GOTU KOLA

OTHER NAME(S):

Brahma-Buti, Brahma-Manduki, Centellase, Centella asiatica, Centella Asiática, Centella Asiatique, Centella coriacea, Divya, Gota Kola, Hydrocotyle asiatica, Hydrocotyle Asiatique, Hydrocotyle Indien, Indischer Wassernabel, Indian Pennywort, Indian Water Navelwort, Ji Xue Cao, Khulakhudi, Luei Gong Gen, Luo De Da, Madecassol, Mandukaparni, Manduk Parani, Mandukig, Marsh Penny, TTFCA, Talepetrako, Thick-Leaved Pennywort, Tsubo-kusa, Tungchian, White Rot.<br/><br/>

Overview

Overview Information

Gotu kola is an herb in the parsley family. It is commonly used in Traditional Chinese and Ayurvedic medicine. The above-ground parts are used to make medicine.

Gotu kola is used to treat bacterial, viral, or parasitic infections such as urinary tract infection (UTI), shingles, leprosy, cholera, dysentery, syphilis, the common cold, the flu, H1N1 (swine) flu, elephantiasis, tuberculosis, and schistosomiasis.

Gotu kola is also used for fatigue, anxiety, depression, Alzheimer's disease, and improving memory and intelligence. Other uses include circulation problems (venous insufficiency) including varicose veins, to stabilize plaques in blood vessels, to prevent blood clots in the legs, and to prevent the damage of small blood vessels in people with diabetes (diabetic microangiopathy).

Some people use gotu kola for wound healing, trauma, sunstroke, tonsillitis, fluid around the lungs (pleurisy), liver disease (hepatitis), jaundice, systemic lupus erythematosus (SLE), stomach pain, diarrhea, indigestion, stomach ulcers, swelling in the lining of the stomach (gastritis), epilepsy, asthma, "tired blood" (anemia), and for helping them live longer.

Some women use gotu kola for preventing pregnancy, absence of menstrual periods, and to arouse sexual desire.

Gotu kola is sometimes applied to the skin for psoriasis, burns, wound healing and reducing scars, including stretch marks caused by pregnancy.

How does it work?

Gotu kola contains certain chemicals that seem to decrease inflammation and also decrease blood pressure in veins. Gotu kola also seems to increase collagen production, which is important for wound healing.

Uses

Uses & Effectiveness?

Possibly Effective for

  • Burns. Applying gotu kola to second-degree burns seems todecrease the time that it takes for burns to heal.
  • Poor circulation that can lead to varicose veins and other conditions (venous insufficiency). Taking gotu kola or a specific extract of gotu kola (Centellase) by mouth for 4-8 weeks seems to improve blood circulation and reduce swelling in people with poor blood circulation in the legs.

Insufficient Evidence for

  • Hardening of the arteries (atherosclerosis). People with atherosclerosis have fatty deposits called plaques along the lining of their blood vessels. There is some evidence that taking gotu kola for 3 months to 4 years, with or without maritime pine, might help stabilize these plaques so they are less likely to break off and trigger clot formation. This could reduce the risk of a heart attack or stroke.
  • Mental function. Early research suggests that taking a combination of gotu kola, ginkgo, and docosahexaenoic acid (DHA) for 4 months does not improve mental function in healthy elderly adults.
  • Preventing blood clots in the legs while flying. Gotu kola might help prevent blood clots from occurring during long plane flights. Early research shows that gotu kola might decrease fluid retention and improve blood circulation in people traveling on airplanes for more than 3 hours. However, it is not known if this finding translates into fewer blood clots.
  • Increasing circulation in people with diabetes. Taking gotu kola for 6-12 months might help increase circulation and decrease fluid retention in people with diabetes whose small blood vessels have been damaged by their disease.
  • Excess scar tissue (keloids). There is some evidence that applying an extract of gotu kola known as Madecassol to the skin might help reduce excess scar tissue.
  • Scarring. Early research suggests that applying a specific gotu kola cream (Alpha Centella, not available in the U.S.) to the skin twice daily for 6-8 weeks after the removal of stitches might help reduce scarring.
  • Schistosomiasis. There is some evidence that gotu kola injected by a healthcare provider might help bladder wounds caused by a parasitic infection called schistosomiasis.
  • Stretch marks associated with pregnancy. Early research shows that applying a specific cream containing gotu kola, vitamin E, and a collagen compound (Trofolastin, not available in the U.S.) daily during the last 6 months of pregnancy reduces stretch marks. There is also some evidence that an ointment containing gotu kola, vitamin E, essential fatty acids, hyaluronic acid, elastin, and menthol (Verum, not available in the U.S.) might help prevent stretch marks during pregnancy. Other early research shows that applying a formula containing hydroxyprolisilane C, rosehip oil, gotu kola triterpenes, and vitamin E (Velastisa Antiestrías, ISDIN) during pregnancy reduces the number and severity of old and new stretch marks. Since all of the tested products contained multiple ingredients, it is not clear if the effects on stretch marks are due to gotu kola or other ingredients.
  • Wound healing. Early evidence shows that applying gotu kola on the skin helps improve wound healing.
  • Anxiety.
  • Common cold and flu.
  • Diarrhea.
  • Fatigue.
  • Hepatitis.
  • Indigestion.
  • Jaundice.
  • Sunstroke.
  • Tonsillitis.
  • Urinary tract infection (UTI).
  • Other conditions.
More evidence is needed to rate the effectiveness of gotu kola for these uses.

Side Effects

Side Effects & Safety

Gotu kola is POSSIBLY SAFE for most people when applied to the skin for up to 12 months or when taken by mouth for up to 8 weeks. When taken by mouth, gotu kola can cause nausea and stomach pain. Rarely, gotu kola may also cause liver problems if taken by mouth. When used on the skin, gotu kola may cause itchiness and redness.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Gotu kola is POSSIBLY SAFE in pregnant women when applied to the skin. But don't take it by mouth. Not enough is known about the safety of taking gotu kola orally. There also isn't enough known about the safety of using gotu kola during breast-feeding. Avoid using it if you are nursing.

Liver disease: There is concern that gotu kola might cause liver damage. People who already have a liver disease such as hepatitis should avoid using gotu kola. It might make liver problems worse.

Surgery: Gotu kola might cause too much sleepiness if combined with medications used during and after surgery. Stop using gotu kola at least 2 weeks before a scheduled surgery.

Interactions

Interactions?

Major Interaction

Do not take this combination

!
  • Sedative medications (CNS depressants) interacts with GOTU KOLA

    Large amounts of gotu kola might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking gotu kola along with sedative medications might cause too much sleepiness.<br/><br/> Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.

Moderate Interaction

Be cautious with this combination

!
  • Medications that can harm the liver (Hepatotoxic drugs) interacts with GOTU KOLA

    Gotu kola might harm the liver. Taking gotu kola along with medication that might also harm the liver can increase the risk of liver damage.<br/><br/> Some medications that can harm the liver include acetaminophen (Tylenol and others), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), fluconazole (Diflucan), itraconazole (Sporanox), erythromycin (Erythrocin, Ilosone, others), phenytoin (Dilantin), lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), and many others.

Dosing

Dosing

The following doses have been studied in scientific research:

ADULTS

BY MOUTH:

  • For poor circulation that can lead to varicose veins and other conditions (venous insufficiency): 60-180 mg of gotu kola extract daily has been used.
APPLIED TO THE SKIN:
  • For burns: A cream containing 3% gotu kola, applied to the burns daily, has been used until the burns heal. A gauze dressing containing 5% gotu kola and 2.5% aloe vera, wrapped around the burns and changed every 3 days, has been used until the burns heal.

View References

REFERENCES:

  • Belcaro G, Laurora G, Cesarone MR, and et al. Efficacy of Centellase (R) in the treatment of venous hypertension evaluated by a combined microcirculatory model. Curr Ther Res 1989;46(6):1015-1026.
  • Belcaro GV, Grimaldi R, Guidi G, and et al. Treatment of diabetic micorangiopathy with TTFCA. A microcirculatory study with laser-Doppler flowmetry, P02/PC02, and capillary permeability measurements. Curr Ther Res 1990;47(3):421-428.
  • Belcaro, G. V., Grimaldi, R., and Guidi, G. Improvement of capillary permeability in patients with venous hypertension after treatment with TTFCA. Angiology 1990;41(7):533-540. View abstract.
  • Bilbao, I., Aguirre, A., Zabala, R., Gonzalez, R., Raton, J., and Diaz Perez, J. L. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis 1995;33(6):435-436. View abstract.
  • Bonte, F., Dumas, M., Chaudagne, C., and Meybeck, A. Influence of asiatic acid, madecassic acid, and asiaticoside on human collagen I synthesis. Planta Med 1994;60(2):133-135. View abstract.
  • Bradwejn J, Koszycki D, Shlik J, and et al. Centella asiatica decreases the acoustic startle response. 152nd Annual Meeting of the American Psychiatric Association, Washington DC, USA (May 15-20) 1999;
  • Bradwejn J, Zhou Y, Koszycki, and et al. Effect of acute administration of Gotu-kola (Centella asiatica) on acoustic startle response in healthy volunteers. XXIst Collegium Internationale Neuro-psychopharmacologicum, Glascow, Scotland (July 12-16) 1998;(Abstract Ref: NRW001)
  • Carlson, J. J., Farquhar, J. W., DiNucci, E., Ausserer, L., Zehnder, J., Miller, D., Berra, K., Hagerty, L., and Haskell, W. L. Safety and efficacy of a ginkgo biloba-containing dietary supplement on cognitive function, quality of life, and platelet function in healthy, cognitively intact older adults. J Am Diet.Assoc 2007;107(3):422-432. View abstract.
  • Cesarone MR, Belcaro G, De Sanctis MT, and et al. Effects of the total triterpenic fraction of Centella asiatica in venous hypertensive microangiopathy: a prospective, placebo-controlled, randomized trial. Angiology 2001;52(10 suppl 2):S15-S18.
  • Cesarone MR, Belcaro G, Rulo A, and et al. Microcirculatory effects of total triterpenic fraction of Centella asiatica in chronic venous hypertension: measurement by laser Doppler, TcPo2-co2, and leg volumetry. Angiology 2001;52(10 suppl 2):S45-S48.
  • Cesarone MR, Incandela L, De Sanctis MT, and et al. Evaluation of treatment of diabetic microangiopathy with total triterpenic fraction of Centella asiatica: a clinical prospective randomized trial with a microcirculatory model. Angiology 2001;52(10 suppl 2):S49-S54.
  • Cesarone, M. R., Laurora, G., De Sanctis, M. T., Incandela, L., Grimaldi, R., Marelli, C., and Belcaro, G. [The microcirculatory activity of Centella asiatica in venous insufficiency. A double-blind study]. Minerva Cardioangiol. 1994;42(6):299-304. View abstract.
  • Chatterjee, T. K., Chakraborty, A., Pathak, M., and Sengupta, G. C. Effects of plant extract Centella asiatica (Linn.) on cold restraint stress ulcer in rats. Indian J.Exp.Biol. 1992;30(10):889-891. View abstract.
  • Danese, P., Carnevali, C., and Bertazzoni, M. G. Allergic contact dermatitis due to Centella asiatica extract. Contact Dermatitis 1994;31(3):201. View abstract.
  • Darnis, F., Orcel, L., Saint-Maur, P. P., and Mamou, P. [Use of a titrated extract of Centella asiatica in chronic hepatic disorders (author's transl)]. Sem.Hop. 11-8-1979;55(37-38):1749-1750. View abstract.
  • De Sanctis MT, Belcaro G, Incandela L, and et al. Treatment of edema and increased capillary filtration in venous hypertension with total triterpenic fraction of Centella asiatica: A clinical, prospective, placebo-controlled, randomized, dose-ranging trial. Angiology 2001;52(10 suppl 2):S55-S59.
  • De Sanctis MT, Incandela L, Cesarone MR, and et al. Acute effects of TTFCA on capillary filtration in severe venous hypertension. Panminerva Medica 1994;36(2):87-90.
  • DeLucia R, Sertie JAA, Camargo EA, and et al. Pharmacologic and toxicological studies on Centella asiatica extract. Fitoterapia 1997;68:413-416.
  • Grimaldi, R., De Ponti, F., D'Angelo, L., Caravaggi, M., Guidi, G., Lecchini, S., Frigo, G. M., and Crema, A. Pharmacokinetics of the total triterpenic fraction of Centella asiatica after single and multiple administrations to healthy volunteers. A new assay for asiatic acid. J Ethnopharmacol. 1990;28(2):235-241. View abstract.
  • Incandela L, Belacaro G, Cesarone MR, and et al. Treatment of diabetic microangiopathy and edema with total triterpenic fraction of Centella asiatica: a prospective, placebo-controlled randomized study. Angiology 2001;52(10 suppl 2):S27-S31.
  • Incandela L, Belcaro G, De Sanctis MT, and et al. Total triterpenic fraction of Centella asiatica in the treatment of venous hypertension: a clinical, prospective, randomized trial using a combined microcirculatory model. Angiology 2001;52(10 suppl 2):S61-S67.
  • Izu, R., Aguirre, A., Gil, N., and Diaz-Perez, J. L. Allergic contact dermatitis from a cream containing Centella asiatica extract. Contact Dermatitis 1992;26(3):192-193. View abstract.
  • Kaziulin, A. N., Petukhov, A. B., and Kucheriavyi, IuA. [Efficiency of includes of bioactive substances in diet of patient with hepatic encephalopathy]. Vopr.Pitan. 2006;75(2):40-44. View abstract.
  • Laerum, O. D. and Iversen, O. H. Reticuloses and epidermal tumors in hairless mice after topical skin applications of cantharidin and asiaticoside. Cancer Res 1972;32(7):1463-1469. View abstract.
  • Marastoni, F., Baldo, A., Redaelli, G., and Ghiringhelli, L. [Centella asiatica extract in venous pathology of the lower limbs and its evaluation as compared with tribenoside]. Minerva Cardioangiol. 1982;30(4):201-207. View abstract.
  • Ming, Z. J., Liu, S. Z., and Cao, L. [Effect of total glucosides of Centella asiatica on antagonizing liver fibrosis induced by dimethylnitrosamine in rats]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2004;24(8):731-734. View abstract.
  • O'Brien, B. Night eating syndrome and Gotu Kola. Ir.Med J 2005;98(10):250-251. View abstract.
  • O'Keeffe, P. A trial of asiaticoside on skin graft donor areas. Br J Plast.Surg 1974;27(2):194-195. View abstract.
  • Ramanathan, M., Sivakumar, S., Anandvijayakumar, P. R., Saravanababu, C., and Pandian, P. R. Neuroprotective evaluation of standardized extract of Centella asciatica in monosodium glutamate treated rats. Indian J Exp Biol 2007;45(5):425-431. View abstract.
  • Rush, W. R., Murray, G. R., and Graham, D. J. The comparative steady-state bioavailability of the active ingredients of Madecassol. Eur J Drug Metab Pharmacokinet. 1993;18(4):323-326. View abstract.
  • Sairam, K., Rao, C. V., and Goel, R. K. Effect of Centella asiatica Linn on physical and chemical factors induced gastric ulceration and secretion in rats. Indian J.Exp.Biol. 2001;39(2):137-142. View abstract.
  • Santucci, B., Picardo, M., and Cristaudo, A. Contact dermatitis due to Centelase. Contact Dermatitis 1985;13(1):39. View abstract.
  • Sarma DNK, Khosa RL, Chansauria JPN, and et al. Antistress activity of Tinospora cordifolia and Centella asiatica extracts. Phytotherapy Research 1996;10(2):181-189.
  • Sasaki, S., Shinkai, H., Akashi, Y., and Kishihara, Y. Studies on the mechanism of action of asiaticoside (Madecassol) on experimental granulation tissue and cultured fibroblasts and its clinical application in systemic scleroderma. Acta Derm.Venereol. 1972;52(2):141-150. View abstract.
  • Shukla, A., Rasik, A. M., and Dhawan, B. N. Asiaticoside-induced elevation of antioxidant levels in healing wounds. Phytother.Res 1999;13(1):50-54. View abstract.
  • Suguna, L., Sivakumar, P., and Chandrakasan, G. Effects of Centella asiatica extract on dermal wound healing in rats. Indian J Exp Biol 1996;34(12):1208-1211. View abstract.
  • Sunilkumar, Parameshwaraiah, S., and Shivakumar, H. G. Evaluation of topical formulations of aqueous extract of Centella asiatica on open wounds in rats. Indian J Exp Biol. 1998;36(6):569-572. View abstract.
  • Tenni, R., Zanaboni, G., De Agostini, M. P., Rossi, A., Bendotti, C., and Cetta, G. Effect of the triterpenoid fraction of Centella asiatica on macromolecules of the connective matrix in human skin fibroblast cultures. Ital.J Biochem 1988;37(2):69-77. View abstract.
  • Velasco, M. and Romero, E. Drug interaction between asiaticoside and some anti-inflammatory drugs in wound healing of the rat. Curr Ther Res Clin Exp 1976;19(1):121-125. View abstract.
  • Vena, G. A. and Angelini, G. Contact allergy to Centelase. Contact Dermatitis 1986;15(2):108-109. View abstract.
  • Vogel HG, DeSouza N, and D'Sa A. Effects of terpenoids isolated from Centella asiatica on granuloma tissue. Acta Therapeutica 1990;16:285-298.
  • Yoosook, C., Bunyapraphatsara, N., Boonyakiat, Y., and Kantasuk, C. Anti-herpes simplex virus activities of crude water extracts of Thai medicinal plants. Phytomedicine. 2000;6(6):411-419. View abstract.
  • Zheng, M. S. An experimental study of the anti-HSV-II action of 500 herbal drugs. J Tradit.Chin Med 1989;9(2):113-116. View abstract.
  • Babu TD, Kuttan G, Padikkala J. Cytotoxic and anti-tumour properties of certain taxa of Umbelliferae with special reference to Centella asiatica (L.) Urban. J Ethnopharmacol 1995;48:53-7. View abstract.
  • Belcaro G, Dugall M, Ippolito E, et al. Pycnogenol and centella asiatica to prevent asymptomatic atherosclerosis progression in clinical events. Minerva Cardioangiol. 2017 Feb;65(1):24-31. View abstract.
  • Belcaro GV, Rulo A, Grimaldi R. Capillary filtration and ankle edema in patients with venous hypertension treated with TTFCA. Angiology 1990;41:12-8.. View abstract.
  • Bilbao I, Aguirre A, Zabala R, et al. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis 1995;33:435-6.
  • Bosse JP, Papillon J, Frenette G, et al. Clinical study of a new antikeloid agent. Ann Plast Surg 1979;3:13,21. View abstract.
  • Bradwejn J, Zhou Y, Koszycki D, Shlik J. A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects. J Clin Psychopharmacol 2000;20:680-4. View abstract.
  • Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the east Asian medical plant Centella asiatica. Phytomedicine 2000;7:427-48. View abstract.
  • Cesarone MR, Belcaro G, De Sanctis MT, et al. Effects of the total triterpenic fraction of Centella asiatica in venous hypertensive microangiopathy: a prospective, placebo-controlled, randomized trial. Angiology 2001;52 Suppl 2:S15-18. View abstract.
  • Cesarone MR, Belcaro G, Nicolaides AN, et al. Increase in echogenicity of echolucent carotid plaques after treatment with total triterpenic fraction of Centella asiatica: a prospective, placebo-controlled, randomized trial. Angiology 2001;52 Suppl 2:S19-25. View abstract.
  • Cesarone MR, Belcaro G, Rulo A, et al. Microcirculatory effects of total triterpenic fraction of Centella asiatica in chronic venous hypertension: measurement by laser Doppler, TcPO2-CO2, and leg volumetry. Angiology 2001;52 Suppl 2:S45-8. View abstract.
  • Cesarone MR, Incandela L, De Sanctis MT, et al. Evaluation of treatment of diabetic microangiopathy with total triterpenic fraction of Centella asiatica: a clinical prospective randomized trial with a microcirculatory model. Angiology 2001;52 Suppl 2:S49-54. View abstract.
  • Cesarone MR, Incandela L, De Sanctis MT, et al. Flight microangiopathy in medium- to long-distance flights: prevention of edema and microcirculation alterations with total triterpenic fraction of Centella asiatica. Angiology 2001;52 Suppl 2:S33-7. View abstract.
  • Chandrika UG, Prasad kumarab PA. Gotu Kola (Centella asiatica): Nutritional Properties and Plausible Health Benefits. Adv Food Nutr Res. 2015;76:125-57. View abstract.
  • Cheng CL, Koo MWL. Effects of Centella asiatica on ethanol induced gastric mucosal lesions in rats. Life Sci 2000;67:2647-53. View abstract.
  • Chong NJ, Azziz Z. A systematic review on the chemical constituents of Centella asiatica. Res J Pharma Biol Chem Sci. 2011;2(3):445-459.
  • Dantuluri S, North-lewis P, Karthik SV. Gotu Kola induced hepatotoxicity in a child - need for caution with alternative remedies. Dig Liver Dis. 2011;43(6):500. View abstract.
  • De Sanctis MT, Belcaro G, Incandela L, et al. Treatment of edema and increased capillary filtration in venous hypertension with total triterpenic fraction of Centella asiatica: a clinical, prospective, placebo-controlled, randomized, dose-ranging trial. Angiology 2001;52 Suppl 2:S55-9. View abstract.
  • Dutta T, Basu UP. Crude extract of Centella asiatica and products derived from its glycosides as oral antifertility agents. Indian J Exp Biol 1968;6:181-2.
  • Eun HC, Lee AY. Contact dermatitis due to madecassol. Contact Dermatitis 1985;13:310-3.. View abstract.
  • Fam A. Use of titrated extract of Centella asiatica (TECA) in bilharzial bladder lesions. Int Surg 1973;58:451-2.
  • García Hernández JÁ, Madera González D, Padilla Castillo M, Figueras Falcón T. Use of a specific anti-stretch mark cream for preventing or reducing the severity of striae gravidarum. Randomized, double-blind, controlled trial. Int J Cosmet Sci. 2013;35(3):233-7. View abstract.
  • Guo JS, Cheng CL, Koo MW. Inhibitory effects of Centella asiatica water extract and asiaticoside on inducible nitric oxide synthase during gastric ulcer healing in rats. Planta Med 2004;70:1150-4. View abstract.
  • Hausen BM. Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer. Contact Dermatitis 1993;29:175-9.. View abstract.
  • Incandela L, Belcaro G, Cesarone MR, et al. Treatment of diabetic microangiopathy and edema with total triterpenic fraction of Centella asiatica: a prospective, placebo-controlled randomized study. Angiology 2001;52 Suppl 2:S27-31. View abstract.
  • Incandela L, Belcaro G, De Sanctis MT, et al. Total triterpenic fraction of Centella asiatica in the treatment of venous hypertension: a clinical, prospective, randomized trial using a combined microcirculatory model. Angiology 2001;52 Suppl 2:S61-7. View abstract.
  • Incandela L, Belcaro G, Nicolaides AN, et al. Modification of the echogenicity of femoral plaques after treatment with total triterpenic fraction of Centella asiatica: a prospective, randomized, placebo-controlled trial. Angiology 2001;52 Suppl 2:S69-73. View abstract.
  • Incandela L, Cesarone MR, Cacchio M, et al. Total triterpenic fraction of Centella asiatica in chronic venous insufficiency and in high-perfusion microangiopathy. Angiology 2001;52 Suppl 2:S9-13. View abstract.
  • Jorge OA, Jorge AD. Hepatotoxicity associated with the ingestion of Centella asiatica. Rev Esp Enferm Dig 2005;97:115-24. View abstract.
  • Kenady DE, Chretien PB, Potvin C, Simon RM. Thymosin reconstitution of T-cell deficits in vitro in cancer patients. Cancer 1977;39:575-80. View abstract.
  • Luzzi R, Belcaro G, Ippolito E. Carotid plaque stabilization induced by the supplement association Pycnogenol and centella asiatica (Centellicum). Minerva Cardioangiol. 2016 Dec;64(6):603-9. View abstract.
  • Mallol J, Belda MA, Costa D, et al. Prophylaxis of striae gravidarum with a topical formulation. A double blind trial. Int J Cosmet Sci 1991;3:51-7.
  • Maquart FX, Chastang F, Simeon A, et al. Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds. Eur J Dermatol 1999;9:289-96. View abstract.
  • Mook-Jung I, Shin JE, Yun SH, et al. Protective effects of asiaticoside derivatives against beta-amyloid neurotoxicity. J Neurosci Res 1999;58:417-25. View abstract.
  • Muangman P, Praditsuktavorn B, Chinaroonchai K, Chuntrasakul C. Clinical efficacy test of polyester containing herbal extract dressings in burn wound healing. Int J Low Extrem Wounds. 2016 Sep;15(3):203-12. View abstract.
  • Pointel JP, Boccalon H, Cloarec M, et al. Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiol 1987;38:46-50. View abstract.
  • Saeidinia A, Keihanian F, Lashkari AP, et al. Partial-thickness burn wounds healing by topical treatment: a randomized controlled comparison between silver sulfadiazine and centiderm. Medicine (Baltimore). 2017 Mar;96(9):e6168. View abstract.
  • Sastravaha G, Yotnuengnit P, Booncong P, Sangtherapitikul P. Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts. A preliminary study. J Int Acad Periodontol 2003;5:106-15. View abstract.
  • Shukla A, Rasik AM, Jain GK, et al. In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. J Ethnopharmacol 1999;65:1-11. View abstract.
  • Widgerow AD, Chait LA, Stals R, Stals PJ. New innovations in scar management. Aesthetic Plast Surg 2000;24:227-34. View abstract.
  • Young GL, Jewell D. Creams for preventing stretch marks in pregnancy. Cochrane Database Syst Rev 2000;(2):CD000066. View abstract.

Vitamins Survey

Have you ever purchased GOTU KOLA?

Did you or will you purchase this product in-store or online?

Where did you or where do you plan to purchase this product?

Where did you or where do you plan to purchase this product?

What factors influenced or will influence your purchase? (check all that apply)

Vitamins Survey

Where did you or where do you plan to purchase this product?

Do you buy vitamins online or instore?

What factors are most important to you? (check all that apply)

More Resources for GOTU KOLA

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.