GREAT PLANTAIN: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Great plantain (Plantago major) is a plant with broad leaves native to Europe and Asia. It now grows worldwide as a weed. It's also used as medicine.

Great plantain contains chemicals that might help decrease pain and swelling, decrease mucous, and open airways. It might also help kill bacteria and fungi.

People use great plantain for cough, mouth sores, obesity, abnormal menstrual bleeding, and many other conditions, but there is no good scientific evidence to support these uses.

Don't confuse great plantain with other plants also known as plantain, such as Asian water plantain, black psyllium, blond psyllium, buckhorn plantain, or buck's-horn plantain. These are not the same.

Uses & Effectiveness ?

We currently have no information for GREAT PLANTAIN overview.

Side Effects

When taken by mouth: Great plantain seed is possibly safe when used for 8-12 weeks. It's usually well-tolerated. There isn't enough reliable information to know if great plantain leaf or leaf extract is safe or what the side effects might be.

When applied to the skin: Great plantain cream is possibly safe when used for up to 2 weeks. It can cause allergic skin reactions in some people.

Special Precautions and Warnings

Pregnancy: It's likely unsafe to use great plantain while pregnant. Great plantain can affect the uterus and might increase the chance of having a miscarriage.

Breast-feeding: There isn't enough reliable information to know if great plantain is safe to use when breast-feeding. Stay on the safe side and avoid use.

Interactions ?

Moderate Interaction

Be cautious with this combination

Warfarin (Coumadin) interacts with GREAT PLANTAIN
Great plantain leaves contain large amounts of vitamin K. Vitamin K is used by the body to help blood clot. Warfarin is used to slow blood clotting. By helping the blood clot, great plantain leaves might decrease the effects of warfarin. Be sure to have your blood checked regularly. The dose of your warfarin might need to be changed.

Dosing

Great plantain seed has most often been used by adults in doses of 1000-1200 mg by mouth 2-3 times daily for 8-12 weeks. Great plantain is also used in mouthwashes and creams. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.

View References

REFERENCES:

Adom MB, Taher M, Mutalabisin MF, et al. Chemical constituents and medical benefits of Plantago major. Biomed Pharmacother. 2017;96:348-360. View abstract.

Baghizadeh A, Davati A, Heidarloo AJ, Emadi F, Aliasl J. Efficacy of Plantago major seed in management of ulcerative colitis symptoms: a randomized, placebo controlled, clinical trial. Complement Ther Clin Pract 2021;44:101444. View abstract.

Cabrera-Jaime S, Martínez C, Ferro-García T, et al. Efficacy of Plantago major, chlorhexidine 0.12% and sodium bicarbonate 5% solution in the treatment of oral mucositis in cancer patients with solid tumour: A feasibility randomised triple-blind phase III clinical trial. Eur J Oncol Nurs. 2018;32:40-47. View abstract.

Carnevali I, La Paglia R, Pauletto L, et al. Efficacy and safety of the syrup "KalobaTUSS®" as a treatment for cough in children: a randomized, double blind, placebo-controlled clinical trial. BMC Pediatr 2021;21(1):29. View abstract.

Chiang LC, Chiang W, Chang MY, Lin CC. In vitro cytotoxic, antiviral and immunomodulatory effects of Plantago major and Plantago asiatica. Am J Chin Med. 2003;31(2):225-34. View abstract.

Farid A, Sheibani M, Shojaii A, Noori M, Motevalian M. Evaluation of anti-inflammatory effects of leaf and seed extracts of Plantago major on acetic acid-induced ulcerative colitis in rats. J Ethnopharmacol 2022;298:115595. View abstract.

Ghanadian M, Soltani R, Homayouni A, Khorvash F, Jouabadi SM, Abdollahzadeh M. The Effect of Plantago major Hydroalcoholic Extract on the Healing of Diabetic Foot and Pressure Ulcers: A Randomized Open-Label Controlled Clinical Trial. Int J Low Extrem Wounds 2022. View abstract.

Ghiasian M, Niroomandi Z, Dastan D, Poorolajal J, Zare F, Ataei S. Clinical and phytochemical studies of Plantago major in pressure ulcer treatment: a randomized controlled trial. Complement Ther Clin Pract 2021;43:101325. View abstract.

Holetz FB, Pessini GL, Sanches NR, et al. Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases. Mem Inst Oswaldo Cruz 2002;97:1027-31. View abstract.

Jazayeri SF, Ghods R, Hashem Dabaghian F, et al. The efficacy of Plantago major seed on liver enzymes in nonalcoholic fatty liver disease: a randomized double-blind clinical trial. Evid Based Complement Alternat Med 2021;2021:6693887. View abstract.

Keshavarzi A, Montaseri H, Akrami R, et al. Therapeutic Efficacy of Great Plantain (Plantago major L.) in the Treatment of Second-Degree Burn Wounds: A Case-Control Study. Int J Clin Pract 2022;2022:4923277. View abstract.

Khodabakhsh M, Mahmoudinia M, Mousavi Bazaz M, et al. The effect of plantain syrup on heavy menstrual bleeding: A randomized triple blind clinical trial. Phytother Res. 2020;34(1):118-125. View abstract.

Najafian Y, Khorasani ZM, Najafi MN, Hamedi SS, Mahjour M, Feyzabadi Z. Efficacy of Aloe vera/ Plantago major gel in diabetic foot ulcer: a randomized double-blind clinical trial. Curr Drug Discov Technol. 2018 Jan 14. doi: 10.2174/1570163815666180115093007. View abstract.

Samuelsen AB. The traditional uses, chemical constituents and biological activities of Plantago major L. A review. J Ethnopharmacol. 2000;71(1-2):1-21. View abstract.

Sharma H, Yunus GY, Mohapatra AK, et al. Antimicrobial efficacy of three medicinal plants Glycyrrhiza glabra, Ficus religiosa, and Plantago major on inhibiting primary plaque colonizers and periodontal pathogens: An in vitro study. Indian J Dent Res. 2016;27(2):200-4. View abstract.

Skrypnik D, Skrypnik K, Pelczynska M, et al. The effect of Plantago major supplementation on leptin and VEGF-A serum levels, endothelial dysfunction and angiogenesis in obese women - a randomised trial. Food Funct 2021;12(4):1708-18. View abstract.

Soltani GM, Hemati S, Sarvizadeh M, Kamalinejad M, Tafazoli V, Latifi SA. Efficacy of the plantago major L. syrup on radiation induced oral mucositis in head and neck cancer patients: A randomized, double blind, placebo-controlled clinical trial. Complement Ther Med. 2020;51:102397. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

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GREAT PLANTAIN - Uses, Side Effects, and More