Teen Suicide, Antidepressant Link Questioned
Close Look Casts Doubt on Depression Drugs as Teen Suicide Cause
Dec. 15, 2004 -- Suicide attempts in depressed teens aren't due to antidepressant drug use, a new study suggests.
Depressed teens who take antidepressants do attempt suicide more often than teens whose depression isn't treated with drugs, find researchers at the University of Colorado Health Science Center. But a closer look at the data - taking into account severity of depression and other factors that influence suicidal behavior - shows that the drugs don't increase teen suicide attempts.
In fact, kids who take the drugs for six months or more are less likely to attempt suicide, report Robert J. Valuck, PhD, RPh, director of pharmaceutical outcomes research at the UCHSC, and colleagues. Their analysis of insurance claims for more than 24,000 depressed 12- to 18-year-olds appears in the current issue of CNS Drugs.
"People see that crude relationship between antidepressants and suicide attempts and say antidepressants are bad," Valuck tells WebMD. "But what if we adjust for all these factors that may contribute to the person's likelihood of attempting suicide? When we do that, the relationship goes away. There are a lot of things going on in teens who attempt suicide. It is not just the antidepressant drugs."
The new report comes on the heels of a recent study that found an increase in suicidal behavior in the days immediately after patients start antidepressant therapy. One of the leaders of that study is James A. Kaye, MD, DrPH, senior epidemiologist for the Boston Collaborative Drug Surveillance Program and associate professor at Boston University School of Public Health.
"They have found essentially the same thing we did: that suicidal attempts are more likely soon after someone is getting treated," Kaye tells WebMD. "It is still controversial whether the drugs are doing something to stimulate suicide or whether it is just that people are at their worst when starting therapy. We sort of favor the latter. This study is supportive of that view -- that it is not the drugs themselves."
Fewer Teen Suicides With Successful Antidepressant Treatment
More and more teens are getting prescriptions for antidepressant drugs. But the study shows that health professionals prescribe antidepressants for only about a third of depressed teens, says study co-author Alexis A. Giese, MD, professor of psychiatry and medical director for acute care and inpatient services at UCHSC.