BLOODROOT

OTHER NAME(S):

Blood Root, Bloodwort, Coon Root, Indian Plant, Indian Red Paint, Pauson, Red Indian Paint, Red Puccoon, Red Root, Sang-Dragon, Sang de Dragon, Sanguinaire, Sanguinaire du Canada, Sanguinaria, Sanguinaria canadensis, Snakebite, Sweet Slumber, Tetterwort.<br/><br/>

Overview

Overview Information

Bloodroot is a plant. People use the underground stem (rhizome) to make medicine.

Bloodroot is used to cause vomiting, empty the bowels, and reduce tooth pain. It is also used to treat croup, hoarseness (laryngitis), sore throat (pharyngitis), poor circulation in the surface blood vessels, nasal polyps, achy joints and muscles (rheumatism), warts, and fever.

Some people apply bloodroot directly to the skin around wounds to remove dead tissue and promote healing. During the mid-1800s, bloodroot extracts were applied to the skin as part of the Fell Technique for treatment of breast tumors.

In dentistry, bloodroot is used on the teeth to reduce the build-up of plaque. Plaque is a film of saliva, mucus, bacteria, and food particles that can promote gum disease.

How does it work?

Bloodroot contains chemicals that might help fight bacteria, inflammation, and plaque.

Uses

Uses & Effectiveness?

Possibly Effective for

  • Dental plaque. Brushing teeth with a specific toothpaste containing bloodroot and zinc chloride (Viadent Original, Vipont Pharmaceuticals) or using a similar toothpaste containing bloodroot, zinc chloride, and fluoride (Viadent Fluoride toothpaste, Vipont Pharmaceuticals) along with a using mouth rinse containing bloodroot and zinc (Viadent Oral Rinse, Vipont Pharmaceuticals) seems to reduce dental plaque. Also, rinsing with bloodroot mouthwash after a professional tooth cleaning seems to slow the regrowth of dental plaque. In addition, using a bloodroot toothpaste (Viadent toothpaste, Viadent Inc.) and rinsing with bloodroot mouthwash (Viadent Oral Rinse, Viadent Inc.) seems to prevent plaque development in teenagers wearing orthodontic devices.
  • Swelling of the gums (gingivitis). Although some conflicting results exist, most research shows that brushing with a toothpaste containing bloodroot and zinc chloride (Viadent Original, Vipont Pharmaceuticals) or using a similar toothpaste containing bloodroot, zinc chloride, and fluoride (Viadent Fluoride toothpaste, Vipont Pharmaceuticals) along with a mouth rinse containing bloodroot and zinc (Viadent Oral Rinse, Vipont Pharmaceuticals) reduces gingivitis. Also, rinsing with bloodroot mouthwash (Viadent Oral Rinse) after a professional tooth cleaning seems to slow the development of gingivitis.

Insufficient Evidence for

  • A serious dental infection (periodontitis). Early research shows that using toothpaste and a mouth rinse containing bloodroot extract and zinc chloride for 2 weeks following usual periodontitis treatment reduces gum swelling and bleeding, but not dental plaque, in people with periodontitis.
  • Coughs.
  • Spasms.
  • Emptying the bowels.
  • Causing vomiting.
  • Wound cleaning.
  • Other conditions.
More evidence is needed to rate the effectiveness of bloodroot for these uses.

Side Effects

Side Effects & Safety

Bloodroot is POSSIBLY SAFE for most people when taken by mouth, short-term. Side effects include nausea, vomiting, drowsiness, and grogginess. Also, skin contact with the fresh plant can cause a rash. Don’t let bloodroot get into your eyes because it can cause irritation.

Long-term use by mouth in high amounts is POSSIBLY UNSAFE. At high doses it can cause low blood pressure, shock, coma, and an eye disease called glaucoma. Also, bloodroot is POSSIBLY UNSAFE when used as a toothpaste and mouthwash. It may increase the risk of developing white patches on the inside of the mouth.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Bloodroot is LIKELY UNSAFE when taken by mouth during pregnancy and POSSIBLY UNSAFE when taken by mouth while breast-feeding.

Stomach or intestinal problems such as infections, Crohn's disease, or other inflammatory conditions: Bloodroot can irritate the digestive tract. Don’t use it if you have any of these conditions.

An eye disease called glaucoma: Bloodroot might affect glaucoma treatment. If you have glaucoma, don’t use bloodroot unless a healthcare professional recommends it and monitors your eye health.

Interactions

Interactions?

We currently have no information for BLOODROOT Interactions.

Dosing

Dosing

The appropriate dose of bloodroot depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for bloodroot. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Abbas, D. K., Thrane, P., and Othman, S. J. Effectiveness of Veadent as a plaque-inhibiting mouthwash. Scand J Dent.Res 1985;93(6):494-497. View abstract.
  • Allen, C. L., Loudon, J., and Mascarenhas, A. K. Sanguinaria-related leukoplakia: epidemiologic and clinicopathologic features of a recently described entity. Gen.Dent. 2001;49(6):608-614. View abstract.
  • Babay, N. and Al Jasser, N. Subgingival irrigation effects of chlorhexidine or sanguinarine on gingivitis in orthodontic patients. J Clin Pediatr Dent. 1996;20(3):225-228. View abstract.
  • Babu, J. P., Waring, M. B., Lyne, S. M., and Dabbous, M. K. Antiplaque activity of a sanguinaria-containing oral rinse: an in vitro study. Compend.Contin.Educ.Dent. 1986;Suppl 7:S209-S211. View abstract.
  • Cullinan, M. P., Powell, R. N., Faddy, M. J., and Seymour, G. J. Efficacy of a dentifrice and oral rinse containing sanguinaria extract in conjunction with initial periodontal therapy. Aust.Dent.J. 1997;42(1):47-51. View abstract.
  • Etemadzadeh, H. and Ainamo, J. Lacking anti-plaque efficacy of 2 sanguinarine mouth rinses. J Clin Periodontol. 1987;14(3):176-180. View abstract.
  • Eversole, L. R., Eversole, G. M., and Kopcik, J. Sanguinaria-associated oral leukoplakia: comparison with other benign and dysplastic leukoplakic lesions. Oral Surg.Oral Med.Oral Pathol.Oral Radiol.Endod. 2000;89(4):455-464. View abstract.
  • Frankos, V. H., Brusick, D. J., Johnson, E. M., Maibach, H. I., Munro, I., Squire, R. A., and Weil, C. S. Safety of Sanguinaria extract as used in commercial toothpaste and oral rinse products. J.Can.Dent.Assoc. 1990;56(7 Suppl):41-47. View abstract.
  • Godowski, K. C. Antimicrobial action of sanguinarine. J Clin Dent. 1989;1(4):96-101. View abstract.
  • Godowski, K. C., Wolff, E. D., Thompson, D. M., Housley, C. J., Polson, A. M., Dunn, R. L., Duke, S. P., Stoller, N. H., and Southard, G. L. Whole mouth microbiota effects following subgingival delivery of sanguinarium. J Periodontol. 1995;66(10):870-877. View abstract.
  • Greenfield, W. and Cuchel, S. J. The use of an oral rinse and dentifrice as a system for reducing dental plaque. Compend Cont Educ Dent 1984;(Supp 5):S82-S86.
  • Grossman, E., Meckel, A. H., Isaacs, R. L., Ferretti, G. A., Sturzenberger, O. P., Bollmer, B. W., Moore, D. J., Lijana, R. C., and Manhart, M. D. A clinical comparison of antibacterial mouthrinses: effects of chlorhexidine, phenolics, and sanguinarine on dental plaque and gingivitis. J Periodontol. 1989;60(8):435-440. View abstract.
  • Hannah, J. J., Johnson, J. D., and Kuftinec, M. M. Long-term clinical evaluation of toothpaste and oral rinse containing sanguinaria extract in controlling plaque, gingival inflammation, and sulcular bleeding during orthodontic treatment. Am.J.Orthod.Dentofacial Orthop. 1989;96(3):199-207. View abstract.
  • Harper, D. S., Mueller, L. J., Fine, J. B., Gordon, J., and Laster, L. L. Clinical efficacy of a dentifrice and oral rinse containing sanguinaria extract and zinc chloride during 6 months of use. J.Periodontol. 1990;61(6):352-358. View abstract.
  • Harper, D. S., Mueller, L. J., Fine, J. B., Gordon, J., and Laster, L. L. Effect of 6 months use of a dentifrice and oral rinse containing sanguinaria extract and zinc chloride upon the microflora of the dental plaque and oral soft tissues. J.Periodontol. 1990;61(6):359-363. View abstract.
  • JOHNSON, C. C., JOHNSON, G., and POE, C. F. Toxicity of alkaloids to certain bacteria. II. Berberine, physostigmine, and sanguinarine. Acta Pharmacol Toxicol (Copenh) 1952;8(1):71-78. View abstract.
  • Klewansky, P. and Roth, D. Sanguinaria in the control of bleeding in periodontal patients. Compend.Contin.Educ.Dent. 1986;Suppl 7:S218-S220. View abstract.
  • Klewansky, P. and Vernier, D. Sanguinarine and the control of plaque in dental practice. Compend Cont Edu Dent 1984;Supp 5:S94-S97.
  • Kopczyk, R. A., Abrams, H., Brown, A. T., Matheny, J. L., and Kaplan, A. L. Clinical and microbiological effects of a sanguinaria-containing mouthrinse and dentifrice with and without fluoride during 6 months of use. J.Periodontol. 1991;62(10):617-622. View abstract.
  • Kroger, P. W., Kopczyk, R. A., Abrams, H., Kaplan, A. L., Matheny, J. K., and Japser, S. J. Effects of a sanguinarine mouthrinse after periodontal surgery. J Dent Res 1988;67:571.
  • Kuftinec, M. M., Mueller-Joseph, L. J., and Kopczyk, R. A. Sanguinaria toothpaste and oral rinse regimen clinical efficacy in short- and long-term trials. J.Can.Dent.Assoc. 1990;56(7 Suppl):31-33. View abstract.
  • Kurbad, A., Gangler, P., and Kaufmann, K. [Evaluation of the efficacy of sanguinarine using the experimental gingivitis model]. Stomatol.DDR. 1990;40(4):157-159. View abstract.
  • Laster, L. L. and Lobene, R. R. New perspectives on Sanguinaria clinicals: individual toothpaste and oral rinse testing. J.Can.Dent.Assoc. 1990;56(7 Suppl):19-30. View abstract.
  • Lobene, R. R., Soparkar, P. M., and Newman, M. B. The effects of a sanguinaria dentrifice on plaque and gingivitis. Compend.Contin.Educ.Dent. 1986;Suppl 7:S185-S188. View abstract.
  • Mahady, G. B., Pendland, S. L., Stoia, A., and Chadwick, L. R. In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis. Phytother Res 2003;17(3):217-221. View abstract.
  • Mallatt, M. E., Beiswanger, B. B., Drook, C. A., Stookey, G. K., Jackson, R. D., and Bricker, S. L. Clinical effect of a sanguinaria dentifrice on plaque and gingivitis in adults. J.Periodontol. 1989;60(2):91-95. View abstract.
  • Mauriello, S. M. and Bader, J. D. Six-month effects of a sanguinarine dentifrice on plaque and gingivitis. J Periodontol. 1988;59(4):238-243. View abstract.
  • Miller, R. A., McIver, J. E., and Gunsolley, J. C. Effects of sanguinaria extract on plaque retention and gingival health. J.Clin.Orthod. 1988;22(5):304-307. View abstract.
  • Moran, J., Addy, M., and Newcombe, R. A clinical trial to assess the efficacy of sanguinarine-zinc mouthrinse (Veadent) compared with chlorhexidine mouthrinse (Corsodyl). J Clin Periodontol. 1988;15(10):612-616. View abstract.
  • Moran, J., Addy, M., and Roberts, S. A comparison of natural product, triclosan and chlorhexidine mouthrinses on 4-day plaque regrowth. J Clin Periodontol. 1992;19(8):578-582. View abstract.
  • Nelson, R. F., Rodasti, P. C., Tichnor, A., and Lio, Y. L. Comparative study of four over-the-counter mouthrinses claiming antiplaque and/or antigingivitis benefits. Clin Prev.Dent. 1991;13(6):30-33. View abstract.
  • Newton, S. M., Lau, C., Gurcha, S. S., Besra, G. S., and Wright, C. W. The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis. J.Ethnopharmacol. 2002;79(1):57-67. View abstract.
  • Nuckols, P. F., Koertge, T. E., Bower, S. B., and Gunsolley, J. C. Effectiveness of a Viadent mouthrinse in para- and quadriplegic patients. J Dent Res 1987;66:369.
  • Palcanis, K. G., Formica, J. V., Miller, R. A., Brooks, C. N., and Gunsolley, J. C. Longitudinal evaluation of sanguinaria: clinical and microbiologic studies. Compend.Contin.Educ.Dent. 1986;Suppl 7:S179-S184. View abstract.
  • Paolantonio, M., Di Murro, C., D'Onofrio, V., Benigni, A., and Scaramella, G. [Comparative evaluation of 2 antiplaque mouthwashes containing chlorhexidine and sanguinarine]. Minerva Stomatol. 1989;38(4):455-459. View abstract.
  • Parsons, L. G., Thomas, L. G., Southard, G. L., Woodall, I. R., and Jones, B. J. Effect of sanguinaria extract on established plaque and gingivitis when supragingivally delivered as a manual rinse or under pressure in an oral irrigator. J.Clin.Periodontol. 1987;14(7):381-385. View abstract.
  • Parsons, L. G., Thomas, L. G., Woodall, I. R., and Jones, B. J. Effect of 0.03% sanguinaria rinse on plaque and gingivitis when delivered as a manual rinse and under pressure in an oral irrigator. Compend.Contin.Educ.Dent. 1986;Suppl 7:S205-S208. View abstract.
  • Polson, A. M., Garrett, S., Stoller, N. H., Bandt, C. L., Hanes, P. J., Killoy, W. J., Southard, G. L., Duke, S. P., Bogle, G. C., Drisko, C. H., and Friesen, L. R. Multi-center comparative evaluation of subgingivally delivered sanguinarine and doxycycline in the treatment of periodontitis. II. Clinical results. J Periodontol. 1997;68(2):119-126. View abstract.
  • Polson, A. M., Stoller, N. H., Hanes, P. J., Bandt, C. L., Garrett, S., and Southard, G. L. 2 multi-center trials assessing the clinical efficacy of 5% sanguinarine in a biodegradable drug delivery system. J Clin Periodontol. 1996;23(8):782-788. View abstract.
  • Quirynen, M., Marechal, M., and van Steenberghe, D. Comparative antiplaque activity of sanguinarine and chlorhexidine in man. J Clin Periodontol. 1990;17(4):223-227. View abstract.
  • Rau, I. and Bossmann, K. [Effects of dequalinium chloride and sanguinarine on the ultrastructure of early supragingival plaque]. Oralprophylaxe. 1991;13(4):133-141. View abstract.
  • Smith, R. M. The physiologic action of sanguinaria, the alkaloid of
  • Southard, G. L., Parsons, L. G., Thomas, L. G., Jr., Boulware, R. T., Woodall, I. R., and Jones, B. J. The relationship of sanguinaria extract concentration and zinc ion to plaque and gingivitis. J.Clin.Periodontol. 1987;14(6):315-319. View abstract.
  • Southard, G. L., Parsons, L. G., Thomas, L. G., Woodall, I. R., and Jones, B. J. Effect of sanguinaria extract on development of plaque and gingivitis when supragingivally delivered as a manual rinse or under pressure in an oral irrigator. J Clin Periodontol. 1987;14(7):377-380. View abstract.
  • Stickl, O. Die bactericide wirkung der extrakte und alkaloide des schollkrautes auf grampositive pathogene mikroorganisme. Z Hyg infektionskr 1928;108:801-867.
  • Tenenbaum, H., Dahan, M., and Soell, M. Effectiveness of a sanguinarine regimen after scaling and root planing. J Periodontol. 1999;70(3):307-311. View abstract.
  • Vichkanova, S. A. and Adgina, V. V. The antifungal properties of Sanguinarine. Antibiotiki (Moscow) 1971;16:609-612.
  • Vichkanova, S. A. and Tolkachev, O. N. Dependence of antimicrobial activity on the structure and reactivity of natural quaternary heteroaromatic compounds and their analogues. Farmatsiya (Mosc.) 1978;27:38.
  • Vichkanova, S. A., Rubinchik, M. A., Adgina, V. V., and Fedorchenko, T. S. A study of the chemotherapeutic action of Sanguinarine. Farmakol Toksokol (Moscow) 1969;32:325-328.
  • Walker, C. Effects of sanguinarine and Sanguinaria extract on the microbiota associated with the oral cavity. J.Can.Dent.Assoc. 1990;56(7 Suppl):13-30. View abstract.
  • Weide, R., Engelhart, S., Farber, H., Kaufmann, F., Heymanns, J., and Koppler, H. [Severe lead poisoning due to Ayurvedic indian plant medicine]. Dtsch.Med.Wochenschr. 11-14-2003;128(46):2418-2420. View abstract.
  • Wennstrom, J. and Lindhe, J. Clinical effectiveness of a sanguinarine mouthrinse on plaque and gingivitis. Journal of Dental Research 1984;63:224.
  • Wennstrom, J. and Lindhe, J. Some effects of a Sanguinarine-containing mouthrinse on developing plaque and gingivitis. J Clin Periodontol. 1985;12(10):867-872. View abstract.
  • Wennstrom, J. and Lindhe, J. The effect of mouthrinses on parameters characterizing human periodontal disease. J Clin Periodontol. 1986;13(1):86-93. View abstract.
  • Becci PJ, Schwartz H, Barnes HH, Southard GL. Short-term toxicity studies of sanguinarine and of two alkaloid extracts of Sanguinaria canadensis L. J Toxicol Environ Health 1987;20:199-208. View abstract.
  • Harkrader RJ, Reinhart PC, Rogers JA, et al. The history, chemistry and pharmacokinetics of Sanguinaria extract. J Can Dent Assoc 1990;56:7-12. View abstract.
  • Seifen E, Adams RJ, Riemer RK. Sanguinarine: a positive inotropic alkaloid which inhibits cardiac Na+,K+-ATPase. Eur J Pharmacol 1979;60:373-7. View abstract.

More Resources for BLOODROOT

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.