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Depression Health Center

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Report: Prozac in Pregnancy Toxic to Fetus

Expert Panel Says Prozac Affects Fetus -- and Adult Sex

WebMD Health News

April 28, 2004 -- Taking the popular antidepressant drug Prozac late in pregnancy may be toxic to the fetus, a government report shows.

Mothers who take Prozac during the third trimester of pregnancy risk premature delivery, the report says. They also put their infants at risk of "poor neonatal adaptation," including:

  • Jitteriness
  • Quick, shallow breathing

  • Low blood sugar

  • Low body temperature

  • Poor muscle tone

  • Trouble breathing

  • Weak or absent cry

  • Diminished reaction to pain

  • Not getting enough oxygen while feeding

  • Increased admission to special-care nurseries

Prozac taken by breastfeeding mothers, the report says, may retard infants' early growth.

These aren't Prozac's only effects on reproduction. The report also says that the antidepressant also has "reproductive toxicity." Adults taking the drug may find sexual orgasm difficult or impossible. And some women taking the drug may have changes in the length of their menstrual cycle.

The report comes from the Center for the Evaluation of Risks to Human Reproduction (CERHR). CERHR is part of the federal National Toxicology Program at the National Institutes of Health. Its job is to convene expert panels to look at possible threats to human reproduction -- including child development.

The chairman of the 12-member Prozac panel was pediatrician and pharmacologist Ronald N. Hines, PhD, co-chief of pediatric pharmacology, pharmacogenetics, and teratology at Medical College of Wisconsin, Milwaukee.

"Patients should be aware that these are the risks of taking Prozac," Hines tells WebMD. "They really should talk with their doctors about them before going on the drug."

Tarra Ryker, spokeswoman for Prozac maker Eli Lilly & Co., says that the risks of untreated depression far outweigh those of properly prescribed antidepressants. Lilly is a WebMD sponsor.

"We don't believe there is sufficient evidence to conclude that Prozac is a developmental or a reproductive toxin," Ryker tells WebMD.

Prozac Benefits -- Even During Pregnancy -- May Outweigh Risks

"There may be some side effects that cannot be avoided, but the benefits of this drug may be so great they outweigh the risks," Hines says.

And the benefits may be huge, says psychiatrist Mark I. Levy, MD, assistant clinical professor at the University of California, San Francisco.

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