Angustura, Angusture, Angusture Vraie, Angostura trifoliata, Bonplandia trifoliata, Carony Bark, Chuspa, Cusparia, Cusparia Bark, Cusparia febrifuga, Cusparia trifoliata, Galipea officinalis, True Angostura.


Overview Information

Angostura is a small tree. It is native to Venezuela and other tropical parts of South America. The bark is used to make medicine.

People use angostura for fever, diarrhea, spasms, preventing the return of malaria, and other conditions, but there is no good scientific evidence to support these uses.

In foods, angostura is used in alcoholic beverages. But "angostura bitters," which is sometimes used in mixing alcoholic beverages, no longer contains angostura. It is now made from gentian and other bitters.

How does it work?

Angostura has chemicals that help reduce spasms.


Uses & Effectiveness?

Insufficient Evidence for

More evidence is needed to rate the effectiveness of angostura for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Angostura extract is LIKELY SAFE for most adults when used in amounts commonly found in foods or drinks. There isn't enough reliable information to know if angostura is safe in medicinal amounts, which are typically larger than the amounts found in foods or drinks. Large doses of angostura might cause nausea and vomiting.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if angostura is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.



We currently have no information for ANGOSTURA Interactions.



The appropriate dose of angostura depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for angostura. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Houghton, P. J., Woldemariam, T. Z., Watanabe, Y., and Yates, M. Activity against Mycobacterium tuberculosis of alkaloid constituents of Angostura bark, Galipea officinalis. Planta Med 1999;65(3):250-254. View abstract.
  • Jacquemond-Collet, I., Benoit-Vical, F., Valentin, A., Stanislas, E., Mallie, M., and Fouraste, I. Antiplasmodial and cytotoxic activity of galipinine and other tetrahydroquinolines from Galipea officinalis. Planta Med 2002;68(1):68-69. View abstract.
  • Jacquemond-Collet, I., Bessiere, J. M., Hannedouche, S., Bertrand, C., Fouraste, I., and Moulis, C. Identification of the alkaloids of Galipea officinalis by gas chromatography-mass spectrometry. Phytochem.Anal. 2001;12(5):312-319. View abstract.
  • Jacquemond-Collet, I., Hannedouche, S., Fouraste, I., and Moulis, C. Novel quinoline alkaloid from trunk bark of Galipea officinalis. Fitoterapia 2000;71(5):605-606. View abstract.
  • Rakotoson, J. H., Fabre, N., Jacquemond-Collet, I., Hannedouche, S., Fouraste, I., and Moulis, C. Alkaloids from Galipea officinalis. Planta Med. 1998;64(8):762-763. View abstract.
  • Smith, S. W., Shah, R. R., Hunt, J. L., and Herzog, C. A. Bidirectional ventricular tachycardia resulting from herbal aconite poisoning. Ann.Emerg.Med. 2005;45(1):100-101. View abstract.
  • Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at:
  • Williamson EM, Evans FJ, eds. Potter's New Cyclopaedia of Botanical Drugs and Preparations. Essex, England: CW Daniel Company Ltd., 1998.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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