Androstenediol used to be available as a dietary supplement in the U.S. But it has been reclassified as a schedule III controlled substance. This means androstenediol is available only as a prescription medicine, and physicians have to follow strict rules when prescribing it. It is banned by the World Anti-Doping Agency (WADA) and the National Collegiate Athletic Association (NCAA) for use by athletes.
Androstenediol is used to increase testosterone levels in the body to improve athletic performance, to enhance response to sexual stimuli in healthy people, to improve sexual problems that prevent satisfaction during sexual activity, and other conditions, but there is no good scientific evidence to support these uses. Androstendiol might also be unsafe.
Uses & Effectiveness
Possibly Ineffective for
- Athletic performance. Androstenediol does not seem to help increase muscle size or strength when taken by mouth for 12 weeks in connection with resistance training.
Insufficient Evidence for
- Increasing energy.
- Improving body recovery and growth from exercise.
- Heightening sexual arousal and performance.
- Increasing a sense of well-being.
- Other conditions.
Special Precautions and Warnings
Heart disease: There is some concern that androstenediol might increase the risk of coronary heart disease.
Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Androstenediol can increase levels of hormones such estrone, estradiol, and testosterone. If you have any condition that might be made worse by exposure to these hormones, don't use androstenediol.
Prostate cancer and benign prostatic hypertrophy (BPH): Androstenediol can increase testosterone levels. There is also developing evidence that androstenediol might help prostate cancer cells grow. If you have a prostate condition, don't use androstenediol.
Estrogens interacts with ANDROSTENEDIOL
Androstenediol seems to increase estrogen levels in the body. Taking androstenediol along with estrogen pills might cause too much estrogen in the body.
Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.
Testosterone interacts with ANDROSTENEDIOL
The body changes androstenediol into testosterone. Taking androstenediol with a testosterone pill might cause there to be too much testosterone in the body. This might increase the chance of testosterone side effects.
Be cautious with this combination
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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.
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© Therapeutic Research Faculty 2020.