Overview

Sitostanol is a plant product. It is made from vegetable oils or the oil from pine tree wood pulp, and is then combined with canola oil.

Sitostanol is most commonly used for heart disease and high cholesterol.

Sitostanol is an ingredient in Benecol margarine and some salad dressings. The U.S. Food and Drug Administration (FDA) allows manufacturers of products that contain sitostanol to claim that the product lowers the risk of getting heart disease. There is plenty of evidence that sitostanol lowers cholesterol levels, but so far there is no proof that long-term use lowers the risk of developing heart disease.

How does it work ?

Sitostanol stops the cholesterol from food entering the body.

Sitostanol stops the cholesterol from food entering the body.

Uses & Effectiveness ?

Likely Effective for

  • High cholesterol. Sitostanol is effective for reducing cholesterol levels in adults with high cholesterol. It doesn't have to be taken with meals to work. Cholesterol levels decrease within 2 to 3 weeks of starting sitostanol. Sitostanol may not have the same effect in all people. About 12% of people do not respond to sitostanol.

    People usually take sitostanol as an ingredient of Benecol margarine. Sitostanol can reduce total and "bad" low-density lipoprotein (LDL) cholesterol levels by 6% to 20%. Most research shows that a dose of about 2-3 grams per day lowers cholesterol the most. Higher doses do not seem to work any better.

Possibly Effective for

  • Inherited tendency towards high cholesterol (familial hypercholesterolemia). Sitostanol is possibly effective for reducing cholesterol levels in children and adults with high cholesterol levels due to familial hypercholesterolemia. Taking sitostanol seems to reduce total cholesterol by 11% to 14% and "bad" low-density lipoprotein (LDL) cholesterol levels by 15% to 33% in people who also take cholesterol-lowering drugs called statins.

Side Effects

When taken by mouth: Sitostanol is LIKELY SAFE for most people when taken by mouth. Adults can safely use sitostanol for up to 1 year, and children can safely use it for up to 3 months. Sitostanol might cause stomach upset or too much fat in the stool (steatorrhea).

There is some concern that sitostanol might decrease absorption of some nutrients since it decreases fat absorption. Sitostanol does seem to reduce the absorption of dietary beta-carotene, but this reduction may not be important to health.

Special Precautions and Warnings

When taken by mouth: Sitostanol is LIKELY SAFE for most people when taken by mouth. Adults can safely use sitostanol for up to 1 year, and children can safely use it for up to 3 months. Sitostanol might cause stomach upset or too much fat in the stool (steatorrhea).

There is some concern that sitostanol might decrease absorption of some nutrients since it decreases fat absorption. Sitostanol does seem to reduce the absorption of dietary beta-carotene, but this reduction may not be important to health.
Pregnancy and breast-feeding: There isn't enough reliable information to know if sitostanol is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Interactions ?

We currently have no information for SITOSTANOL overview.

Dosing

The following doses have been studied in scientific research:

ADULTS

BY MOUTH:
  • For high cholesterol: 200 mg to 9 grams of sitostanol has been used daily, but doses of 2-3 grams daily are most common. Doses above 2-3 grams daily may be only slightly more effective. Single daily doses seem to be as effective as divided doses taken twice or three times daily.
  • For reducing cholesterol levels in adults with an inherited tendency towards high cholesterol (familial hypercholesterolemia): About 2 grams of sitostanol has been taken daily for up to 3 months.
CHILDREN

BY MOUTH:
  • For high cholesterol: 1.5 grams of sitostanol has been used daily in children aged 6 years.
  • For reducing cholesterol levels in children with an inherited tendency towards high cholesterol (familial hypercholesterolemia): 1.5-6 grams of sitostanol per day have been used in children aged 2-15 years.
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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.