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    Depression Medicines

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    Are other medicines used with the antidepressants?

    Other medicines may be prescribed in addition to antidepressants, particularly in treatment resistant depression. Here are examples of medicines that may be used to augment as an add-on to antidepressant treatment.

    • Several specific antipsychotic medications have been shown to enhance the effects of an antidepressant when an initial response is poor. These include Abilify (aripiprazole), Seroquel (quetiapine) and Rexulti (brexpiprazole). Symbyax, a combination of the antipsychotic drug Zyprexa (olanzapine) and an SSRI (Prozac, or fluoxetine), is approved for treatment-resistant depression or depression in people with bipolar disorder.
    • Lithium carbonate, usually thought of for its mood stabilizing effects in bipolar disorder, has also long been considered a useful add-on treatment to antidepressants for people with major depressive disorder.
    • Stimulant medicines (such as methylphenidate (Ritalin) or lisdexamfetamine (Vyvanse)) are sometimes used "off label" as add-on treatments for some forms of depression.
    • Buspar (buspirone), an anti-anxiety medicine, also is sometimes useful for depression when added to an antidepressant drug.
    • Your doctor may recommend or prescribe other medications or supplements not FDA approved for use in depression.

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