Sida cordifolia contains ephedrine, which is an amphetamine-like stimulant that can cause harmful side effects. Since April 2004, the US Food and Drug Administration (FDA) has banned the sale of ephedra, Sida cordifolia, and other products that contain ephedrine.
Despite serious safety concerns, Sida cordifolia is used to treat asthma, tuberculosis, the common cold, flu, headaches, nasal congestion, cough and wheezing, urinary tract infections, sore mouth, and fluid retention (edema). It is also used for heart disease, stroke, facial paralysis, tissue pain and swelling (inflammation), sciatic nerve pain, psychiatric conditions such as schizophrenia, nerve pain, nerve inflammation, and achy joints (rheumatoid arthritis).
In herbal combinations, Sida cordifolia is used for weight loss, erectile dysfunction (ED), sinus problems, allergies, asthma, bronchitis, and weak bones (osteoporosis).
In combination with ginger, Sida cordifolia root is used for fever.
In combination with milk and sugar, Sida cordifolia root is used for urinary urgency (urinary incontinence) and vaginal discharges (leukorrhea).
Sida cordifolia is applied directly to the skin for numbness, nerve pain, muscle cramps, skin disorders, tumors, joint pain (osteoarthritis and rheumatoid arthritis), healing wounds, ulcers, scorpion sting, snakebite, and as a massage oil.
How does it work ?
Uses & Effectiveness ?
Insufficient Evidence for
- Achy joints (rheumatoid arthritis).
- Common cold.
- Erectile dysfunction (ED).
- Facial paralysis.
- Fluid retention (edema).
- Heart disease.
- Nasal congestion.
- Nerve pain and inflammation.
- Psychiatric conditions such as schizophrenia.
- Sciatic nerve pain.
- Sore mouth.
- Tissue pain and swelling (inflammation).
- Urinary tract infections (UTIs).
- Weak bones (osteoporosis).
- Weight loss.
- Other conditions.
Sida cordifolia might also cause dizziness, restlessness, irritability, insomnia, headache, lack of appetite, nausea, vomiting, flushing, tingling, difficulty urinating, and pounding heartbeat.
Do not use Sida cordifolia with other stimulants such as caffeine. This might increase the chance of having side effects, including life-threatening ones. Sources of caffeine include coffee, tea, kola nut, guarana, and mate.
Special Precautions and Warnings
Sida cordifolia might also cause dizziness, restlessness, irritability, insomnia, headache, lack of appetite, nausea, vomiting, flushing, tingling, difficulty urinating, and pounding heartbeat.
Do not use Sida cordifolia with other stimulants such as caffeine. This might increase the chance of having side effects, including life-threatening ones. Sources of caffeine include coffee, tea, kola nut, guarana, and mate. Pregnancy and breast-feeding: Sida cordifolia is LIKELY UNSAFE. Do not use.
Chest pain (angina): Sida cordifolia can make angina worse because it stimulates the heart. Sida cordifolia is unsafe for anyone to use, but it is particularly unsafe if you have angina. Do not use.
Anxiety: Sida cordifolia can stimulate the nervous system. Large doses might make anxiety worse. Do not use.
Irregular heartbeat (arrhythmia), rapid heartbeat (tachycardia), heart disease, or heart conditions such as long QT interval syndrome: Because Sida cordifolia stimulates the heart, it might make these conditions worse. Sida cordifolia is unsafe for anyone to use, but it is particularly unsafe if you have an irregular, rapid heartbeat, or heart disease. Do not use.
Diabetes: Sida cordifolia might interfere with blood sugar control, and might worsen high blood pressure and circulatory problems in people with diabetes. Do not use.
Essential tremor: Sida cordifolia might make essential tremor worse due to its stimulant effects. Do not use.
High blood pressure: Sida cordifolia might make high blood pressure worse. Sida cordifolia is unsafe for anyone to use, but it is particularly unsafe if you have high blood pressure. Do not use.
Thyroid problems: There is a concern that Sida cordifolia might stimulate the thyroid and make thyroid problems worse. Do not use.
Kidney stones: The ephedrine in Sida cordifolia might cause kidney stones. This is especially harmful if you already have kidney stones. Do not use.
Glaucoma: Sida cordifolia might make glaucoma worse by causing the pupils to dilate. Do not use.
A tumor on the adrenal gland (pheochromocytoma): Sida cordifolia might make the symptoms of pheochromocytoma worse. Do not use.
Medications that can cause an irregular heartbeat (QT interval-prolonging drugs) interacts with SIDA CORDIFOLIA
Sida cordifolia might cause an irregular heartbeat. Taking Sida cordifolia along with medications that can also cause an irregular heartbeat might have an additive effect. This might increase the risk of serious side effects such as irregular heartbeats that are too fast and sudden cardiac death.
Some medications that can cause an irregular heartbeat include amiodarone (Cordarone), disopyramide (Norpace), dofetilide (Tikosyn), ibutilide (Corvert), procainamide (Pronestyl), quinidine, sotalol (Betapace), thioridazine (Mellaril), and many others.
Methylxanthines interacts with SIDA CORDIFOLIA
Sida cordifolia can simulate the body. Methylxanthines also stimulate the body. Taking Sida cordifolia with methylxanthines might cause side effects such as jitteriness, nervousness, a fast heartbeat, high blood pressure, and anxiety.
Methylxanthines include aminophylline, caffeine, and theophylline.
Stimulant drugs interacts with SIDA CORDIFOLIA
Stimulant drugs speed up the nervous system and can make you feel jittery and speed up your heartbeat. Sida cordifolia can also speed up the nervous system. Taking Sida cordifolia along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with Sida cordifolia.
Some stimulant drugs include diethylpropion (Tenuate), epinephrine, phentermine (Ionamin), pseudoephedrine (Sudafed), and many others.
Do not take this combination
Dexamethasone (Decadron) interacts with SIDA CORDIFOLIA
The body breaks down dexamethasone (Decadron) to get rid of it. Sida cordifolia might increase how quickly the body breaks down dexamethasone (Decadron). By increasing how quickly the body breaks down dexamethasone (Decadron) Sida cordifolia might decrease the effectiveness of dexamethasone (Decadron).
Ergot derivatives interacts with SIDA CORDIFOLIA
Sida cordifolia can increase blood pressure. Ergot derivatives can also increase blood pressure. Taking Sida cordifolia with ergot derivatives might increase blood pressure too much.
Some of these ergot derivatives include bromocriptine (Parlodel), dihydroergotamine (Migranal, DHE-45), ergotamine (Cafergot), and pergolide (Permax).
Medications for depression (MAOIs) interacts with SIDA CORDIFOLIA
Sida cordifolia contains chemicals that stimulate the body. Some medications used for depression can increase these chemicals. Taking Sida cordifolia with these medications used for depression might cause too much stimulation. This could cause serious side effects including fast heartbeat, high blood pressure, seizures, nervousness, and others.
Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.
Medications for diabetes (Antidiabetes drugs) interacts with SIDA CORDIFOLIA
Sida cordifolia might increase blood sugar. Diabetes medications are used to lower blood sugar. By increasing blood sugar, Sida cordifolia might decrease the effectiveness of diabetes medications. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Be cautious with this combination
Ashok, P., Arulmozhi, S., Bhaskara, B. P., and Rajendran, R. D. Comparative Food Intake Inhibitory Activity of Sida cordifolia Bala L. and Withania somniferia L. in rats. Journal of Natural Remedies 2007;7(2):289-293.
Dhalwal, K., Deshpande, Y. S., Purohit, A. P., and Kadam, S. S. Evaluation of the Antioxidant Activity of Sida cordifolia Bala. Pharmaceutical Biology 2005;43(9):754-761.
Franco, C. I., Morais, L. C., Quintans-Junior, L. J., Almeida, R. N., and Antoniolli, A. R. CNS pharmacological effects of the hydroalcoholic extract of Sida cordifolia L. leaves. J Ethnopharmacol. 4-26-2005;98(3):275-279. View abstract.
Medeiros, I. A., Santos, M. R., Nascimento, N. M., and Duarte, J. C. Cardiovascular effects of Sida cordifolia leaves extract in rats. Fitoterapia 2006;77(1):19-27. View abstract.
Philip, B. K., Muralidharan, A., Natarajan, B., Varadamurthy, S., and Venkataraman, S. Preliminary evaluation of anti-pyretic and anti-ulcerogenic activities of Sida cordifolia methanolic extract. Fitoterapia 2008;79(3):229-231. View abstract.
Santos, M. R., Nascimento, N. M., Antoniolli, A. R., and Medeiros, I. A. Endothelium-derived factors and k+ channels are involved in the vasorelaxation induced by Sida cordifolia L. in the rat superior mesenteric artery. Pharmazie 2006;61(5):466-469. View abstract.
Silva, R. L., Melo, G. B., Melo, V. A., Antoniolli, A. R., Michellone, P. R., Zucoloto, S., Picinato, M. A., Franco, C. F., Mota, Gde A., and Silva, Ode C. Effect of the aqueous extract of Sida cordifolia on liver regeneration after partial hepatectomy. Acta Cir.Bras. 2006;21 Suppl 1:37-39. View abstract.
Sutradhar, R. K., Rahman, A. M., Ahmad, M., Bachar, S. C., Saha, A., and Roy, T. G. Anti-inflammatory and analgesic alkaloid from Sida cordifolia linn. Pak.J Pharm Sci 2007;20(3):185-188. View abstract.
Anon. Sida Cordifolia Linn. Available at: https://www.modern-natural.com/sida_cordifolia.htm (Accessed 9 March 2000).
Anon. Sida Cordifolia. Metro Marketing, Inc. Available at: https://metromkt.net/viable/1sidacor.shtml (Accessed 9 March 2000).
Baker J, Zhang X, Boucher T, Keyler D. Investigation of quality in ephedrine-containing dietary supplements. Journal of Herbal Pharmacotherapy 2003;3:5-17.
Bell DG, Jacobs I, Ellerington K. Effect of caffeine and ephedrine ingestion on anaerobic exercise performance. Med Sci Sports Exerc 2001;33:1399-403. View abstract.
Boozer CN, Daly PA, Homel P, et al. Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial. Int J Obes Relat Metab Disord 2002;26:593-604. View abstract.
Boozer CN, Nasser JA, Heymsfield SB, et al. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. Int J Obes Relat Metab Disord 2001;25:316-24. View abstract.
Brooks SM, Sholiton LJ, Werk EE Jr, Altenau P. The effects of ephedrine and theophylline on dexamethasone metabolism in bronchial asthma. J Clin Pharmacol 1977;17:308-18. View abstract.
Caron MF, Hotsko AL, Robertson S, et al. Electrocardiographic and hemodynamic effects of Panax ginseng. Ann Pharmacother 2002;36:758-63.. View abstract.
Dinda B, Das N, Dinda S, et al. The genus Sida L. - A traditional medicine: its ethnopharmacological, phytochemical and pharmacological data for commercial exploitation in herbal drugs industry. J Ethnopharmacol 2015;176:135-76. View abstract.
Doyle H, Kargin M. Herbal stimulant containing ephedrine has also caused psychosis. BMJ 1996;313:756. View abstract.
Dulloo AG, Miller DS. Ephedrine, caffeine and aspirin: "over-the-counter" drugs that interact to stimulate thermogenesis in the obese. Nutrition 1989;5:7-9.
Dulloo AG, Miller DS. Aspirin as a promoter of ephedrine-induced thermogenesis: potential use in the treatment of obesity. Am J Clin Nutr 1987;45:564-9. View abstract.
Dulloo AG. Herbal simulation of ephedrine and caffeine in treatment of obesity. Int J Obes Relat Metab Disord 2002;26:590-2.
FDA Takes Aim at Ephedra. The Washington Post. Available at: https://www.washingtonpost.com/archive/politics/2000/03/19/fda-takes-aim-at-ephedra/4ce534a7-d291-44ec-88a8-38e97ff27e3b/ (Accessed 19 March 2000).
FDA. Proposed rule: dietary supplements containing ephedrine alkaloids. Available at: www.verity.fda.gov (Accessed 25 January 2000).
Food and Drug Administration, HHS. Final rule declaring dietary supplements containing ephedrine alkaloids adulterated because they present an unreasonable risk; Final rule. Fed Regist 2004;69:6787-6854. View abstract.
For Dieter, Nearly the Ultimate Loss. The Washington Post. Available at: https://www.washingtonpost.com/archive/politics/2000/03/19/for-dieter-nearly-the-ultimate-loss/c0f07474-489d-4f44-bc17-1f1367c956ae/ (Accessed 19 March 2000).
Franzotti EM, Santos CV, Rodrigues HM, et al. Anti-inflammatory, analgesic activity and acute toxicity of Sida cordifolia L. (Malva-branca). J Ethnopharmacol 2000;72:273-7. View abstract.
Gardner SF, Franks AM, Gurley BJ, et al. Effect of a multicomponent, ephedra-containing dietary supplement (Metabolife 356) on Holter monitoring and hemostatic parameters in healthy volunteers. Am J Cardiol 2003;91:1510-3, A9.
Greenway FL, Raum WJ, DeLany JP. The effect of an herbal dietary supplement containing ephedrine and caffeine on oxygen consumption in humans. J Altern Complement Med 2000;6:553-5. View abstract.
Gunatilaka AA, Sotheeswaran S, Balasubramaniam S, et al. Studies on medicinal plants of Sri Lanka. III. Pharmacologically important alkaloids of some sida species. Planta Med 1980;39:66-72.
Gurley BJ, Gardner SF, Hubbard MA. Content versus label claims in ephedra-containing dietary supplements. Am J Health Syst Pharm 2000;57:963-9. View abstract.
Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000;343:1833-8. View abstract.
Haller CA, Jacob P 3rd, Benowitz NL. Enhanced stimulant and metabolic effects of combined ephedrine and caffeine. Clin Pharmacol Ther 2004;75:259-73. View abstract.
Haller CA, Jacob P 3rd, Benowitz NL. Pharmacology of ephedra alkaloids and caffeine after single-dose dietary supplement use. Clin Pharmacol Ther 2002;71:421-32. View abstract.
Homer KA, Manji F, Beighton D. Inhibition of peptidase and glycosidase activities of Porphyromonas gingivalis, Bacteroides intermedius and Treponema denticola by plant extracts. J Clin Periodontol 1992;19:305-10. View abstract.
Horton TJ, Geissler CA. Aspirin potentiates the effect of ephedrine on the thermogenic response to a meal in obese but not lean women. Int J Obes 1991;15:359-66. View abstract.
Jacobs KM, Hirsch KA. Psychiatric complications of Ma-huang. Psychosomatics 2000;41:58-62. View abstract.
Jenkins DJ, Wesson V, Wolever TM, et al. Wholemeal versus wholegrain breads: proportion of whole or cracked grain and the glycaemic response. BMJ 1988;297:958-60. View abstract.
Kalman D, Incledon T, Gaunaurd I, et al. An acute clinical trial evaluating the cardiovascular effects of an herbal ephedra-caffeine weight loss product in healthy overweight adults. Int J Obes 2002;26:1363-66.. View abstract.
Kanth VR, Diwan PV. Analgesic, anti-inflammatory and hypoglycaemic activities of Sida cordifolia. Phytother Res 1999;13:75-7. View abstract.
Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. View abstract.
Konate K, Bassole IH, Hilou A, et al. Toxicity assessment and analgesic activity investigation of aqueous acetone extracts of Sida acuta Burn f. and Sida cordifolia L. (Malvaceae), medicinal plans of Burkina Faso. BMC Complement Altern Med 2012;12:120. View abstract.
Leikin JB, Klein L. Ephedra causes myocarditis. Clin Toxicol 2000;38:353-4.
Levisky JA, Karch SB, Bowerman DL, et al. False-positive RIA for methamphetamine following ingestion of an Ephedra-derived herbal product. J Anal Toxicol 2003;27:123-4.
Louis E. Tremor disorders: identification and treatment. Medical Update for Psychiatrists 1997;2:172-6.
McBride BF, Karapanos AK, Krudysz A, et al. Electrocardiographic and hemodynamic effects of a multicomponent dietary supplement containing ephedra and caffeine: a randomized controlled trial. JAMA 2004;291:216-21. View abstract.
Momin MA, Bellah SF, Rahman SM, et al. Phytopharmacological evaluation of ethanol extract of Sida cordifolia L. roots. Asian Pac J Trop Biomed 2014;4(1):18-24. View abstract.
Morgenstern LB, Viscoli CM, Kernan WN, et al. Use of Ephedra-containing products and risk for hemorrhagic stroke. Neurology 2003;60:132-5. . View abstract.
Okada S, Rohan PJ, Miller FW, et al. Myopathies following ingestion of special nutritional products. Arthritis Rheum 1996;39:349.
Phosphatidylcholine. Altern Med Rev 2002;7(2):150-4. View abstract.
Powell T, Hsu FF, Turk J, Hruska K. Ma-huang strikes again: ephedrine nephrolithiasis. Am J Kidney Dis 1998;32:153-9. View abstract.
Ros JJ, Pelders MG, De Smet PA. A case of positive doping associated with a botanical food supplement. Pharm World Sci 1999;21:44-6. View abstract.
Samenuk D, Link MS, Homoud MK, et al. Adverse cardiovascular events temporally associated with ma huang, an herbal source of ephedrine. Mayo Clin Proc 2002;77:12-6. View abstract.
Schweinfurth J, Pribitkin E. Sudden hearing loss associated with ephedra use. Am J Health Syst Pharm 2003;60:375-7.
Soni MG, Carabin IG, Griffiths JC, Burdock GA. Safety of ephedra: lessons learned. Toxicol Lett 2004;150:97-110. View abstract.
Sumanth M, Mustafa SS. Antistress, adoptogenic activity of Sida cordifolia roots in mice. Indian J Pharm Sci 2009;71(3):323-4. View abstract.
Theoharides TC. Sudden death of a healthy college student related to ephedrine toxicity from a ma-huang containing drink. J Clin Psychopharmacol 1997;17:437-9.
Ujino H, Morimoto O, Yukioka H, Fujimori M. [Acute angle-closure glaucoma after total hip replacement surgery]. Masui 1997;46:823-6. View abstract.
Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3. View abstract.
Walton R, Manos GH. Psychosis related to ephedra-containing herbal supplement use. South Med J 2003;96:718-20.. View abstract.
White LM, Gardner SF, Gurley BJ, et al. Pharmacokinetics and Cardiovascular Effects of Ma-Huang (Ephedra sinica) in Normotensive Adults. J Clin Pharmacol 1997;37:116-22. View abstract.
Wilson BE, Hobbs WN. Case report: pseudoephedrine-associated thyroid storm: thyroid hormone-catecholamine interactions. Am J Med Sci 1993;306:317-9. View abstract.
Yates KM, O'Connor A, Horsley CA. "Herbal Ecstasy": a case series of adverse reactions. N Z Med J 2000;113:315-7.. View abstract.
Zaacks SM, Klein L, Tan CD, et al. Hypersensitivity myocarditis associated with ephedra use. J Toxicol Clin Toxicol 1999;37:485-9. View abstract.
You Might Also Like
CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.
This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.