LARCH ARABINOGALACTAN

OTHER NAME(S):

Abies gmelinii, AG, Ara-6, Arabinogalactan de Alerce, Arabinogalactan, Arabinogalactane, Arabinogalactane de Meleze, Arabinogalactane de Mélèze, Arabinogalactin, Arabinogalactine, Dietary Fiber, Fibre Alimentaire, Fibre Soluble, Gmelinii, Gomme de Mélèze, Larch, Larch Gum, Larch Tree, Larix, Larix dahurica, Larix decidua, Larix europaea, Larix gmelinii, Larix laricina, Larix occidentalis, Lch, Mélèze, Mélèze d’Europe, Mongolian Larch, Mongolian Larchwood, Pinus Larix, Soluble Fiber, Stractan, Western Larch, Western Larch Arabinogalactan, Wood Gum, Wood Sugar.<br/><br/>

Overview

Overview Information

Arabinogalactan is a starch-like chemical that is found in many plants. It is found in highest concentrations in larch trees. Larch arabinogalactan is used for medicine. Most of the larch arabinogalactan you will find in stores is produced from western larch or eastern larch trees. However, larch arabinogalactan can also be produced by other larch tree species.

Larch arabinogalactan is used for infections, including the common cold, flu, H1N1 (swine) flu, ear infections in children, and HIV/AIDS. It is also used to treat liver cancer, as well as a brain condition caused by liver damage (hepatic encephalopathy). Some people use it to provide dietary fiber, lower cholesterol, and to boost the immune system.

In foods, larch arabinogalactan is used as a stabilizer, binder, and sweetener.

How does it work?

Larch arabinogalactan is a fiber that ferments in the intestine. It might increase intestinal bacteria, such as Lactobacillus, and have other effects that could be beneficial to digestive tract health. There is also information that suggests larch arabinogalactan might boost the immune system and help prevent cancer cells in the liver from growing.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Common cold. Early research shows that taking 4.5 grams of a specific larch arabinogalactan extract daily for 12 weeks does not lower the overall number of colds or reduce cold symptoms in people who frequently suffer from cold symptoms. But more people taking larch arabinogalactan seem to avoid getting the cold compared to people taking a placebo pill.
  • High cholesterol. Early research shows that taking larch arabinogalactan does not lower total cholesterol, low-density lipoprotein (LDL or "bad") cholesterol, other blood fats called triglycerides, body weight, blood pressure, or sugar levels in healthy people. It is not yet known whether larch arabinogalactan improves these outcomes in people with high cholesterol.
  • Pneumonia. Early research shows that taking 4.5 grams of a specific larch arabinogalactan product daily increases the immune system response to pneumonia vaccines. It’s not known if this helps prevent pneumonia.
  • Flu.
  • H1N1 (swine) flu.
  • Liver disease.
  • Liver cancer.
  • Earache (otitis media).
  • HIV/AIDS.
  • Dietary fiber supplementation.
  • Boosting the immune system.
  • Inflammation.
  • Other conditions.
More evidence is needed to rate the effectiveness of larch arabinogalactan for these uses.

Side Effects

Side Effects & Safety

Larch arabinogalactan is LIKELY SAFE when eaten in food amounts. It’s POSSIBLY SAFE when taken by mouth in appropriate amounts for less than 6 months. It can cause side effects such as bloating and intestinal gas (flatulence). Not enough is known about the safety of long-term use of larch arabinogalactan.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking larch arabinogalactan if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

“Auto-immune diseases” such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: Larch arabinogalactan might cause the immune system to become more active, and this could increase the symptoms of auto-immune diseases. If you have one of these conditions, it’s best to avoid using larch arabinogalactan.

Organ transplant recipients: Larch arabinogalactan might increase the risk of organ transplant rejection. If you have received an organ transplant, don’t use larch arabinogalactan until more is known.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Medications that decrease the immune system (Immunosuppressants) interacts with LARCH ARABINOGALACTAN

    Larch arabinogalactan seems to increase the immune system. By increasing the immune system larch arabinogalactan might decrease the effectiveness of medications that decrease the immune system.<br/><br/> Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.

Dosing

Dosing

The appropriate dose of larch arabinogalactan depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for larch arabinogalactan. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Hirayama, T. Relationship of soybean paste soup intake to gastric cancer risk. Nutr Cancer 1982;3(4):223-233. View abstract.
  • Hirota, T., Ikeda, H., and Hirota, K. [Present knowledge in nutritional aspects of fracture]. Clin Calcium 2006;16(12):2017-2025. View abstract.
  • Ho, S. C., Woo, J., Lam, S., Chen, Y., Sham, A., and Lau, J. Soy protein consumption and bone mass in early postmenopausal Chinese women. Osteoporos.Int. 2003;14(10):835-842. View abstract.
  • Hoie, L. H., Graubaum, H. J., Harde, A., Gruenwald, J., and Wernecke, K. D. Lipid-lowering effect of 2 dosages of a soy protein supplement in hypercholesterolemia. Adv.Ther 2005;22(2):175-186. View abstract.
  • Hoie, L. H., Guldstrand, M., Sjoholm, A., Graubaum, H. J., Gruenwald, J., Zunft, H. J., and Lueder, W. Cholesterol-lowering effects of a new isolated soy protein with high levels of nondenaturated protein in hypercholesterolemic patients. Adv Ther 2007;24(2):439-447. View abstract.
  • Hoie, L. H., Morgenstern, E. C., Gruenwald, J., Graubaum, H. J., Busch, R., Luder, W., and Zunft, H. J. A double-blind placebo-controlled clinical trial compares the cholesterol-lowering effects of two different soy protein preparations in hypercholesterolemic subjects. Eur.J.Nutr. 2005;44(2):65-71. View abstract.
  • Holmes WL, Rubel GB, and Hood SE. Comparison of the effect of dietary meat versus dietary soybean protein on plasma lipids of hyperlipidemic individuals. Atherosclerosis 1980;36:379-387.
  • Holst-Jensen, S. E., Pfeiffer-Jensen, M., Monsrud, M., Tarp, U., Buus, A., Hessov, I., Thorling, E., and Stengaard-Pedersen, K. Treatment of rheumatoid arthritis with a peptide diet: a randomized, controlled trial. Scand.J.Rheumatol. 1998;27(5):329-336. View abstract.
  • Hooper, L., Kroon, P. A., Rimm, E. B., Cohn, J. S., Harvey, I., Le Cornu, K. A., Ryder, J. J., Hall, W. L., and Cassidy, A. Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2008;88(1):38-50. View abstract.
  • Hori, G., Wang, M. F., Chan, Y. C., Komatsu, T., Wong, Y., Chen, T. H., Yamamoto, K., Nagaoka, S., and Yamamoto, S. Soy protein hydrolyzate with bound phospholipids reduces serum cholesterol levels in hypercholesterolemic adult male volunteers. Biosci.Biotechnol.Biochem 2001;65(1):72-78. View abstract.
  • Horiuchi, T., Onouchi, T., Takahashi, M., Ito, H., and Orimo, H. Effect of soy protein on bone metabolism in postmenopausal Japanese women. Osteoporos.Int. 2000;11(8):721-724. View abstract.
  • Hsu, C. S., Shen, W. W., Hsueh, Y. M., and Yeh, S. L. Soy isoflavone supplementation in postmenopausal women. Effects on plasma lipids, antioxidant enzyme activities and bone density. J Reprod.Med 2001;46(3):221-226. View abstract.
  • Huang, H. Y., Yang, H. P., Yang, H. T., Yang, T. C., Shieh, M. J., and Huang, S. Y. One-year soy isoflavone supplementation prevents early postmenopausal bone loss but without a dose-dependent effect. J.Nutr.Biochem. 2006;17(8):509-517. View abstract.
  • Huff, M. W., Giovannetti, P. M., and Wolfe, B. M. Turnover of very low-density lipoprotein-apoprotein B is increased by substitution of soybean protein for meat and dairy protein in the diets of hypercholesterolemic men. Am J Clin Nutr 1984;39(6):888-897. View abstract.
  • Hunt, K. J., Hung, S. K., and Ernst, E. Botanical extracts as anti-aging preparations for the skin: a systematic review. Drugs Aging 12-1-2010;27(12):973-985. View abstract.
  • Hwang, Y. W., Kim, S. Y., Jee, S. H., Kim, Y. N., and Nam, C. M. Soy food consumption and risk of prostate cancer: a meta-analysis of observational studies. Nutr.Cancer 2009;61(5):598-606. View abstract.
  • Iacovou, M., Ralston, R. A., Muir, J., Walker, K. Z., and Truby, H. Dietary management of infantile colic: a systematic review. Matern.Child Health J. 2012;16(6):1319-1331. View abstract.
  • Itsiopoulos, C., Hodge, A., and Kaimakamis, M. Can the Mediterranean diet prevent prostate cancer? Mol.Nutr.Food Res. 2009;53(2):227-239. View abstract.
  • Iyngkaran, N., Yadav, M., Looi, L. M., Boey, C. G., Lam, K. L., Balabaskaran, S., and Puthucheary, S. D. Effect of soy protein on the small bowel mucosa of young infants recovering from acute gastroenteritis. J Pediatr.Gastroenterol.Nutr 1988;7(1):68-75. View abstract.
  • Izumi, T., Saito, M., Obata, A., Arii, M., Yamaguchi, H., and Matsuyama, A. Oral intake of soy isoflavone aglycone improves the aged skin of adult women. J Nutr Sci Vitaminol.(Tokyo) 2007;53(1):57-62. View abstract.
  • Jacques, H., Laurin, D., Moorjani, S., Steinke, F. H., Gagne, C., Brun, D., and Lupien, P. J. Influence of diets containing cow's milk or soy protein beverage on plasma lipids in children with familial hypercholesterolemia. J.Am.Coll.Nutr. 1992;11 Suppl:69S-73S. View abstract.
  • Jehn, C. F., Boulikas, T., Kourvetaris, A., Possinger, K., and Luftner, D. Pharmacokinetics of liposomal cisplatin (lipoplatin) in combination with 5-FU in patients with advanced head and neck cancer: first results of a phase III study. Anticancer Res 2007;27(1A):471-475. View abstract.
  • Jenkins, D. J., Kendall, C. W., Vidgen, E., Vuksan, V., Jackson, C. J., Augustin, L. S., Lee, B., Garsetti, M., Agarwal, S., Rao, A. V., Cagampang, G. B., and Fulgoni, V., III. Effect of soy-based breakfast cereal on blood lipids and oxidized low- density lipoprotein. Metabolism 2000;49(11):1496-1500. View abstract.
  • Jenkins, D. J., Wolever, T. M., Spiller, G., Buckley, G., Lam, Y., Jenkins, A. L., and Josse, R. G. Hypocholesterolemic effect of vegetable protein in a hypocaloric diet. Atherosclerosis 1989;78(2-3):99-107. View abstract.
  • Johnstone, D. E. and Dutton, A. M. Dietary prophylaxis of allergic disease in children. The New England Journal of Medicine 1966;374:715-719.
  • Kalhan, R., Smith, L. J., Nlend, M. C., Nair, A., Hixon, J. L., and Sporn, P. H. A mechanism of benefit of soy genistein in asthma: inhibition of eosinophil p38-dependent leukotriene synthesis. Clin Exp Allergy 2008;38(1):103-112. View abstract.
  • Kalman, D., Feldman, S., Martinez, M., Krieger, D. R., and Tallon, M. J. Effect of protein source and resistance training on body composition and sex hormones. J.Int.Soc.Sports Nutr. 2007;4:4. View abstract.
  • Kardinaal, A. F., Morton, M. S., Bruggemann-Rotgans, I. E., and van Beresteijn, E. C. Phyto-oestrogen excretion and rate of bone loss in postmenopausal women. Eur.J.Clin.Nutr. 1998;52(11):850-855. View abstract.
  • Kelley, K. W. and Carroll, D. G. Evaluating the evidence for over-the-counter alternatives for relief of hot flashes in menopausal women. J.Am.Pharm.Assoc.(2003.) 2010;50(5):e106-e115. View abstract.
  • Kemp, A. S., Hill, D. J., Allen, K. J., Anderson, K., Davidson, G. P., Day, A. S., Heine, R. G., Peake, J. E., Prescott, S. L., Shugg, A. W., and Sinn, J. K. Guidelines for the use of infant formulas to treat cows milk protein allergy: an Australian consensus panel opinion. Med J Aust 1-21-2008;188(2):109-112. View abstract.
  • Key, T. J., Sharp, G. B., Appleby, P. N., Beral, V., Goodman, M. T., Soda, M., and Mabuchi, K. Soya foods and breast cancer risk: a prospective study in Hiroshima and Nagasaki, Japan. Br J Cancer 1999;81(7):1248-1256. View abstract.
  • Khalil, D. A., Lucas, E. A., Juma, S., Smith, B. J., Payton, M. E., and Arjmandi, B. H. Soy protein supplementation increases serum insulin-like growth factor-I in young and old men but does not affect markers of bone metabolism. J.Nutr. 2002;132(9):2605-2608. View abstract.
  • Khanna, D., Sethi, G., Ahn, K. S., Pandey, M. K., Kunnumakkara, A. B., Sung, B., Aggarwal, A., and Aggarwal, B. B. Natural products as a gold mine for arthritis treatment. Curr Opin Pharmacol 2007;7(3):344-351. View abstract.
  • Kim, H., Xu, J., Su, Y., Xia, H., Li, L., Peterson, G., Murphy-Ullrich, J., and Barnes, S. Actions of the soy phytoestrogen genistein in models of human chronic disease: potential involvement of transforming growth factor beta. Biochem Soc Trans. 2001;29(Pt 2):216-222. View abstract.
  • Kim, J., Kang, M., Lee, J. S., Inoue, M., Sasazuki, S., and Tsugane, S. Fermented and non-fermented soy food consumption and gastric cancer in Japanese and Korean populations: a meta-analysis of observational studies. Cancer Sci. 2011;102(1):231-244. View abstract.
  • Marett R, Slavin JL. No long-term benefits of supplementation with arabinogalactan on serum lipids and glucose. J Am Diet Assoc 2004;104:636-9. View abstract.
  • Riede L, Grube B, Gruenwald J. Larch arabinogalactan effects on reducing incidence of upper respiratory tract infections. Curr Med Res Opin 2013;29(3):251-8. View abstract.
  • Robinson RR, Feirtag J, Slavin JL. Effects of dietary arabinogalactan on gastrointestinal and blood parameters in healthy human subjects. J Am Coll Nutr 2001;20:279-85. View abstract.
  • Udani JK, Singh BB, Barrett ML, Singh VJ. Proprietary arabinogalactan extract increases antibody response to the pneumonia vaccine: a randomized, double-blind, placebo-controlled, pilot study in healthy volunteers. Nutr J 2010;9:32. View abstract.
  • Ambrus, J. L., Ambrus, C. M., Shields, R., Mink, I. B., and Cleveland, C. Effect of galactose and sugar substitutes on blood insulin levels in normal and obese individuals. J.Med. 1976;7(6):429-438. View abstract.
  • Bayliss, C. E. and Houston, A. P. Characterization of plant polysaccharide- and mucin-fermenting anaerobic bacteria from human feces. Appl.Environ.Microbiol. 1984;48(3):626-632. View abstract.
  • Beuth, J., Ko, H. L., Oette, K., Pulverer, G., Roszkowski, K., and Uhlenbruck, G. Inhibition of liver metastasis in mice by blocking hepatocyte lectins with arabinogalactan infusions and D-galactose. J.Cancer Res.Clin.Oncol. 1987;113(1):51-55. View abstract.
  • Beuth, J., Ko, H. L., Schirrmacher, V., Uhlenbruck, G., and Pulverer, G. Inhibition of liver tumor cell colonization in two animal tumor models by lectin blocking with D-galactose or arabinogalactan. Clin.Exp.Metastasis 1988;6(2):115-120. View abstract.
  • Egert, D. and Beuscher, N. Studies on antigen specifity of immunoreactive arabinogalactan proteins extracted from Baptisia tinctoria and Echinacea purpurea. Planta Med. 1992;58(2):163-165. View abstract.
  • Hagmar, B., Ryd, W., and Skomedal, H. Arabinogalactan blockade of experimental metastases to liver by murine hepatoma. Invasion Metastasis 1991;11(6):348-355. View abstract.
  • Hauer, J. and Anderer, F. A. Mechanism of stimulation of human natural killer cytotoxicity by arabinogalactan from Larix occidentalis. Cancer Immunol.Immunother. 1993;36(4):237-244. View abstract.
  • Larch arabinogalactan. Altern.Med.Rev. 2000;5(5):463-466. View abstract.
  • Macfarlane, S., McBain, A. J., and Macfarlane, G. T. Consequences of biofilm and sessile growth in the large intestine. Adv.Dent.Res. 1997;11(1):59-68. View abstract.
  • Nergard, C. S., Diallo, D., Michaelsen, T. E., Malterud, K. E., Kiyohara, H., Matsumoto, T., Yamada, H., and Paulsen, B. S. Isolation, partial characterisation and immunomodulating activities of polysaccharides from Vernonia kotschyana Sch. Bip. ex Walp. J.Ethnopharmacol. 2004;91(1):141-152. View abstract.
  • Nergard, C. S., Matsumoto, T., Inngjerdingen, M., Inngjerdingen, K., Hokputsa, S., Harding, S. E., Michaelsen, T. E., Diallo, D., Kiyohara, H., Paulsen, B. S., and Yamada, H. Structural and immunological studies of a pectin and a pectic arabinogalactan from Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae). Carbohydr.Res. 1-17-2005;340(1):115-130. View abstract.
  • Odonmazig, P., Ebringerova, A., Machova, E., and Alfoldi, J. Structural and molecular properties of the arabinogalactan isolated from Mongolian larchwood (Larix dahurica L.). Carbohydr.Res. 1-15-1994;252:317-324. View abstract.
  • Rampton, D. S., Cohen, S. L., Crammond, V. D., Gibbons, J., Lilburn, M. F., Rabet, J. Y., Vince, A. J., Wager, J. D., and Wrong, O. M. Treatment of chronic renal failure with dietary fiber. Clin.Nephrol. 1984;21(3):159-163. View abstract.
  • Salyers, A. A., Arthur, R., and Kuritza, A. Digestion of larch arabinogalactan by a strain of human colonic Bacteroides growing in continuous culture. J.Agric.Food Chem. 1981;29(3):475-480. View abstract.
  • Salyers, A. A., Vercellotti, J. R., West, S. E., and Wilkins, T. D. Fermentation of mucin and plant polysaccharides by strains of Bacteroides from the human colon. Appl.Environ.Microbiol. 1977;33(2):319-322. View abstract.
  • Schepetkin, I. A., Faulkner, C. L., Nelson-Overton, L. K., Wiley, J. A., and Quinn, M. T. Macrophage immunomodulatory activity of polysaccharides isolated from Juniperus scopolorum. Int.Immunopharmacol. 2005;5(13-14):1783-1799. View abstract.
  • Thude, S., Classen, B., Blaschek, W., Barz, D., and Thude, H. Binding studies of an arabinogalactan-protein from Echinacea purpurea to leucocytes. Phytomedicine. 2006;13(6):425-427. View abstract.
  • Uhlenbruck, G., Beuth, J., Oette, K., Roszkowski, W., Ko, H. L., and Pulverer, G. Prevention of experimental liver metastases by arabinogalactan. Naturwissenschaften 1986;73(10):626-627. View abstract.
  • Vince, A. J., McNeil, N. I., Wager, J. D., and Wrong, O. M. The effect of lactulose, pectin, arabinogalactan and cellulose on the production of organic acids and metabolism of ammonia by intestinal bacteria in a faecal incubation system. Br.J.Nutr. 1990;63(1):17-26. View abstract.
  • Yamada, H., Kiyohara, H., Cyong, J. C., and Otsuka, Y. Structural characterisation of an anti-complementary arabinogalactan from the roots of Angelica acutiloba Kitagawa. Carbohydr.Res. 2-1-1987;159(2):275-291. View abstract.
  • Yamamoto, S., Sakai, I., and Iseki, S. Purification, composition and immunochemical properties of arabinogalactan-protein H active glycopeptides from Euonymus sieboldiana seeds. Immunol.Commun. 1981;10(3):215-236. View abstract.
  • Anon. Best herb for fighting off colds. Bottom Line 1999;20:1.
  • D'Adamo P. Larch arabinogalactan. J Naturopath Med 1996;6:33-7.
  • Dion C, Chappuis E, Ripoll C. Does larch arabinogalactan enhance immune function? A review of mechanistic and clinical trials. Nutr Metab (Lond) 2016;13:28. View abstract.
  • GRAS Notices. U.S. Food & Drug Administration Web site. Available at: http://www.accessdata.fda.gov/scripts/fdcc/?set=GRASNotices. Accessed October 2016.
  • Grube B, Stier H, Riede L, Gruenwald J. Tolerability of a proprietary larch arabinogalactan extract: a randomized, double-blind, placebo-controlled clinical trial in healthy subjects. Food Nutr Sci 2012;3:1533-8.
  • Kelly GS. Larch arabinogalactan: Clinical relevance of a novel immune-enhancing polysaccharide. Alt Med Rev 1999;4:96-103. View abstract.
  • Khvostov MV, Borisov SA, Tolstikova TG, et al. Supramolecular complex of ibuprofen with larch polysaccharide arabinogalactan: studies on bioavailability and pharmacokinetics. Eur J Drug Metab Pharmacokinet 2017 Jun;42(3):431-440. View abstract.
  • Kim LS, Burkholder PM, Waters RF. Effects of low-dose larch arabinogalactan from Larix occidentalis: a randomized, double-blind, placebo-controlled pilot study. Complement Health Pract Rev 2002;7(2):221-9.
  • Kim LS, Waters RF, Burkholder PM. Immunological activity of larch arabinogalactan and Echinacea: a preliminary, randomized, double-blind, placebo-controlled trial. Altern Med Rev 2002;7:138-49. View abstract.
  • Kind LS, Macedo-Sobrinho B, Ako D. Enhanced vascular permeability induced in mice by larch arabinogalactan. Immunology 1970;19:799-807. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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