GAMMA BUTYROLACTONE (GBL): Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Gamma butyrolactone (GBL) is a chemical. People use it as medicine. Be careful not to confuse GBL with gamma-hydroxybutyrate (GHB) or butanediol.

Despite being illegal and carrying serious safety concerns, people use GBL as a recreational drug or for purposes such as sleep, sexual performance, and many others, but there is no scientific evidence to support these uses. Using GBL can be unsafe and cause severe side effects including addiction, withdrawal, coma, and death.

How does it work ?

GBL is converted in the body to gamma hydroxybutyrate (GHB) which affects several nerve pathways in the brain.

Interactions ?

Moderate Interaction

Be cautious with this combination

Alcohol (Ethanol) interacts with GAMMA BUTYROLACTONE (GBL)
Alcohol can cause sleepiness and drowsiness. Taking GBL along with alcohol might greatly increase sleepiness and drowsiness caused by alcohol. Taking GBL along with alcohol can lead to serious side effects. Do not take GBL if you have been drinking.
Amphetamines interacts with GAMMA BUTYROLACTONE (GBL)
Amphetamines are drugs that can speed up your nervous system. GBL is changed in the body to GHB (gamma-hydroxybutyrate). GHB can slow down your nervous system. Taking GBL along with amphetamines can lead to serious side effects.
Haloperidol (Haldol) interacts with GAMMA BUTYROLACTONE (GBL)
GBL can affect the brain. Haloperidol can also affect the brain. Taking haloperidol along with GBL might cause serious side effects. However, healthcare providers may sometimes use haloperidol to treat certain side effects or symptoms of withdrawal from GBL.
Medications for mental conditions (Antipsychotic drugs) interacts with GAMMA BUTYROLACTONE (GBL)
GBL can affect the brain. Antipsychotic drugs also affect the brain. Taking GBL along with these medications might increase the effects and serious side effects of GBL. However, healthcare providers may sometimes use these medications to treat certain side effects or symptoms of withdrawal from GBL.

Some of these medications include fluphenazine (Permitil, Prolixin), haloperidol (Haldol), chlorpromazine (Thorazine), prochlorperazine (Compazine), thioridazine (Mellaril), trifluoperazine (Stelazine), and others.
Medications for pain (Narcotic drugs) interacts with GAMMA BUTYROLACTONE (GBL)
Some medications for pain can cause sleepiness and drowsiness. GBL might also cause sleepiness and drowsiness. Taking GBL along with some medications for pain might cause severe side effects. Do not take GBL if you are taking medications for pain.

Some medications for pain include meperidine (Demerol), hydrocodone, morphine, OxyContin, and many others.
Medications used to prevent seizures (Anticonvulsants) interacts with GAMMA BUTYROLACTONE (GBL)
Medications used to prevent seizures affect chemicals in the brain. GBL is changed in the body to one of these brain chemicals called GABA. Taking GBL along with medications used to prevent seizures might decrease the effects of these medications and increase the risk for seizure.

Some medications used to prevent seizures include phenobarbital, primidone (Mysoline), valproic acid (Depakene), gabapentin (Neurontin), carbamazepine (Tegretol), phenytoin (Dilantin), and others.
Muscle relaxants interacts with GAMMA BUTYROLACTONE (GBL)
Muscle relaxants can cause drowsiness. GBL can also cause drowsiness. Taking GBL along with muscle relaxants might cause too much drowsiness and serious side effects. Do not take GBL if you are taking muscle relaxants.

Some of these muscle relaxants include carisoprodol (Soma), pipecuronium (Arduan), orphenadrine (Banflex, Disipal), cyclobenzaprine, gallamine (Flaxedil), atracurium (Tracrium), pancuronium (Pavulon), succinylcholine (Anectine), and others.
Naloxone (Narcan) interacts with GAMMA BUTYROLACTONE (GBL)
GBL is changed by the body to another chemical. This chemical is called GHB. GHB can affect the brain. Taking naloxone along with GBL might decrease the effects of naloxone.
Ritonavir (Norvir) interacts with GAMMA BUTYROLACTONE (GBL)
Ritonavir is commonly used for HIV/AIDS. Taking ritonavir with GBL might decrease how quickly the body gets rid of GBL. This could increase the effects of GBL and cause serious side effects.
Saquinavir (Fortovase, Invirase) interacts with GAMMA BUTYROLACTONE (GBL)
Saquinavir is commonly used for HIV/AIDS. Taking this medication with GBL might decrease how fast the body gets rid of GBL. This could increase the effects of GBL and cause serious side effects.
Sedative medications (Benzodiazepines) interacts with GAMMA BUTYROLACTONE (GBL)
GBL might cause sleepiness and drowsiness. Medications that cause sleepiness and drowsiness are called sedatives. Taking GBL along with sedative medications might cause serious side effects. However, healthcare providers may sometimes use sedative medications to treat certain side effects or symptoms of withdrawal from GBL.

Some of these sedative medications include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others.
Sedative medications (CNS depressants) interacts with GAMMA BUTYROLACTONE (GBL)
GBL might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking GBL along with sedative medications might cause serious side effects. Do not take GBL if you are taking sedative medications.

Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.

View References

REFERENCES:

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GAMMA BUTYROLACTONE (GBL) - Uses, Side Effects, and More

Overview

How does it work ?

Uses & Effectiveness ?

Side Effects

Special Precautions and Warnings

Interactions ?

Moderate Interaction

Alcohol (Ethanol) interacts with GAMMA BUTYROLACTONE (GBL)

Amphetamines interacts with GAMMA BUTYROLACTONE (GBL)

Haloperidol (Haldol) interacts with GAMMA BUTYROLACTONE (GBL)

Medications for mental conditions (Antipsychotic drugs) interacts with GAMMA BUTYROLACTONE (GBL)

Medications for pain (Narcotic drugs) interacts with GAMMA BUTYROLACTONE (GBL)

Medications used to prevent seizures (Anticonvulsants) interacts with GAMMA BUTYROLACTONE (GBL)

Muscle relaxants interacts with GAMMA BUTYROLACTONE (GBL)

Naloxone (Narcan) interacts with GAMMA BUTYROLACTONE (GBL)

Ritonavir (Norvir) interacts with GAMMA BUTYROLACTONE (GBL)

Saquinavir (Fortovase, Invirase) interacts with GAMMA BUTYROLACTONE (GBL)

Sedative medications (Benzodiazepines) interacts with GAMMA BUTYROLACTONE (GBL)

Sedative medications (CNS depressants) interacts with GAMMA BUTYROLACTONE (GBL)

Dosing

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