Skip to content

    Depression Health Center

    Font Size
    A
    A
    A

    FDA OKs Abilify for Depression

    Antipsychotic Drug Approved for Use in Addition to Antidepressants for Treating Depression
    By
    WebMD Health News
    Reviewed by Louise Chang, MD

    Nov. 20, 2007 -- The FDA has approved the antipsychotic drug Abilify for treatment of depression when used along with antidepressants.

    Abilify isn't a new drug; it was first approved five years ago.

    But it's the first drug approved by the FDA as an addition to antidepressants for adults with major depressive disorder, according to Otsuka Pharmaceutical Co. and Bristol-Myers Squibb.

    Abilify was discovered by Otsuka Pharmaceutical Company, which partners with Bristol-Myers Squibb to sell Abilify in the U.S. and Europe.

    In a news release, the drug companies report that the FDA's latest approval for Abilify was based on two studies that each lasted for six weeks.

    Together, the studies included 743 depressed adults whose depression hadn't lifted despite the fact that they were taking antidepressants.

    All of the patients kept taking antidepressants during the study. They also took Abilify or a placebo pill, without knowing which was which.

    Before-and-after surveys show that the patients taking Abilify got more depression relief than those taking the placebo.

    In those studies, Abilify's most common side effects were fidgeting, restlessness, insomnia, constipation, fatigue, and blurred vision.

    Earlier this month, the FDA approved Abilify to treat schizophrenia in teens aged 13-17. But Abilify isn't approved to treat depression in children.

    Today on WebMD

    contemplation
    Differences between feeling depressed and feeling blue.
    jk rowling
    Famous people who've struggled with persistent sadness.
     
    depressed man sitting on hallway floor
    Learn the truth about this serious illness.
    Sad woman looking out of the window
    Tips to stay the treatment course.
     
    unhappy teen boy
    Health Check
    jk rowling
    Slideshow
     
    Pills with smiley faces
    Article
    Teen girl huddled outside house
    Article
     
    Depressed man sitting in hospital hallway
    Article
    antidepressants slideshow
    Article
     
    pill bottle
    Article
    Winding path
    Article