People take black pepper by mouth for arthritis, asthma, upset stomach, and many other conditions, but there is no good scientific evidence to support these uses.
People inhale black pepper oil to prevent falls, to help quit smoking and reduce cravings, and for many other conditions, but there is no good scientific evidence to support these uses.
In foods, black pepper and black pepper oil are used as a spice.
How does it work ?
Uses & Effectiveness ?
Insufficient Evidence for
- Athletic performance. Early research in men who are not trained athletes shows that taking a supplement containing black pepper and other ingredients before exercise does not improve performance.
- Fall prevention. Early research shows that applying black pepper oil near the right side of the nose in order to inhale the scent improves stability in older people when their eyes are closed. This improvement is similar to applying and inhaling lavender oil.
- Fatigue. Early research shows that taking black pepper does not improve attention or mental energy in adults with low energy levels.
- Insect bite. Early research shows that applying a specific product (Trikatu) containing black pepper and other ingredients directly to mosquito bites does not reduce the size, redness, or itchiness of the bites.
- Quitting smoking. Early research in men who smoke shows that puffing on a vapor device containing black pepper oil over 3 hours may reduce cigarette cravings and anxiety. Also, early research in adults who are addicted to chewing, dipping, or smokingtobacco shows that inhaling a drop of black pepper oil on a tissue might reduce cravings.
- Trouble swallowing. Some children with different medical conditions, including brain disorders, are fed through a tube (enteral nutrition) because they are not able to eat food consistently. Early research in these children shows that applying black pepper oil to the nostrils or nasal cavity for one minute before meals can improve swallowing and the amount of food they can eat. Other early research in older adults who have had a stroke and are living in a long-term care nursing home, shows that applying black pepper oil near the nostrils for one minute before meals can improve swallowing.
- A skin disorder that causes white patches to develop on the skin (vitiligo).
- A bacterial infection that causes diarrhea (cholera).
- Discolored skin (vitiligo).
- Itchy skin caused by mites (scabies).
- Menstrual pain.
- Nerve pain.
- Sex drive.
- Stuffy nose.
- Sinus infection.
- Upset stomach.
- Weight loss.
- Other conditions.
When applied to the skin: Black pepper oil is POSSIBLY SAFE. If it gets into the eyes, black pepper can burn. Some people might develop an allergy to black pepper.
When inhaled: Black pepper oil is POSSIBLY SAFE when inhaled through the nose or mouth. Black pepper might have a burning aftertaste and it might upset the stomach. Inhaling black pepper oil through the nose or mouth can cause cough. Some people might develop an allergy to black pepper.
Special Precautions and Warnings
There isn't enough reliable information available to know if applying black pepper to the skin is safe while pregnant.
Breast-feeding: Black pepper is LIKELY SAFE when taken by mouth in amounts commonly found in foods. There isn't enough reliable information to know if black pepper is safe when used as medicine when breast-feeding. Stay on the safe side and stick to food amounts.
Children: Black pepper is LIKELY SAFE when taken by mouth in amounts commonly found in foods. It is POSSIBLY UNSAFE when taken by mouth in large amounts. Deaths in children have been reported from large amounts of black pepper accidentally entering the lungs. There isn't enough reliable information available to know if applying black pepper oil to the skin is safe for children.
Bleeding conditions: Piperine, a chemical in black pepper, might slow blood clotting. In theory, taking black pepper in amounts greater than those in food might increase the risk of bleeding in people with bleeding disorders.
Diabetes: Black pepper might affect blood sugar levels. In theory, taking black pepper in amounts greater than those in food might affect blood sugar control in people with diabetes. Dosing adjustments for diabetes medications might be needed.
Surgery: Piperine, a chemical in black pepper, might slow blood clotting and affect blood sugar levels. In theory, taking black pepper in amounts treater than those found in food might cause bleeding complications or affect blood sugar levels during surgery. You should stop taking black pepper in amounts greater than those in food at least 2 weeks before surgery.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with BLACK PEPPER AND WHITE PEPPER
Some medications are changed and broken down by the liver.
Black and white pepper might decrease how quickly the liver breaks down some medications. Taking pepper along with some medications that are broken down by the liver can increase the chance of side effects from some medications. Before taking black or white pepper, talk to your healthcare provider if you are taking any medications that are changed by the liver.
Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.
Medications moved by pumps in cells (P-Glycoprotein Substrates) interacts with BLACK PEPPER AND WHITE PEPPER
Some medications are moved by pumps in cells. Black and white pepper might make these pumps less active and increase how much of some medications get absorbed by the body. This might cause more side effects from some medications.
Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, digoxin, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.
Phenytoin (Dilantin) interacts with BLACK PEPPER AND WHITE PEPPER
Black and white pepper might increase how much phenytoin (Dilantin) the body absorbs. Taking black and white pepper along with phenytoin (Dilantin) might increase the effects and side effects of phenytoin (Dilantin).
Propranolol (Inderal) interacts with BLACK PEPPER AND WHITE PEPPER
Black and white pepper might increase how much propranolol (Inderal) the body absorbs. Taking black and white pepper along with propranolol (Inderal) might increase the effects and side effects of propranolol (Inderal).
Rifampin interacts with BLACK PEPPER AND WHITE PEPPER
Black and white pepper might increase how much rifampin the body absorbs. Taking black and white pepper along with rifampin might increase the effects and side effects of rifampin.
Theophylline interacts with BLACK PEPPER AND WHITE PEPPER
Black pepper and white pepper can increase how much theophylline the body can absorb. This might cause increased effects and side effects of theophylline.
Lithium interacts with BLACK PEPPER AND WHITE PEPPER
Black pepper and white pepper might have an effect like a water pill or "diuretic." Taking black pepper and white pepper might decrease how well the body gets rid of lithium. This could increase how much lithium is in the body and result in serious side effects. Talk with your healthcare provider before using this product if you are taking lithium. Your lithium dose might need to be changed.
Be cautious with this combination
Carbamazepine (Tegretol) interacts with BLACK PEPPER AND WHITE PEPPER
Black and white pepper might increase the amount of carbamazepine (Tegretol) absorbed by the body. It might also decrease how quickly the body breaks down and gets rid of carbamazepine. This could increase how much carbamazepine is in the body and potentially increase the chance of side effects. However, there is not enough known about this potential interaction to know if it is a big concern.
Be watchful with this combination
Amer, A. and Mehlhorn, H. Persistency of larvicidal effects of plant oil extracts under different storage conditions. Parasitol.Res. 2006;99(4):473-477. View abstract.
Chaubey, M. K. Fumigant toxicity of essential oils from some common spices against pulse beetle, Callosobruchus chinensis (Coleoptera: Bruchidae). J Oleo.Sci 2008;57(3):171-179. View abstract.
Chaudhry, N. M. and Tariq, P. Bactericidal activity of black pepper, bay leaf, aniseed and coriander against oral isolates. Pak.J Pharm Sci 2006;19(3):214-218. View abstract.
Dearlove, R. P., Greenspan, P., Hartle, D. K., Swanson, R. B., and Hargrove, J. L. Inhibition of protein glycation by extracts of culinary herbs and spices. J Med Food 2008;11(2):275-281. View abstract.
George, D. R., Sparagano, O. A., Port, G., Okello, E., Shiel, R. S., and Guy, J. H. Repellence of plant essential oils to Dermanyssus gallinae and toxicity to the non-target invertebrate Tenebrio molitor. Vet.Parasitol. 5-26-2009;162(1-2):129-134. View abstract.
Hasegawa, G. R. Proposals for chemical weapons during the American Civil War. Mil.Med. 2008;173(5):499-506. View abstract.
Hendrix, C. R., Housh, T. J., Mielke, M., Zuniga, J. M., Camic, C. L., Johnson, G. O., Schmidt, R. J., and Housh, D. J. Acute effects of a caffeine-containing supplement on bench press and leg extension strength and time to exhaustion during cycle ergometry. J Strength.Cond.Res 2010;24(3):859-865. View abstract.
Marotta, R. B. and Floch, M. H. Diet and nutrition in ulcer disease. Med Clin North Am 1991;75(4):967-979. View abstract.
O'Mahony, R., Al Khtheeri, H., Weerasekera, D., Fernando, N., Vaira, D., Holton, J., and Basset, C. Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori. World J Gastroenterol. 12-21-2005;11(47):7499-7507. View abstract.
Panossian, A., Nikoyan, N., Ohanyan, N., Hovhannisyan, A., Abrahamyan, H., Gabrielyan, E., and Wikman, G. Comparative study of Rhodiola preparations on behavioral despair of rats. Phytomedicine. 2008;15(1-2):84-91. View abstract.
Saraswat, M., Muthenna, P., Suryanarayana, P., Petrash, J. M., and Reddy, G. B. Dietary sources of aldose reductase inhibitors: prospects for alleviating diabetic complications. Asia Pac.J Clin Nutr. 2008;17(4):558-565. View abstract.
Saraswat, M., Reddy, P. Y., Muthenna, P., and Reddy, G. B. Prevention of non-enzymic glycation of proteins by dietary agents: prospects for alleviating diabetic complications. Br.J Nutr. 2009;101(11):1714-1721. View abstract.
Subehan, Usia, T., Iwata, H., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. J Ethnopharmacol. 5-24-2006;105(3):449-455. View abstract.
Tantaoui-Elaraki, A. and Beraoud, L. Inhibition of growth and aflatoxin production in Aspergillus parasiticus by essential oils of selected plant materials. J Environ.Pathol.Toxicol Oncol. 1994;13(1):67-72. View abstract.
Thavara, U., Tawatsin, A., Bhakdeenuan, P., Wongsinkongman, P., Boonruad, T., Bansiddhi, J., Chavalittumrong, P., Komalamisra, N., Siriyasatien, P., and Mulla, M. S. Repellent activity of essential oils against cockroaches (Dictyoptera: Blattidae, Blattellidae, and Blaberidae) in Thailand. Southeast Asian J Trop.Med.Public Health 2007;38(4):663-673. View abstract.
Topal, U., Sasaki, M., Goto, M., and Otles, S. Chemical compositions and antioxidant properties of essential oils from nine species of Turkish plants obtained by supercritical carbon dioxide extraction and steam distillation. Int.J.Food Sci.Nutr. 2008;59(7-8):619-634. View abstract.
Vasudevan, K., Vembar, S., Veeraraghavan, K., and Haranath, P. S. Influence of intragastric perfusion of aqueous spice extracts on acid secretion in anesthetized albino rats. Indian J.Gastroenterol. 2000;19(2):53-56. View abstract.
65 Navarro, I. T., Vidotto, O., Giraldi, N., and Mitsuka, R. [Resistance of Toxoplasma gondii to sodium chloride and condiments in pork sausage]. Bol.Oficina Sanit.Panam. 1992;112(2):138-143. View abstract.
Agbor, G. A., Vinson, J. A., Oben, J. E., and Ngogang, J. Y. In vitro antioxidant activity of three Piper species. J Herb.Pharmacother. 2007;7(2):49-64. View abstract.
Aher, S., Biradar, S., Gopu, C. L., and Paradkar, A. Novel pepper extract for enhanced P-glycoprotein inhibition. J Pharm.Pharmacol. 2009;61(9):1179-1186. View abstract.
Andaya, B. Women and Economic Change: The Pepper Trade in Pre-Modern Southeast Asia. Journal of the Economic & Social History of the Orient 1995;38(2):165-190.
Bajad, S., Bedi, K. L., Singla, A. K., and Johri, R. K. Antidiarrhoeal activity of piperine in mice. Planta Med 2001;67(3):284-287. View abstract.
Bano G, Amla V, Raina RK, et al. The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers. Planta Med 1987;53:568-9.
Bano G, et al. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol 1991;41;615-7. View abstract.
Bezerra, D. P., Pessoa, C., de Moraes, M. O., Silveira, E. R., Lima, M. A., Elmiro, F. J., and Costa-Lotufo, L. V. Antiproliferative effects of two amides, piperine and piplartine, from Piper species. Z.Naturforsch.C. 2005;60(7-8):539-543. View abstract.
Bhardwaj RK, Glaeser H, Becquemont L, et al. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002;302:645-50. View abstract.
Capasso, R., Izzo, A. A., Borrelli, F., Russo, A., Sautebin, L., Pinto, A., Capasso, F., and Mascolo, N. Effect of piperine, the active ingredient of black pepper, on intestinal secretion in mice. Life Sci 9-27-2002;71(19):2311-2317. View abstract.
Cohle SD, Trestrail JD III, Graham MA, et al. Fatal pepper aspiration. Am J Dis Child 1988;142:633-6. View abstract.
Cordell B, Buckle J. The effects of aromatherapy on nicotine craving on a U.S. campus: a small comparison study. J Altern Complement Med. 2013 Aug;19(8):709-13. doi: 10.1089/acm.2012.0537. Epub 2013 Mar 28. View abstract.
Dorman HJ, Deans SG. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol 2000;88:308-16. View abstract.
Duessel, S., Heuertz, R. M., and Ezekiel, U. R. Growth inhibition of human colon cancer cells by plant compounds. Clin Lab Sci. 2008;21(3):151-157. View abstract.
Ebihara, T., Ebihara, S., Maruyama, M., Kobayashi, M., Itou, A., Arai, H., and Sasaki, H. A randomized trial of olfactory stimulation using black pepper oil in older people with swallowing dysfunction. J Am Geriatr Soc 2006;54(9):1401-1406.View abstract.
el Mofty, M. M., Soliman, A. A., Abdel-Gawad, A. F., Sakr, S. A., and Shwaireb, M. H. Carcinogenicity testing of black pepper (Piper nigrum) using the Egyptian toad (Bufo regularis) as a quick biological test animal. Oncology 1988;45(3):247-252. View abstract.
el-Mofty MM, Khudoley VV, Shwaireb MH. Carcinogenic effect of force-feeding an extract of black pepper (Piper nigrum) in Egyptian toads (Bufo regularis). Oncology 1991;48:347-50. View abstract.
Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
Faas, L., Venkatasamy, R., Hider, R. C., Young, A. R., and Soumyanath, A. In vivo evaluation of piperine and synthetic analogues as potential treatments for vitiligo using a sparsely pigmented mouse model. Br.J Dermatol. 2008;158(5):941-950. View abstract.
Freeman, S., Ebihara, S., Ebihara, T., Niu, K., Kohzuki, M., Arai, H., and Butler, J. P. Olfactory stimuli and enhanced postural stability in older adults. Gait.Posture. 2009;29(4):658-660. View abstract.
Freire-de-Lima, L., Ribeiro, T. S., Rocha, G. M., Brandao, B. A., Romeiro, A., Mendonca-Previato, L., Previato, J. O., de Lima, M. E., de Carvalho, T. M., and Heise, N. The toxic effects of piperine against Trypanosoma cruzi: ultrastructural alterations and reversible blockage of cytokinesis in epimastigote forms. Parasitol.Res. 2008;102(5):1059-1067. View abstract.
Friedman, M., Levin, C. E., Lee, S. U., Lee, J. S., Ohnisi-Kameyama, M., and Kozukue, N. Analysis by HPLC and LC/MS of pungent piperamides in commercial black, white, green, and red whole and ground peppercorns. J Agric.Food Chem. 5-14-2008;56(9):3028-3036. View abstract.
Gimenez L, Zacharisen M. Severe pepper allergy in a young child. WMJ. 2011 Jun;110(3):138-9. View abstract.
Gregersen NT, Belza A, Jensen MG, Ritz C, Bitz C, Hels O, Frandsen E, Mela DJ, Astrup A. Acute effects of mustard, horseradish, black pepper and ginger on energy expenditure, appetite, ad libitum energy intake and energy balance in human subjects. Br J Nutr. 2013 Feb 14;109(3):556-63. View abstract.
Gulcin, I. The antioxidant and radical scavenging activities of black pepper (Piper nigrum) seeds. Int.J Food Sci Nutr. 2005;56(7):491-499. View abstract.
Hamada, T. [Studies on the crude drugs used for the folk medicine described in "mimi-bukuro"]. Yakushigaku.Zasshi 1995;30(1):46-53. View abstract.
Han X, Beaumont C, Rodriguez D, Bahr T. Black pepper (Piper nigrum) essential oil demonstrates tissue remodeling and metabolism modulating potential in human cells. Phytother Res. 2018;32(9):1848-1852. View abstract.
Han, Y., Chin Tan, T. M., and Lim, L. Y. In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression. Toxicol.Appl.Pharmacol. 8-1-2008;230(3):283-289. View abstract.
Hiwale, A. R., Dhuley, J. N., and Naik, S. R. Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats. Indian J Exp.Biol. 2002;40(3):277-281. View abstract.
Kamble VA. Spice derived essential oils: effective antifungal and possible therapeutic agents. Journal of Herbs, Spices & Medicinal Plants 2008;14(3-4):129-143.
Kapoor, I. P., Singh, B., Singh, G., De Heluani, C. S., De Lampasona, M. P., and Catalan, C. A. Chemistry and in vitro antioxidant activity of volatile oil and oleoresins of black pepper (Piper nigrum). J Agric.Food Chem. 6-24-2009;57(12):5358-5364. View abstract.
Kasibhatta, R. and Naidu, M. U. Influence of piperine on the pharmacokinetics of nevirapine under fasting conditions: a randomised, crossover, placebo-controlled study. Drugs R.D. 2007;8(6):383-391. View abstract.
Khajuria A, Zutshi U, Bedi KL. Permeability characteristics of piperine on oral absorption-an active alkaloid from peppers and a bioavailability enhancer. Indian J Exp Biol 1998;36:46-50. View abstract.
Koul, I. B. and Kapil, A. Evaluation of the liver protective potential of piperine, an active principle of black and long peppers. Planta Med 1993;59(5):413-417. View abstract.
Krishnakumar, N., Manoharan, S., Palaniappan, P. R., Venkatachalam, P., and Manohar, M. G. Chemopreventive efficacy of piperine in 7,12-dimethyl benz [a] anthracene (DMBA)-induced hamster buccal pouch carcinogenesis: an FT-IR study. Food Chem.Toxicol. 2009;47(11):2813-2820. View abstract.
Kristiniak S, Harpel J, Breckenridge DM, Buckle J. Black pepper essential oil to enhance intravenous catheter insertion in patients with poor vein visibility: a controlled study. J Altern Complement Med. 2012;18(11):1003-7. View abstract.
Lawless, H. and Stevens, D. A. Effects of oral chemical irritation on taste. Physiol Behav. 1984;32(6):995-998. View abstract.
Lin, J. K. Food-borne amines and amides as potential precursors of endogenous carcinogens. Proc Natl.Sci Counc.Repub.China B 1986;10(1):20-34. View abstract.
Lin, Z., Hoult, J. R., Bennett, D. C., and Raman, A. Stimulation of mouse melanocyte proliferation by Piper nigrum fruit extract and its main alkaloid, piperine. Planta Med 1999;65(7):600-603. View abstract.
Lin, Z., Liao, Y., Venkatasamy, R., Hider, R. C., and Soumyanath, A. Amides from Piper nigrum L. with dissimilar effects on melanocyte proliferation in-vitro. J Pharm.Pharmacol. 2007;59(4):529-536. View abstract.
Lindheimer JB, Loy BD, O'Connor PJ. Short-term effects of black pepper (Piper nigrum) and rosemary (Rosmarinus officinalis and Rosmarinnus eriocalyx) on sustained attention and on energy and fatigue mood states in young adults with low energy. J Med Food. 2013;16(8):765-771.
Maenthaisong R, Chaiyakunapruk N, Tiyaboonchai W, Tawatsin A, Rojanawiwat A, Thavara U. Efficacy and safety of topical Trikatu preparation in, relieving mosquito bite reactions: a randomized controlled trial. Complement Ther Med 2014;22(1):34-9. View abstract.
Matsuda, H., Ninomiya, K., Morikawa, T., Yasuda, D., Yamaguchi, I., and Yoshikawa, M. Hepatoprotective amide constituents from the fruit of Piper chaba: Structural requirements, mode of action, and new amides. Bioorg.Med Chem. 10-15-2009;17(20):7313-7323. View abstract.
McNamara, F. N., Randall, A., and Gunthorpe, M. J. Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br J Pharmacol 2005;144(6):781-790. View abstract.
Meghwal M, Goswami TK. Piper nigrum and piperine: an update. Phytother Res. 2013;27(8):1121-30. View abstract.
Mohtar, M., Johari, S. A., Li, A. R., Isa, M. M., Mustafa, S., Ali, A. M., and Basri, D. F. Inhibitory and resistance-modifying potential of plant-based alkaloids against methicillin-resistant Staphylococcus aureus (MRSA). Curr.Microbiol. 2009;59(2):181-186. View abstract.
Mujumdar, A. M., Dhuley, J. N., Deshmukh, V. K., Raman, P. H., Thorat, S. L., and Naik, S. R. Effect of piperine on pentobarbitone induced hypnosis in rats. Indian J Exp.Biol. 1990;28(5):486-487. View Abstract.
Munakata, M., Kobayashi, K., Niisato-Nezu, J., Tanaka, S., Kakisaka, Y., Ebihara, T., Ebihara, S., Haginoya, K., Tsuchiya, S., and Onuma, A. Olfactory stimulation using black pepper oil facilitates oral feeding in pediatric patients receiving long-term enteral nutrition. Tohoku J Exp.Med 2008;214(4):327-332. View abstract.
Myers, B. M., Smith, J. L., and Graham, D. Y. Effect of red pepper and black pepper on the stomach. Am J Gastroenterol 1987;82(3):211-214. View abstract.
Nalini N, Sabitha K, Viswanathan P, Menon VP. Influence of spices on the bacterial (enzyme) activity in experimental colon cancer. J Ethnopharmacol 1998;62:15-24. View abstract.
Naseri, M. K. and Yahyavi, H. Antispasmodic effect of Piper nigrum fruit hot water extract on rat ileum. Pak.J Biol.Sci 6-1-2008;11(11):1492-1496. View abstract.
Ngamo, L. S., Ngassoum, M. B., Jirovetz, L., Ousman, A., Nukenine, E. C., and Mukala, O. E. Protection of stored maize against Sitophilus zeamais (Motsch.) by use of essential oils of spices from Cameroon. Meded.Rijksuniv.Gent Fak.Landbouwkd.Toegep.Biol.Wet. 2001;66(2a):473-478. View abstract.
Ononiwu, I. M., Ibeneme, C. E., and Ebong, O. O. Effects of piperine on gastric acid secretion in albino rats. Afr.J Med Med Sci 2002;31(4):293-295. View abstract.
Panda, S. and Kar, A. Piperine lowers the serum concentrations of thyroid hormones, glucose and hepatic 5'D activity in adult male mice. Horm.Metab Res. 2003;35(9):523-526. View abstract.
Park, I. K., Lee, S. G., Shin, S. C., Park, J. D., and Ahn, Y. J. Larvicidal activity of isobutylamides identified in Piper nigrum fruits against three mosquito species. J Agric.Food Chem. 3-27-2002;50(7):1866-1870. View abstract.
Pattanaik S, Hota D, Prabhakar S, et al. Pharmacokinetic interaction of a single dose of piperine with steady-state carbamazepine in epilepsy patients. Phytother Res 2009;23:1281-6. View abstract.
Pires, OC. Preliminary comparative analysis of the acute toxicity and median lethal dose LD50 of the fruit of the Brazilian black pepper Schinus terebinthifolius Raddi and black pepper Piper nigrum L. Acta Farmaceutica Bonaerense (Argentina) 2004;23:176-182.
Piyachaturawat, P., Kingkaeohoi, S., and Toskulkao, C. Potentiation of carbon tetrachloride hepatotoxicity by piperine. Drug Chem.Toxicol. 1995;18(4):333-344. View abstract.
Raay, B., Medda, S., Mukhopadhyay, S., and Basu, M. K. Targeting of piperine intercalated in mannose-coated liposomes in experimental leishmaniasis. Indian J Biochem.Biophys. 1999;36(4):248-251. View abstract.
Raghavendra, R. H. and Naidu, K. A. Spice active principles as the inhibitors of human platelet aggregation and thromboxane biosynthesis. Prostaglandins Leukot.Essent.Fatty Acids 2009;81(1):73-78. View abstract.
Reen, R. K., Roesch, S. F., Kiefer, F., Wiebel, F. J., and Singh, J. Piperine impairs cytochrome P4501A1 activity by direct interaction with the enzyme and not by down regulation of CYP1A1 gene expression in the rat hepatoma 5L cell line. Biochem.Biophys.Res.Commun. 1-17-1996;218(2):562-569. View abstract.
Reen, R. K., Wiebel, F. J., and Singh, J. Piperine inhibits aflatoxin B1-induced cytotoxicity and genotoxicity in V79 Chinese hamster cells genetically engineered to express rat cytochrome P4502B1. J Ethnopharmacol. 1997;58(3):165-173. View abstract.
Ren T, Yang M, Xiao M, Zhu J, Xie W, Zuo Z. Time-dependent inhibition of carbamazepine metabolism by piperine in anti-epileptic treatment. Life Sci. 2019;218:314-323. View abstract.
Ribeiro, T. S., Freire-de-Lima, L., Previato, J. O., Mendonca-Previato, L., Heise, N., and de Lima, M. E. Toxic effects of natural piperine and its derivatives on epimastigotes and amastigotes of Trypanosoma cruzi. Bioorg.Med Chem.Lett. 7-5-2004;14(13):3555-3558. View abstract.
Rondanelli M, Opizzi A, Perna S, Faliva M, Solerte SB, Fioravanti M, Klersy C, Edda C, Maddalena P, Luciano S, Paola C, Emanuela C, Claudia S, Donini LM. Acute effect on satiety, resting energy expenditure, respiratory quotient, glucagon-like peptide-1, free fatty acids, and glycerol following consumption of a combination of bioactive food ingredients in overweight subjects. J Am Coll Nutr. 2013;32(1):41-9. View abstract.
Rose, J. E. and Behm, F. M. Inhalation of vapor from black pepper extract reduces smoking withdrawal symptoms. Drug Alcohol Depend. 1994;34(3):225-229. View abstract.
Saxena, R., Venkaiah, K., Anitha, P., Venu, L., and Raghunath, M. Antioxidant activity of commonly consumed plant foods of India: contribution of their phenolic content. Int.J Food Sci Nutr. 2007;58(4):250-260. View abstract.
Scott, I. M., Gagnon, N., Lesage, L., Philogene, B. J., and Arnason, J. T. Efficacy of botanical insecticides from Piper species (Piperaceae) extracts for control of Ruropean chafer (Coleoptera: Scarabaeidae). J Econ.Entomol. 2005;98(3):845-855. View abstract.
Selvendiran, K., Banu, S. M., and Sakthisekaran, D. Oral supplementation of piperine leads to altered phase II enzymes and reduced DNA damage and DNA-protein cross links in Benzo(a)pyrene induced experimental lung carcinogenesis. Mol.Cell Biochem. 2005;268(1-2):141-147. View abstract.
Selvendiran, K., Banu, S. M., and Sakthisekaran, D. Protective effect of piperine on benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice. Clin Chim.Acta 2004;350(1-2):73-78. View abstract.
Selvendiran, K., Thirunavukkarasu, C., Singh, J. P., Padmavathi, R., and Sakthisekaran, D. Chemopreventive effect of piperine on mitochondrial TCA cycle and phase-I and glutathione-metabolizing enzymes in benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. Mol.Cell Biochem. 2005;271(1-2):101-106. View abstract.
Shafiee A, Hoormand M, Shahidi-Dadras M, Abadi A. The effect of topical piperine combined with narrowband UVB on vitiligo treatment: A clinical trial study. Phytother Res. 2018;32(9):1812-1817. View abstract.
Sharma, P., Varma, M. V., Chawla, H. P., and Panchagnula, R. In situ and in vivo efficacy of peroral absorption enhancers in rats and correlation to in vitro mechanistic studies. Farmaco 2005;60(11-12):874-883. View abstract.
Sheahan K, Page DV, Kemper T, Suarez R. Childhood sudden death secondary to accidental aspiration of black pepper. Am J Forensic Med Pathol 1988;9:51-3. View abstract.
Shenoy, N. R. and Choughuley, A. S. Characterization of potentially mutagenic products from the nitrosation of piperine. Cancer Lett. 7-10-1992;64(3):235-239. View abstract.
Siddiqui, B. S., Gulzar, T., Mahmood, A., Begum, S., Khan, B., and Afshan, F. New insecticidal amides from petroleum ether extract of dried Piper nigrum L. whole fruits. Chem.Pharm.Bull (Tokyo) 2004;52(11):1349-1352. View abstract.
Simas, N. K., Lima, Eda C., Kuster, R. M., Lage, C. L., and Oliveira Filho, A. M. Potential use of Piper nigrum ethanol extract against pyrethroid-resistant Aedes aegypti larvae. Rev.Soc.Bras.Med Trop. 2007;40(4):405-407. View abstract.
Singh A, Rao AR. Evaluation of the modulatory influence of black pepper (Piper nigrum, L.) on the hepatic detoxication system. Cancer Lett 1993;72:5-9. View abstract.
Singh, J., Reen, R. K., and Wiebel, F. J. Piperine, a major ingredient of black and long peppers, protects against AFB1-induced cytotoxicity and micronuclei formation in H4IIEC3 rat hepatoma cells. Cancer Lett. 11-11-1994;86(2):195-200. View abstract.
Song, Q. F., Qu, Y. C., Zheng, H. B., Zhang, G. H., Lin, H. G., and Yang, J. L. [Differentiation of erythroleukemia K562 cells induced by piperine]. Ai.Zheng. 2008;27(6):571-574. View abstract.
Subehan, Usia, T., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of human liver microsomal cytochrome P450 2D6 (CYP2D6) by alkamides of Piper nigrum. Planta Med 2006;72(6):527-532. View abstract.
Taqvi, SI, Shah, AJ, and Gilani, AH. Insight into the possible mechanism of antidiarrheal and antispasmodic activities of piperine. Pharmaceutical Biology (Netherlands) 2009;47(660):664.
Unnikrishnan, M. C. and Kuttan, R. Tumour reducing and anticarcinogenic activity of selected spices. Cancer Lett. 5-15-1990;51(1):85-89. View abstract.
Usia, T., Iwata, H., Hiratsuka, A., Watabe, T., Kadota, S., and Tezuka, Y. CYP3A4 and CYP2D6 inhibitory activities of Indonesian medicinal plants. Phytomedicine. 2006;13(1-2):67-73. View abstract.
Veerareddy, P. R., Vobalaboina, V., and Nahid, A. Formulation and evaluation of oil-in-water emulsions of piperine in visceral leishmaniasis. Pharmazie 2004;59(3):194-197. View abstract.
Velpandian T, Jasuja R, Bhardwaj RK, et al. Piperine in food: interference in the pharmacokinetics of phenytoin. Eur J Drug Metab Pharmacokinet 2001;26:241-7. View abstract.
Vijayakumar, R. S., Surya, D., and Nalini, N. Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress. Redox.Rep. 2004;9(2):105-110. View abstract.
Wrba, H., el Mofty, M. M., Schwaireb, M. H., and Dutter, A. Carcinogenicity testing of some constituents of black pepper (Piper nigrum). Exp.Toxicol.Pathol. 1992;44(2):61-65. View abstract.
Zutshi, R. K., Singh, R., Zutshi, U., Johri, R. K., and Atal, C. K. Influence of piperine on rifampicin blood levels in patients of pulmonary tuberculosis. J Assoc.Physicians India 1985;33(3):223-224. View abstract.
Amer, A. and Mehlhorn, H. Larvicidal effects of various essential oils against Aedes, Anopheles, and Culex larvae (Diptera, Culicidae). Parasitol.Res. 2006;99(4):466-472. View abstract.
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