SIDA CORDIFOLIA: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Sida cordifolia is a plant. The seeds, leaves, and root are used to make medicine.

Sida cordifolia contains ephedrine, which is an amphetamine-like stimulant that can cause harmful side effects. Since April 2004, the US Food and Drug Administration (FDA) has banned the sale of ephedra, Sida cordifolia, and other products that contain ephedrine.

Despite serious safety concerns, Sida cordifolia is used to treat asthma, tuberculosis, the common cold, flu, headaches, nasal congestion, cough and wheezing, urinary tract infections, sore mouth, and fluid retention (edema). It is also used for heart disease, stroke, facial paralysis, tissue pain and swelling (inflammation), sciatic nerve pain, psychiatric conditions such as schizophrenia, nerve pain, nerve inflammation, and achy joints (rheumatoid arthritis).

In herbal combinations, Sida cordifolia is used for weight loss, erectile dysfunction (ED), sinus problems, allergies, asthma, bronchitis, and weak bones (osteoporosis).

In combination with ginger, Sida cordifolia root is used for fever.

In combination with milk and sugar, Sida cordifolia root is used for urinary urgency (urinary incontinence) and vaginal discharges (leukorrhea).

Sida cordifolia is applied directly to the skin for numbness, nerve pain, muscle cramps, skin disorders, tumors, joint pain (osteoarthritis and rheumatoid arthritis), healing wounds, ulcers, scorpion sting, snakebite, and as a massage oil.

How does it work ?

Sida cordifolia plant contains ephedrine, which is an amphetamine-like stimulant. It is unknown how Sida cordifolia might work for other medicinal uses.

Interactions ?

Major Interaction

Do not take this combination

Medications that can cause an irregular heartbeat (QT interval-prolonging drugs) interacts with SIDA CORDIFOLIA
Country mallow can increase the speed of your heartbeat. Taking country mallow along with medications that can cause an irregular heartbeat might cause serious side effects including heart attack.
Some medications that can cause an irregular heartbeat include amiodarone (Cordarone), disopyramide (Norpace), dofetilide (Tikosyn), ibutilide (Corvert), procainamide (Pronestyl), quinidine, sotalol (Betapace), thioridazine (Mellaril), and many others.
Methylxanthines interacts with SIDA CORDIFOLIA
Country mallow can simulate the body. Methylxanthines also stimulate the body. Taking country mallow with methylxanthines might cause side effects such as jitteriness, nervousness, a fast heartbeat, high blood pressure, and anxiety.
Methylxanthines include aminophylline, caffeine, and theophylline.
Stimulant drugs interacts with SIDA CORDIFOLIA
Stimulant drugs speed up the nervous system and can make you feel jittery and speed up your heartbeat. Country mallow can also speed up the nervous system. Taking country mallow along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with country mallow.
Some stimulant drugs include diethylpropion (Tenuate), epinephrine, phentermine (Ionamin), pseudoephedrine (Sudafed), and many others.

Moderate Interaction

Be cautious with this combination

Dexamethasone (Decadron) interacts with SIDA CORDIFOLIA
The body breaks down dexamethasone (Decadron) to get rid of it. Country mallow might increase how quickly the body breaks down dexamethasone (Decadron). By increasing how quickly the body breaks down dexamethasone (Decadron) country mallow might decrease the effectiveness of dexamethasone (Decadron).
Ergot Derivatives interacts with SIDA CORDIFOLIA
Country mallow can increase blood pressure. Ergot derivatives can also increase blood pressure. Taking country mallow with ergot derivatives might increase blood pressure too much.
Some of these ergot derivatives include bromocriptine (Parlodel), dihydroergotamine (Migranal, DHE-45), ergotamine (Cafergot), and pergolide (Permax).
Medications for depression (MAOIs) interacts with SIDA CORDIFOLIA
Country mallow contains chemicals that stimulate the body. Some medications used for depression can increase these chemicals. Taking country mallow with these medications used for depression might cause too much stimulation. This could cause serious side effects including fast heartbeat, high blood pressure, seizures, nervousness, and others.
Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.
Medications for diabetes (Antidiabetes drugs) interacts with SIDA CORDIFOLIA
Country mallow might increase blood sugar. Diabetes medications are used to lower blood sugar. By increasing blood sugar, country mallow might decrease the effectiveness of diabetes medications. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

View References

REFERENCES:

Sutradhar, R. K., Rahman, A. M., Ahmad, M., Bachar, S. C., Saha, A., and Roy, T. G. Anti-inflammatory and analgesic alkaloid from Sida cordifolia linn. Pak.J Pharm Sci 2007;20(3):185-188. View abstract.

Anon. Sida Cordifolia Linn. Available at: https://www.modern-natural.com/sida_cordifolia.htm (Accessed 9 March 2000).

Anon. Sida Cordifolia. Metro Marketing, Inc. Available at: https://metromkt.net/viable/1sidacor.shtml (Accessed 9 March 2000).

Baker J, Zhang X, Boucher T, Keyler D. Investigation of quality in ephedrine-containing dietary supplements. Journal of Herbal Pharmacotherapy 2003;3:5-17.

Bell DG, Jacobs I, Ellerington K. Effect of caffeine and ephedrine ingestion on anaerobic exercise performance. Med Sci Sports Exerc 2001;33:1399-403. View abstract.

Boozer CN, Daly PA, Homel P, et al. Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial. Int J Obes Relat Metab Disord 2002;26:593-604. View abstract.

Boozer CN, Nasser JA, Heymsfield SB, et al. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. Int J Obes Relat Metab Disord 2001;25:316-24. View abstract.

Brooks SM, Sholiton LJ, Werk EE Jr, Altenau P. The effects of ephedrine and theophylline on dexamethasone metabolism in bronchial asthma. J Clin Pharmacol 1977;17:308-18. View abstract.

Caron MF, Hotsko AL, Robertson S, et al. Electrocardiographic and hemodynamic effects of Panax ginseng. Ann Pharmacother 2002;36:758-63.. View abstract.

Dinda B, Das N, Dinda S, et al. The genus Sida L. - A traditional medicine: its ethnopharmacological, phytochemical and pharmacological data for commercial exploitation in herbal drugs industry. J Ethnopharmacol 2015;176:135-76. View abstract.

Doyle H, Kargin M. Herbal stimulant containing ephedrine has also caused psychosis. BMJ 1996;313:756. View abstract.

Dulloo AG, Miller DS. Ephedrine, caffeine and aspirin: "over-the-counter" drugs that interact to stimulate thermogenesis in the obese. Nutrition 1989;5:7-9.

Dulloo AG, Miller DS. Aspirin as a promoter of ephedrine-induced thermogenesis: potential use in the treatment of obesity. Am J Clin Nutr 1987;45:564-9. View abstract.

Dulloo AG. Herbal simulation of ephedrine and caffeine in treatment of obesity. Int J Obes Relat Metab Disord 2002;26:590-2.

FDA Takes Aim at Ephedra. The Washington Post. Available at: https://www.washingtonpost.com/archive/politics/2000/03/19/fda-takes-aim-at-ephedra/4ce534a7-d291-44ec-88a8-38e97ff27e3b/ (Accessed 19 March 2000).

FDA. Proposed rule: dietary supplements containing ephedrine alkaloids. Available at: www.verity.fda.gov (Accessed 25 January 2000).

Food and Drug Administration, HHS. Final rule declaring dietary supplements containing ephedrine alkaloids adulterated because they present an unreasonable risk; Final rule. Fed Regist 2004;69:6787-6854. View abstract.

For Dieter, Nearly the Ultimate Loss. The Washington Post. Available at: https://www.washingtonpost.com/archive/politics/2000/03/19/for-dieter-nearly-the-ultimate-loss/c0f07474-489d-4f44-bc17-1f1367c956ae/ (Accessed 19 March 2000).

Franzotti EM, Santos CV, Rodrigues HM, et al. Anti-inflammatory, analgesic activity and acute toxicity of Sida cordifolia L. (Malva-branca). J Ethnopharmacol 2000;72:273-7. View abstract.

Gardner SF, Franks AM, Gurley BJ, et al. Effect of a multicomponent, ephedra-containing dietary supplement (Metabolife 356) on Holter monitoring and hemostatic parameters in healthy volunteers. Am J Cardiol 2003;91:1510-3, A9.

Greenway FL, Raum WJ, DeLany JP. The effect of an herbal dietary supplement containing ephedrine and caffeine on oxygen consumption in humans. J Altern Complement Med 2000;6:553-5. View abstract.

Gunatilaka AA, Sotheeswaran S, Balasubramaniam S, et al. Studies on medicinal plants of Sri Lanka. III. Pharmacologically important alkaloids of some sida species. Planta Med 1980;39:66-72.

Gurley BJ, Gardner SF, Hubbard MA. Content versus label claims in ephedra-containing dietary supplements. Am J Health Syst Pharm 2000;57:963-9. View abstract.

Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000;343:1833-8. View abstract.

Haller CA, Jacob P 3rd, Benowitz NL. Enhanced stimulant and metabolic effects of combined ephedrine and caffeine. Clin Pharmacol Ther 2004;75:259-73. View abstract.

Haller CA, Jacob P 3rd, Benowitz NL. Pharmacology of ephedra alkaloids and caffeine after single-dose dietary supplement use. Clin Pharmacol Ther 2002;71:421-32. View abstract.

Homer KA, Manji F, Beighton D. Inhibition of peptidase and glycosidase activities of Porphyromonas gingivalis, Bacteroides intermedius and Treponema denticola by plant extracts. J Clin Periodontol 1992;19:305-10. View abstract.

Horton TJ, Geissler CA. Aspirin potentiates the effect of ephedrine on the thermogenic response to a meal in obese but not lean women. Int J Obes 1991;15:359-66. View abstract.

Jacobs KM, Hirsch KA. Psychiatric complications of Ma-huang. Psychosomatics 2000;41:58-62. View abstract.

Jenkins DJ, Wesson V, Wolever TM, et al. Wholemeal versus wholegrain breads: proportion of whole or cracked grain and the glycaemic response. BMJ 1988;297:958-60. View abstract.

Kalman D, Incledon T, Gaunaurd I, et al. An acute clinical trial evaluating the cardiovascular effects of an herbal ephedra-caffeine weight loss product in healthy overweight adults. Int J Obes 2002;26:1363-66.. View abstract.

Kanth VR, Diwan PV. Analgesic, anti-inflammatory and hypoglycaemic activities of Sida cordifolia. Phytother Res 1999;13:75-7. View abstract.

Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. View abstract.

Konate K, Bassole IH, Hilou A, et al. Toxicity assessment and analgesic activity investigation of aqueous acetone extracts of Sida acuta Burn f. and Sida cordifolia L. (Malvaceae), medicinal plans of Burkina Faso. BMC Complement Altern Med 2012;12:120. View abstract.

Leikin JB, Klein L. Ephedra causes myocarditis. Clin Toxicol 2000;38:353-4.

Levisky JA, Karch SB, Bowerman DL, et al. False-positive RIA for methamphetamine following ingestion of an Ephedra-derived herbal product. J Anal Toxicol 2003;27:123-4.

Louis E. Tremor disorders: identification and treatment. Medical Update for Psychiatrists 1997;2:172-6.

McBride BF, Karapanos AK, Krudysz A, et al. Electrocardiographic and hemodynamic effects of a multicomponent dietary supplement containing ephedra and caffeine: a randomized controlled trial. JAMA 2004;291:216-21. View abstract.

Momin MA, Bellah SF, Rahman SM, et al. Phytopharmacological evaluation of ethanol extract of Sida cordifolia L. roots. Asian Pac J Trop Biomed 2014;4(1):18-24. View abstract.

Morgenstern LB, Viscoli CM, Kernan WN, et al. Use of Ephedra-containing products and risk for hemorrhagic stroke. Neurology 2003;60:132-5. . View abstract.

Okada S, Rohan PJ, Miller FW, et al. Myopathies following ingestion of special nutritional products. Arthritis Rheum 1996;39:349.

Phosphatidylcholine. Altern Med Rev 2002;7(2):150-4. View abstract.

Powell T, Hsu FF, Turk J, Hruska K. Ma-huang strikes again: ephedrine nephrolithiasis. Am J Kidney Dis 1998;32:153-9. View abstract.

Ros JJ, Pelders MG, De Smet PA. A case of positive doping associated with a botanical food supplement. Pharm World Sci 1999;21:44-6. View abstract.

Samenuk D, Link MS, Homoud MK, et al. Adverse cardiovascular events temporally associated with ma huang, an herbal source of ephedrine. Mayo Clin Proc 2002;77:12-6. View abstract.

Schweinfurth J, Pribitkin E. Sudden hearing loss associated with ephedra use. Am J Health Syst Pharm 2003;60:375-7.

Soni MG, Carabin IG, Griffiths JC, Burdock GA. Safety of ephedra: lessons learned. Toxicol Lett 2004;150:97-110. View abstract.

Sumanth M, Mustafa SS. Antistress, adoptogenic activity of Sida cordifolia roots in mice. Indian J Pharm Sci 2009;71(3):323-4. View abstract.

Theoharides TC. Sudden death of a healthy college student related to ephedrine toxicity from a ma-huang containing drink. J Clin Psychopharmacol 1997;17:437-9.

Ujino H, Morimoto O, Yukioka H, Fujimori M. [Acute angle-closure glaucoma after total hip replacement surgery]. Masui 1997;46:823-6. View abstract.

Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3. View abstract.

Walton R, Manos GH. Psychosis related to ephedra-containing herbal supplement use. South Med J 2003;96:718-20.. View abstract.

White LM, Gardner SF, Gurley BJ, et al. Pharmacokinetics and Cardiovascular Effects of Ma-Huang (Ephedra sinica) in Normotensive Adults. J Clin Pharmacol 1997;37:116-22. View abstract.

Wilson BE, Hobbs WN. Case report: pseudoephedrine-associated thyroid storm: thyroid hormone-catecholamine interactions. Am J Med Sci 1993;306:317-9. View abstract.

Yates KM, O'Connor A, Horsley CA. "Herbal Ecstasy": a case series of adverse reactions. N Z Med J 2000;113:315-7.. View abstract.

Zaacks SM, Klein L, Tan CD, et al. Hypersensitivity myocarditis associated with ephedra use. J Toxicol Clin Toxicol 1999;37:485-9. View abstract.

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© Therapeutic Research Faculty 2020.

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SIDA CORDIFOLIA

Overview

How does it work ?

Uses & Effectiveness ?

Insufficient Evidence for

Side Effects

Special Precautions and Warnings

Interactions ?

Major Interaction

Medications that can cause an irregular heartbeat (QT interval-prolonging drugs) interacts with SIDA CORDIFOLIA

Methylxanthines interacts with SIDA CORDIFOLIA

Stimulant drugs interacts with SIDA CORDIFOLIA

Moderate Interaction

Dexamethasone (Decadron) interacts with SIDA CORDIFOLIA

Ergot Derivatives interacts with SIDA CORDIFOLIA

Medications for depression (MAOIs) interacts with SIDA CORDIFOLIA

Medications for diabetes (Antidiabetes drugs) interacts with SIDA CORDIFOLIA

Dosing

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