CHIRATA

OTHER NAME(S):

Bitter Stick, Bitterstick, Chirayta, Chiretta, Chirette, Chirette des Indes, East Indian Balmony, Genciana de la India, Gentiana chirata, Gentiana chirayita, Indian Bolonong, Indian Gentian, Kairata, Kirata, Swertia chirata, Swertia chirayita, Yin Du Zhang Ya Cai.<br/><br/>

Overview

Overview Information

Chirata is an herb. People use the parts that grow above the ground to make medicine.

Chirata is used for fever, constipation, upset stomach, loss of appetite, intestinal worms, skin diseases, and cancer. Some people use it as “a bitter tonic.”

In India, it has been used for malaria, when combined with the seeds of divi-divi (Guilandina bonducella).

In manufacturing, chirata is used in alcoholic and non-alcoholic beverages.

How does it work?

Chirata contains a chemical that may help reduce swelling (inflammation) and might also fight malaria.

Uses

Uses & Effectiveness?

Insufficient Evidence for

More evidence is needed to rate the effectiveness of chirata for these uses.

Side Effects

Side Effects & Safety

Chirata is LIKELY SAFE when taken by mouth in the amounts found in beverages. However, there isn't enough information available to know if chirata is safe in larger medicinal amounts.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking chirata if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Diabetes. Chirata might lower blood sugar levels in some people. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use chirata as a medicine.

Intestinal (duodenal) ulcers: Chirata can make ulcers in the intestine worse.

Surgery. Chirata might lower blood sugar. In theory, chirata might interfere with blood sugar control during and after surgical procedures. Stop using chirata as a medicine at least two weeks before a scheduled surgery.

Interactions

Interactions?

We currently have no information for CHIRATA Interactions.

Dosing

Dosing

The appropriate dose of chirata for use as treatment depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for chirata. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Anon. Bitter fraction of Swertia chirata can prevent carcinogenic risk due to DMBA exposure. INDIAN JOURNAL OF MEDICAL RESEARCH 2005;121:135.
  • Awasthi AK, Bisht GS Anroop B. In vitro antimicrobial activity of Swertia chirata. Indian Journal of Natural Products 2005;21:27-29.
  • Balaraju K, Agastian P Ignacimuthu S. Micropropagation of Swertia chirata Buch.-Hams. ex Wall.: a critically endangered medicinal herb. ACTA PHYSIOLOGIAE PLANTARUM 2009;31(3):487-494.
  • BENNAROCHE L, VERNEY AM DEFAYE G DEBELMAS AM. TRITERPENES OF GENTIANACEES - SWERTIA-CHIRATA HAM. COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L ACADEMIE DES SCIENCES SERIE D 1975;280(21):2493-2495.
  • Bhandari P, Kumar N Gupta AP Singh B Kaul VK. Micro-LC determination of swertiamarin in Swertia species and bacoside-A in Bacopa monnieri. CHROMATOGRAPHIA 2006;64(9-10):599-602.
  • Bhattacharya, S. K., Reddy, P. K., Ghosal, S., Singh, A. K., and Sharma, P. V. Chemical constituents of Gentianaceae XIX: CNS-depressant effects of swertiamarin. J.Pharm.Sci. 1976;65(10):1547-1549. View abstract.
  • CHAKRAVARTY AK, DAS B MASUDA K AGETA H. CHIRATENOL, A NOVEL REARRANGED HOPANE TRITERPENOID FROM SWERTIA-CHIRATA. TETRAHEDRON LETTERS 1990;31(52):7649-7652.
  • CHAKRAVARTY AK, DAS B PAKRASHI SC MCPHAIL DR MCPHAIL AT. X-RAY CRYSTAL-STRUCTURE OF SWERTANONE, A TRITERPENE OF NEW SKELETAL TYPE FROM SWERTIA-CHIRATA BUCH HAM. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS 4-1-1989;7:438-440.
  • CHAKRAVARTY AK, MUKHOPADHYAY S DAS B. SWERTANE TRITERPENOIDS FROM SWERTIA-CHIRATA. PHYTOCHEMISTRY 1991;30(12):4087-4092.
  • CHAKRAVARTY AK, MUKHOPADHYAY S MASUDA K AGETA H. KAIRATENOL, YET ANOTHER NOVEL MIGRATED GAMMACERANE TRITERPENOID FROM SWERTIA-CHIRATA. TETRAHEDRON LETTERS 1-1-1992;33(1):125-126.
  • CHAKRAVARTY AK, MUKHOPADHYAY S MOITRA SK DAS B. (-)-SYRINGARESINOL, A HEPATOPROTECTIVE AGENT AND OTHER CONSTITUENTS FROM SWERTIA-CHIRATA. INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY 1994;33(4):405-408.
  • Chakravarty AK, Sarkar T Das B Masuda K Shiojima K. A new chiratane triterpenoid from Swertia chirata. INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY. 2001;40(3):228-231.
  • CHAUDHURI PK, DANIEWSKI WM. UNAMBIGUOUS ASSIGNMENTS OF THE H-1 AND C-13 CHEMICAL-SHIFTS OF THE MAJOR BITTER PRINCIPLE OF SWERTIA-CHIRATA BY 2D NMR-STUDY AND CHARACTERIZATION OF OTHER CONSTITUENTS. POLISH JOURNAL OF CHEMISTRY 1995;69(11):1514-1519.
  • Chaudhuri RK, Pal A Jha TB. Conservation of Swertia chirata through direct shoot multiplication from leaf explants. PLANT BIOTECHNOLOGY REPORTS 2008;2(3):213-218.
  • Chaudhuri RK, Pal A Jha TB. Production of genetically uniform plants from nodal explants of Swertia chirata Buch.-Ham. ex Wall. - an endangered medicinal herb. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT 2007;43(5):467-472.
  • Chaudhuri RK, Pal A Jha TB. Regeneration and characterization of Swertia chirata Buch.-Ham. Ex Wall. plants from immature seed cultures. SCIENTIA HORTICULTURAE 3-3-2009;120(1):107-114.
  • DALAL SR, SHAH RC. SWERCHIRIN, A NEW XANTHONE FROM SWERTIA-CHIRATA. CHEMISTRY & INDUSTRY 1956;26:664.
  • Ghosal, S., Sharma, P. V., Chaudhuri, R. K., and Bhattacharya, S. K. Chemical constituents of the gentianaceae V: tetraoxygenated xanthones of Swertia chirata Buch.-Ham. J.Pharm.Sci. 1973;62(6):926-930. View abstract.
  • Gowadia N, Vasudevan TN. Studies on effect of some medicinal plants on pancreatic lipase activity using spectrophotometric method. ASIAN JOURNAL OF CHEMISTRY 2000;12(3):847-852.
  • Hussain AI, Anwar F Bhatti HN Rashid U. Phytochemical and in vitro anthelmintic screening of Butea frondosa and Swertia chirata from Pakistan. JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN 2006;28(1):84-92.
  • Iqbal, Z., Lateef, M., Khan, M. N., Jabbar, A., and Akhtar, M. S. Anthelmintic activity of Swertia chirata against gastrointestinal nematodes of sheep. Fitoterapia 2006;77(6):463-465. View abstract.
  • Joshi P, Dhawan V. Swertia chirayita - an overview. CURRENT SCIENCE 8-25-2005;89(4):635-640.
  • Karan, M., Vasisht, K., and Handa, S. S. Antihepatotoxic activity of Swertia chirata on carbon tetrachloride induced hepatotoxicity in rats. Phytother.Res. 1999;13(1):24-30. View abstract.
  • Karan, M., Vasisht, K., and Handa, S. S. Antihepatotoxic activity of Swertia chirata on paracetamol and galactosamine induced hepatotoxicity in rats. Phytother.Res. 1999;13(2):95-101. View abstract.
  • Keil, M., Hartle, B., Guillaume, A., and Psiorz, M. Production of amarogentin in root cultures of Swertia chirata. Planta Med. 2000;66(5):452-457. View abstract.
  • Khanom, F., Kayahara, H., and Tadasa, K. Superoxide-scavenging and prolyl endopeptidase inhibitory activities of Bangladeshi indigenous medicinal plants. Biosci.Biotechnol.Biochem. 2000;64(4):837-840. View abstract.
  • Khanom, F., Kayahara, H., and Tadasa, K. Tyrosinase inhibitory activity of Bangladeshi indigenous medicinal plants. Biosci.Biotechnol.Biochem. 2000;64(9):1967-1969. View abstract.
  • Koul, S., Suri, K. A., Dutt, P., Sambyal, M., Ahuja, A., and Kaul, M. K. Protocol for in vitro regeneration and marker glycoside assessment in Swertia chirata Buch-Ham. Methods Mol.Biol. 2009;547:139-153. View abstract.
  • Madhuri S, Pandey G. Some dietary agricultural plants with anticancer properties. PLANT ARCHIVES 2008;8(1):13-16.
  • Manjunath KP, Shivakumar H Prakash T Patil KS Rao RN et al. Anthelmintic activity of roots of <it>Swertia chirata</it>. Indian Journal of Natural Products 2006;22:8-10.
  • Medda, S., Mukhopadhyay, S., and Basu, M. K. Evaluation of the in-vivo activity and toxicity of amarogentin, an antileishmanial agent, in both liposomal and niosomal forms. J.Antimicrob.Chemother. 1999;44(6):791-794. View abstract.
  • Mukherjee B, Mukherjee SK. Blood sugar lowering activity of Swertia chirata (Buch.-Ham.) extract. Int.J.Crude Drug Res. 1987;25:97-102.
  • Mukherjee, S., Sur, A., and Maiti, B. R. Hepatoprotective effect of Swertia chirata on rat. Indian J.Exp.Biol. 1997;35(4):384-388. View abstract.
  • Pant N, Jain DC Bhakuni RS. Phytochemicals from genus Swertia and their biological activities. SO INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY 2000;39(8):565-586.
  • Pant N, Jain DC Bhakuni RS. Some chemical constituents of Swertia chirata. INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY 2002;41(9):1980-1986.
  • Prashanth, D., Amit, A., Samiulla, D. S., Asha, M. K., and Padmaja, R. alpha-Glucosidase inhibitory activity of Mangifera indica bark. Fitoterapia 2001;72(6):686-688. View abstract.
  • Rafatullah, S., Tariq, M., Mossa, J. S., al-Yahya, M. A., al-Said, M. S., and Ageel, A. M. Protective effect of Swertia chirata against indomethacin and other ulcerogenic agent-induced gastric ulcers. Drugs Exp.Clin.Res. 1993;19(2):69-73. View abstract.
  • Rai LK, Prasad P Sharma E. Conservation threats to some important medicinal plants of the Sikkim Himalaya. BIOLOGICAL CONSERVATION 2000;93(1):27-33.
  • Rao TVRK, Das M. In-vitro inhibition of mineralisation of urinary stone forming minerals by some medicinal plant extracts. ASIAN JOURNAL OF CHEMISTRY 2000;12(3):719-722.
  • Rawat MSM, Dutt KR. Comparison of ethyl acetate extracts of Allium cepa bulbs, Luffa acutangula fruits, Nyctanthes arbostristis leaves, Swertia chirata twigs and Woodfordia floribunda leaves with Silymarin for hepatoprotective activity. PLANT ARCHIVES 2007;7(1):183-186.
  • Ray, S., Majumder, H. K., Chakravarty, A. K., Mukhopadhyay, S., Gil, R. R., and Cordell, G. A. Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani. J.Nat.Prod. 1996;59(1):27-29. View abstract.
  • Reen, R. K., Karan, M., Singh, K., Karan, V., Johri, R. K., and Singh, J. Screening of various Swertia species extracts in primary monolayer cultures of rat hepatocytes against carbon tetrachloride- and paracetamol-induced toxicity. J.Ethnopharmacol. 2001;75(2-3):239-247. View abstract.
  • Saha, P. and Das, S. Regulation of hazardous exposure by protective exposure: modulation of phase II detoxification and lipid peroxidation by Camellia sinensis and Swertia chirata. Teratog.Carcinog.Mutagen. 2003;Suppl 1:313-322. View abstract.
  • Saha, P., Mandal, S., Das, A., and Das, S. Amarogentin can reduce hyperproliferation by downregulation of Cox-II and upregulation of apoptosis in mouse skin carcinogenesis model. Cancer Lett. 12-8-2006;244(2):252-259. View abstract.
  • Saha, P., Mandal, S., Das, A., Das, P. C., and Das, S. Evaluation of the anticarcinogenic activity of Swertia chirata Buch.Ham, an Indian medicinal plant, on DMBA-induced mouse skin carcinogenesis model. Phytother.Res. 2004;18(5):373-378. View abstract.
  • Scartezzini, P. and Speroni, E. Review on some plants of Indian traditional medicine with antioxidant activity. J Ethnopharmacol. 2000;71(1-2):23-43. View abstract.
  • Sekar, B. C., Mukherjee, B., Chakravarti, R. B., and Mukherjee, S. K. Effect of different fractions of Swertia chirayita on the blood sugar level of albino rats. J.Ethnopharmacol. 1987;21(2):175-181. View abstract.
  • Sharma PV. Alkaloids of Swertia chirata Buch.-Ham. Indian Journal of Pharmaceutical Sciences 1982;44:36.
  • Singha UK, Guru PY Sen AB Tandon JS. Antileishmanial activity of traditional plants against Leishmania donovani in golden hamsters. International Journal of Pharmacognosy 1992;30:289-295.
  • Suryawanshi, S., Asthana, R. K., and Gupta, R. C. Assessment of systemic interaction between Swertia chirata extract and its Bioactive constituents in rabbits. Phytother.Res. 2009;23(7):1036-1038. View abstract.
  • Suryawanshi, S., Asthana, R. K., and Gupta, R. C. Simultaneous estimation of mangiferin and four secoiridoid glycosides in rat plasma using liquid chromatography tandem mass spectrometry and its application to pharmacokinetic study of herbal preparation. J.Chromatogr.B Analyt.Technol.Biomed.Life Sci. 10-15-2007;858(1-2):211-219. View abstract.
  • Suryawanshi, S., Mehrotra, N., Asthana, R. K., and Gupta, R. C. Liquid chromatography/tandem mass spectrometric study and analysis of xanthone and secoiridoid glycoside composition of Swertia chirata, a potent antidiabetic. Rapid Commun.Mass Spectrom. 2006;20(24):3761-3768. View abstract.
  • Tripathi R, Mohan H Kamat JP. Modulation of oxidative damage by natural products. FOOD CHEMISTRY 2007;100(1):81-90.
  • Verma, H., Patil, P. R., Kolhapure, R. M., and Gopalkrishna, V. Antiviral activity of the Indian medicinal plant extract Swertia chirata against herpes simplex viruses: a study by in-vitro and molecular approach. Indian J.Med.Microbiol. 2008;26(4):322-326. View abstract.
  • Vishwakarma SL, Bagul MS Rajani M Goyal RK. A sensitive HPTLC method for estimation of Swertiamarin in Enicostemma littorale Blume, Swertia chirata (Wall) Clarke, and in formulations containing E-littorale. JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC 2004;17(2):128-131.
  • Wang CZ, Maier UH Eisenreich W Adam P Obersteiner I Keil M Bacher A Zenk MH. Unexpected biosynthetic precursors of amarogentin - A retrobiosynthetic C-13 NMR study. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2001;8:1459-1465.
  • Wang, C. Z., Maier, U. H., Keil, M., Zenk, M. H., Bacher, A., Rohdich, F., and Eisenreich, W. Phenylalanine-independent biosynthesis of 1,3,5,8-tetrahydroxyxanthone. A retrobiosynthetic NMR study with root cultures of Swertia chirata. Eur.J.Biochem. 2003;270(14):2950-2958. View abstract.
  • Wang, Z., Ma, C., Tang, S., Xiao, H., Kakiuchi, N., Kida, H., and Hattori, M. Qualitative and quantitative analysis of Swertia herbs by high performance liquid chromatography-diode array detector-mass spectrometry (HPLC-DAD-MS). Chem.Pharm.Bull.(Tokyo) 2008;56(4):485-490. View abstract.
  • Wawrosch C, Hugh-Bloch A Hostettmann K Kopp B. <it>Swertia chirata</it> Buch.-Ham. ex Wall. (Gentianaceae). an endangered Himalayan medicinal plant: comparative study of the secondary compound patterns in market drug, in vitro-cultivated, and micropropagated field grown samples. Scientia Pharmaceutica 2005;73:127-137.
  • Wawrosch C, Maskay N Kopp B. Micropropagation of the threatened Nepalese medicinal plant Swertia chirata Buch.-Ham. ex Wall. PLANT CELL REPORTS 1999;18(12):997-1001.
  • Yarnell E, Abascal K. Botanical treatment and prevention of malaria: part 2 -- selected botanicals. Alternative & Complementary Therapies 2004;10(5):277-284.
  • Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  • Franklyn AJ, Bettenridge J, Daykin J, et al. Long-term thyroxine treatment and bone mineral density. Lancet 1992;340:9-13. View abstract.
  • Williamson EM, Evans FJ, eds. Potter's New Cyclopaedia of Botanical Drugs and Preparations. Essex, England: CW Daniel Company Ltd., 1998.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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