Chicken Collagen Type II, Chicken Type II Collagen, Colágeno de Pollo, Collagen II, Collagen Type II, Collagène de Poulet, Collagène de Type II, Collagène de Type II de Cartilage de Poulet, Collagène de Type II Hydrolysé, Hydrolyzed Chicken Collagen Type II, Hydrolyzed Collagen Type II, Type II Collagen.


Overview Information

Native collagen type II is a protein that is part of cartilage, bone, and other tissues in animals and humans. Most collagen type II in supplements comes from chicken. Some collagen type II comes from cows.

Collagen type II is used for osteoarthritis. It is also used for other types of joint and muscle pain, but there is no good scientific evidence to support these other uses.

How does it work?

Collagen type II is said to work by causing the body to produce substances that fight pain and swelling. But this is unproven.


Uses & Effectiveness?

Possibly Effective for

  • Osteoarthritis. Taking collagen type II by mouth for up to 6 months seems to improve self-reported symptoms of osteoarthritis such as stiffness and pain. It might work better than taking a combination of chondroitin sulfate and glucosamine. Most research has investigated a specific product called UC-II. But there's no evidence that collagen type II can prevent joint space narrowing in people with osteoarthritis.

Possibly Ineffective for

  • Rheumatoid arthritis (RA). The best evidence suggests that taking collagen type II doesn't greatly improve symptoms of RA. In fact, using it in place of drugs for RA such as methotrexate might make symptoms worse.

Insufficient Evidence for

  • Joint pain. Taking collagen type II may help people with joint pain move their knee better during exercise. It might also help these people exercise for longer before feeling joint pain. But more research is needed to confirm.
  • Swelling (inflammation) of the eye (uveitis). Early research shows that taking collagen type II doesn't improve eye symptoms in children with uveitis related to juvenile rheumatoid arthritis.
  • Pain associated with joint pain after surgery, pain after injury, and back and neck pain.
  • Other conditions.
More evidence is needed to rate the effectiveness of collagen type II (native) for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Collagen type II is POSSIBLY SAFE when taken by mouth, short-term. Collagen type II has been safely used in research in doses up to 40 mg daily for up to 24 weeks. Some people might have stomach problems after taking collagen type II. Headache, difficulty sleeping, dizziness, swelling, and liver problems have also occurred. But these events are uncommon.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if collagen type II is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Collagen allergies: People who are allergic to other types of collagen should not use collagen type II. Other collagen products have been associated with allergic reactions.



We currently have no information for COLLAGEN TYPE II (NATIVE) Interactions.



The appropriate dose of collagen type II depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for collagen type II. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Hauselmann, H. J., Caravatti, M., Seifert, B., Wang, K., Bruckner, P., Stucki, G., and Michel, B. A. Can collagen type II sustain a methotrexate-induced therapeutic effect in patients with long-standing rheumatoid arthritis? A double-blind, randomized trial. Br J Rheumatol 1998;37(10):1110-1117. View abstract.
  • McKown, K. M., Carbone, L. D., Kaplan, S. B., Aelion, J. A., Lohr, K. M., Cremer, M. A., Bustillo, J., Gonzalez, M., Kaeley, G., Steere, E. L., Somes, G. W., Myers, L. K., Seyer, J. M., Kang, A. H., and Postlethwaite, A. E. Lack of efficacy of oral bovine type II collagen added to existing therapy in rheumatoid arthritis. Arthritis Rheum 1999;42(6):1204-1208. View abstract.
  • Trentham, D. E., Dynesius-Trentham, R. A., Orav, E. J., Combitchi, D., Lorenzo, C., Sewell, K. L., Hafler, D. A., and Weiner, H. L. Effects of oral administration of type II collagen on rheumatoid arthritis. Science 9-24-1993;261(5129):1727-1730. View abstract.
  • Zhang, L. L., Wei, W., Xiao, F., Xu, J. H., Bao, C. D., Ni, L. Q., and Li, X. F. A randomized, double-blind, multicenter, controlled clinical trial of chicken type II collagen in patients with rheumatoid arthritis. Arthritis Rheum 7-15-2008;59(7):905-910. View abstract.
  • AutoImmune Inc. announces phase III trial results for Colloral. URL (Accessed 24 October 1999).
  • Barclay TS, Tsourounis C, McCart GM. Glucosamine. Ann Pharmacother 1998;32:574-9. View abstract.
  • Barnett ML, Combitchi D, Trentham DE. A pilot trial of oral type II collagen in the treatment of juvenile rheumatoid arthritis. Arthritis Rheum 1996;39:623-8. View abstract.
  • Barnett ML, Kremer JM, St.Clair W, et al. Treatment of rheumatoid arthritis with oral type II collagen. Arthritis Rheum 1998;41:290-7. View abstract.
  • Cazzola M, Antivalle M, Sarzi-Puttini P, Dell'Acqua D, Panni B, Caruso I. Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study. Clin Exp Rheumatol. 2000;18(5):571-7. View abstract.
  • Crowley DC, Lau FC, Sharma P, Evans M, Guthrie N, Bagchi M, et al Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int J Med Sci. 2009 Oct 9;6(6):312-21. No doi View abstract.
  • Kalden JR, Sieper J. Oral collagen in the treatment of rheumatoid arthritis [editorial]. Arthritis Rheum 1998;41:191-4.
  • Lugo JP, Saiyed ZM, Lane NE. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study.Nutr J. 2016;15:14. doi: 10.1186/s12937-016-0130-8. View abstract.
  • Lugo JP, Saiyed ZM, Lau FC, et al. Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. J Int Soc Sports Nutr. 2013;10(1):48. View abstract.
  • Mullins RJ, Richards C, Walker T. Allergic reactions to oral, surgical and topical bovine collagen. Anaphylactic risk for surgeons. Aust N Z J Ophthalmol 1996;24:257-60. View abstract.
  • Thompson DJ, Barron KS, Whitcup SM, Robinson MR. The safety and efficacy of chicken type II collagen on uveitis associated with juvenile rheumatoid arthritis. Ocul Immunol Inflamm. 2002;10(2):83-91. View abstract.
  • Trentham DE. Oral tolerization as a treatment of rheumatoid arthritis. Rheum Dis Clin North Am 1998;24:525-36. View abstract.
  • Wei W, Zhang LL, Xu JH, et al. A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis. Arthritis Res Ther. 2009;11(6):R180. View abstract.
  • Xie Q, Shi R, Xu G, et al. Effects of AR7 Joint Complex on arthralgia for patients with osteoarthritis: results of a three-month study in Shanghai, China. Nutr J. 2008 Oct 27;7:31. View abstract.

Vitamins Survey

Have you ever purchased COLLAGEN TYPE II (NATIVE)?

Did you or will you purchase this product in-store or online?

Where did you or where do you plan to purchase this product?

Where did you or where do you plan to purchase this product?

What factors influenced or will influence your purchase? (check all that apply)

Vitamins Survey

Where did you or where do you plan to purchase this product?

Do you buy vitamins online or instore?

What factors are most important to you? (check all that apply)

This survey is being conducted by the WebMD marketing sciences department.Read More

More Resources for COLLAGEN TYPE II (NATIVE)

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty .