Absinthe Sauvage, Ajenjo Silvestre, Annual Mugwort, Annual Wormwood, Armoise Amère, Armoise Annuelle, Artémise, Artemisia annua, Artemisia, Artemisinin, Chinese Wormwood, Ching-hao, Herba Artemisiae Annuae, Herbe aux Cent Goûts, Huang Hua Guo, Qing Hao, Qinghaosu, Sourcil de Lune, Sweet Wormwood.<br/><br/>
Overview InformationSweet Annie is an herb. The parts that grow above the ground are used to make medicine.
Sweet Annie is used most commonly for malaria. It contains a chemical that can be changed in the laboratory to make it more effective against malaria. This lab-made product is sold as a prescription drug for malaria in Asia, Africa, and Europe.
Sweet Annie is also used for bacterial infections such as dysentery and tuberculosis; illnesses caused by worms, other parasites, and mites; fungal infections; and viral infections such as the common cold. Other uses include treatment of upset stomach, fever, yellowed skin (jaundice), psoriasis, systemic lupus erythematosus (SLE) and other autoimmune disorders, loss of appetite, blood vessel disorders, constipation, gallbladder disorders, stomach pain, painful menstruation, and joint pain (rheumatism).
People with AIDS sometimes use sweet Annie to prevent an often fatal type of lung infection called pneumocystis pneumonia (PCP) that is caused by a fungus.
Sweet Annie is sometimes applied directly to the skin for bacterial and fungal infections, arthritis and other joint pain, bruises, nerve pain, and sprains.
How does it work?Sweet Annie contains a chemical called artemisinin that seems to be effective against the parasites that cause malaria. Some drug manufacturers make anti-malarial medications from artemisinin that they have modified in the laboratory.
Sweet Annie should not be used alone for malaria since it may only inactivate the parasites that cause malaria, not actually kill them. The amount of artemisinin in sweet Annie might be too small to kill all the parasites that cause malaria, but large enough to make these parasites resistant to further treatment with more powerful malaria drugs that also contain artemisinin.
Many researchers are investigating new ways to increase the amount of artemisinin in sweet Annie.
Uses & Effectiveness
Insufficient Evidence for
- Malaria. Taking sweet Annie tea for 4-7 days might improve symptoms and decrease the number of active parasites in people with malaria. The tea should not be boiled, because heat will destroy the chemical that seems to fight malaria. There is some concern that if sweet Annie tea is used alone instead of in combination with usual malaria treatments it might only inactivate the malaria parasites, not actually kill them.
- AIDS-related infections.
- Bacterial infections.
- Fungal infections.
- Common cold.
- Gallbladder disorders.
- Upset stomach.
- Yellowing of the skin (jaundice).
- Night sweats.
- Painful menstruation.
- Other conditions.
Side Effects & SafetySweet Annie is POSSIBLY SAFE for most adults when taken by mouth. The tea of sweet Annie might cause upset stomach and vomiting. It might also cause an allergic reaction in some people including a rash and cough.
There has been one report of liver damage in a person who took doses of sweet Annie that were too large. But liver damage has not been reported in people taking typical doses.
Not enough is known about the safety of applying sweet Annie directly to the skin.
Special Precautions & Warnings:Pregnancy and breast-feeding: Sweet Annie is LIKELY UNSAFE when taken by mouth during pregnancy. Animal studies show that drugs made in the laboratory from artemisinin, a chemical found in sweet Annie, can cause death of the fetus or birth defects when used early in the pregnancy. The safety of using sweet Annie during the last 6 months of pregnancy is not known. Nevertheless, the World Health Organization considers drugs made in the laboratory from artemisinin acceptable to use during the last six months of pregnancy, if no other malaria treatment is available.
The safety of using sweet Annie during breast-feeding is not known. Stay on the safe side and avoid use.
Allergy to ragweed and related plants: Sweet Annie may cause an allergic reaction in people who are sensitive to the Asteraceae/Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many others. If you have allergies, be sure to check with your healthcare provider before taking sweet Annie.
We currently have no information for SWEET ANNIE Interactions.
The appropriate dose of sweet Annie depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for sweet Annie. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
- Bertea, C. M., Freije, J. R., van der, Woude H., Verstappen, F. W., Perk, L., Marquez, V., De Kraker, J. W., Posthumus, M. A., Jansen, B. J., de Groot, A., Franssen, M. C., and Bouwmeester, H. J. Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua. Planta Med 2005;71(1):40-47. View abstract.
- Chan, K. L., Yuen, K. H., Jinadasa, S., Peh, K. K., and Toh, W. T. A high-performance liquid chromatography analysis of plasma artemisinin using a glassy carbon electrode for reductive electrochemical detection. Planta Med 1997;63(1):66-69. View abstract.
- Chen, H. H., Zhou, H. J., Wu, G. D., and Lou, X. E. Inhibitory effects of artesunate on angiogenesis and on expressions of vascular endothelial growth factor and VEGF receptor KDR/flk-1. Pharmacology 2004;71(1):1-9. View abstract.
- Delfosse, M. [Artemisia annua for the treatment of malaria]. J Pharm Belg. 1998;53(4):276-277. View abstract.
- Dobson, M. J. Bitter-sweet solutions for malaria: exploring natural remedies from the past. Parassitologia 1998;40(1-2):69-81. View abstract.
- Efferth, T. Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells. Curr Drug Targets. 2006;7(4):407-421. View abstract.
- Efferth, T., Dunstan, H., Sauerbrey, A., Miyachi, H., and Chitambar, C. R. The anti-malarial artesunate is also active against cancer. Int J Oncol 2001;18(4):767-773. View abstract.
- Fattorusso, E., Parapini, S., Campagnuolo, C., Basilico, N., Taglialatela-Scafati, O., and Taramelli, D. Activity against Plasmodium falciparum of cycloperoxide compounds obtained from the sponge Plakortis simplex. J Antimicrob.Chemother. 2002;50(6):883-888. View abstract.
- Haynes, R. K. From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements. Curr Top Med Chem 2006;6(5):509-537. View abstract.
- Heide, L. Artemisinin in traditional tea preparations of Artemisia annua. Trans R.Soc Trop.Med Hyg 2006;100(8):802. View abstract.
- Ho, N. K. Traditional Chinese medicine and treatment of neonatal jaundice. Singapore Med J 1996;37(6):645-651. View abstract.
- Hsu, E. The history of qing hao in the Chinese materia medica. Trans R.Soc Trop.Med Hyg 2006;100(6):505-508. View abstract.
- Juteau, F., Masotti, V., Bessiere, J. M., Dherbomez, M., and Viano, J. Antibacterial and antioxidant activities of Artemisia annua essential oil. Fitoterapia 2002;73(6):532-535. View abstract.
- Li, Y. and Wu, Y. L. How Chinese scientists discovered qinghaosu (artemisinin) and developed its derivatives? What are the future perspectives? Med Trop.(Mars.) 1998;58(3 Suppl):9-12. View abstract.
- Lommen, W. J., Schenk, E., Bouwmeester, H. J., and Verstappen, F. W. Trichome dynamics and artemisinin accumulation during development and senescence of Artemisia annua leaves. Planta Med 2006;72(4):336-345. View abstract.
- Phan, V. T. [Artemisinine and artesunate in the treatment of malaria in Vietnam (1984-1999)]. Bull Soc.Pathol.Exot. 2002;95(2):86-88. View abstract.
- Romero, M. R., Serrano, M. A., Vallejo, M., Efferth, T., Alvarez, M., and Marin, J. J. Antiviral effect of artemisinin from Artemisia annua against a model member of the Flaviviridae family, the bovine viral diarrhoea virus (BVDV). Planta Med 2006;72(13):1169-1174. View abstract.
- Shen, M., Ge, H. L., He, Y. X., Song, Q. L., and Zhang, H. Z. Immunosuppressive action of Qinghaosu. Sci Sin.[B] 1984;27(4):398-406. View abstract.
- Singh, N. P. and Lai, H. C. Artemisinin induces apoptosis in human cancer cells. Anticancer Res 2004;24(4):2277-2280. View abstract.
- Singh, N. P. and Lai, H. C. Synergistic cytotoxicity of artemisinin and sodium butyrate on human cancer cells. Anticancer Res 2005;25(6B):4325-4331. View abstract.
- Trevett, A. and Lalloo, D. A new look at an old drug: artemesinin and qinghaosu. P.N G Med J 1992;35(4):264-269. View abstract.
- Van der, Meersch H. [Review of the use of artemisinin and its derivatives in the treatment of malaria]. J Pharm Belg. 2005;60(1):23-29. View abstract.
- White, N. J. Artemisinin: current status. Trans.R.Soc.Trop.Med Hyg. 1994;88 Suppl 1:S3-S4. View abstract.
- Wu, G. D., Zhou, H. J., and Wu, X. H. Apoptosis of human umbilical vein endothelial cells induced by artesunate. Vascul.Pharmacol. 2004;41(6):205-212. View abstract.
- Yance, D. R., Jr. and Sagar, S. M. Targeting angiogenesis with integrative cancer therapies. Integr.Cancer Ther. 2006;5(1):9-29. View abstract.
- Zhao, K. C. and Song, Z. Y. [Pharmacokinetics of dihydroqinghaosu in human volunteers and comparison with qinghaosu]. Yao Xue.Xue.Bao. 1993;28(5):342-346. View abstract.
- Ziffer, H., Highet, R. J., and Klayman, D. L. Artemisinin: an endoperoxidic antimalarial from Artemisia annua L. Fortschr.Chem Org.Naturst. 1997;72:121-214. View abstract.
- Abdin MZ, Israr M, Rehman RU, Jain SK. Artemisinin, a novel antimalarial drug: biochemical and molecular approaches for enhanced production. Planta Med 2003;69:289-99. View abstract.
- Centers for Disease Control and Prevention (CDC). Hepatitis temporally associated with an herbal supplement containing artemisinin-Washington, 2008. MMWR Morb Mortal Wkly Rep 2009;58:854-8. View abstract.
- Dellicour S, Hall S, Chandramohan D, Greenwood B. The safety of artemisinins during pregnancy: a pressing question. Malar J 2007;6:15. View abstract.
- Eckstein-Ludwig U, Webb RJ, Van Goethem ID, et al. Artemisinins target the SERCA of Plasmodium falciparum. Nature 2003;424:957-61. View abstract.
- Huang L, Liu JF, Liu LX, et al. [Antipyretic and anti-inflammatory effects of Artemisia annua L]. Chung Kuo Chung Yao Tsa Chih 1993;18:44-48,63-4. View abstract.
- Miller LG, Panosian CB. Ataxia and slurred speech after artesunate treatment for falciparum malaria [letter]. N Engl J Med 1997;336:1328.
- Moneton P, Ducret JP. Positioning, labeling and control of medical information: artesunate strategy and Arsumax development story. Med Trop (Mars) 1998;58:70-2. View abstract.
- Mueller MS, Karhagomba IB, Hirt HM, Wemakor E. The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects. J Ethnopharmacol 2000;73:487-93. View abstract.
- Mueller MS, Runyambo N, Wagner I, et al. Randomized controlled trial of a traditional preparation of Artemisia annua L. (Annual Wormwood) in the treatment of malaria. Trans R Soc Trop Med Hyg 2004;98:318-21. View abstract.
- Pittler MH, Ernst E. Artemether for severe malaria: a meta-analysis of randomized clinical trials. Clin Infect Dis 1999;28:597-601. View abstract.
- Rath K, Taxis K, Walz G, et al. Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (annual wormwood). Am J Trop Med Hyg 2004;70:128-32. View abstract.
- van Agtmael MA, Eggelte TA, van Boxtel CJ. Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication. Trends Pharmacol Sci 1999;20:199-205. View abstract.
- Wan YD, Zang QZ, Wang JS. [Studies on the antimalarial action of gelatin capsule of Artemisia annua]. Chung Kuo Chi Sheng Chung Hsueh Yu Chi Sheng Chung Ping Tsa Chih 1992;10:290-4. View abstract.
- Xing J, Kirby BJ, Whittington D, et al. Evaluation of P450 inhibition and induction by artemisinin antimalarials in human liver microsomes and primary human hepatocytes. Drug Metabl Dispos 2012;40(9):1757-64. View abstract.
- Zheng GQ. Cytotoxic terpenoids and flavonoids from Artemisia annua. Planta Med 1994;60:54-7. View abstract.
- Bailey, N. J., Wang, Y., Sampson, J., Davis, W., Whitcombe, I., Hylands, P. J., Croft, S. L., and Holmes, E. Prediction of anti-plasmodial activity of Artemisia annua extracts: application of 1H NMR spectroscopy and chemometrics. J Pharm Biomed Anal. 4-1-2004;35(1):117-126. View abstract.
- Benakis, A., Paris, M., Loutan, L., Plessas, C. T., and Plessas, S. T. Pharmacokinetics of artemisinin and artesunate after oral administration in healthy volunteers. Am J Trop.Med Hyg 1997;56(1):17-23. View abstract.
- Berger, T. G., Dieckmann, D., Efferth, T., Schultz, E. S., Funk, J. O., Baur, A., and Schuler, G. Artesunate in the treatment of metastatic uveal melanoma--first experiences. Oncol Rep. 2005;14(6):1599-1603. View abstract.
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