Breitwegerich, Broadleaf Plantain, Common Plantain, Daun Sendok, Erva-De-Orelha, General Plantain, Grand Plantain, Greater Plantain, Groblad, Large Plantain, Lisan Al-Hamal, Llantén, Plantago major, Plantago Mayor, Plantain, Plantain à Bouquet, Plantain Commun, Plantain à Feuilles Larges, Plantain Majeur, Plantain des Oiseaux, Tanchagem, White Man's Foot.


Overview Information

Great plantain is a plant with broad leaves. It is native to Europe and parts of Asia. It now grows worldwide as a weed. The leaves and seed are used to make medicine. Be careful not to confuse great plantain with buckhorn plantain, water plantain, or other similar sounding medicines.

Great plantain is used for swelling (inflammation) of the bladder, hemorrhoids, stomach ulcers, common cold, irregular menstrual bleeding, and other conditions, but there is no good scientific evidence to support these uses.

How does it work?

Great plantain contains substances which might help decrease pain and swelling (inflammation), decrease mucous (phlegm) production, and open airways. It might also be able to kill bacteria and fungi.


Uses & Effectiveness?

Insufficient Evidence for

  • Swelling (inflammation) and sores inside the mouth (oral mucositis). Rinsing the mouth with a great plantain solution doesn't seem to heal mouth sores in people with cancer more than using mouth rinses containing sodium bicarbonate or chlorhexidine. But this study may have been too small to detect between group differences.
  • Swelling (inflammation) of the bladder (cystitis).
  • Constipation.
  • Hemorrhoids.
  • Diarrhea.
  • Stomach ulcers.
  • Upset stomach.
  • Diabetes.
  • Swelling (inflammation) of the main airways in the lung (bronchitis).
  • Common cold.
  • Irregular menstrual bleeding.
  • Liver problems.
  • Epilepsy.
  • Fever.
  • Skin conditions, when applied to the skin.
  • Pink eye or eye irritation, when applied to the eye.
  • Earache, when applied to the ear.
  • Toothache, when applied to the affected area.
  • Bad breath, when applied inside the mouth.
  • Other conditions.
More evidence is needed to rate the effectiveness of great plantain for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: There isn't enough reliable information to know if great plantain is safe. It might cause side effects such as diarrhea in some people.

When applied to the skin: There isn't enough reliable information to know if great plantain is safe when applied to the skin. It can cause allergic skin reactions in some people.

Special Precautions & Warnings:

Pregnancy: It's LIKELY UNSAFE to use great plantain if you are pregnant. Great plantain can affect the uterus and might increase the chance of having a miscarriage.

Breast-feeding: There isn't enough reliable information to know if great plantain is safe to use when breast-feeding. Stay on the safe side and avoid use.



Moderate Interaction

Be cautious with this combination

  • Warfarin (Coumadin) interacts with GREAT PLANTAIN

    Great plantain contains large amounts of vitamin K. Vitamin K is used by the body to help blood clot. Warfarin (Coumadin) is used to slow blood clotting. By helping the blood clot, great plantain might decrease the effectiveness of warfarin (Coumadin). Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.



The appropriate dose of great plantain depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for great plantain. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Adom MB, Taher M, Mutalabisin MF, et al. Chemical constituents and medical benefits of Plantago major. Biomed Pharmacother. 2017;96:348-360. View abstract.
  • Cabrera-Jaime S, Martínez C, Ferro-García T, et al. Efficacy of Plantago major, chlorhexidine 0.12% and sodium bicarbonate 5% solution in the treatment of oral mucositis in cancer patients with solid tumour: A feasibility randomised triple-blind phase III clinical trial. Eur J Oncol Nurs. 2018;32:40-47. View abstract.
  • Chiang LC, Chiang W, Chang MY, Lin CC. In vitro cytotoxic, antiviral and immunomodulatory effects of Plantago major and Plantago asiatica. Am J Chin Med. 2003;31(2):225-34. View abstract.
  • Holetz FB, Pessini GL, Sanches NR, et al. Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases. Mem Inst Oswaldo Cruz 2002;97:1027-31. View abstract.
  • Lui MFG, Chow HKD, Wong WMK, Tsang WNW. Melatonin affects postural control in community-dwelling older adults while dual-tasking: a randomized observation study. J Aging Phys Act. 2018 May 29:1-24. View abstract.
  • Samuelsen AB. The traditional uses, chemical constituents and biological activities of Plantago major L. A review. J Ethnopharmacol. 2000;71(1-2):1-21. View abstract.
  • Sharma H, Yunus GY, Mohapatra AK, et al. Antimicrobial efficacy of three medicinal plants Glycyrrhiza glabra, Ficus religiosa, and Plantago major on inhibiting primary plaque colonizers and periodontal pathogens: An in vitro study. Indian J Dent Res. 2016;27(2):200-4. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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