THUNDER GOD VINE

OTHER NAME(S):

Huang-T'eng Ken, Lei Gong Teng, Lei-Kung T'eng, Seven Step Vine, Taso-Ho-Hua, Threewingnut, Tonnerre de la Vigne de Dieu, Tripterigium Wilfordii, Tripterygium wilfordii, Vigne du Tonnerre Divin, Yellow Vine.<br/><br/>

Overview

Overview Information

Thunder god vine is an herb. Its leaves and root are used to make medicine.

Thunder god vine is used for rheumatoid arthritis (RA), a type of arthritis that mainly affects the spine (ankylosing spondylitis), abnormally heavy bleeding during menstrual periods (menorrhagia), multiple sclerosis (MS), a type of inflammatory bowel disease (Crohn disease), kidney disease, and as a male contraceptive. It is also used for fever, cancer, an autoimmune disease that causes widespread swelling (systemic lupus erythematosus or SLE), HIV/AIDS, and scaly, itchy skin (psoriasis).

Thunder god vine is sometimes applied to the skin for rheumatoid arthritis (RA).

Thunder god vine has also been used non-medicinally as an insecticide against maggots or larvae, and as a rat and bird poison.

How does it work?

Thunder god vine contains chemicals that might relieve swelling (inflammation) and change the way the immune system works. This might help with arthritis and other conditions. Also, thunder god vine contains chemicals that might decrease male fertility by changing sperm.

Uses

Uses & Effectiveness?

Possibly Effective for

  • A type of inflammatory bowel disease (Crohn disease). People with Crohn disease can sometimes go into 'remission'. However, symptoms usually come back. Most research shows that taking specific thunder god vine products made in China might be useful for people in remission. Thunder god vine might prevent symptoms of Crohn disease from recurring or slow down how quickly they come back. Thunder god vine seems to be at least as effective as medications normally used by people with Crohn disease.
  • A condition that slowly leads to kidney disease (IgA nephropathy). People with this kidney disease take steroids and other drugs to help them go in to 'remission'. Most research shows that taking thunder god vine can help people with IgA nephropathy go in to remission. It can also help more people taking steroids to go in to remission.
  • A group of symptoms that indicate kidney damage (nephrotic syndrome). Most research shows that thunder god vine may be effective for nephrotic syndrome in adults and children. It seems to help people with this condition go in to 'remission'. Thunder god vine might be more effective than steroids and might make steroids work better when used together.
  • Scaly, itchy skin (psoriasis). Research shows that taking thunder god vine is as effective as a medication called acitretin for reducing itchy, scaly skin in people with psoriasis.
  • Rheumatoid arthritis (RA). Taking thunder god vine by mouth seems to relieve joint pain and swelling and improve physical function in people with RA. It seems to be at least as effective as common medications for RA symptoms. It also seems to improve the effectiveness of other medications. Applying a liquid preparation (tincture) of thunder god vine to the skin over affected joints seems to decrease joint tenderness, stiffness, and swelling.

Insufficient Evidence for

  • A type of arthritis that mainly affects the spine (ankylosing spondylitis). Early research shows that taking thunder god vine improves pain and function in people with this type of arthritis.
  • Birth control. Early research shows that taking thunder god vine by mouth might be useful as a male contraceptive. Fertility returns about 6 weeks after men stop taking thunder god vine.
  • Kidney damage in people with diabetes (diabetic nephropathy). Early research shows that taking thunder god vine seems to help to heal damaged kidneys in people with diabetes. It might work as well as a drug called valsartan.
  • Kidney transplant. Early research shows that taking thunder god vine along with cyclosporine and prednisone might improve the function and survival of the transplanted kidney compared to treatment with azathioprine, cyclosporine, and prednisone.
  • An autoimmune disease that causes widespread swelling (systemic lupus erythematosus or SLE). Some early research shows that thunder god vine may be effective for kidney problems (nephritis) associated with SLE. However, taking thunder god vine along with prednisone does not appear to improve symptoms better than prednisone alone.
  • HIV/AIDS.
  • Menstrual cramps (dysmenorrhea).
  • Multiple sclerosis (MS).
  • Other conditions.
More evidence is needed to rate the effectiveness of thunder god vine for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Thunder god vine is POSSIBLY SAFE for most people. It can cause many side effects such as stomach upset, making fewer blood cells, missed menstrual periods, skin reactions, vomiting, diarrhea, and kidney problems.

When applied to the skin: Thunder god vine is POSSIBLY SAFE when applied to the skin in appropriate amounts.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Thunder god vine is LIKELY UNSAFE to take by mouth during pregnancy. It might cause birth defects.

Not enough is known about the safety of using thunder god vine during breast-feeding. Stay on the safe side and avoid use.

Weakened immune system: Large doses of thunder god vine might weaken the immune system. If you already have a weakened immune system due to HIV/AIDS, or from taking certain medications, avoid using thunder god vine. It might decrease your body's ability to fight off infection.

Weakened bones (osteoporosis): Thunder god vine can reduce bone strength. If you have osteoporosis or are likely to develop it, don't use thunder god vine.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Medications that decrease the immune system (Immunosuppressants) interacts with THUNDER GOD VINE

    Large doses of thunder god vine might decrease the immune system. Taking thunder god vine along with other medications that decrease the immune system might decrease the immune system too much. Avoid taking thunder god vine with medications that decrease the immune system.<br /> Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.

Dosing

Dosing

The following doses have been studied in scientific research:

ADULTS

BY MOUTH:

  • For Crohn disease: 1-2 mg per kg of body weight of thunder god vine extract daily for 52 weeks.
  • For a condition that slowly leads to kidney disease (IgA nephropathy): 1-2 mg per kg of body weight of thunder god vine extract daily for up to 6 months.
  • For a group of symptoms that indicate kidney damage (nephrotic syndrome): 0.5-2 mg per kg of body weight of thunder god vine extract daily for up to 9 months.
  • For scaly, itchy skin (psoriasis): 20 mg of thunder god vine extract three times daily for 8 weeks.
  • For rheumatoid arthritis (RA): 30-570 mg of thunder god vine extract per day for up to 24 weeks.
APPLIED TO THE SKIN:
  • For rheumatoid arthritis (RA): A tincture of thunder god vine applied over affected joints five to six times daily.
CHILDREN

BY MOUTH:
  • For a group of symptoms that indicate kidney damage (nephrotic syndrome): 1 mg per kg of body weight of thunder god vine daily for up to 20 weeks.

View References

REFERENCES:

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.