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Selective Serotonin Reuptake Inhibitors (SSRIs) for PTSD


Generic Name Brand Name
fluoxetine Prozac
fluvoxamine Luvox
paroxetine Paxil
sertraline Zoloft

How It Works

Chemicals in your brain affect the way you feel. When you have post-traumatic stress disorder (PTSD) or depression, you may not have enough of a chemical called serotonin. Selective serotonin reuptake inhibitors (SSRIs) raise the level of serotonin in your brain.

Why It Is Used

SSRIs often are used to treat all the symptoms of PTSD, as well as other conditions like depression or anxiety. These medicines also treat the sleep problems you may have with PTSD.

How Well It Works

Studies have shown that SSRIs improve symptoms of non-combat-related PTSD when compared with a placebo. Some studies are mixed about whether SSRIs work as well for veterans with combat-related PTSD.2

SSRIs can help more types of symptoms than other medicines can.

Side Effects

All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.

Here are some important things to think about:

  • Usually the benefits of the medicine are more important than any minor side effects.
  • Side effects may go away after you take the medicine for a while.
  • If side effects still bother you and you wonder if you should keep taking the medicine, call your doctor. He or she may be able to lower your dose or change your medicine. Do not suddenly quit taking your medicine unless your doctor tells you to.

Call 911 or other emergency services right away if you have:

Call your doctor if you have:

Common side effects of this medicine include:

The U.S. Food and Drug Administration (FDA) has issued an advisory on antidepressant medicines and the risk of suicide. Talk with your doctor about these possible side effects and the warning signs of suicide.

The FDA has issued a warning about taking triptans, used for headaches, with SSRIs (selective serotonin reuptake inhibitors) or SNRIs (selective serotonin/norepinephrine reuptake inhibitors). Taking these medicines together can cause a very rare but serious condition called serotonin syndrome.

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

Never suddenly stop taking antidepressants. The use of any antidepressant should be tapered off slowly and only under the supervision of a doctor. Abruptly stopping antidepressant medicine can cause negative side effects or a relapse of symptoms.

SSRIs can be safer than tricyclic or tetracyclic antidepressants, because they do not cause death if taken in large quantities (overdose). SSRIs usually are well tolerated and effective. SSRIs also may be safer for older adults, because the side effects are more tolerable.

People with liver disease usually require lower doses of SSRIs.

Studies have found that daily use of SSRIs may increase the risk of bone fracture in adults over age 50. Talk with your doctor about this risk before taking an SSRI.

SSRIs make bleeding more likely in the upper gastrointestinal tract (stomach and esophagus). Taking SSRIs with NSAIDs (such as Advil or Aleve) makes bleeding even more likely. Taking medicines that control acid in the stomach may help.3

SSRIs are also used to treat depression. SSRIs alone are not commonly used if you have episodes of mania, such as in bipolar disorder.

Sexual dysfunction can be a significant problem for some people while taking an SSRI. A medicine such as sildenafil (Viagra) may help both men and women who have sexual problems caused by SSRIs.1, 4

Taking medicine

Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.

There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.

Advice for women

Women who take an SSRI during pregnancy have a slightly higher chance of having a baby with birth defects. If you are pregnant, you and your doctor must weigh the risks of taking an SSRI against the risks of not treating your PTSD.


Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.

Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.


  1. Lam RW, et al. (2009). Canadian Network for Mood and Anxiety Treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults: III. Pharmacotherapy. Journal of Affective Disorders, 117(Suppl 1): S26-S43.

  2. Benedek DM, et al. (2009). Guideline Watch: Practice Guideline for the Treatment of Patients With Acute Stress Disorder and Posttraumatic Stress Disorder. Arlington, VA: American Psychiatric Association. Available online:

  3. Abajo FJ, Garcia-Rodriguez LA (2008). Risk of upper gastrointestinal tract bleeding associated with selective serotonin reuptake inhibitors and venlafaxine therapy. Archives of General Psychiatry, 65(7): 795-803.

  4. Nurnberg GH, et al. (2008). Sildenafil treatment of women with antidepressant-associated sexual dysfunction: A randomized controlled trial. JAMA, 300(4): 395-404.

ByHealthwise Staff
Primary Medical ReviewerAdam Husney, MD - Family Medicine
Specialist Medical ReviewerJessica Hamblen, PhD - Post Traumatic Stress Disorder

Current as ofNovember 14, 2014

WebMD Medical Reference from Healthwise

Last Updated: November 14, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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