Ananas, Ananus ananus, Ananas comosus, Ananus duckei, Ananas sativus, Bromelaine, Bromélaïne, Bromelains, Bromelainum, Bromelia ananus, Bromelia comosa, Bromelin, Bromelina, Broméline, Concentré de Protéase Végétale, Enzyme d’Ananas, Extrait d’Ananas, pHysioprotease, Pineapple, Pineapple Enzyme, Pineapple Extract, Plant Protease Concentrate.


Overview Information

Bromelain is a group of enzymes found in pineapple juice and in the pineapple stem. People use it as a medicine.

Bromelain is used for pain, muscle soreness, and many other conditions, but there is no good scientific evidence to support these uses.

How does it work?

Bromelain seems to cause the body to produce substances that fight pain and swelling (inflammation).

Bromelain also contains chemicals that interfere with the growth of tumor cells and slow blood clotting.


Uses & Effectiveness?

Possibly Ineffective for

  • Muscle soreness caused by exercise. Taking bromelain by mouth after intense exercise does not prevent muscle soreness. It also doesn't reduce pain or weakness or improve flexibility.

Insufficient Evidence for

  • Burns. Early research shows that applying gel containing bromelain enzymes under a wound dressing helps remove dead tissue from second- and third-degree burns.
  • Kidney stones. Early research found that adding bromelain to tamsulosin might help the body get rid of kidney stones.
  • Knee pain. Early research shows that taking bromelain by mouth might reduce mild knee pain.
  • Osteoarthritis. Taking bromelain by mouth alone doesn't seem to help arthritis pain.
  • A skin condition that causes small, scaling, raised spots (pityriasis lichenoides chronica or PLC). Early research shows that bromelain might help treat episodes of PLC.
  • Pain after surgery. Some research shows that bromelain slightly reduces pain after removal of wisdom teeth. But it doesn't seem to reduce lockjaw or swelling.
  • Rheumatoid arthritis (RA). Early research shows that bromelain can reduce joint swelling in people with rheumatoid arthritis. But this research is not very reliable.
  • Swelling (inflammation) of the nasal cavity and sinuses (rhinosinusitis). Early research shows that taking bromelain along with decongestants, antihistamines, or antibiotics helps reduce nasal swelling in people with sinusitis. But this research is not very reliable.
  • A type of inflammatory bowel disease (ulcerative colitis). Early research shows that bromelain helps alleviate ulcerative colitis symptoms in people that do not get enough relief after standard therapy.
  • An adverse skin reaction caused by cancer drug treatment (chemotherapy-induced acral erythema).
  • Infections of the kidney, bladder, or urethra (urinary tract infections or UTIs).
  • Painful conditions caused by overuse of tendons (tendinopathy).
  • Hay fever.
  • Improving antibiotic absorption.
  • Inflammation.
  • Preventing cancer.
  • Shortening of labor.
  • Other conditions.
More evidence is needed to rate the effectiveness of bromelain for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Bromelain is POSSIBLY SAFE for most people when taken by mouth in appropriate amounts. Bromelain may cause some side effects, such as diarrhea and stomach and intestinal discomfort. Bromelain may also cause allergic reactions, especially in people who have other allergies. If you have allergies, be sure to check with your healthcare provider before taking bromelain.

When applied to the skin: Bromelain is POSSIBLY SAFE for most people when applied to the skin in appropriate amounts.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of bromelain during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Allergies: If you are allergic to pineapple, latex, wheat, celery, papain, carrot, fennel, cypress pollen, or grass pollen, you might have an allergic reaction to bromelain.

Surgery: Bromelain might increase the risk of bleeding during and after surgery. Stop using bromelain at least 2 weeks before a scheduled surgery.



Moderate Interaction

Be cautious with this combination

  • Amoxicillin (Amoxil, Trimox) interacts with BROMELAIN

    Taking bromelain might increase how much amoxicillin is in the body. Taking bromelain along with amoxicillin might increase effects and side effects of amoxicillin.

  • Antibiotics (Tetracycline antibiotics) interacts with BROMELAIN

    Taking bromelain might increase how much antibiotic the body absorbs. Taking bromelain along with some antibiotics might increase effects and side effects of some antibiotics called tetracyclines.

    Some tetracyclines include demeclocycline (Declomycin), minocycline (Minocin), and tetracycline (Achromycin).

  • Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with BROMELAIN

    Bromelain might slow blood clotting. Taking bromelain along with medications that also slow clotting might increase the chances of bruising and bleeding.

    Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.



The following doses have been studied in scientific research:


  • For osteoarthritis: a combination product (Phlogenzym), which contains rutin 100 mg, trypsin 48 mg, and bromelain 90 mg, given as 2 tablets 3 times daily has been used.

View References


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