Overview

Chondroitin sulfate is a chemical found in human and animal cartilage. It is commonly used by mouth with glucosamine or other ingredients for osteoarthritis.

Chondroitin sulfate is one of the building blocks of cartilage. In osteoarthritis, the cartilage in the joints breaks down. Taking chondroitin sulfate might slow this breakdown. It is usually manufactured from animal sources, such as shark and cow cartilage. It can also be made in a lab.

Chondroitin sulfate is used for osteoarthritis and cataracts. It is often used together with other ingredients, including manganese ascorbate, hyaluronic acid, collagen peptides, or glucosamine. Chondroitin sulfate is also used for many other conditions, but there is no good scientific evidence to support these uses.

How does it work ?

Uses & Effectiveness ?

Possibly Effective for

  • Cataracts. An injectable solution containing chondroitin sulfate and sodium hyaluronate is approved by the FDA to protect the eye during cataract surgery. It is not clear if using it in a different form will help.
  • Osteoarthritis. Taking chondroitin sulfate by mouth seems to provide some relief from osteoarthritis pain and improve function. High quality, pharmaceutical-grade products have shown the most benefit. Chondrosulf (IBSA Institut Biochimique SA), Chondrosan (Bioiberica, S.A.) and Structrum (Laboratoires Pierre Fabre) are examples of these products.
There is interest in using chondroitin sulfate for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: Chondroitin sulfate is likely safe when used for up to 6 years. It can cause some mild stomach pain and nausea. Other possible side effects include bloating, diarrhea, and constipation.

When placed into the eye: Chondroitin sulfate is possibly safe when used together with other ingredients in an eye drop.

Special Precautions and Warnings

Pregnancy and breast-feeding: There isn't enough reliable information to know if chondroitin sulfate is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Asthma: There is some concern that chondroitin sulfate might make asthma worse. If you have asthma, use chondroitin sulfate cautiously.

Prostate cancer: Early research suggests that chondroitin might cause the spread or recurrence of prostate cancer. This effect has not been shown with chondroitin sulfate supplements. However, until more is known, do not take chondroitin sulfate if you have prostate cancer or are at high risk for developing it (you have a brother or father with prostate cancer).

Interactions ?

    Moderate Interaction

    Be cautious with this combination

  • Warfarin (Coumadin) interacts with CHONDROITIN SULFATE

    Warfarin (Coumadin) is used to slow blood clotting. There are several reports showing that taking chondroitin with glucosamine increases the effect of warfarin (Coumadin) on blood clotting. This can cause bruising and bleeding that can be serious. Don't take chondroitin if you are taking warfarin (Coumadin).

Dosing

Chondroitin sulfate is most commonly used by adults in doses of 800-1200 mg per day, for up to 2 years.

There is concern that some chondroitin sulfate products are not labeled accurately. Some products might contain no chondroitin, while other products might contain more than the amount stated on the product's label. Because of these issues, the effects of different chondroitin products may vary. Speak with a healthcare provider to find out what dose or product might be best.
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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2018.