People use bupleurum for liver infections, respiratory infections, digestion problems, menstrual problems, and many other conditions, but there is no good scientific evidence to support these uses.
How does it work ?
Uses & Effectiveness ?
Insufficient Evidence for
- Depression. Studies from China show that Chinese herbal combinations which include bupleurum might help reduce symptoms of depression, especially when combined with conventional antidepressant medicines.
- Swelling (inflammation) of the liver caused by the hepatitis B virus (hepatitis B). Early research shows that an herbal combination containing bupleurum (Sho-saiko-to) might help the body to fight off chronic hepatitis B infection.
- Flu (influenza). Early research shows that an herbal combination containing bupleurum (chima qingwen) might help the body to fight off a type of flu known as H1N1.
- Liver cancer. People with hepatitis B can develop liver scarring (cirrhosis), which can increase their risk of developing liver cancer. Early research shows that an herbal combination containing bupleurum (Sho-saiko-to) can reduce the risk of liver cancer in some people with hepatitis B and cirrhosis.
- Chest pain (angina).
- High cholesterol.
- Joint pain (rheumatism).
- Liver disorders.
- Loss of appetite.
- Muscle cramps.
- Painful periods (dysmenorrhea).
- Premenstrual syndrome (PMS).
- Ringing in the ears.
- Stimulating the adrenal gland.
- The common cold.
- Trouble sleeping (insomnia).
- Other conditions.
Special Precautions and Warnings
"Auto-immune diseases" such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: Bupleurum might cause the immune system to become more active, and this could increase the symptoms of auto-immune diseases. If you have one of these conditions, it's best to avoid using bupleurum.
Bleeding disorders: Chemicals in bupleurum, called saikosaponins, might slow blood clotting. In theory, taking bupleurum might make bleeding disorders worse.
Diabetes: Chemicals in bupleurum, called saikosaponins, might slow blood clotting. Monitor your blood sugar carefully if you have diabetes and use bupleurum. The dose of your diabetes medication may need to be changed.
Surgery: Chemicals in bupleurum called saikosaponins might prolong bleeding. Stop taking saikosaponins at least two weeks before a scheduled surgery.
Medications that decrease the immune system (Immunosuppressants) interacts with BUPLEURUM
Bupleurum might increase the immune system. By increasing the immune system, bupleurum might decrease the effectiveness of medications that are used to decrease the immune system.
Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.
Medications for diabetes (Antidiabetes drugs) interacts with BUPLEURUM
Chemicals in bupleurum, called saikosaponins, might increase blood sugar. Diabetes medications are used to lower blood sugar. Taking bupleurum along with diabetes medications might interfere with blood sugar control. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with BUPLEURUM
Chemicals in bupleurum, called saikosaponins, might slow blood clotting. Taking bupleurum along with medications that also slow blood clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin; clopidogrel (Plavix); nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others); dalteparin (Fragmin); enoxaparin (Lovenox); heparin; warfarin (Coumadin); and others.
Be cautious with this combination
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