COLTSFOOT

OTHER NAME(S):

Ass's Foot, Brandlattich, British Tobacco, Bullsfoot, Chasse-Toux, Coughwort, Farfarae Folium Leaf, Fieldhove, Filuis Ante Patrem, Flower Velure, Foal's Foot, Foalswort, Guflatich, Hallfoot, Herbe aux Pattes, Herbe de Saint-Guérin, Horsefoot, Horsehoof, Kuandong Hua, Kwandong Hwa, Pas Diane, Pas d'Ane, Pas d'Âne, Pas-d’Âne, Pas-de-Baudet, Pferdefut, Pied-de-Cheval, Plisson, Procheton, Taconnet, Tussilage, Tussilage Pas d’Âne, Tussilago farfara, Uña de Caballo.<br/><br/>

Overview

Overview Information

Coltsfoot is a plant. The leaf is used to make medicine.

Despite serious safety concerns, people take coltsfoot for lung problems such as bronchitis, asthma, and whooping cough (pertussis). They also take it for upper respiratory tract complaints including sore mouth and throat, cough, and hoarseness.

Some people inhale coltsfoot for coughs and wheezing.

How does it work?

The chemicals in coltsfoot might fight pain and swelling (inflammation).

Uses

Uses & Effectiveness?

Insufficient Evidence for

More evidence is needed to rate the effectiveness of coltsfoot for these uses.

Side Effects

Side Effects & Safety

Coltsfoot is considered UNSAFE. It contains chemicals called hepatotoxic pyrrolizidine alkaloids (PAs) that can damage the liver or cause cancer. Dietary supplement products sold in the US are not required to state the amount of PAs they may contain. So, if the package doesn’t say the product is certified hepatotoxic PA- free, you can assume that there are probably hepatotoxic PAs in it. Avoid using coltsfoot products that are not certified and labeled as hepatotoxic PA-free.

Special Precautions & Warnings:

Coltsfoot is considered UNSAFE for anyone, but people with the following conditions should be especially careful about avoiding this plant:

Pregnancy and breast-feeding: Coltsfoot preparations containing hepatotoxic PAs might cause birth defects and liver damage. It’s not known whether coltsfoot preparations that are free of these chemicals are safe to use during pregnancy. So, it’s best to avoid using coltsfoot altogether if you are pregnant.

If you are breast-feeding, don’t take coltsfoot either. Hepatotoxic PAs can get into breast milk. Even if the product is certified hepatotoxic PA-free, it’s best to avoid use. Not enough is known about the safety of using hepatotoxic PA-free coltsfoot during breast-feeding.

Allergy to ragweed and related plants: Coltsfoot may cause an allergic reaction in people who are allergic to the Asteraceae/Compositae plant family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many others. If you have allergies, be sure to check with your healthcare provider before taking coltsfoot.

High blood pressure, heart disease: There is a concern that coltsfoot taken in large amounts might interfere with treatment for these conditions. Don’t use coltsfoot if you have these conditions.

Liver disease: There is a concern that hepatotoxic PAs might make liver disease worse. Don’t use coltsfoot if you have this condition.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Medications for high blood pressure (Antihypertensive drugs) interacts with COLTSFOOT

    Excessive doses of coltsfoot seem to increase blood pressure. By increasing blood pressure coltsfoot might decrease the effectiveness of medications for high blood pressure.<br><nb>Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.

  • Medications that increase break down of other medications by the liver (Cytochrome P450 3A4 (CYP3A4) inducers) interacts with COLTSFOOT

    Coltsfoot is broken down by the liver. Some chemicals that form when the liver breaks down coltsfoot can be harmful. Medications that cause the liver to break down coltsfoot might enhance the toxic effects of chemicals contained in coltsfoot.<br><nb>Some of these medicines include carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), and others.

  • Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with COLTSFOOT

    Coltsfoot might slow blood clotting. Taking coltsfoot along with medications that also slow clotting might increase the chances of bruising and bleeding.<br><nb>Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Dosing

Dosing

The appropriate dose of coltsfoot depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for coltsfoot. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Fu, J. X. [Measurement of MEFV in 66 cases of asthma in the convalescent stage and after treatment with Chinese herbs]. Zhong.Xi.Yi.Jie.He.Za Zhi. 1989;9(11):658-9, 644. View abstract.
  • Roder, E., Wiedenfeld, H., and Jost, E. J. [Tussilagine - a New Pyrrolizidine Alkaloid from Tussilago farfara.]. Planta Med 1981;43(9):99-102. View abstract.
  • Willett, K. L., Roth, R. A., and Walker, L. Workshop overview: Hepatotoxicity assessment for botanical dietary supplements. Toxicol Sci 2004;79(1):4-9. View abstract.
  • Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. View abstract.
  • Food and Drug Administration. FDA Advises Dietary Supplement Manufacturers to Remove Comfrey Products From the Market. July 6, 2001. Available at: http://www.cfsan.fda.gov/~dms/dspltr06.html.
  • Freshour JE, Odle B, Rikhye S, Stewart DW. Coltsfoot as a potential cause of deep vein thrombosis and pulmonary embolism in a patient also consuming kava and blue vervain. J Diet Suppl 2012;9:149-54. View abstract.
  • Haller CA, Jacob P 3rd, Benowitz NL. Enhanced stimulant and metabolic effects of combined ephedrine and caffeine. Clin Pharmacol Ther 2004;75:259-73. View abstract.
  • Hwang SB, Chang MN, Garcia ML, et al. L-652,469--a dual receptor antagonist of platelet activating factor and dihydropyridines from Tussilago farfara L. Eur J Pharmacol 1987;141:269-81. View abstract.
  • Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. View abstract.
  • Li YP, Wang YM. Evaluation of tussilagone: a cardiovascular-respiratory stimulant isolated from Chinese herbal medicine. Gen Pharmacol 1988;19:261-3. View abstract.
  • Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  • Roulet M, Laurini R, Rivier L, Calame A. Hepatic veno-occlusive disease in newborn infant of a woman drinking herbal tea. J Pediatr 1988;112:433-6.
  • Sperl W, Stuppner H, Gassner I, et al. Reversible hepatic veno-occlusive disease in an infant after consumption of pyrrolizidine-containing herbal tea. Eur J Pediatr 1995;154:112-6. View abstract.
  • Vukovich MD, Schoorman R, Heilman C, et al. Caffeine-herbal ephedra combination increases resting energy expenditure, heart rate and blood pressure. Clin Exp Pharmacol Physiol 2005;32:47-53. View abstract.
  • Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. View abstract.
  • WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  • Wilson BE, Hobbs WN. Case report: pseudoephedrine-associated thyroid storm: thyroid hormone-catecholamine interactions. Am J Med Sci 1993;306:317-9. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.