Androstenediol is a type of chemical known as a steroid. It is converted in the body to testosterone and other sex hormones.

Androstenediol used to be available as a dietary supplement in the U.S. But it has been reclassified as a schedule III controlled substance. This means androstenediol is available only as a prescription medicine, and physicians have to follow strict rules when prescribing it. It is banned by the World Anti-Doping Agency (WADA) and the National Collegiate Athletic Association (NCAA) for use by athletes.

Androstenediol is used to increase testosterone levels in the body to improve athletic performance, to enhance response to sexual stimuli in healthy people, to improve sexual problems that prevent satisfaction during sexual activity, and other conditions, but there is no good scientific evidence to support these uses. Androstendiol might also be unsafe.

How does it work?

Androstenediol is a steroid hormone used by the body to make testosterone and estrogen.

Uses

Uses & Effectiveness?

Possibly Ineffective for

  • Athletic performance. Androstenediol does not seem to help increase muscle size or strength when taken by mouth for 12 weeks in connection with resistance training.

Insufficient Evidence for

  • Increasing energy.
  • Improving body recovery and growth from exercise.
  • Heightening sexual arousal and performance.
  • Increasing a sense of well-being.
  • Other conditions.
More evidence is needed to rate the effectiveness of androstenediol for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Androstenediol is POSSIBLY UNSAFE for most people when taken by mouth. There is some concern that products can vary from what is listed on the label. Women who take androstenediol might develop some male characteristics including deepening of the voice, facial hair growth, acne, abnormal menstrual periods, male-pattern baldness, thickening of the skin, and depression.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if androstenediol is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Heart disease: There is some concern that androstenediol might increase the risk of coronary heart disease.

Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Androstenediol can increase levels of hormones such estrone, estradiol, and testosterone. If you have any condition that might be made worse by exposure to these hormones, don't use androstenediol.

Prostate cancer and benign prostatic hypertrophy (BPH): Androstenediol can increase testosterone levels. There is also developing evidence that androstenediol might help prostate cancer cells grow. If you have a prostate condition, don't use androstenediol.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Estrogens interacts with ANDROSTENEDIOL

    Androstenediol seems to increase estrogen levels in the body. Taking androstenediol along with estrogen pills might cause too much estrogen in the body.
    Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.

  • Testosterone interacts with ANDROSTENEDIOL

    The body changes androstenediol into testosterone. Taking androstenediol with a testosterone pill might cause there to be too much testosterone in the body. This might increase the chance of testosterone side effects.

Dosing

Dosing

The appropriate dose of androstenediol depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for androstenediol. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Ando, S., De Amicis, F., Rago, V., Carpino, A., Maggiolini, M., Panno, M. L., and Lanzino, M. Breast cancer: from estrogen to androgen receptor. Mol Cell Endocrinol. 7-31-2002;193(1-2):121-128. View abstract.
  • Ayotte, C., Levesque, J. F., Cle, roux M., Lajeunesse, A., Goudreault, D., and Fakirian, A. Sport nutritional supplements: quality and doping controls. Can J Appl Physiol 2001;26 Suppl:S120-S129. View abstract.
  • Battista, V., Combs, J., and Warme, W. J. Asynchronous bilateral achilles tendon ruptures and androstenediol use. Am J Sports Med 2003;31(6):1007-1009. View abstract.
  • Broeder, C. E. Oral andro-related prohormone supplementation: do the potential risks outweigh the benefits? Can J Appl Physiol 2003;28(1):102-116. View abstract.
  • Brown, G. A. and McKenzie, D. Acute resistance exercise does not change the hormonal response to sublingual androstenediol intake. Eur J Appl Physiol 2006;97(4):404-412. View abstract.
  • Brown, G. A., Vukovich, M., and King, D. S. Testosterone prohormone supplements. Med Sci Sports Exerc 2006;38(8):1451-1461. View abstract.
  • Foster, Z. J. and Housner, J. A. Anabolic-androgenic steroids and testosterone precursors: ergogenic aids and sport. Curr.Sports Med Rep 2004;3(4):234-241. View abstract.
  • Lardy, H., Marwah, A., and Marwah, P. C(19)-5-ene steroids in nature. Vitam.Horm. 2005;71:263-299. View abstract.
  • Leszczynski, D. E. and Schafer, R. M. Metabolic conversion of six steroid hormones by human plasma high-density lipoprotein. Biochim.Biophys.Acta 4-24-1991;1083(1):18-28. View abstract.
  • Purohit, A., Woo, L. W., Chander, S. K., Newman, S. P., Ireson, C., Ho, Y., Grasso, A., Leese, M. P., Potter, B. V., and Reed, M. J. Steroid sulphatase inhibitors for breast cancer therapy. J Steroid Biochem Mol Biol 2003;86(3-5):423-432. View abstract.
  • Reilly, C. A. and Crouch, D. J. Analysis of the nutritional supplement 1AD, its metabolites, and related endogenous hormones in biological matrices using liquid chromatography-tandem mass spectrometry. J Anal.Toxicol 2004;28(1):1-10. View abstract.
  • Saudan, C., Baume, N., Robinson, N., Avois, L., Mangin, P., and Saugy, M. Testosterone and doping control. Br J Sports Med 2006;40 Suppl 1:i21-i24. View abstract.
  • Shackleton, C. H., Roitman, E., Phillips, A., and Chang, T. Androstanediol and 5-androstenediol profiling for detecting exogenously administered dihydrotestosterone, epitestosterone, and dehydroepiandrosterone: potential use in gas chromatography isotope ratio mass spectrometry. Steroids 1997;62(10):665-673. View abstract.
  • Ziegenfuss, T. N., Berardi, J. M., and Lowery, L. M. Effects of prohormone supplementation in humans: a review. Can J Appl Physiol 2002;27(6):628-646. View abstract.
  • Anabolic Steroid Act, Public Law No. 108-358, 2004.
  • Broeder CE, Quindry J, Brittingham K, et al. The Andro Project: physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program. Arch Intern Med 2000;160:3093-104. View abstract.
  • Brown GA, Martini ER, Roberts BS, et al. Acute hormonal response to sublingual androstenediol intake in young men. J Appl Physiol 2002;92:142-6. View abstract.
  • Green GA, Catlin DH, Starcevic B. Analysis of over-the-counter dietary supplements. Clin J Sport Med 2001;11:254-9.. View abstract.
  • Miyamoto H, Yeh S, Lardy H, et al. Delta5-androstenediol is a natural hormone with androgenic activity in human prostate cancer cells. Proc Natl Acad Sci USA 1998;95:11083-88. View abstract.
  • National Collegiate Athletic Association. NCAA Banned-Drug Classes 2005-2006. Available at: https://www1.ncaa.org/membership/ed_outreach/health-safety/drug_testing/banned_drug_classes.pdf.
  • The world antidoping code international standard prohibited list January 2019. World Anti-Doping Agency. https://www.wada-ama.org/sites/default/files/wada_2019_english_prohibited_list.pdf. Accessed November 13, 2019.

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