Cafe, Café, Café Arabica, Café Robusta, Caffea, Coffea arabica, Coffea arnoldiana, Coffea bukobensis, Coffea canephora, Coffea Cruda, Coffea liberica, Coffea robusta, Espresso, Expresso, Java, Mocha.<br/><br/>
Overview InformationCoffee is a drink made from coffee beans, which are the roasted fruit of the Coffea arabica bush.
People most commonly drink coffee to relieve mental and physical fatigue and to increase mental alertness. Coffee is also used to prevent Parkinson disease, Alzheimer disease, dementia, and cognitive decline. It is also used to prevent gallstones, gout, type 2 diabetes, and certain types of cancer.
Rectally, coffee is used as an enema to treat cancer. Coffee enemas are used as a part of the "Gerson Therapy." In the Gerson Therapy, cancer patients are treated with caffeinated coffee in the form of enemas every four hours on a daily basis. During the treatment people are given a diet of liver, vegetables, and a variety of other supplements. This type of therapy is considered an unacceptable medical practice in the U.S.
How does it work?Coffee contains caffeine. Caffeine works by stimulating the central nervous system (CNS), heart, and muscles. Coffee also contains other chemicals that might have other benefits.
Uses & Effectiveness
Likely Effective for
- Mental alertness. Drinking coffee and other beverages that contain caffeine throughout the day seems to increase alertness and clear thinking. Caffeine can also improve alertness after sleep deprivation. Even one drink of coffee can reduce fatigue and increase alertness.
Possibly Effective for
- Impaired movement of food through the intestines after surgery. Drinking coffee might shorten the time until first bowel movement after having part of the colon removed or after having surgery for gynecological cancers.
- Diabetes. People who drink more coffee seems to have a lower risk of developing type 2 diabetes. The greater the intake of coffee, the lower the risk.
- Gallbladder disease. People who drink beverages such as coffee that provide at least 400 mg of caffeine per day seem to have a lower risk of developing gallstones. The greater the intake of caffeine, the lower the risk.
- High cholesterol. Drinking caffeinated coffee seems to reduce levels of total cholesterol, LDL or "bad cholesterol," and blood fats called triglycerides by a small amount. Drinking at least 6-8 cups of caffeinated coffee per day might have the greatest benefit. Drinking decaffeinated coffee does not appear to have the same effect.
- Low blood pressure. Drinking caffeinated beverages like coffee seems to increase blood pressure in elderly people who experience dizziness after meals due to low blood pressure.
- Death from any cause. People who drink coffee every day seem to have a lower chance of dying from any cause or from heart disease compared to those who never drink coffee. It's unclear if drinking coffee is linked with a lower chance of death due to cancer.
- Parkinson disease. There is evidence that people who drink caffeinated beverages such as coffee, tea, and cola have a decreased risk of Parkinson disease. Interestingly, coffee does not seem to help prevent Parkinson disease in people who smoke cigarettes.
Possibly Ineffective for
- Cancer of the esophagus. People who drink more coffee don't seem to have a lower chance of developing cancer of the esophagus.
Insufficient Evidence for
- Hardening of the arteries (atherosclerosis). The buildup of calcium-containing plaque in the arteries is an early sign of possible atherosclerosis. Drinking coffee doesn't seem to be linked with a lower buildup of calcium-containing plaque in the arteries.
- Bladder cancer. Some evidence suggests that people who drink more coffee have a lower chance of developing bladder cancer. But other research suggest that people who drink more coffee might have a higher risk of developing bladder cancer.
- Breast cancer. People who drink more coffee don't seem to have a lower chance of developing breast cancer.
- Memory and thinking skills (cognitive function). There is developing evidence that drinking more coffee over a lifetime might improve thinking skills among women older than 80 years of age.
- Colon cancer, rectal cancer. There is some evidence that Japanese people who drink more coffee have a lower chance of developing colon or rectal cancer. But other research conducted in North America and Europe has not found a link between drinking coffee and the risk of colon and rectal cancer.
- Endometrial cancer. The effect of coffee on the risk of endometrial cancer is unclear. Some research suggests that women who drink more coffee have a lower risk of developing endometrial cancer. But other research has not found a link between drinking coffee and the risk of endometrial cancer.
- Gout. There is some evidence that both caffeinated and decaffeinated coffee seem to help to prevent gout. But caffeinated coffee seems to work better.
- High blood pressure. People who drink coffee long-term seem to have a lower chance of developing high blood pressure. But smoking seems to diminish this benefit.
- Lung cancer. Some research suggests that drinking caffeinated coffee may help to prevent lung cancer, but other research disagrees. It's too early to draw firm conclusions. Meanwhile, some research suggests that drinking decaffeinated coffee may help to prevent lung cancer.
- The most serious type of skin cancer (melanoma). When factors such as age and sun exposure are taken into account, drinking coffee doesn't seem to be linked with a lower chance of developing skin cancer.
- Obesity. The effect of coffee on weight loss in people who are overweight or obese is unclear. Results from research are conflicting. Some research suggests that taking coffee chemicals, called mannooligosaccharides, for 12 weeks might help with weight loss in men, but not women. Drinking a dark roast coffee seems to help reduce food intake and help with weight loss, whereas a light roast coffee does not. Other research suggests that drinking coffee with or without caffeine does not help with weight loss.
- Prostate cancer. In general, people who drink coffee don't seem to have a lower risk of developing prostate cancer. But drinking more coffee has been linked with a lower risk of localized prostate cancer. This is prostate cancer that has not spread outside the prostate.
- Skin cancer. Some research shows that drinking many cups of coffee per day might reduce the risk of a specific form of skin cancer called basal cell carcinoma but not other forms of skin cancer. Drinking decaf or decaffeinated coffee does not have any effect on skin cancer risk. The effect on skin cancer might be with caffeine and not coffee.
- Alzheimer disease and other types of dementia.
- Other conditions.
Side Effects & SafetyCoffee is LIKELY SAFE for most healthy adults when consumed in moderate amounts (about 4 cups per day).
Coffee containing caffeine can cause insomnia, nervousness and restlessness, stomach upset, nausea and vomiting, increased heart and breathing rate, and other side effects.
Drinking unfiltered coffee can increase total cholesterol, low-density lipoprotein (LDL) cholesterol, and levels of another type of blood fat called triglycerides. This might increase the risk of developing heart disease. Using coffee filters helps to reduce these effects on cholesterol.
Caffeinated coffee is POSSIBLY UNSAFE when taken by mouth for a long time or in high doses (more than 4 cups per day). Drinking large amounts of caffeinated coffee might cause headache, anxiety, agitation, ringing in the ears, and irregular heartbeats. Drinking more than 6 cups daily might cause "caffeinism" with symptoms such as anxiety or agitation. Also, people who drink a lot of caffeinated coffee every day may need to drink more coffee to get the same effects. They may also become "dependent" on coffee to the point that they develop withdrawal symptoms if they suddenly stop drinking it.
There is some concern that drinking more than 5 cups of coffee per day might not be safe for people with heart disease. But for people who don't have heart disease, drinking several cups daily does not seem to increase the chance of developing a heart problem. There is also concern that occasional coffee drinking might trigger a heart attack in some people. People who usually don't drink more than one cup of coffee daily and also have multiple risk factors for heart disease seem to have an increased risk for heart attack within an hour after drinking coffee. But people who regularly drink greater amounts do not seem to have this risk.
There is some concern that drinking coffee might increase the risk of some types of cancers. However, there is no good evidence that coffee increases the risk of any type of cancer. Scientists continue to look at this.
Coffee is also POSSIBLY UNSAFE when given rectally as an enema. Coffee enemas have been linked to cases of severe side effects, including death.
Special Precautions & Warnings:Pregnancy and breast-feeding: Caffeinated coffee is POSSIBLY SAFE for pregnant women in amounts of 3 cups per day or less. This amount of coffee provides about 300 mg of caffeine. Consuming larger amounts during pregnancy or when breast-feeding is POSSIBLY UNSAFE. Drinking more than 3 cups per day during pregnancy has been linked to an increased risk of miscarriage, premature birth, and low birth weight. These risks increase as the amount of coffee the mother drinks during pregnancy increases. Also, caffeine can pass into breast milk, so nursing mothers should closely monitor caffeine intake to make sure it is on the low side (1-2 cups per day). High intake of caffeine by nursing mothers can cause sleep problems, irritability, and increased bowel activity in breast-fed infants.
Children: Caffeinated coffee is POSSIBLY SAFE when taken by children and adolescents in amounts commonly found in foods and beverages.
Anxiety disorders: The caffeine in coffee might make anxiety worse.
Bipolar disorder: The caffeine in coffee might make symptoms of mania worse.
Bleeding disorders: There is some concern that coffee might make bleeding disorders worse.
Heart disease: Drinking unfiltered (boiled) coffee increases the amount of cholesterol and other fats in the blood, and also raises the level of homocysteine, all of which are associated with an increased risk of developing heart disease. Some research suggests an association between heart attacks and drinking coffee.
Diabetes: Some research suggests that caffeine contained in coffee might change the way people with diabetes process sugar. Caffeine has been reported to cause increases as well as decreases in blood sugar. Use caffeine with caution if you have diabetes and monitor your blood sugar carefully.
Diarrhea: Coffee contains caffeine. The caffeine in coffee, especially when taken in large amounts, can worsen diarrhea.
Glaucoma: Drinking caffeinated coffee increases pressure inside the eye. The increase starts within 30 minutes and lasts for at least 90 minutes.
High blood pressure: Drinking caffeinated coffee might increase blood pressure in people with high blood pressure. However, this effect might be less in people who drink coffee regularly.
Irritable bowel syndrome (IBS): Coffee contains caffeine. The caffeine in coffee, especially when taken in large amounts, can worsen diarrhea and might worsen symptoms of IBS.
Thinning bones (osteoporosis): Drinking caffeinated coffee can increase the amount of calcium that is flushed out in the urine. This might weaken bones. If you have osteoporosis, limit caffeine consumption to less than 300 mg per day (less than 3 cups of caffeinated coffee). Taking calcium supplements may help to make up for calcium that is lost. If you are generally healthy and getting enough calcium from your food and supplements, taking up to 400 mg of caffeine daily (about 4 cups of coffee) doesn't seem to increase the risk of getting osteoporosis. Postmenopausal women who have an inherited condition that keeps them from processing vitamin D normally, should be especially cautious when using caffeine.
Do not take this combination
Ephedrine interacts with COFFEE
Stimulant drugs speed up the nervous system. The caffeine in coffee and ephedrine are both stimulant drugs. Drinking coffee and taking ephedrine might cause too much stimulation and sometimes serious side effects and heart problems. Do not take caffeine-containing products and ephedrine at the same time.
Be cautious with this combination
Adenosine (Adenocard) interacts with COFFEE
The caffeine in coffee might block the affects of adenosine (Adenocard). Adenosine (Adenocard) is often used by doctors to do a test on the heart. This test is called a cardiac stress test. Stop consuming coffee or other caffeine-containing products at least 24 hours before a cardiac stress test.
Alcohol interacts with COFFEE
The body breaks down the caffeine in coffee to get rid of it. Alcohol can decrease how quickly the body breaks down caffeine. Taking coffee along with alcohol might cause too much caffeine in the bloodstream and caffeine side effects including jitteriness, headache, and fast heartbeat.
Alendronate (Fosamax) interacts with COFFEE
Coffee can decrease how much alendronate (Fosamax) the body absorbs. Taking coffee and alendronate (Fosamax) at the same time can decrease the effectiveness of alendronate (Fosamax). Don't drink coffee within two hours of taking alendronate (Fosamax).
Antibiotics (Quinolone antibiotics) interacts with COFFEE
The body breaks down caffeine to get rid of it. Some antibiotics might decrease how quickly the body breaks down caffeine. Taking these antibiotics along with coffee can increase the risk of side effects including jitteriness, headache, increased heart rate, and other side effects.<br/><br/> Some antibiotics that decrease how quickly the body breaks down caffeine include ciprofloxacin (Cipro), enoxacin (Penetrex), norfloxacin (Chibroxin, Noroxin), sparfloxacin (Zagam), trovafloxacin (Trovan), and grepafloxacin (Raxar).
Clozapine (Clozaril) interacts with COFFEE
The body breaks down clozapine (Clozaril) to get rid of it. The caffeine in coffee might decrease how fast the body breaks down clozapine (Clozaril). Taking coffee along with clozapine (Clozaril) can increase the effects and side effects of clozapine (Clozaril).
Dipyridamole (Persantine) interacts with COFFEE
The caffeine in coffee might block the affects of dipyridamole (Persantine). Dipyridamole (Persantine) is often used by doctors to do a test on the heart. This test is called a cardiac stress test. Stop drinking coffee or other caffeine-containing products at least 24 hours before a cardiac stress test.
Disulfiram (Antabuse) interacts with COFFEE
The body breaks down the caffeine in coffee to get rid of it. Disulfiram (Antabuse) can decrease how quickly the body gets rid of caffeine. Taking coffee along with disulfiram (Antabuse) might increase the effects and side effects of coffee including jitteriness, hyperactivity, irritability, and others.
Estrogens interacts with COFFEE
The body breaks down the caffeine in coffee to get rid of it. Estrogens can decrease how quickly the body breaks down caffeine. Taking estrogen pills and drinking coffee can cause jitteriness, headache, fast heartbeat, and other side effects. If you take estrogen pills limit your caffeine intake.<br/><br/> Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.
Fluvoxamine (Luvox) interacts with COFFEE
The body breaks down the caffeine in coffee to get rid of it. Fluvoxamine (Luvox) can decrease how quickly the body breaks down caffeine. Taking caffeine along with fluvoxamine (Luvox) might cause too much caffeine in the body, and increase the effects and side effects of caffeine.
Levothyroxine (Synthroid, Levothroid, Levoxyl, and others) interacts with COFFEE
Drinking some types of coffee might reduce the amount of levothyroxine that is absorbed when taken by mouth. This can decrease how well levothyroxine works. Avoid drinking coffee at the same time that you take levothyroxine and for an hour afterwards.
Lithium interacts with COFFEE
You body naturally gets rid of lithium. The caffeine in coffee can increase how quickly your body gets rid of lithium. If you take products that contain caffeine and you take lithium, stop taking caffeine products slowly. Stopping caffeine too quickly can increase the side effects of lithium.
Medications for depression (MAOIs) interacts with COFFEE
The caffeine in coffee can stimulate the body. Some medications used for depression can also stimulate the body. Drinking coffee and taking some medications for depression might cause too much stimulation and serious side effects including fast heartbeat, high blood pressure, nervousness, and others.<br/><br/> Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.
Medications for depression (Tricyclic Antidepressants) interacts with COFFEE
Coffee contains chemicals called tannins. Tannins can bind to many medications and decrease how much medicine the body absorbs. To avoid this interaction avoid coffee one hour before and two hours after taking medications for depression called tricyclic antidepressants.<br/><br/> Some medications for depression include amitriptyline (Elavil) or imipramine (Tofranil, Janimine).
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with COFFEE
Coffee might slow blood clotting. Taking coffee along with medications that also slow clotting might increase the chances of bruising and bleeding.<br/><br/> Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
Pentobarbital (Nembutal) interacts with COFFEE
The stimulant effects of the caffeine in coffee can block the sleep-producing effects of pentobarbital.
Phenothiazines interacts with COFFEE
Coffee contains chemicals called tannins. Tannins can bind to many medications and decrease how much medicine the body absorbs. To avoid this interaction avoid coffee one hour before and two hours after taking phenothiazine medications.<br/><br/> Some phenothiazine medications include fluphenazine (Permitil, Prolixin), chlorpromazine (Thorazine), haloperidol (Haldol), prochlorperazine (Compazine), thioridazine (Mellaril), and trifluoperazine (Stelazine).
Phenylpropanolamine interacts with COFFEE
The caffeine in coffee can stimulate the body. Phenylpropanolamine can also stimulate the body. Taking caffeine and phenylpropanolamine together might cause too much stimulation and increase heartbeat, blood pressure, and cause nervousness.
Riluzole (Rilutek) interacts with COFFEE
The body breaks down riluzole (Rilutek) to get rid of it. Drinking coffee can decrease how fast the body breaks down riluzole (Rilutek) and increase the effects and side effects of riluzole.
Stimulant drugs interacts with COFFEE
Stimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heartbeat. The caffeine in coffee can also speed up the nervous system. Drinking coffee along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with coffee.<br/><br/> Some stimulant drugs include diethylpropion (Tenuate), epinephrine, phentermine (Ionamin), pseudoephedrine (Sudafed), and many others.
Theophylline interacts with COFFEE
The caffeine in coffee works similarly to theophylline. Caffeine can also decrease how quickly the body gets rid of theophylline. Drinking coffee and taking theophylline might increase the effects and side effects of theophylline.
Verapamil (Calan, Covera, Isoptin, Verelan) interacts with COFFEE
The body breaks down the caffeine in coffee to get rid of it. Verapamil (Calan, Covera, Isoptin, Verelan) can decrease how quickly the body gets rid of caffeine. Drinking coffee and taking verapamil (Calan, Covera, Isoptin, Verelan) can increase the risk of side effects for coffee including jitteriness, headache, and an increased heartbeat.
Be watchful with this combination
Birth control pills (Contraceptive drugs) interacts with COFFEE
The body breaks down the caffeine in coffee to get rid of it. Birth control pills can decrease how quickly the body breaks down caffeine. Taking coffee along with birth control pills can cause jitteriness, headache, fast heartbeat, and other side effects.<br/><br/> Some birth control pills include ethinyl estradiol and levonorgestrel (Triphasil), ethinyl estradiol and norethindrone (Ortho-Novum 1/35, Ortho-Novum 7/7/7), and others.
Cimetidine (Tagamet) interacts with COFFEE
The body breaks down the caffeine in coffee to get rid of it. Cimetidine (Tagamet) can decrease how quickly your body breaks down caffeine. Taking cimetidine (Tagamet) along with coffee might increase the chance of caffeine side effects including jitteriness, headache, fast heartbeat, and others.
Fluconazole (Diflucan) interacts with COFFEE
The body breaks down the caffeine in coffee to get rid of it. Fluconazole (Diflucan) might decrease how quickly the body gets rid of caffeine. Taking fluconazole (Diflucan) and drinking coffee might increase the effects and side effects of coffee including nervousness, anxiety, and insomnia.
Medications for diabetes (Antidiabetes drugs) interacts with COFFEE
Coffee might increase blood sugar. Diabetes medications are used to lower blood sugar. By increasing blood sugar, coffee might decrease the effectiveness of diabetes medications. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.<br/><br/> Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Mexiletine (Mexitil) interacts with COFFEE
Coffee contains caffeine. The body breaks down caffeine to get rid of it. Mexiletine (Mexitil) can decrease how quickly the body breaks down caffeine. Taking Mexiletine (Mexitil) along with coffee might increase the caffeine effects and side effects of coffee.
Terbinafine (Lamisil) interacts with COFFEE
The body breaks down the caffeine in coffee to get rid of it. Terbinafine (Lamisil) can decrease how fast the body gets rid of caffeine and increase the risk of side effects including jitteriness, headache, increased heartbeat, and other effects.
The following doses have been studied in scientific research:
- For headache or improving mental alertness: The typical dose of caffeine is up to 250 mg per day, which is about 2 cups of coffee. Even a single cup of coffee with caffeine can be used.
- For Parkinson disease: Three to four cups of caffeinated coffee per day or 421 mg to 2716 mg total caffeine. However, a significantly lower risk of developing Parkinson disease has also been associated with as little as 124 mg to 208 mg of caffeine (approximately one to two cups of coffee). In women, more moderate caffeinated coffee intake, one to three cups per day, seems to be best.
- For death from any cause: At least one cup of ground, instant, or decaffeinated coffee per day has been used long-term.
- For gallbladder disease: 400 mg or more of caffeine per day, which is about two or more cups of coffee. However, drinking at least 800 mg caffeine per day (four or more cups of coffee) seems to work best.
- For high cholesterol: Six to eight cups of caffeinated coffee per day has been used.
- For diabetes: 900 mg caffeine per day (six or more cups of coffee per day) long-term.
- Impaired movement of food through the intestines after surgery: 100 mL of coffee three times a day starting after surgery and continuing until the first bowel movement has been used.
Brewed coffee contains around 100-150 mg caffeine per cup. Instant coffee contains 85-100 mg caffeine per cup. Decaffeinated coffee contains approximately 8 mg caffeine per cup. Darker roasts contain less caffeine due to the roasting process.
- Michels KB, Holmberg L, Bergkvist L, Wolk A. Coffee, tea, and caffeine consumption and breast cancer incidence in a cohort of Swedish women. Ann Epidemiol 2002;12:21-6. View abstract.
- Migliardi JR, Armellino JJ, Friedman M, et al. Caffeine as an analgesic adjuvant in tension headache. Clin Pharmacol Ther 1994;56:576-86. View abstract.
- Müller SA, Rahbari NN, Schneider F, et al. Randomized clinical trial on the effect of coffee on postoperative ileus following elective colectomy. Br J Surg 2012;99(11):1530-8. View abstract.
- Nawrot P, Jordan S, Eastwood J, et al. Effects of caffeine on human health. Food Addit Contam 2003;20:1-30. View abstract.
- Nix D, Zelenitsky S, Symonds W, et al. The effect of fluconazole on the pharmacokinetics of caffeine in young and elderly subjects. Clin Pharmacol Ther 1992;51:183.
- Nurminen ML, Niittynen L, Korpela R, Vapaatalo H. Coffee, caffeine and blood pressure: a critical review. Eur J Clin Nutr 1999;53:831-9. View abstract.
- Olthof MR, Hollman PC, Zock PL, Katan MB. Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans. Am J Clin Nutr 2001;73:532-8. View abstract.
- Panagiotakos DB, Pitsavos C, Chrysohoou C, et al. The J-shaped effect of coffee consumption on the risk of developing acute coronary syndromes: the CARDIO2000 case-control study. J Nutr 2003;133:3228-32. View abstract.
- Petrie HJ, Chown SE, Belfie LM, et al. Caffeine ingestion increases the insulin response to an oral-glucose-tolerance test in obese men before and after weight loss. Am J Clin Nutr 2004;80:22-8. View abstract.
- Pollock BG, Wylie M, Stack JA, et al. Inhibition of caffeine metabolism by estrogen replacement therapy in postmenopausal women. J Clin Pharmacol 1999;39:936-40. View abstract.
- Porta M, Malats N, Alguacil J, et al. Coffee, pancreatic cancer, and K-ras mutations: updating the research agenda. J Epidemiol Community Health 2000;54:656-9.
- Raaska K, Raitasuo V, Laitila J, Neuvonen PJ. Effect of caffeine-containing versus decaffeinated coffee on serum clozapine concentrations in hospitalised patients. Basic Clin Pharmacol Toxicol 2004;94:13-8. View abstract.
- Rakic V, Beilin LJ, Burke V. Effect of coffee and tea drinking on postprandial hypotension in older men and women. Clin Exp Pharmacol Physiol 1996;23:559-63. View abstract.
- Rapuri PB, Gallagher JC, Kinyamu HK, Ryschon KL. Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes. Am J Clin Nutr 2001;74:694-700. View abstract.
- Reed A, James N, Sikora K. Juices, coffee enemas, and cancer. Lancet 1990;336:677-8.
- Robinson LE, Savani S, Battram DS, et al. Caffeine ingestion before an oral glucose tolerance test impairs blood glucose management in men with type 2 diabetes. J Nutr 2004;134:2528-33. View abstract.
- Ross GW, Abbott RD, Petrovitch H, et al. Association of coffee and caffeine intake with the risk of parkinson disease. JAMA 2000;283:2674-9. View abstract.
- Ruhl CE, Everhart JE. Association of coffee consumption with gallbladder disease. Am J Epidemiol 2000;152:1034-8. View abstract.
- Salazar-Martinez E, Willett WC, Ascherio A, et al. Coffee consumption and risk for type 2 diabetes mellitus. Ann Intern Med 2004;140:1-8. View abstract.
- Samarrae WA, Truswell AS. Short-term effect of coffee on blood fibrinolytic activity in healthy adults. Atherosclerosis 1977;26:255-60. View abstract.
- Sanderink GJ, Bournique B, Stevens J, et al. Involvement of human CYP1A isoenzymes in the metabolism and drug interactions of riluzole in vitro. Pharmacol Exp Ther 1997;282:1465-72. View abstract.
- Sanikini H, Dik VK, Siersema PD, Bhoo-Pathy N, Uiterwaal CS, Peeters PH, González CA, Zamora-Ros R, Overvad K, Tjønneland A, Roswall N, Boutron-Ruault MC, Fagherazzi G, Racine A, Kühn T, Katzke V, Boeing H, Trichopoulou A, Trichopoulos D, Lagiou P, Palli D, Grioni S, Vineis P, Tumino R, Panico S, Weiderpass E, Skeie G, Braaten T, Huerta JM, Sánchez-Cantalejo E, Barricarte A, Sonestedt E, Wallstrom P, Nilsson LM, Johansson I, Bradbury KE, Khaw KT, Wareham N, Huybrechts I, Freisling H, Cross AJ, Riboli E, Bueno-de-Mesquita HB. Total, caffeinated and decaffeinated coffee and tea intake and gastric cancer risk: results from the EPIC cohort study. Int J Cancer. 2015 15;136(6):E720-30. doi: 10.1002/ijc.29223. Epub 2014 29. View abstract.
- Savitz DA, Chan RL, Herring AH, et al. Caffeine and miscarriage risk. Epidemiology 2008;19:55-62. View abstract.
- Schabath MB, Hernandez LM, Wu X, et al. Dietary phytoestrogens and lung cancer risk. JAMA 2005;294:1493-1504. View abstract.
- Shils ME, Herman MG. Unproved dietary claims in the treatment of patients with cancer. Bull N Y Acad Med 1982;58:323-39.
- Sinclair CJ, Geiger JD. Caffeine use in sports. A pharmacological review. J Sports Med Phys Fitness 2000;40:71-9. View abstract.
- Smith A. Effects of caffeine on human behavior. Food Chem Toxicol 2002;40:1243-55. View abstract.
- St-Onge MP, Salinardi T, Herron-Rubin K, Black RM. A weight-loss diet including coffee-derived mannooligosaccharides enhances adipose tissue loss in overweight men but not women. Obesity (Silver Spring) 2012;20(2):343-8. View abstract.
- Stanek EJ, Melko GP, Charland SL. Xanthine interference with dipyridamole-thallium-201 myocardial imaging. Pharmacother 1995;29:425-7. View abstract.
- Sugiyama K, Sugawara Y, Tomata Y, Nishino Y, Fukao A, Tsuji I. The association between coffee consumption and bladder cancer incidence in a pooled analysis of the Miyagi Cohort Study and Ohsaki Cohort Study. Eur J Cancer Prev. 2017 Mar;26(2):125-130. doi: 10.1097/CEJ.0000000000000226. View abstract.
- Tavani A, La Vecchia C. Coffee and cancer: a review of epidemiological studies, 1990-1999. Eur J Cancer Prev 2000;9:241-56. View abstract.
- Tavani A, Pregnolato A, La Vecchia C, et al. Coffee consumption and the risk of breast cancer. Eur J Cancer Prev 1998;7:77-82. View abstract.
- The National Toxicology Program (NTP). Caffeine. Center for the Evaluation of Risks to Human Reproduction (CERHR). Available at: http://cerhr.niehs.nih.gov/common/caffeine.html.
- Tofler OB, Foy S, Ng K, et al. Coffee and coronary heart disease. Heart Lung and Circulation 2001;10:116-20.
- Tuomilehto J, Hu G, Bidel S, et al. Coffee Consumption and Risk of Type 2 Diabetes Mellitus Among Middle-aged Finnish Men and Women. JAMA 2004;291:1213-9. View abstract.
- Underwood DA. Which medications should be held before a pharmacologic or exercise stress test? Cleve Clin J Med 2002;69:449-50. View abstract.
- Urgert R, Meyboom S, Kuilman M, et al. Comparison of effect of cafetiere and filtered coffee on serum concentrations of liver aminotransferases and lipids: six month randomised controlled trial. BMJ 1996;313:1362-6.. View abstract.
- Urgert R, Vliet TV, Zock PL, et al. Heavy coffee consumption and plasma homocysteine: a randomized controlled trial in healthy volunteers. Am J Clin Nutr 2000;72:1107-10. View abstract.
- Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3. View abstract.
- van der Hoeven N, Visser I, Schene A, van den Born BJ. Severe hypertension related to caffeinated coffee and tranylcypromine: a case report. Ann Intern Med. 2014 May 6;160(9):657-8. doi: 10.7326/L14-5009-8. No abstract available. View abstract.
- Vandeberghe K, Gillis N, Van Leemputte M, et al. Caffeine counteracts the ergogenic action of muscle creatine loading. J Appl Physiol 1996;80:452-7. View abstract.
- Vieira AR, Abar L, Chan DSM, et al. Foods and beverages and colorectal cancer risk: a systematic review and meta-analysis of cohort studies, an update of the evidence of the WCRF-AICR Continuous Update Project. Ann Oncol. 2017 Aug 1;28(8):1788-1802. doi: 10.1093/annonc/mdx171. View abstract.
- Voskoboinik A, Kalman JM, Kistler PM. Caffeine and arrhythmias: time to grind the data. JACC: Clin Electrophysiol. 2018;4(4):425-32.
- Wahllander A, Paumgartner G. Effect of ketoconazole and terbinafine on the pharmacokinetics of caffeine in healthy volunteers. Eur J Clin Pharmacol 1989;37:279-83. View abstract.
- Wakabayashi K, Kono S, Shinchi K, et al. Habitual coffee consumption and blood pressure: A study of self-defense officials in Japan. Eur J Epidemiol 1998;14:669-73. View abstract.
- Wallach J. Interpretation of Diagnostic Tests. A synopsis of Laboratory Medicine. Fifth ed; Boston, MA: Little Brown, 1992.
- Wang Y, Yu X, Wu Y, Zhang D. Coffee and tea consumption and risk of lung cancer: a dose-response analysis of observational studies. Lung Cancer. 2012;78(2):169-70. View abstract.
- Watson JM, Jenkins EJ, Hamilton P, et al. Influence of caffeine on the frequency and perception of hypoglycemia in free-living patients with type 1 diabetes. Diabetes Care 2000;23:455-9. View abstract.
- Watson JM, Sherwin RS, Deary IJ, et al. Dissociation of augmented physiological, hormonal and cognitive responses to hypoglycaemia with sustained caffeine use. Clin Sci (Lond) 2003;104:447-54. View abstract.
- Wedick NM, Brennan AM, Sun Q, Hu FB, Mantzoros CS, van Dam RM. Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trial. Nutr J 2011;10:93. View abstract.
- Weng X, Odouli R, Li DK. Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study. Am J Obstet Gynecol 2008;198:279.e1-8. View abstract.
- Wikoff D, Welsh BT, Henderson R, et al. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food Chem Toxicol 2017;109:585-648. View abstract.
- Williams MH, Branch JD. Creatine supplementation and exercise performance: an update. J Am Coll Nutr 1998;17:216-34. View abstract.
- Winkelmayer WC, Stampfer MJ, Willett WC, Curhan GC. Habitual caffeine intake and the risk of hypertension in women. JAMA 2005;294:2330-5. View abstract.
- Wisborg K, Kesmodel U, Bech BH, et al. Maternal consumption of coffee during pregnancy and stillbirth and infant death in first year of life: prospective study. BMJ 2003;326:420.. View abstract.
- Wu W, Tong Y, Zhao Q, Yu G, Wei X, Lu Q. Coffee consumption and bladder cancer: a meta-analysis of observational studies. Sci Rep. 2015 Mar 12;5:9051. doi: 10.1038/srep09051. View abstract.
- Xia J, Chen J, Xue JX, Yang J, Wang ZJ. An up-to-date meta analysis of coffee consumption and risk of prostate cancer. Urol J. 2017 Aug 29;14(5):4079-4088. No doi. View abstract.
- Zheng JS, Yang J, Fu YQ, Huang T, Huang YJ, Li D. Effects of green tea, black tea, and coffee consumption on the risk of esophageal cancer: a systematic review and meta-analysis of observational studies. Nutr Cancer. 2013;65(1):1-16. View abstract.
- Zheng XM, Williams RC. Serum caffeine levels after 24-hour abstention: clinical implications on dipyridamole (201)Tl myocardial perfusion imaging. J Nucl Med Technol 2002;30:123-7. View abstract.
- Zuchinali P, Riberio PA, Pimentel M, da Rosa PR, Zimerman LI, Rohde LE. Effect of caffeine on ventricular arrhythmia: a systematic review and meta-analysis of experimental and clinical studies. Europace 2016 Feb;18(2):257-66. View abstract.
- Birkett, N. J. and Logan, A. G. Caffeine-containing beverages and the prevalence of hypertension. J Hypertens.Suppl 1988;6(4):S620-S622. View abstract.
- Casiglia, E., Bongiovi, S., Paleari, C. D., Petucco, S., Boni, M., Colangeli, G., Penzo, M., and Pessina, A. C. Haemodynamic effects of coffee and caffeine in normal volunteers: a placebo-controlled clinical study. J.Intern.Med. 1991;229(6):501-504. View abstract.
- Conen, D., Chiuve, S. E., Everett, B. M., Zhang, S. M., Buring, J. E., and Albert, C. M. Caffeine consumption and incident atrial fibrillation in women. Am J Clin Nutr 2010;92(3):509-514. View abstract.
- Farag, N. H., Whitsett, T. L., McKey, B. S., Wilson, M. F., Vincent, A. S., Everson-Rose, S. A., and Lovallo, W. R. Caffeine and blood pressure response: sex, age, and hormonal status. J Womens Health (Larchmt.) 2010;19(6):1171-1176. View abstract.
- Floegel, A., Pischon, T., Bergmann, M. M., Teucher, B., Kaaks, R., and Boeing, H. Coffee consumption and risk of chronic disease in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study. Am J Clin.Nutr. 2012;95(4):901-908. View abstract.
- Fotherby, M. D., Ghandi, C., Haigh, R. A., Macdonald, T. A., and Potter, J. F. Sustained caffeine use has no pressor effect in the elderly. Cardiology in the Elderly 1994;2(6):499-503.
- Gronroos, N. N. and Alonso, A. Diet and risk of atrial fibrillation - epidemiologic and clinical evidence -. Circ.J 2010;74(10):2029-2038. View abstract.
- Lopez-Garcia, E., Rodriguez-Artalejo, F., Rexrode, K. M., Logroscino, G., Hu, F. B., and van Dam, R. M. Coffee consumption and risk of stroke in women. Circulation 3-3-2009;119(8):1116-1123. View abstract.
- Mort, J. R. and Kruse, H. R. Timing of blood pressure measurement related to caffeine consumption. Ann Pharmacother. 2008;42(1):105-110. View abstract.
- Mostofsky, E., Schlaug, G., Mukamal, K. J., Rosamond, W. D., and Mittleman, M. A. Coffee and acute ischemic stroke onset: the Stroke Onset Study. Neurology 11-2-2010;75(18):1583-1588. View abstract.
- Quinlan, P., Lane, J., and Aspinall, L. Effects of hot tea, coffee and water ingestion on physiological responses and mood: the role of caffeine, water and beverage type. Psychopharmacology (Berl) 1997;134(2):164-173. View abstract.
- Reis, J. P., Loria, C. M., Steffen, L. M., Zhou, X., van, Horn L., Siscovick, D. S., Jacobs, D. R., Jr., and Carr, J. J. Coffee, decaffeinated coffee, caffeine, and tea consumption in young adulthood and atherosclerosis later in life: the CARDIA study. Arterioscler.Thromb.Vasc.Biol 2010;30(10):2059-2066. View abstract.
- Sung, B. H., Whitsett, T. L., Lovallo, W. R., al'Absi, M., Pincomb, G. A., and Wilson, M. F. Prolonged increase in blood pressure by a single oral dose of caffeine in mildly hypertensive men. Am.J Hypertens. 1994;7(8):755-758. View abstract.
- Zhang, W., Lopez-Garcia, E., Li, T. Y., Hu, F. B., and van Dam, R. M. Coffee consumption and risk of cardiovascular diseases and all-cause mortality among men with type 2 diabetes. Diabetes Care 2009;32(6):1043-1045. View abstract.
- Abernethy DR, Todd EL. Impairment of caffeine clearance by chronic use of low-dose oestrogen-containing oral contraceptives. Eur J Clin Pharmacol 1985;28:425-8. View abstract.
- Ali M, Afzal M. A potent inhibitor of thrombin stimulated platelet thromboxane formation from unprocessed tea. Prostaglandins Leukot Med 1987;27:9-13. View abstract.
- American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 2001;108:776-89. View abstract.
- Anon. Filtering the news about coffee. University of California, Berkeley Wellness Letter 2001:17:1-2.
- Anon. Roasting process to pump up cancer fighting properties of coffee unveiled by oncology sciences corp. PRNewswire 2000; Jun 30. www.prnewswire.com (Accessed 3 July 2000).
- Aqel RA, Zoghbi GJ, Trimm JR, et al. Effect of caffeine administered intravenously on intracoronary-administered adenosine-induced coronary hemodynamics in patients with coronary artery disease. Am J Cardiol 2004;93:343-6. View abstract.
- Ardlie NG, Glew G, Schultz BG, Schwartz CJ. Inhibition and reversal of platelet aggregation by methyl xanthines. Thromb Diath Haemorrh 1967;18:670-3. View abstract.
- Arnlov J, Vessby B. Coffee consumption and insulin sensitivity. JAMA 2004;291:1199-201.
- Ascherio A, Zhang SM, Hernan MA, et al. Prospective study of caffeine intake and risk of Parkinson's disease in men and women. Proceedings 125th Ann Mtg Am Neurological Assn. Boston, MA: 2000;Oct 15-18:42 (abstract 53).
- Avisar R, Avisar E, Weinberger D. Effect of coffee consumption on intraocular pressure. Ann Pharmacother 2002;36:992-5.. View abstract.
- Bak AA, Grobbee DE. The effect of serum cholesterol levels of coffee brewed by filtering or boiling. N Engl J Med 1989;321:1432-7. View abstract.
- Baker JA, McCann SE, Reid ME, et al. Associations between black tea and coffee consumption and risk of lung cancer among current and former smokers. Nutr Cancer 2005;52:15-21. View abstract.
- Bara AI, Barley EA. Caffeine for asthma. Cochrane Database Syst Rev 2001;4:CD001112.. View abstract.
- Baylin A, Hernandez-Diaz S, Kabagambe EK, et al. Transient exposure to coffee as a trigger of a first nonfatal myocardial infarction. Epidemiology 2006;17:506-11. View abstract.
- Beach CA, Mays DC, Guiler RC, et al. Inhibition of elimination of caffeine by disulfiram in normal subjects and recovering alcoholics. Clin Pharmacol Ther 1986;39:265-70. View abstract.
- Bell DG, Jacobs I, Ellerington K. Effect of caffeine and ephedrine ingestion on anaerobic exercise performance. Med Sci Sports Exerc 2001;33:1399-403. View abstract.
- Benowitz NL, Osterloh J, Goldschlager N, et al. Massive catecholamine release from caffeine poisoning. JAMA 1982;248:1097-8. View abstract.
- Benvenga S. Bartolone L, Pappalardo MA, et al. Altered intestinal absorption of L-thyroxine caused by coffee. Thyroid 2008;18:293-301. View abstract.
- Bischoff HA, Stahelin HB, Dick W, et al. Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 2003;18:343-51.. View abstract.
- Boozer CN, Nasser JA, Heymsfield SB, et al. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. Int J Obes Relat Metab Disord 2001;25:316-24. View abstract.
- Bracken MB, Triche EW, Belanger K, et al. Association of maternal caffeine consumption with decrements in fetal growth. Am J Epidemiol 2003;157:456-66.. View abstract.
- Brenner H, Rothenbacher D, Bode G, Adler G. Relation of smoking and alcohol and coffee consumption to active Helicobacter pylori infection: cross sectional study. BMJ 1997;315:1489-92. View abstract.
- Briggs GB, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1998.
- Brown BT. Treating cancer with coffee enemas and diet. JAMA 1993;269:1635-6.
- Brown NJ, Ryder D, Branch RA. A pharmacodynamic interaction between caffeine and phenylpropanolamine. Clin Pharmacol Ther 1991;50:363-71. View abstract.
- Cai L, Ma D, Zhang Y, Liu Z, Wang P. The effect of coffee consumption on serum lipids: a meta-analysis of randomized controlled trials. Eur J Clin Nutr. 2012 Aug;66(8):872-7. doi: 10.1038/ejcn.2012.68. View abstract.
- Caini S, Cattaruzza MS, Bendinelli et al. Coffee, tea and caffeine intake and the risk of non-melanoma skin cancer: a review of the literature and meta-analysis. Eur J Nutr. 2017 Feb;56(1):1-12. doi: 10.1007/s00394-016-1253-6. View abstract.
- Caldeira D, Martins C, Alves LB, Pereira H, Ferreira JJ, Costa J. Caffeine does not increase the risk of atrial fibrillation: a systematic review and meta-analysis of observational studies. Heart. 2013;99(19):1383-9. doi: 10.1136/heartjnl-2013-303950. Review. View abstract.
- Cannon ME, Cooke CT, McCarthy JS. Caffeine-induced cardiac arrhythmia: an unrecognised danger of healthfood products. Med J Aust 2001;174:520-1. View abstract.
- Carbo M, Segura J, De la Torre R, et al. Effect of quinolones on caffeine disposition. Clin Pharmacol Ther 1989;45:234-40. View abstract.
- Carrillo JA, Benitez J. Clinically significant pharmacokinetic interactions between dietary caffeine and medications. Clin Pharmacokinet 2000;39:127-53. View abstract.
- Checkoway H, Powers K, Smith-Weller T, et al. Parkinson's disease risks associated with cigarette smoking, alcohol consumption, and caffeine intake. Am J Epidemiol 2002;155:732-8.. View abstract.
- Cheng M, Hu Z, Lu X, Huang J, Gu D. Caffeine intake and atrial fibrillation incidence: dose response meta-analysis of prospective cohort studies. Can J Cardiol. 2014 Apr;30(4):448-54. doi: 10.1016/j.cjca.2013.12.026. Epub 2014 2. Review. View abstract.
- Chiaffarino F, Bravi F, Cipriani S, Parazzini F, Ricci E, Viganò P, La Vecchia C. Coffee and caffeine intake and risk of endometriosis: a meta-analysis. Eur J Nutr. 2014 Oct;53(7):1573-9. doi: 10.1007/s00394-014-0662-7. Epub 2014 31. View abstract.
- Chiu KM. Efficacy of calcium supplements on bone mass in postmenopausal women. J Gerontol A Biol Sci Med Sci 1999;54:M275-80. View abstract.
- Choi HK, Willett W, Curhan G. Coffee consumption and risk of incident gout in men: a prospective study. Arthritis Rheum 2007;56:2049-55. View abstract.
- Coffee consumption and calcified atherosclerotic plaques in the coronary arteries: The NHLBI Family Heart Study. Patel YR, Gadiraju TV, Ellison RC, et al. Clin Nutr ESPEN. 2017 Feb;17:18-21. doi: 10.1016/j.clnesp.2016.12.003. View abstract.
- Crippa A, Discacciati A, Larsson SC, Wolk A, Orsini N. Coffee consumption and mortality from all causes, cardiovascular disease, and cancer: a dose-response meta-analysis. Am J Epidemiol. 2014 Oct 15;180(8):763-75. doi: 10.1093/aje/kwu194. View abstract.
- de Roos B, Caslake MJ, Stalenhoef AF, et al. The coffee diterpene cafestol increases plasma triacylglycerol by increasing the production rate of large VLDL apolipoprotein B in healthy normolipidemic subjects. Am J Clin Nutr 2001;73:45-52. View abstract.
- Dews PB, Curtis GL, Hanford KJ, O'Brien CP. The frequency of caffeine withdrawal in a population-based survey and in a controlled, blinded pilot experiment. J Clin Pharmacol 1999;39:1221-32. View abstract.
- Dews PB, O'Brien CP, Bergman J. Caffeine: behavioral effects of withdrawal and related issues. Food Chem Toxicol 2002;40:1257-61. View abstract.
- Ding M, Bhupathiraju SN, Chen M, van Dam RM, Hu FB. Caffeinated and decaffeinated coffee consumption and risk of type 2 diabetes: a systematic review and a dose-response meta-analysis. Diabetes Care. 2014 ;37(2):569-86. doi: 10.2337/dc13-1203. Review. View abstract.
- Discacciati A, Orsini N, Wolk A. Coffee consumption and risk of nonaggressive, aggressive and fatal prostate cancer--a dose-response meta-analysis. Ann Oncol. 2014 Mar;25(3):584-91. doi: 10.1093/annonc/mdt420. View abstract.
- Dixit S, Stein PK, Dewland TA, Dukes JW, Vittinghoff E, Heckbert SR, Marcus GM. Consumption of Caffeinated Products and Cardiac Ectopy. J Am Heart Assoc. 2016 26;5(1). pii: e002503. doi: 10.1161/JAHA.115.002503. View abstract.
- Durlach PJ. The effects of a low dose of caffeine on cognitive performance. Psychopharmacology (Berl) 1998;140:116-9. View abstract.
- Durrant KL. Known and hidden sources of caffeine in drug, food, and natural products. J Am Pharm Assoc 2002;42:625-37. View abstract.
- Ernst E. Colonic irrigation and the theory of autointoxication: A triumph of ignorance over science. J Clin Gastroenterol 1997;24:196-8. View abstract.
- Eskenazi B. Caffeine—filtering the facts. N Engl J Med 1999;341:1688-9. View abstract.
- FDA. Proposed rule: dietary supplements containing ephedrine alkaloids. Available at: www.verity.fda.gov (Accessed 25 January 2000).
- Fernandes O, Sabharwal M, Smiley T, et al. Moderate to heavy caffeine consumption during pregnancy and relationship to spontaneous abortion and abnormal fetal growth: a meta-analysis. Reprod Toxicol 1998;12:435-44. View abstract.
- Ferrini RL, Barrett-Connor E. Caffeine intake and endogenous sex steroid levels in postmenopausal women. The Rancho Bernardo Study. Am J Epidemiol 1996:144:642-4. View abstract.
- Food and Nutrition Board, Institute of Medicine. Nutrition during lactation. Washington, DC: National Academy Press, 1991. Available at: http://books.nap.edu/books/0309043913/html.
- Forrest WH Jr, Bellville JW, Brown BW Jr. The interaction of caffeine with pentobarbital as a nighttime hypnotic. Anesthesiology 1972;36:37-41. View abstract.
- Gerson M. The cure of advanced cancer by diet therapy: a summary of 30 years of clinical experimentation. Physiol Chem Phys 1978;10:449-64. View abstract.
- Gertz BJ, Holland SD, Kline WF, et al. Studies of the oral bioavailability of alendronate. Clin Pharmacol Ther 1995;58:288-98. View abstract.
- Green S. A critique of the rationale for cancer treatment with coffee enemas and diet. JAMA 1992;268:3224-7.
- Grosso G, Micek A, Godos J, et al. Long-term coffee consumption is associated with decreased incidence of new-onset hypertension: a dose-response meta-analysis. Nutrients. 2017 Aug 17;9(8). pii: E890. doi: 10.3390/nu9080890. View abstract.
- Grubben MJ, Boers GH, Blom HJ, et al. Unfiltered coffee increases plasma homocysteine concentrations in healthy volunteers: a randomized trial. Am J Clin Nutr 2000;71:480-4. View abstract.
- Güngördük K, Özdemir IA, Güngördük Ö, Gülseren V, Gokçü M, Sanci M. Effects of coffee consumption on gut recovery after surgery of gynecological cancer patients: a randomized controlled trial. Am J Obstet Gynecol. 2017 Feb;216(2):145.e1-145.e7. doi: 10.1016/j.ajog.2016.10.019. View abstract.
- Hagg S, Spigset O, Mjorndal T, Dahlqvist R. Effect of caffeine on clozapine pharmacokinetics in healthy volunteers. Br J Clin Pharmacol 2000;49:59-63. View abstract.
- Haller CA, Benowitz NL, Jacob P 3rd. Hemodynamic effects of ephedra-free weight-loss supplements in humans. Am J Med 2005;118:998-1003.. View abstract.
- Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000;343:1833-8. View abstract.
- Harder S, Fuhr U, Staib AH, Wolff T. Ciprofloxacin-caffeine: a drug interaction established using in vivo and in vitro investigations. Am J Med 1989;87:89S-91S. View abstract.
- Hartman TJ, Tangrea JA, Pietinen P, et al. Tea and coffee consumption and risk of colon and rectal cancer in middle-aged Finnish men. Nutr Cancer 1998;31:41-8. View abstract.
- Healy DP, Polk RE, Kanawati L, et al. Interaction between oral ciprofloxacin and caffeine in normal volunteers. Antimicrob Agents Chemother 1989;33:474-8. View abstract.
- Heliovaara M, Aho K, Knekt P, et al. Coffee consumption, rheumatoid factor, and the risk of rheumatoid arthritis. Ann Rheum Dis 2000;59:631-5. View abstract.
- Heseltine D, Dakkak M, woodhouse K, et al. The effect of caffeine on postprandial hypotension in the elderly. J Am Geriatr Soc 1991;39:160-4. View abstract.
- Hindmarch I, Quinlan PT, Moore KL, Parkin C. The effects of black tea and other beverages on aspects of cognition and psychomotor performance. Psychopharmacol 1998;139:230-8. View abstract.
- Hodgson JM, Puddey IB, Burke V, et al. Effects on blood pressure of drinking green and black tea. J Hypertens 1999;17:457-63. View abstract.
- Holmgren P, Norden-Pettersson L, Ahlner J. Caffeine fatalities--four case reports. Forensic Sci Int 2004;139:71-3. View abstract.
- Horner NK, Lampe JW. Potential mechanisms of diet therapy for fibrocystic breast conditions show inadequate evidence of effectiveness. J Am Diet Assoc 2000;100:1368-80. View abstract.
- Huxley R, Lee CM, Barzi F, et al. Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: a systematic review with meta-analysis. Arch Intern Med. 2009 Dec 14;169(22):2053-63. doi: 10.1001/archinternmed.2009.439. View abstract.
- Infante S, Baeza ML, Calvo M, et al. Anaphylaxis due to caffeine. Allergy 2003;58:681-2. View abstract.
- Inoue M, Tajima K, Hirose K, et al. Tea and coffee consumption and the risk of digestive tract cancers: data from a comparative case-referent study in Japan. Cancer Causes Control 1998;9:209-16.. View abstract.
- Institute of Medicine. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. Washington, DC: National Academy Press, 2001. Available at: http://books.nap.edu/books/0309082587/html/index.html.
- Iso H, Date C, Wakai K, et al; JACC Study Group. The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults. Ann Intern Med 2006;144:554-62. View abstract.
- Jacobsen BK, Heuch I. Coffee, K-ras mutations and pancreatic cancer: a heterogeneous aetiology or an artefact? J Epidemiol Community Health 2000;54:654-5.
- Jee SH, He J, Appel LJ, et al. Coffee consumption and serum lipids: a meta-analysis of randomized controlled clinical trials. Am J Epidemiol 2001:153:353-62. View abstract.
- Jefferson JW. Lithium tremor and caffeine intake: two cases of drinking less and shaking more. J Clin Psychiatry 1988;49:72-3. View abstract.
- Jiang X, Zhang D, Jiang W. Coffee and caffeine intake and incidence of type 2 diabetes mellitus: a meta-analysis of prospective studies. Eur J Nutr. 2014 Feb;53(1):25-38. doi: 10.1007/s00394-013-0603-x. Epub 2013 23. Review. View abstract.
- Jiang W, Wu Y, Jiang X. Coffee and caffeine intake and breast cancer risk: an updated dose-response meta-analysis of 37 published studies. Gynecol Oncol. 2013 Jun;129(3):620-9. doi: 10.1016/j.ygyno.2013.03.014. Epub 2013 25. Review. View abstract.
- Jiwani AZ, Rhee DJ, Brauner SC, Gardiner MF, Chen TC, Shen LQ, Chen SH, Grosskreutz CL, Chang KK, Kloek CE, Greenstein SH, Borboli-Gerogiannis S, Pasquale DL, Chaudhry S, Loomis S, Wiggs JL, Pasquale LR, Turalba AV. Effects of caffeinated coffee consumption on intraocular pressure, ocular perfusion pressure, and ocular pulse amplitude: a randomized controlled trial. Eye (Lond). 2012;26(8):1122-30. doi: 10.1038/eye.2012.113. Epub 2012 Jun 8. View abstract.
- Joeres R, Klinker H, Heusler H, et al. Influence of mexiletine on caffeine elimination. Pharmacol Ther 1987;33:163-9. View abstract.
- Johnson-Kozlow M, Kritz-Silverstein D, Barrett-Connor E, et al. Coffee consumption and cognitive function among older adults. Am J Epidemiol 2002;156:842-50.. View abstract.
- Juliano LM, Griffiths RR. A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features. Psychopharmacology (Berl) 2004;176:1-29. View abstract.
- Kamimori GH, Penetar DM, Headley DB, et al. Effect of three caffeine doses on plasma catecholamines and alertness during prolonged wakefulness. Eur J Clin Pharmacol 2000;56:537-44.. View abstract.
- Klag MJ, Wang NY, Meoni LA, et al. Coffee intake and risk of hypertension: The John Hopkins precursors study. Arch Intern Med 2002;162:657-62. View abstract.
- Klebanoff MA, Levine RJ, DerSimonian R, et al. Maternal serum paraxanthine, a caffeine metabolite, and the risk of spontaneous abortion. N Engl J Med 1999;341:1639-44. View abstract.
- Kleemola P, Jousilahti P, Pietinen P, et al. Coffee consumption and the risk of coronary heart disease and death. Arch Intern Med 2000;160:3393-400.. View abstract.
- Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. View abstract.
- Kotyczka C, Boettler U, Lang R, et al. Dark roast coffee is more effective than light roast coffee in reducing body weight, and in restoring red blood cell vitamin E and glutathione concentrations in healthy volunteers. Mol Nutr Food Res 2011;55(10):1582-6. View abstract.
- Kulhanek F, Linde OK, Meisenberg G. Precipitation of antipsychotic drugs in interaction with coffee or tea. Lancet 1979;2:1130. View abstract.
- Kunitake Y, Mizoguchi Y, Sogawa R, et al. Effect of excessive coffee consumption on the clinical course of a patient with bipolar disorder: a case report and literature review. Clin Neuropharmacol. 2017 Jul/Aug;40(4):160-162. doi: 10.1097/WNF.0000000000000222. View abstract.
- Kuper HE, Mucci LA, Trichopoulos D. Coffee, pancreatic cancer, and the question of causation. J Epidemiol Community Health 2000;54:650-1.
- Lafranconi A, Micek A, Galvano F, et al. Coffee decreases the risk of endometrial cancer: A dose-response meta-analysis of prospective cohort studies. Nutrients. 2017 Nov 9;9(11). pii: E1223. doi: 10.3390/nu9111223. View abstract.
- Lagier D, Nee L, Guieu R, et al. Peri-operative oral caffeine does not prevent postoperative atrial fibrillation after heart valve surgery with cardiopulmonary bypass: a randomized controlled clinical trial. Eur J Anaesthesiol. 2018 Apr 26. [Epub ahead of print] View abstract.
- Lake CR, Rosenberg DB, Gallant S, et al. Phenylpropanolamine increases plasma caffeine levels. Clin Pharmacol Ther 1990;47:675-85. View abstract.
- Lane JD, Barkauskas CE, Surwit RS, Feinglos MN. Caffeine impairs glucose metabolism in type 2 diabetes. Diabetes Care 2004;27:2047-8. View abstract.
- Lasswell WL Jr, Weber SS, Wilkins JM. In vitro interaction of neuroleptics and tricylic antidepressants with coffee, tea, and gallotannic acid. J Pharm Sci 1984;73:1056-8. View abstract.
- Leitzmann MF, Willett WC, Rimm EB, et al. A Prospective study of coffee consumption and the risk of symptomatic gallstone disease in men. JAMA 1999;281:2106-12. View abstract.
- Leson CL, McGuigan MA, Bryson SM. Caffeine overdose in an adolescent male. J Toxicol Clin Toxicol 1988;26:407-15. View abstract.
- Li XJ, Ren ZJ, Qin JW, et al. Coffee consumption and risk of breast cancer: an up-to-date meta-analysis. PLoS One. 2013;8(1):e52681. doi: 10.1371/journal.pone.0052681. View abstract.
- Lloyd T, Johnson-Rollings N, Eggli DF, et al. Bone status among postmenopausal women with different habitual caffeine intakes: a longitudinal investigation. J Am Coll Nutr 2000;19:256-61. View abstract.
- Loftfield E, Cornelis MC, Caporaso N, Yu K, Sinha R, Freedman N. Association of coffee drinking With mortality by genetic variation in caffeine metabolism: findings from the UK biobank. JAMA Intern Med. 2018 Aug 1;178(8):1086-1097. doi: 10.1001/jamainternmed.2018.2425. View abstract.
- Lopez-Garcia E, van Dam RM, Willett WC, et al. Coffee consumption and coronary heart disease in men and women: a prospective cohort study. Circulation 2006;113:2045-53. View abstract.
- Margolin KA, Green MR. Polymicrobial enteric septicemia from coffee enemas. West J Med 1984;140:460.
- Massey LK, Whiting SJ. Caffeine, urinary calcium, calcium metabolism and bone. J Nutr 1993;123:1611-4. View abstract.
- Massey LK. Is caffeine a risk factor for bone loss in the elderly? Am J Clin Nutr 2001;74:569-70. View abstract.
- May DC, Jarboe CH, VanBakel AB, Williams WM. Effects of cimetidine on caffeine disposition in smokers and nonsmokers. Clin Pharmacol Ther 1982;31:656-61. View abstract.
- McGowan JD, Altman RE, Kanto WP Jr. Neonatal withdrawal symptoms after chronic maternal ingestion of caffeine. South Med J 1988;81:1092-4.. View abstract.
- Mester R, Toren P, Mizrachi I, et al. Caffeine withdrawal increases lithium blood levels. Biol Psychiatry 1995;37:348-50. View abstract.
- Mets M, Baas D, van Boven I, Olivier B, Verster J. Effects of coffee on driving performance during prolonged simulated highway driving. Psychopharmacology (Berl) 2012;222(2):337-42. View abstract.
- Michaud DS, Giovannucci E, Willett WC, et al. Coffee and alcohol consumption and risk of pancreatic cancer in two prospective United States cohorts. Cancer Epidemiol Biomarkers Prev 2001;10:429-37. View abstract.
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