AGRIMONY

OTHER NAME(S):

Agrimone, Agrimonia, Agrimonia eupatoria, Aigremoine, Aigremoine Eupatoire, Church Steeples, Churchsteeples, Cockeburr, Cocklebur, Common Agrimony, Da Hua Long Ya Cao, Eupatoire-des-Anciens, Fragrant Agrimony, Francormier, Herba Agrimoniae, Herbe-de-Saint-Guillaume, Herbe de Sainte Madeleine, Philanthropos, Soubeirette, Sticklewort, Thé des Bois, Thé du Nord, Toute-Bonne.

Overview

Overview Information

Agrimony is an herb. People dry the seeds and the parts that grow above the ground to make medicine.

Agrimony is used for liver, kidney, and stomach problems, and other conditions, but there is no good scientific evidence to support these uses.

Be careful not to confuse agrimony with hemp agrimony, liverwort, and potentilla.

How does it work?

Agrimony contains chemicals called tannins, which are thought to help conditions such as diarrhea.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Diarrhea.
  • Irritable bowel syndrome (IBS).
  • Kidney problems.
  • Liver problems.
  • Sore throat.
  • Upset stomach.
  • Other conditions.
More evidence is needed to rate the effectiveness of agrimony for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Agrimony is POSSIBLY SAFE for most adults when used short-term. Traditionally, agrimony herb seems to be safe in doses of 3 grams daily. Also, taking agrimony extract seems to be safe in doses of 160 mg daily. But large amounts of agrimony are POSSIBLY UNSAFE. Agrimony contains chemicals called tannins. In large amounts, tannins may cause side effects such as stomach irritation, nausea, vomiting, and liver injury. Large amounts of tannins might also increase the risk of certain cancers. But these side effects have not been reported with agrimony.

When applied to the skin: Agrimony is POSSIBLY SAFE for most adults when used short-term. But applying large amounts of agrimony is POSSIBLY UNSAFE. Agrimony contains chemicals called tannins. There is concern that tannins might cause serious side effects if absorbed through the skin in large amounts. But these serious side effects have not been reported with agrimony. However, agrimony can make some people's skin extra sensitive to sunlight and more likely to burn.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Agrimony is POSSIBLY UNSAFE during pregnancy because it might affect the menstrual cycle. There isn't enough reliable information to know if agrimony is safe to use when breast-feeding. Stay on the safe side and avoid use.

Diabetes: Agrimony might lower blood sugar levels. People with diabetes should monitor their blood glucose levels closely. If you have diabetes, it's best to check with your healthcare provider before starting agrimony.

Surgery: Agrimony might affect blood sugar levels, so there is a concern that it might interfere with blood sugar control during and after surgery. Stop using agrimony at least 2 weeks before a scheduled surgery.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Medications for diabetes (Antidiabetes drugs) interacts with AGRIMONY

    Agrimony might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking agrimony along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
    Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Dosing

Dosing

The appropriate dose of agrimony depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for agrimony. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Chakarski I. Clinical study of a herb combination consisting of Agrimonia eupatoria, Hipericum perforatum, Plantago major, Mentha piperita, Matricaria chamomila for the treatment of patients with chronic gastroduodenitis. Probl Vatr Med 1982;10:78-84.
  • Gao K, Zhou L, Chen J. Experimental study on decoctum Agrimonia pilosa Ledeb-induced apoptosis in HL-60 cells in vitro. Zhong Yao Cai 2000;23(9):561-562.
  • Ivanova D, Gerova D, Chervenkov T. Polyphenols and antioxidant capacity of Bulgarian medicinal plants. J Ethnopharmacol 2005;96(1-2):145-150.
  • Lev, E. [Some evidence for the use of doctrine of signatures in the land of Israel and its environs during the Middle Ages]. Harefuah 2002;141(7):651-5, 664. View abstract.
  • Li Y, Ooi LS, Wang H, et al. Antiviral activities of medicinal herbs traditionally used in southern mainland China. Phytother Res 2004;18(9):718-722. View abstract.
  • Miyamoto K, Kishi N, Koshiura R. Antitumor effect of agrimoniin, a tannin of Agrimonia pilosa Ledeb., on transplantable rodent tumors. Jpn J Pharmacol 1987;43(2):187-195. View abstract.
  • Park EJ, Oh H, Kang TH, et al. An isocoumarin with hepatoprotective activity in Hep G2 and primary hepatocytes from Agrimonia pilosa. Arch Pharm Res 2004;27(9):944-946. View abstract.
  • Patrascu V, Chebac PI. [Favorable therapeutic results in cutaneous porphyria obtained with Agrimonia eupatoria]. Revista De Medicina Interna Neurologie Psihiatrie Neurochirurgie Dermato Venerologie Serie Dermato Venerologia 1984;29(2):153-157.
  • PETROVSKII GA, ZAPADNIUK VI, PASECHNIK IK, et al. [Cholagogue effect of Bupleurum exaltatum, Agrimonia asiatica, Leontopodium ochroleucum, and Veronica virginica.]. Farmakol Toksikol 1957;20(1):75-77. View abstract.
  • Cho YM, Kwon JE, Lee M, et al. Agrimonia eupatoria L. (Agrimony) extract alters liver health in subjects with elevated alanine transaminase levels: A controlled, randomized, and double-blind trial. J Med Food. 2018;21(3):282-288. View abstract.
  • Copland A, Nahar L, Tomlinson CT, et al. Antibacterial and free radical scavenging activity of the seeds of Agrimonia eupatoria. Fitoterapia 2003;74:133-5. View abstract.
  • Ear candling. Health Canada, December 2006. Available at: https://www.hc-sc.gc.ca/iyh-vsv/med/ear-oreille_e.html (Accessed 8 January 2008).
  • Granica S, Krupa K, Klebowska A, Kiss A. Development and validation of HPLC-DAD-CAD-MS(3) method for qualitative and quantitative standardization of polyphenols in Agrimoniae eupatoriae herba. J Pharmaceut Biomed Anal 2013;86:112-22. View abstract.
  • Gray AM, Flatt PR. Actions of the traditional anti-diabetic plant, Agrimony eupatoria (agrimony): effects on hyperglycaemia, cellular glucose metabolism and insulin secretion. Br J Nutr 1998;80:109-14. View abstract.
  • Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia 1990;33:462-4. View abstract.
  • Venskutonis PR, Skemaite M, Ragazinskiene O. Radical scavenging capacity of Agrimonia eupatoria and Agrimonia procera. Fitoterapia 2007;78:166-8. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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