Aak, Ak, Akada, Alarka, Arbre de Satan, Arbre à Soie, Arbre à Soie du Sénégal, Arka, Asclepias procera, Calotropis procera, Dead Sea Apple, Mudar Bark, Muder Yercum, Pommier de Sodome, Sodom-Apple, Swallow-Wort.<br/><br/>


Overview Information

Calotropis is a plant. People use the bark and root bark for medicine.

Despite serious safety concerns, calotropis is used for digestive disorders including diarrhea, constipation and stomach ulcers; for painful conditions including toothache, cramps, and joint pain; and for parasitic infections including elephantiasis and worms. Some people use calotropis for syphilis, boils, inflammation (swelling), epilepsy, hysteria, fever, muscular spasm, warts, leprosy, gout, snakebites, and cancer.

In inhalation therapy, smoke from the bark is inhaled for coughs, asthma, and to cause sweating.

How does it work?

Calotropis contains chemicals that might help thin mucous and make it easier to cough up. In studies in animals, calotropis has shown some activity against pain, inflammation, bacteria, fever, and ulcers caused by alcohol and medications such as aspirin, indomethacin (Indocin), and others.


Uses & Effectiveness?

Insufficient Evidence for

More evidence is needed to rate the effectiveness of calotropis for these uses.

Side Effects

Side Effects & Safety

Calotropis is UNSAFE, especially in high doses. It contains chemicals that can interfere with heart function, particularly at high doses. It can cause serious side effects including vomiting, diarrhea, slow heartbeat, convulsions, and death.

It’s not known whether it’s safe to inhale calotropis smoke.

Special Precautions & Warnings:

Pregnancy and breast-feeding: It’s UNSAFE to use calotropis during pregnancy and breast-feeding. Avoid use.



Moderate Interaction

Be cautious with this combination

  • Digoxin (Lanoxin) interacts with CALOTROPIS

    Digoxin (Lanoxin) helps the heart beat more strongly. Calotropis also seems to affect the heart. Taking calotropis along with digoxin can increase the effects of digoxin and increase the risk of side effects. Do not take calotropis if you are taking digoxin (Lanoxin) without talking to your healthcare professional.

  • Lithium interacts with CALOTROPIS

    Calotropis might have an effect like a water pill or "diuretic." Taking calotropis might decrease how well the body gets rid of lithium. This could increase how much lithium is in the body and result in serious side effects. Talk with your healthcare provider before using this product if you are taking lithium. Your lithium dose might need to be changed.

  • Stimulant laxatives interacts with CALOTROPIS

    Calotropis can affect the heart. The heart uses potassium. Laxatives called stimulant laxatives can decrease potassium levels in the body. Low potassium levels can increase the chance of side effects from calotropis.<br><nb>Some stimulant laxatives include bisacodyl (Correctol, Dulcolax), cascara, castor oil (Purge), senna (Senokot), and others.

  • Water pills (Diuretic drugs) interacts with CALOTROPIS

    Calotropis might affect the heart. "Water pills" can decrease potassium in the body. Low potassium levels can also affect the heart and increase the risk of side effects from calotropis.<br><nb>Some "water pills" that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Microzide), and others.



The appropriate dose of calotropis depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for calotropis. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Al-Mezaine HS, Al-Amry MA, Al-Assiri A, et al. Corneal endothelial cytotoxicity of the Calotropis procera (ushaar) plant. Cornea. 2008 May;27(4):504-6. View abstract.
  • Al-Mezaine HS, Al-Rajhi AA, Al-Assiri A, Wagoner MD. Calotropis procera (ushaar) keratitis. Am J Ophthalmol. 2005 Jan;139(1):199-202. View abstract.
  • Basak SK, Bhaumik A, Mohanta A, Singhal P. Ocular toxicity by latex of Calotropis procera (Sodom apple). Indian J Ophthalmol. 2009 May-Jun;57(3):232-4. View abstract.
  • Biedner B, Rothkoff L, Witztum A. Calotropis procera (Sodom apple) latex keratoconjunctivitis. Isr J Med Sci. 1977 Sep;13(9):914-6. View abstract.
  • Handa F, Sadana JK, Sharma PK. Allergic contact dermatitis due to the plant Calotropis procera (Vern: AK). A case report. Indian J Dermatol. 1984 Jul;29(3):27-9. View abstract.
  • Kumar VL, Basu N. Anti-inflammatory activity of the latex of Calotropis procera. J Ethnopharmacol 1994;44:123-5. View abstract.
  • Mascolo N, Sharma R, Jain SC, et al. Ethnopharmacology of Calotropis procera flowers. J Ethnopharmacol 1988;22:211-21. View abstract.
  • Mossa JS, Tariq M, Mohsin A, et al. Pharmacological studies on aerial parts of Calotropis procera. Am J Chin Med 1991;19:223-31. View abstract.
  • Osol and Farar. The Dispensatory of the United States of America. 25th ed. JB Lippincott Co., 1955.
  • Sen T, Basu A, Chaudhuri AK. Studies on the possible mechanism of the gastric mucosal protection by Calotropis procera - involvement of 5-lipoxygenase pathway. Fund Clin Pharmacol 1998;12:82-7. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.