BUPLEURUM

OTHER NAME(S):

Bei Chai Hu, Bupleuri, Bupleurum Chinese, upleurum chinense, Bupleurum exaltatum, Bupleurum falcatum, Bupleurum fruticosum, Bupleurum longifolium, Bupleurum multinerve, Bupleurum octoradiatum, Bupleurum rotundifolium, Bupleurum scorzonerifolium, Bupl&egrave;vre, Bupl&egrave;vre Chinois, Bupl&egrave;vre à Feuilles Rondes, Bupl&egrave;vre à Feuilles de Scorson&egrave;re, Bupl&egrave;vre à Longues Feuilles, Bupl&egrave;vre Ligneux, Chai Hu, Chi Hu, Chinese Bupleurum, Chinese Thoroughwax, Hare's Ear Root, Radix Bupleuri, Saiko, Shrubby Hare's-ear, Sickle-leaf Hare's-ear, Thoroughwax.<br/><br/>

Overview

Overview Information

Bupleurum is a plant. People use the root for medicine.

Bupleurum is used for respiratory infections, including the flu (influenza), swine flu, the common cold, bronchitis, and pneumonia; and symptoms of these infections, including fever and cough.

Some people use bupleurum for digestion problems including indigestion, diarrhea, and constipation.

Women sometimes use it for premenstrual syndrome (PMS) and painful periods (dysmenorrhea).

Bupleurum is also used for fatigue, headache, ringing in the ears (tinnitus), trouble sleeping (insomnia), depression, liver disorders, and loss of appetite (anorexia).

Other uses include treatment of cancer, malaria, chest pain (angina), epilepsy, pain, muscle cramps, joint pain (rheumatism), asthma, ulcers, hemorrhoids, and high cholesterol.

Bupleurum is included in many herbal combination products. For example, it is included in a Chinese herbal formula used for treating a blood disorder called thrombocytopenic purpura and in a Japanese herbal formula (Sho-saiko-to, TJ-9, Xiao-chai-hu-tang) used for treating various chronic liver diseases such as hepatitis. Sho-saiko-to is currently being evaluated in a phase II trial at Memorial Sloan-Kettering Cancer Center for use in treating hepatitis C.

Bupleurum is also used in combination with Panax ginseng and licorice to help stimulate adrenal gland function, particularly in patients with a history of long-term use of corticosteroid drugs.

How does it work?

Bupleurum might stimulate the cells of the immune system to work harder. It might also have other effects, but none of these are proven in humans.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Fevers.
  • Flu.
  • The common cold.
  • Cough.
  • Fatigue.
  • Headache.
  • Ringing in the ears.
  • Liver disorders.
  • Blood disorders.
  • Stimulating the immune system.
  • Other conditions.
More evidence is needed to rate the effectiveness of bupleurum for these uses.

Side Effects

Side Effects & Safety

There isn't enough information to know if bupleurum is safe. However, some side effects have been reported, including increased bowel movements, intestinal gas, and drowsiness. In combination with other herbs, such as in the Japanese herbal formula called Sho-saiko-to, it has caused serious lung and breathing problems.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking bupleurum if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

“Auto-immune diseases” such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: Bupleurum might cause the immune system to become more active, and this could increase the symptoms of auto-immune diseases. If you have one of these conditions, it’s best to avoid using bupleurum.

Bleeding disorders: Chemicals in bupleurum, called saikosaponins, might slow blood clotting. In theory, taking bupleurum might make bleeding disorders worse.

Diabetes: Chemicals in bupleurum, called saikosaponins, might slow blood clotting. Monitor your blood sugar carefully if you have diabetes and use bupleurum. The dose of your diabetes medication may need to be changed.

Surgery: Chemicals in bupleurum called saikosaponins might prolong bleeding. Stop taking saikosaponins at least two weeks before a scheduled surgery.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Medications that decrease the immune system (Immunosuppressants) interacts with BUPLEURUM

    Bupleurum might increase the immune system. By increasing the immune system, bupleurum might decrease the effectiveness of medications that are used to decrease the immune system.<br/><br/> Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.

Dosing

Dosing

The appropriate dose of bupleurum depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for bupleurum. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Abe H, Orita M, Konishi H, and et al. Effects of saikosaponin-d on aminonucleoside nephrosis in rats. Eur J Pharmacol 1-21-1986;120(2):171-178. View abstract.
  • Abe H, Sakaguchi M, Anno M, and et al. Erythrocyte membrane stabilization by plant saponins and sapogenins. Naunyn Schmiedebergs Arch Pharmacol. 1981;316(3):262-265. View abstract.
  • Abe, H., Sakaguchi, M., Odashima, S., and Arichi, S. Protective effect of saikosaponin-d isolated from Bupleurum falcatum L. on CCl4-induced liver injury in the rat. Naunyn Schmiedebergs Arch.Pharmacol 1982;320(3):266-271. View abstract.
  • Cao, S. L., Chen, E., Zhang, Q. Z., and Jiang, X. G. A novel nasal delivery system of a Chinese traditional medicine, Radix Bupleuri, based on the concept of ion-activated in situ gel. Arch Pharm.Res 2007;30(8):1014-1019. View abstract.
  • Chin, H. W., Lin, C. C., and Tang, K. S. The hepatoprotective effects of Taiwan folk medicine ham-hong-chho in rats. Am J Chin Med. 1996;24(3-4):231-240. View abstract.
  • Duan, Y., Zhao, X., Xu, X., Yang, J., and Li, Z. Treatment of primary thrombocytopenic purpura by modified minor decoction of bupleurum. J Tradit.Chin Med. 1995;15(2):96-98. View abstract.
  • Fujiwara K and Ogihara Y. Pharmacological effects of oral saikosaponin a may differ depending on conditions of the gastrointestinal tract. Life Sci 7-28-1986;39(4):297-301. View abstract.
  • Haranaka, K., Satomi, N., Sakurai, A., Haranaka, R., Okada, N., and Kobayashi, M. Antitumor activities and tumor necrosis factor producibility of traditional Chinese medicines and crude drugs. Cancer Immunol Immunother. 1985;20(1):1-5. View abstract.
  • He, Y., Hu, Z. F., Li, P., Xiao, C., Chen, Y. W., Li, K. M., Guo, J. Z., Pan, L., and Xiong, J. P. [Experimental study of saikosaponin-D (SSd) on lipid peroxidation of hepatic fibrosis on rat]. Zhongguo Zhong.Yao Za Zhi. 2008;33(8):915-919. View abstract.
  • Hiai S, Yokoyama H, Nagasawa T, and et al. Stimulation of the pituitary-adrenocortical axis by saikosaponin of Bupleuri radix. Chemical and Pharmaceutical Bulletin (Tokyo) 1981;29(2):495-499. View abstract.
  • Hirayama, C., Okumura, M., Tanikawa, K., and et al. A multicenter randomized controlled clinical trial of Shosaiko-to in chronic active hepatitis. Gastroenterol Jpn 1989;24(6):715-719. View abstract.
  • Hsu, Y. L., Kuo, P. L., Weng, T. C., Yen, M. H., Chiang, L. C., and Lin, C. C. The antiproliferative activity of saponin-enriched fraction from Bupleurum Kaoi is through Fas-dependent apoptotic pathway in human non-small cell lung cancer A549 cells. Biol Pharm Bull. 2004;27(7):1112-1115. View abstract.
  • Hung CR, Wu TS, and Chang TY. Comparison between the effects of crude saikosaponin and 16, 16-dimethyl prostaglandin E2 on tannic acid-induced gastric mucosal damage in rats. Chin J Physiol 1993;36(4):211-217. View abstract.
  • Kakumu S, Yoshioka K, Wakita T, and et al. Effects of TJ-9 Sho-saiko-to (kampo medicine) on interferon gamma and antibody production specific for hepatitis B virus antigen in patients with type B chronic hepatitis. Int J Immunopharmacol 1991;13(2-3):141-146. View abstract.
  • Kida, H., Akao, T., Meselhy, M. R., and Hattori, M. Enzymes responsible for the metabolism of saikosaponins from Eubacterium sp. A-44, a human intestinal anaerobe. Biol.Pharm.Bull 1997;20(12):1274-1278. View abstract.
  • Liang, H., Zhao, Y., Bai, Y., Zhang, R., and Tu, G. [A new saikosaponin from Bupleurum chinense DC.]. Yao Xue.Xue.Bao. 1998;33(4):282-285. View abstract.
  • Liang, H., Zhao, Y., Qiu, H., Huang, J., and Zhang, R. [A new saikosaponin from Bupleurum Chinese DC]. Yao Xue.Xue.Bao. 1998;33(1):37-41. View abstract.
  • Lin CC, Chiu HF, Ye MH, and et al. The pharmacological and pathological studies on Taiwan folk medicine (III): The effects of bupleurum kaoi and cultivated bupleurum falcatum var. komarowi. Am J Chin Med 1990;18(3-4):105-112. View abstract.
  • Matsuura K, Kawakita T, Nakai S, and et al. Role of B-lymphocytes in the immunopharmacological effects of a traditional Chinese medicine, xiao-chai-hu-tang (shosaiko-to). Int J Immunopharmacol 1993;15(2):237-243. View abstract.
  • Motoo Y and Sawabu N. Antitumor effects of saikosaponins, baicalin and baicalein on human hepatoma cell lines. Cancer Lett 10-28-1994;86(1):91-95. View abstract.
  • Nose, M., Amagaya, S., and Ogihara, Y. Corticosterone secretion-inducing activity of saikosaponin metabolites formed in the alimentary tract. Chem.Pharm.Bull (Tokyo) 1989;37(10):2736-2740. View abstract.
  • Oka H, Yamamoto S, Kuroki T, and et al. Prospective study of chemoprevention of hepatocellular carcinoma with Sho-saiko-to (TJ-9). Cancer 9-1-1995;76(5):743-749. View abstract.
  • Shimizu K, Amagaya S, and Ogihara Y. Structural transformation of saikosaponins by gastric juice and intestinal flora. J Pharmacobiodyn 1985;8(9):718-725. View abstract.
  • Sugiyama H, Nagai M, Kotajima F, and et al. [A case of interstitial pneumonia with chronic hepatitis C following interferon-alfa and sho-saiko-to therapy]. Arerugi 1995;44(7):711-714. View abstract.
  • Sun XB, Matsumoto T, and Yamada H. Effects of a polysaccharide fraction from the roots of Bupleurum falcatum L. on experimental gastric ulcer models in rats and mice. J Pharm Pharmacol 1991;43(10):699-704. View abstract.
  • Tajiri, H., Kozaiwa, K., Ozaki, Y., Miki, K., Shimuzu, K., and Okada, S. Effect of sho-saiko-to(xiao-chai-hu-tang) on HBeAg clearance in children with chronic hepatitis B virus infection and with sustained liver disease. Am J Chin Med 1991;19(2):121-129. View abstract.
  • Takagi K and Shibata M. [Pharmacological studies on Bupleurum falcatum L. I. Acute toxicity and central depressant action of crude saikosides]. Yakugaku Zasshi 1969;89(5):712-720. View abstract.
  • Tanaka S, Takahashi A, Onoda K, and et al. [Toxicological studies on biological effects of the herbal drug extracts in rats and mice. II. Moutan bark, Glycyrrhiza and Bupleurum root]. Yakugaku Zasshi 1986;106(8):671-686. View abstract.
  • Ushio Y and Abe H. Inactivation of measles virus and herpes simplex virus by saikosaponin d. Planta Med 1992;58(2):171-173. View abstract.
  • Ushio Y and Abe H. The effects of saikosaponin on macrophage functions and lymphocyte proliferation. Planta Med 1991;57(6):511-514. View abstract.
  • Wu, S. J., Lin, Y. H., Chu, C. C., Tsai, Y. H., and Chao, J. C. Curcumin or saikosaponin a improves hepatic antioxidant capacity and protects against CCl4-induced liver injury in rats. J Med.Food 2008;11(2):224-229. View abstract.
  • Xie, Y., Lu, W., Cao, S., Jiang, X., Yin, M., and Tang, W. Preparation of bupleurum nasal spray and evaluation on its safety and efficacy. Chem Pharm Bull.(Tokyo) 2006;54(1):48-53. View abstract.
  • Yokoyama H, Hiai S, and Oura H. Chemical structures and corticosterone secretion-inducing activities of saikosaponins. Chem Pharm Bull (Tokyo) 1981;29(2):500-504. View abstract.
  • Zhang, S., Cheng, Z., Huang, B., and Li, J. [The effect of he jie decoction on the TCRV beta 7 of chronic hepatitis B patients]. Zhong.Yao Cai. 2002;25(6):451-453. View abstract.
  • Zong Z, Fujikawa-Yamamoto K, Tanino M, and et al. Saikosaponin b2-induced apoptosis of cultured B16 melanoma cell line through down-regulation of PKC activity. Biochem Biophys Res Commun 2-15-1996;219(2):480-485. View abstract.
  • Ahn BZ, Yoon YD, Lee YH, et al. Inhibitory effect of bupleuri radix saponins on adhesion of some solid tumor cells and relation to hemolytic action: screening of 232 herbal drugs for anti-cell adhesion. Planta Med 1998;64:220-4. View abstract.
  • Bermejo Benito P, Abad Martinez MJ, Silvan Sen AM, et al. In vivo and in vitro antiinflammatory activity of saikosaponins. Life Sci 1998;63:1147-56. View abstract.
  • Bupleurum falcatum Bitter & cool. The Australian Naturopath Network web site. Available at: www.comcen.com.au/~sburgess/herbs/Monographs/bupleuru.htm
  • Chang WC, Hsu FL. Inhibition of platelet activation and endothelial cell injury by flavan-3-ol and saikosaponin compounds. Prostaglandins Leukot Essent Fatty Acids 1991;44:51-6. View abstract.
  • Chitturi S, Farrell GC. Hepatotoxic slimming aids and other herbal hepatotoxins. J Gastroenterol Hepatol 2008;23:366-73. View abstract.
  • Chiu HF, Lin CC, Yen MH, et al. Pharmacological and pathological studies on hepatic protective crude drugs from Taiwan (V): The effects of Bombax malabarica and Scutellaria rivularis. Am J Chin Med 1992;20:257-64. View abstract.
  • Daibo A, Yoshida Y, Kitazawa S, et al. [A case of pneumonitis and hepatic injury caused by a herbal drug (sho-saiko-to)]. Nippon Kyobu Shikkan Gakkai Zasshi 1992;30:1583-8. View abstract.
  • Estevez-Braun A, Estevez-Reyes R, Moujir LM, et al. Antibiotic activity and absolute configuation of 8S-heptadeca-2(Z),9(Z)-diene-4,6-diyne-1,8-diol from Bupleurum salicifolium. J Nat Prod 1994;57:1178-82. View abstract.
  • Guinea MC, Parellada J, Lacaille-Dubois MA, Wagner H. Biologically active triterpene saponins from Bupleurum fruticosum. Planta Med 1994;60:163-7. View abstract.
  • Hattori T, Ito M, Suzuki Y. [Studies on antinephritic effects of plant components in rats (1). Effects of saikosaponins original-type anti-GBM nephritis in rats and its mechanisms]. Nippon Yakurigaku Zasshi 1991;97:13-21. View abstract.
  • Ishizaki T, Sasaki F, Ameshima S, et al. Pneumonitis during interferon and/or herbal drug therapy in patients with chronic active hepatitis. Eur Respir J 1996;9:2691-6. View abstract.
  • Izumi S, Ohno N, Kawakita T, et al. Wide range of molecular weight distribution of mitogenic substance(s) in the hot water extract of a Chinese herbal medicine, Bupleurum chinense. Biol Pharm Bull 1997;20:759-64. View abstract.
  • Jing H, Jiang Y, Luo S. [Chemical constituents of the roots of Bupleurum longicaule Wall. ex DC. var. franchetii de Boiss and B. chaishoui Shan et Sheh]. Chung Kuo Chung Yao Tsa Chih 1996;21:739-41,762. View abstract.
  • Just MJ, Recio MC, Giner RM, et al. Anti-inflammatory activity of unusual lupane saponins from Bupleurum fruticescens. Planta Med 1998;64:404-7. View abstract.
  • Kato M, Pu MY, Isobe K, et al. Characterization of the immunoregulatory action of saikosaponin-d. Cell Immunol 1994;159:15-25. View abstract.
  • Kobashi Y, Nakajima M, Niki Y, Matsushima T. [A case of acute eosinophilic pneumonia due to Sho-saiko-to]. Nippon Kyobu Shikkan Gakkai Zasshi 1997;35:1372-7. View abstract.
  • Lorente I, Ocete MA, Zarzuelo A, et al. Bioactivity of the essential oil of Bupleurum fruticosum. J Nat Prod 1989;52:267-72. View abstract.
  • Martin S, Padilla E, Ocete MA, et al. Anti-inflammatory activity of the essential oil of Bupleurum fruticescens. Planta Med 1993;59:533-6. View abstract.
  • Matsumoto T, Moriguchi R, Yamada H. Role of polymorphonuclear leucocytes and oxygen-derived free radicals in the formation of gastric lesions induced by HCl/ethanol, and a possible mechanism of protection by anti-ulcer polysaccharide. J Pharm Pharmacol 1993;45:535-9. View abstract.
  • Matsumoto T, Yamada H. Regulation of immune complexes binding of macrophages by pectic polysaccharide from Bupleurum falcatum L.: pharmacological evidence for the requirement of intracellular calcium/calmodulin on Fc receptor up-regulation by bupleuran 2IIb. J Pharm Pharmacol 1995;47:152-6. View abstract.
  • Miyazaki E, Ando M, Ih K, et al. [Pulmonary edema associated with the Chinese medicine shosaikoto]. Nihon Kokyuki Gakkai Zasshi 1998;36:776-80. View abstract.
  • Nakagawa A, Yamaguchi T, Takao T, Amano H. [Five cases of drug induced pneumonitis due to Sho-saiko-to or interferon-alpha or both]. Nippon Kyobu Shikkan Gakkai Zasshi 1995;33:1361-6. View abstract.
  • Piras G, Makino M, Baba M. Sho-saiko-to, a traditional Kampo medicine, enhances the anti-HIV-1 activity of lamivudine (3TC) in vitro. Microbiol Immunol 1997;41:835-9. View abstract.
  • Sato A, Toyoshima M, Kondo A, et al. [Pneumonitis induced by the herbal medicine Sho-saiko-to in Japan]. Nippon Kyobu Shikkan Gakkai Zasshi 1997;35:391-5. View abstract.
  • Sugiyama H, Nagai M, Kotajima F, et al. [A case of interstitial pneumonia with chronic hepatitis C following interferon-alfa and sho-saiko-to therapy]. Arerugi 1995;44:711-4.
  • Ushio Y, Oda Y, Abe H. Effect of saikosaponin on the immune responses in mice. Int J Immunopharmacol 1991;13:501-8. View abstract.
  • Wada Y, Kubo M. [Acute lymphoblastic leukemia complicated by type C hepatitis during treatment and further by acute interstitial pneumonia due to sho-saiko-to in 7-year-old]. Arerugi 1997;46:1148-55. View abstract.
  • Yamada H. [Structure and pharmacological activity of pectic polysaccharides from the roots of Bupleurum falcatum L]. Nippon Yakurigaku Zasshi 1995;106:229-37. View abstract.
  • Yen MH, Lin CC, Chuang CH, Liu SY. Evaluation of root quality of Bupleurum species by TLC scanner and the liver protective effects of xiao-chai-hu-tang prepared using three different Bupleurum species. J Ethnopharmacol 1991;34:155-65. View abstract.
  • Zhang H, Huang J. Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases. Chung Hsi I Chieh Ho Tsa Chih 1990;10:278-9, 260. View abstract.

More Resources for BUPLEURUM

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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