Overview

Androstenediol is a type of chemical known as a steroid. It is converted in the body to testosterone and other sex hormones.

Androstenediol used to be available as a dietary supplement in the U.S. But it has been reclassified as a schedule III controlled substance. This means androstenediol is available only as a prescription medicine, and physicians have to follow strict rules when prescribing it. It is banned by the World Anti-Doping Agency (WADA) and the National Collegiate Athletic Association (NCAA) for use by athletes.

Androstenediol is used to increase testosterone levels in the body to improve athletic performance, to enhance response to sexual stimuli in healthy people, to improve sexual problems that prevent satisfaction during sexual activity, and other conditions, but there is no good scientific evidence to support these uses. Androstendiol might also be unsafe.

How does it work ?

Androstenediol is a steroid hormone used by the body to make testosterone and estrogen.

Uses & Effectiveness ?

Possibly Ineffective for

  • Athletic performance. Androstenediol does not seem to help increase muscle size or strength when taken by mouth for 12 weeks in connection with resistance training.

Insufficient Evidence for

  • Increasing energy.
  • Improving body recovery and growth from exercise.
  • Heightening sexual arousal and performance.
  • Increasing a sense of well-being.
  • Other conditions.
More evidence is needed to rate the effectiveness of androstenediol for these uses.

Side Effects

When taken by mouth: Androstenediol is POSSIBLY UNSAFE for most people when taken by mouth. There is some concern that products can vary from what is listed on the label. Women who take androstenediol might develop some male characteristics including deepening of the voice, facial hair growth, acne, abnormal menstrual periods, male-pattern baldness, thickening of the skin, and depression.

Special Precautions and Warnings

When taken by mouth: Androstenediol is POSSIBLY UNSAFE for most people when taken by mouth. There is some concern that products can vary from what is listed on the label. Women who take androstenediol might develop some male characteristics including deepening of the voice, facial hair growth, acne, abnormal menstrual periods, male-pattern baldness, thickening of the skin, and depression. Pregnancy and breast-feeding: There isn't enough reliable information to know if androstenediol is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Heart disease: There is some concern that androstenediol might increase the risk of coronary heart disease.

Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Androstenediol can increase levels of hormones such estrone, estradiol, and testosterone. If you have any condition that might be made worse by exposure to these hormones, don't use androstenediol.

Prostate cancer and benign prostatic hypertrophy (BPH): Androstenediol can increase testosterone levels. There is also developing evidence that androstenediol might help prostate cancer cells grow. If you have a prostate condition, don't use androstenediol.

Interactions ?

    Moderate Interaction

    Be cautious with this combination

  • Estrogens interacts with ANDROSTENEDIOL

    Androstenediol seems to increase estrogen levels in the body. Taking androstenediol along with estrogen pills might cause too much estrogen in the body.

    Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.

  • Testosterone interacts with ANDROSTENEDIOL

    The body changes androstenediol into testosterone. Taking androstenediol with a testosterone pill might cause there to be too much testosterone in the body. This might increase the chance of testosterone side effects.

Dosing

The appropriate dose of androstenediol depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for androstenediol. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.